• 대한한의학회지
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• 제36권4호
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• pp.80-103
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• 2015

Background: This study investigated current research trends in bee venom acupuncture in Korea. Materials and methods: The literature in Korea was reviewed using the search engines Science and Technology Society Village, Korean Studies Information Service System, National Discovery for Science Leaders, and Oriental Medicine Advanced Searching Integrated System. The keywords searched were "bee venom," "apitoxin," "apitherapy," and "bee sting." We selected 412 studies, which included Korean literary studies, experimental studies, and clinical studies. Results: We classified them by publication year, research type, disease and topic, and quality assessment. Among bee venom-related studies, clinical studies (235 studies) outnumbered experimental studies (149 studies) and literary studies (28 studies). Nineteen experimental studies concentrated on the theme of "anticancer." In the type analysis of clinical studies, lumbar disorders comprised 45 of 235 studies, followed by the effect on body. Forty-two randomized controlled trials (RCTs) have been published from 2003 to date (2015). Twenty-two studies used appropriate randomization methods. Fourteen studies had a Jadad score of 4-5 points; 15 studies, 1-3 points; and 13 studies, 0 points. Conclusions: Bee venom treatment is based on Korean traditional medicine theory. Numerous research studies suggest its effectiveness. Effort and academic approach on bee venom are expected to receive a positive evaluation.

• 한국임상수의학회지
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• 제15권2호
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• pp.247-250
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• 1998

This study was designed to examine therapeutic effect of honeybee venom on wound healing in tail-docked dog. Blood samples were taken of jugular vein and hematological values were analyzed in condition of pre,3- and 6-day after canine caudectomy. Apitherapy group was subcutaneously treated with an Italian honeybee(Apis mellifera ligustica). Antibiotic therapeutic group was intramuscularly iaiected with a standard dosage ol'penicluin ,G procaine(20,000 Units/kg of body weight). Changes of leucocyte, erynlrocytel hematocrit, platelet and fibrinogen were not significantly different between bee sting and penicillin injection during wound healing. No changes of wound healing in tine tests, groups were onseren. Whole honeybee venom has been shown to have a antiinflammatory effect in tail-docked dog. It may be concluded that honeybee venom is effective drug being useful far wound healing and disinfection without tissue trauma in dog.

• 한국응급구조학회지
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• 제17권1호
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• pp.63-78
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• 2013

Purpose : This study aimed to improve quality of prehospital emergency care for the insect bite patients by figuring out its current situations and problems. Methods : This study was conducted to 219 insect bite patients who were transferred to the hospital by 119 ambulance in D-City from July 1, 2009 to June 30, 2011. This study was a descriptive study by 119 run sheets. A total of 171 emergency medical technicians(EMTs) working in D-city and C-province completed the questionnaire. All of data were analyzed by SPSS 18.0. Results : Among the 219 patients, bee sting accounted for 62.6% and wasp sting accounted for 20.1%. Some patients complained of dizziness, headache, dyspnea, and disturbance of consciousness. The 119 EMTs initially treated the patients with oxygen supply to 57 patients (31.1%). Knowledge toward insect bite was statistically significant (p=.000) between advanced EMTs and basic EMTs. The obstacle to the prehospital care, many EMTs answered that the obstacle was due to the lack of 119 EMTs. Conclusion : It is necessary to differentiate the patients' symptoms and provide the better prehospital emergency care to verify the exact symptoms and signs.

• 동서간호학연구지
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• 제3권1호
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• pp.17-26
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• 1998

