• The Korean Journal of Physiology and Pharmacology
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• v.26 no.6
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• pp.469-478
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• 2022

WNT signaling plays an important role in cardiac development, but abnormal activity is often associated with cardiac hypertrophy, myocardial infarction, remodeling, and heart failure. The effect of WNT signaling on regulation of atrial natriuretic peptide (ANP) secretion is unclear. Therefore, the purpose of this study was to investigate the effect of Wnt agonist 1 (Wnta1) on ANP secretion and mechanical dynamics in beating rat atria. Wnta1 treatment significantly increased atrial ANP secretion and pulse pressure; these effects were blocked by U73122, an antagonist of phospholipase C. U73122 also abolished the effects of Wnta1-mediated upregulation of protein kinase C (PKC) β and γ expression, and the PKC antagonist Go 6983 eliminated Wnta1-induced secretion of ANP. In addition, Wnta1 upregulated levels of phospho-transforming growth factor-β activated kinase 1 (p-TAK1), TAK1 banding 1 (TAB1) and phospho-activating transcription factor 2 (p-ATF2); these effects were blocked by both U73122 and Go 6983. Wnta1-induced ATF2 was abrogated by inhibition of TAK1. Furthermore, Wnta1 upregulated the expression of T cell factor (TCF) 3, TCF4, and lymphoid enhancer factor 1 (LEF1), and these effects were blocked by U73122 and Go 6983. Tak1 inhibition abolished the Wnta1-induced expression of TCF3, TCF4, and LEF1 and Wnta1-mediated ANP secretion and changes in mechanical dynamics. These results suggest that Wnta1 increased the secretion of ANP and mechanical dynamics in beating rat atria by activation of PKC-TAK1-ATF2-TCF3/LEF1 and TCF4/LEF1 signaling mainly via the WNT/Ca²⁺ pathway. It is also suggested that WNT-ANP signaling is implicated in cardiac physiology and pathophysiology.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.50 no.11
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• pp.783-789
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• 2022

In a recent study, it was observed that the combustion gas entering the post chamber of a hybrid rocket contains vortices with very small size and high frequency characteristics. In addition, it was observed that small vortices collided with the nozzle wall to create a counter-flow, resulting in additional combustion with ignition delay. This study investigated the physical relationship between ignition delay induced by the counter-flow and the formation of beating pressure. To do this, a newly modified model was proposed by including ignition delay in the existing energy kicked oscillator model proposed by Culick. Numerical results show that the ignition delay is an important factor in determining the occurrence of the combustion pressure beats through the periodic formation of thermoacoustic coupling. In addition, when the ignition delay was reduced by increasing the post chamber length, the phase difference between the energy kick and the pressure generation was increased, the periodic pressure beats did not occur at all.

• The Journal of the Acoustical Society of Korea
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• v.25 no.8
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• pp.362-369
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• 2006

In this paper, we improve a Physical modeling of sanio gayageum and synthesize sounds by right-hand playing styles. Parameters of loop filter are estimated from decay region of recorded sound. That results in improved accuracy and reduction of computational costs. Body is implemented to a resonator which has characteristics of main resonances extracted from impulse response. Residual signal with main resonances removed is used as excitation signal of proposed model. Amok alter is approximated to frequency response of amok and is implemented to the 15th order all-role digital filter. Beating (by middle and index finger) among the right-hand playing styles is represented by feedforward comb filter. Parameters of this filter are extracted from recorded sound. The synthesized sounds using improved physical model of sanjo gayageum. plucking and beating, are pretty similar to original sounds.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2000.06a
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• pp.263-268
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• 2000

In this paper, a new indirect feedback active noise control (ANC) scheme based on the fundamental frequency estimation is proposed for systems with a harmonic noise. When reference signals necessary for feedforward ANC configuration is difficult to obtain, the conventional ANC algorithms for multi-tonal noise do not measure the reference signals but generate them with the estimated frequencies. However, the beating phenomena, in which certain frequency components of the noise vanish intermittently, may make the adaptive frequency estimation difficult. The confusion in the estimated frequencies due to the beating phenomena makes the generated reference signals worthless. The proposed algorithm consists of two parts. The first part is a reference generator using the fundamental frequency estimation and the second one is the conventional feedforward control. We propose the fundamental frequency estimation algorithm using decision rules, which is insensitive to the beating phenomena. In addition, the proposed fundamental frequency estimation algorithm has good tracking capability and lower variance of frequency estimation error than that of the conventional cascade ANF method. We are also able to control all interested modes of the noise, even which cannot be estimated by the conventional frequency estimation method because of the poor SIN ratio. We verify the performance of the proposed ANC method through simulations for the measured cabin noise of a passenger ship and the measured time-varying engine booming noise of a passenger vehicle.

• Proceedings of the Optical Society of Korea Conference
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• 2004.02a
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• pp.152-153
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• 2004

• Proceedings of the KSR Conference
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• 2006.05b
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• pp.380-387
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• 2006

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.45 no.1
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• pp.6-12
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• 2013

TFormic acid-hydrogen peroxide (or performic acid) pulping process needs milder reaction condition than other chemical pulping process. Two-step formic acid-hydrogen peroxide pulping process can produce the chemical pulp with similar pulp yield and lignin content compared with soda-anthraquinone process. Formic acid-hydrogen peroxide pulp can be produced less xylan content than other alkaline pulps, which favor for dissolving pulp production. Formic acid-hydrogen peroxide pulp showed better response beating than soda-anthraquinone(AQ) pulps with reaching target freeness with less beating. Also, formic acid-hydrogen peroxide pulp had better tensile index at similar freeness level compared with soda-AQ pulps.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.45 no.5
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• pp.56-63
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• 2013

In this study, paper mill applicability of two kinds of cotton pulps which have different initial freeness, fiber length and intrinsic fiber strength were investigated. Basic properties such as CED viscosity, fiber length, and crystallinity of major two kinds of cotton pulps were analyzed, and beatability of cotton pulps and physical properties of handsheet made from two kinds of cotton pulps were compared. Laboratory beating was performed at different refining conditions such as refining loads and freenesses. Relationship between beating degree and physical properties of handsheet were compared to seek optimum condition of refining for different cotton pulps application to paper mill.

• Journal of Chest Surgery
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• v.32 no.5
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• pp.480-483
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• 1999

The widely accepted method for coronary artery bypass grafting(CABG) is performing the distal coronary artery anastomoses on the flaccid and nonbeating heart with the aid of cardiopulmonary bypass(CPB) and cardioplegic arrest. However, current cardioplegic techniques are not consistent in avoiding myocardial ischemic damages especially in high risk patients undergoing CABG. In this regard, "Off-Pump" seems to be an ideal method for preventing myocardial ischemic damage and adverse effects during CPB. However, "Off-pump" CABG is not always technically feasible. We report 2 cases of "On-pump" CABG performed on the beating heart in high risk patients; The first patient had left ventricular dysfunction(Ejection Fraction=25%), and the second patient had cardiogenic shock after percutaneous transluminal coronary angioplasty.

• Journal of Chest Surgery
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• v.37 no.6
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• pp.543-545
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• 2004

Postinfarction ventricular septal defect often induces cardiogenic shock and requires operative treatment early after myocardial infarction. Although the operative mortality of this disease has decreased during the past 3 decades, it is still relatively high. In this case, to prevent global myocardial ischemia, we used the technique of repair of postinfarction ventricular septal defect on a beating heart. This approach does not requir aortic cross-clamping and provides superior myocardial protection.