• KSBB Journal
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• 제14권3호
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• pp.284-290
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• 1999

우수한 셀룰로오스 생산 균주인 Acetobacter xylinum BRC5의 교반배양에 의한 셀룰로오스 생산성을 향상시키기 위하여 fed-batch 배양을 하였으며, 기질공급속도, 기질 공급량 및 용존 산소의 영향을 검토하였다. 초기 glucose 양을 변화시켜 회분배양하였을 때 glucose 농도가 10 및 20 g/L인 경우 셀룰로오스 생산량은 각각 2.05와 4.10 g/L이였으며 glucose에 대한 셀룰로오스 수율 (Yp/s)은 0.21이었다. 초기 glucose 농도 40g/L일 때 셀룰로오스 수율을 향상시키기 위해서 초기 glucose 농도 20 g/L에서 회분배양을 시작하여 glucose가 gluconic acid로 완전히 전환된 시점부터 추가적으로 glucose를 공급하여 fed-batch 배양기간에 glucose 공급속도는 셀룰로오스 생산성에 큰 영향을 미쳐 20g/L의 glucose를 2.22 g/L.h의 속도로 9시간 첨가하여 fed-batch 배양한 결과 셀룰로오스 생성량이 10 g/L로 가장 우수하여 초기 glucose 농도 20 g/L로 회분배양하였을 때 비하여 약 2배 증가하였으며, $Y_{P/S}$도 0.26으로 현저히 향상되었다. 또한 동일조건으로 fed-batch 배양하면서 glucose 공급량을 증가시켜 40g/L의 glucose를 추가적으로 첨가한 경우 셀룰로오스 생산량은 10.7g/L는 거의 증가되지 않았으며, $Y_{P/S}$가 0.18로 감소하였다. 이는 셀룰로오스 농도가 증가함에 따라 산소 공급이 부족하기 때문이므로 용존산소(DOT)를 2~15% 포화범위에서 조절하여 fed-batch 배양했을 때 DOT를 10% 수준으로 유지하면서 fed-batch 배양기간에 40g/L의 glucose를 추가공급 했을 때 셀룰로오스 생성량은 15.3 g/L로 증가되었고 이때 $Y_{P/S}$는 0.26로 향상되었다. 이는 DO를 제어하지 않는 경우에 비하여 셀룰로오스 생성량이 1.5배 증가한 결과이다.

• 한국산업경영시스템학회:학술대회논문집
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• 한국산업경영시스템학회 2002년도 춘계학술대회
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• pp.387-396
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• 2002

Batch processes are a significant class of processes in the process industry and play an important role in the production of high quality speciality materials. Examples include the production of semiconductors, chemicals, pharmaceuticals, and biochemicals. With on-line sensors connected to most batch processes, massive amounts of data are being collected routinely during the batch on easily measured process variables such as temperatures, pressures, and flowrates. In this paper, multivariate SPC charts for on-line monitoring of the progress of new batches are developed which utilize the information in the on-line measurements in real-time. We propose the formation of statistical model which describes the normal operation of a batch at each time interval during the batch operation. An on-line monitoring scheme based on the proposed method can handle both cross-correlation among process variables at any one time and auto-correlation over time. And the control limits for the monitoring charts are established from sound statistical framework unlike previous researches which use the external reference distribution. The proposed charts perform real-time, on-line monitoring to ensure that the batch is progressing in a manner that will lead to a high-quality product or to detect and indicate faults that can be corrected prior to completion of the batch. This approach is capable of tracking the progress of new batch runs, identifying the time periods in which the fault occurred and detecting underlying cause.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2008년도 한국우주과학회보 제17권2호
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• pp.34.2-34.2
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• 2008

The batch least square filter is widely used for ground estimations. However, in orbit determination (OD) under inaccurate initial conditions and few measurement data the performance by the batch least square filter can lead an unstable results. To complement weak part of the batch filter, the batch unscented transformation without any linearization process is developed by ACL (Astrodynamics and Control Laboratory) in YONSEI University. In this paper, the batch unscented transformation is introduced and applied to satellite orbit determination using Satellite Laser Ranging (SLR) data. Only range of the satellite measured from ground tracking stations is used for measurement data. The results of simulation test are compared with those of the weighted batch least square filter for various initial states errors (position and velocity). Simulation results show that the batch unscented transformation is comparable or slightly superior to batch least square filter in the orbit determination.