The purposes of this study were to identify the contents, frequency of use, and the rationales of folk remedies frequently used for first aid at home for stomachache, vomiting, strain, food poisoning, vaginal bleeding, or wounds of snake or dog bite, or bee sting. As the method of the study, data were collected by conducting a questionnaire of 185 persons, who filled it out or who were interviewed from May to August in 1998. The collected data was analyzed by using frequency and the rationales for the contents of the folk remedies were described base on literatures. The results were as follows,. 1. The folk remedies for stomachache in frequency order were 'warming the abdomen', 'rubbing the abdomen with a hand', or 'pricking a finger to bleed', which have the rationals. 2. The folk remedies for vomiting in frequency order are 'drinking water of watery radish' and 'pricking a finger to bleed', which have the rationales. 3. The folk remedies for strain in frequency order are 'soaking the affected area into cold water or applying an ice pack' and 'after soaking jasmine in water, making a dough with flour, and then attaching it on the affected area', which have the rationales, Additionally, although the frequencies are low, 'drinking brewed Achyranthis Radix' and 'applying brewed leaves and stalks of Sambuci Cortex' have the rationales. 4. The folk remedies for food poisoning in frequency order are 'drinking black beans and licorice brewed together' and 'eating mung beans', which have the scientific grounds. 5. The folk remedies for bloody discharge in frequency order are 'drinking brewed lotus root' and 'eating boiled chicken stuffed with root of bell-flower'. However, 'drinking brewed Thujae orientalis Folium' has the rationales. 6. The folk remedy for snake bite wounds that has the scientific grounds is 'sucking blood by a person without hurt in the mouth'. However, quite a lot of people apply alum or soy paste, which has no rationales. 7. The folk remedies for the bee sting in frequency order are 'after removing the sting, applying soy paste or sauce' and 'applying saliva'. No rationales for 'applying saliva' have been found. 8. The folk remedy for the dog bite wound that has the rationales is 'applying juice of leaves or stalks of Xanthii Fructus'. However, 85% of surveyed people use remedies that have no scientific grounds, such as 'applying burnt dog hair mixed with (sesame) oil' and 'applying soy paste or sauce'. Various materials are used in folk remedies for first aid treatment as shown above. Some of the folk remedies have the rationales since their medicinal actions have been found. However, the medicinal actions of the majority have not been found, but only known that they are effective, Especially for the materials except botanical drugs, they are used without knowing the effects since their components and pharmacognosies have not been described in any literature. The results of this research may be used for materials to educate the surveyed people or to consult them. Accordingly, the folk remedies that have the rationales are required to continue to study to find out the effects.

• Journal of Ecology and Environment
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• 제38권3호
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• pp.389-395
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• 2015

The composition of the Martes flavigula diet has been extensively studied, but little is known about its insect component. This study characterized the insect diet and insect nest materials in the feces of M. flavigula. A total of 952 fecal samples were collected in Jirisan National Park from January 2009 to November 2011, and 1379 species or taxonomic groups were identified. M. flavigula fed on insects (8.7%) and bee wax (5.0%), which comprised 2.9% and 4.4% of the dry weight of M. flavigula feces, respectively. A total of 12 insect species belonging to 8 families in 3 orders were identified. The most frequently found insects were Hymenoptera (frequency of occurrence, FO, 89.1), including Vespa simillima simillima (FO, 37.3) and Vespula koreensis koreensis (FO, 20.0). The Vespidae constituted the majority of the insect diet in autumn when the diversity of marten's prey was strongly reduced, probably because the numbers of social insects were sufficient for M. flavigula. In addition, the data suggest that M. flavigula attacks the nests of social wasps in late autumn when males do not have a venomous sting and new queens are less aggressive than workers. Bee wax appeared in all seasons and the highest rate was from spring to early summer. However, the remains of honeybees were not found in feces; thus, M. flavigula presumably eats honey but not honeybees.

• 한국임상수의학회지
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• 제24권4호
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• pp.499-502
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• 2007

본 연구는 전기충격 요법으로 얻은 한국산 건조봉독을 랫드의 포르말린 시험으로 항통각 효능을 관찰하였다. 실험동물로 수컷 Spraque-Dawley 랫드(평균 체중 265.38g, 6주령) 56마리를 각 군당 8마리씩 4개군으로 분류하였다. 봉독 투여군은 6 mg/kg 투여군과 0.6 mg/kg 투여군, 0.06 mg/kg 투여군으로 분류하였고, 대조군에는 생리식염수를 투여하였다. 건조 봉독은 포르말린을 투여하기 15분 전에 족삼리(ST-36)에 피하로 투여하였다. 통증은 1%포르말린 $50{\mu}l$을 랫드의 우측 뒷발바닥의 피하에 투여하여 유발하였다. 랫드가 포르말린을 투여한 후 우측 후지를 입으로 핥거나 깨무는 등의 행동을 포르말린 유발 통증행동으로 평가하였으며, 포르말린 투여 후 60분간 랫드의 통증 반응을 관찰하였다. 랫드의 통증반응은 첫 10분간은 5분 간격으로 관찰하였고, 10분 후부터 60분까지 10분 간격으로 관찰하였다. 한국산 건조 봉독은 봉독 투여 후 10분 이내에는 통증 억제 반응을 나타내지 않았으나, 봉독 투여 10분 후에 용량 의존적인 통증 억제 반응을 보였다. 이상의 결과에서 랫드의 포르말린 시험에서 한국산 건조봉독의 통증 억제 반응은 봉독량에 의존성을 보였고, 통증치료에 있어 다른 약물을 대체하여 사용될 수 있을 것으로 생각된다.

• 한국임상수의학회지
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• 제27권6호
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• pp.663-667
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• 2010

본 연구는 설치모델 동물에서 봉독의 항통각 효과를 평가하고, 한국산 봉독과 미국산 봉독의 항통각 효과를 비교하는 것이 주된 관심이다. 한국산 봉독은 특별히 고안된 봉독 추출기를 사용하여 일벌 (Apis mellifera L.)에 전기충격을 가하여 생봉독을 수집하였으며, 수집된 생봉독은 봉독 건조기를 이용하여 봉독을 건조하였다. 미국산 봉독은 미국 시그마회사에서 상업적으로 판매되는 건조 봉독을 이용하였다. 한국산 봉독과 미국산 건조봉독을 생리식염수에 희석하여 체중 kg당 6 mg과 0.6 mg, 0.06 mg을 마우스와 랫드에 피하로 투여하여 항진통 효과를 조사하였다. 항통각 효과는 한국산 봉독과 미국산 봉독은 서로 비슷하였으며, 봉독의 용량이 많을수록 항통각 효과가 크게 나타났다. 이상의 결과에서 한국산 건조 봉독은 통증 치료에 사용될 수 있을 것으로 생각된다.

• 한국임상수의학회지
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• 제24권3호
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• pp.320-324
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• 2007

본 연구에서는 마우스의 복부 신전시험을 통해 한국산 건조 봉독의 진통 효과를 평가하였다. 한국산 봉독은 특별히 고안된 봉독 추출기를 사용하여 일벌 (Apis mellifera L.)에 전기 충격을 가하여 생봉독을 수집하였으며, 수집된 생봉독은 봉독 건조기를 이용하여 봉독을 건조하였다. 실험 동물은 수컷 ICR 마우스 (체중 30-35 g, 6주령) 56마리를 각 군당 8마리씩 4개군으로 분류하였다. 건조 봉독은 6 mg/kg 투여군, 0.6 mg/kg 투여군, 0.6 mg/kg을 투여군 및 생리식염수를 투여한 대조군으로 각각 분류하였다. 한국산 건조 봉독은 마우스에 피하로 투여하였고, 봉독투여 30분후에는 0.9% 초산을 복강으로 투여하였다. 마우스의 복부의 신전 반사 횟수는 초산 투여 후 60분 동안 측정하였다. 초산 투여 후 3-9분에는 복부신전 반사를 보였고, 20분 후에는 가장 심한 복부신전 반사가 있었고 60분 후에는 반응이 거의 소실되었다. 한국산 건조 봉독의 복부 신전반응은 용량에 의존적으로 억제되었다. 이러한 결과에서 한국산 건조봉독은 통증치료에 있어 다른 약물을 대체하여 사용될 수 있을 것으로 생각된다.

• 한방재활의학과학회지
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• 제30권4호
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• pp.133-142
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• 2020

Objectives Studies on Chinese herbal injections are increasing. But, its safety are still not well reported. We have reviewed the literature related to the safety of Chinese herbal injection, especially those related to anaphylaxis. Methods The PubMed database was used to select the literatures related to anaphylaxis in China and to study the quality control and safety of Chinese herbal injection. Results Chinese herbal injection is a major traditional medical treatment in China, but it is the cause of adverse drug reactions including anaphylaxis. In order to solve this problem, various proposals have been made to identify the pharmacological and chemical causes of major side effects and to use them safely clinically. In addition, various researches have been conducted from preclinical to postmarketing surveillance to secure the safety of Chinese herbal injection. Based on this, it was found that various efforts are needed to secure the safety of bee sting needles. Conclusion In order to secure the safety of chinese herbal injections, it is necessary to identify the main mechanism of action and the pharmacological components contributing to it, and to develop a standardized formulation based on this. In addition, institutional pharmacovigilance is required.

• 한국컴퓨터정보학회논문지
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• 제24권8호
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• pp.123-129
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• 2019

This study selected all patients with acute poisoning carried by the 119 emergency services in K-Province from January 1 to December 31, 2015 for complete enumeration. The subjects were 1,627 patients who were classified as poisoning suspected in chemicals and animal/insect poisoning by Rescue Emergency Activity Information System(Emergency Statistics) in fire-fighting portal system of K-province fire-fighting officers. The 119 activity journals were analyzed retrospectively. The major results are as follows. Regarding the demographic characteristics of the elderly and the non-elderly, the most people were unemployed in the elderly group, other job, the non elderly group about their occupations and in both groups, the most people lived in rural areas about their living places. Regarding the poisoning characteristics of the elderly and the non-elderly, the most causing substance was bee sting about the poisoning causing substances and most of patients didn't get drunken about drunken state in both group. Regarding the time factors of the elderly and the non-elderly, both groups had the most accidents in afternoon about the poisoning time and in summer about the seasonal distribution.