• 한국건축시공학회지
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• 제13권6호
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• pp.565-578
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• 2013

Batch production is common in repetitive construction projects, and it is not unusual for different batch sizes to be used by contractors in one project. While several scheduling methods, such as the Linear Scheduling Method (LSM) and the Repetitive Scheduling Method (RSM) have been proposed and used, no mathematical method for repetitive construction projects has been developed, and it is difficult to consider different batch sizes with the existing methods. An original mathematical algorithm for scheduling repetitive projects with different batch sizes is proposed in this study. This algorithm is illustrated with assumptions of resource continuity and single path in a project and introduces new terms, control batch and critical batch. The algorithm logics and mathematical equations are validated by comparison with the outcomes from a graphical scheduling approach through a simple and practical hypothetic project. As a result, it is expected that the proposed algorithm can be easily adapted and extended to computer software for scheduling, and can be a starting point for research on batch size management in repetitive construction projects.

• 대한산업공학회지
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• 제33권2호
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• pp.246-253
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• 2007

All of the machines in a production line can be classified into bottleneck and non-bottleneck machines. A bottleneck is a resource whose capacity limits the throughput of the whole production facility. This paper addresses a batch sizing problem at the bottleneck machine. Traditionally, most batch sizing decisions have been made based on the EOQ (economic order quantity) model where setup and inventory costs are considered while throughput rate is assumed to be given. However, since batch size affects the capacity of the bottleneck machine, the throughput rate may not be constant. As the batch size increases, the frequency of the setup decreases. The saved setup time can be transferred to processing time, which results in higher throughput. But, the larger batch size may also result in longer lead time and larger WIP inventory level. This paper presents an alternative method to determine batch size at the bottleneck machine in a manufacturing line. A linear search algorithm is introduced to find optimal throughput rate and batch size at the same time. Numerical examples are provided to see how the proposed method works and to investigate the effects of some parameters.

• Biotechnology and Bioprocess Engineering:BBE
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• 제5권5호
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• pp.340-344
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• 2000

Microbial oxidation of D-sorbitol to L-sorbose by Acetobacter suboxydans is of commercial importance since it is the only biochemical process in vitamin C synthesis. The main bottleneck in the batch oxidation of sorbitol to sorbose is that the process is severely inhibited by sorbitol. Suitable fed-batch fermentation designs can eliminate the inherent substrate inhibition and improve sorbose productivity. Fed-batch sorbose fermentations were conducted by using two nutrient feeding strategies. For fed-batch fermentation with pulse feeding, highly concentrated sorbitor (600g/L) along with other nutrients were fed intermittently in four pulses of 0.5 liter in response to the increased DO signal. The fed-batch fermentation was over in 24h with a sorbose productivity of 13.40g/L/h and a final sorbose concentration of 320.48g/L. On the other hand, in fed-batch fermentation with multiple feeds, two pulse feeds of 0.5 liter nutrient medium containing 600g/L sorbitol was followed by the addition of 1.5 liter nutrient medium containing 600g/L sorbitol at a constant feed rate of 0.36L/h till the full working capacity of the reactor. The fermentation was completed in 24h with an enhanced sorbose productivity of 15.09g/L/h and a sorbose concentration of 332.60g/L. The sorbose concentration and productivity obtained by multiple feeding of nutrients was found to be higher than that obtained by pulse feeding and was therefore a better strategy for fed-batch sorbose fermentation.

• 제어로봇시스템학회논문지
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• 제18권3호
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• pp.285-294
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• 2012

Using bearing measurement only, target motion state is not directly obtained so that TMA (Target Motion Analysis) is needed for this situation. TMA is a nonlinear estimation technique used in passive SONAR systems. Also it is the one of important techniques for underwater combat management systems. TMA can be divided to two parts: batch estimation and sequential estimation. It is preferable to use sequential estimation for reducing computational load as well as adaptively to target maneuvers, batch estimation is still required to attain target initial state vector for convergence of sequential estimation. Selection of batch time interval which depends on observability is critical in TMA performance. Batch estimation in general utilizes predetermined batch time interval. In this paper, we propose a new method called the BTIS (Batch Time Interval and Initial State Estimation). The proposed BTIS estimates target initial status and determines the batch time interval sequentially by using a bank of GMM-TS (Gaussian Mixture Measurement-Track Splitting) filters. The performance of the proposal method is verified by a Monte Carlo simulation study.

• Journal of Microbiology and Biotechnology
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• 제8권3호
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• pp.203-207
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• 1998

Fed-batch fermentations with different feeding media were carried out in order to increase the productivity of invertase expression using a recombinant Saccharomyces cerevisiae containing plasmid pRB58. Two batch cultures showed the expression of the SUC2 gene at a low concentration of glucose, suggesting that glucose concentration could be used as a control variable in a fed-batch operation mode. In the fed-batch culture by feeding the basal medium, cell mass and specific invertase activity did not increase much as compared with the simple batch culture. A series of fed-batch cultures revealed that the sucrose-supplemented medium increased cell mass whereas the enriched medium did specific invertase activity. To capitalize on the synergism of the sucrose-supplemented medium and the enriched medium, the sucrose-supplemented enriched medium was used as a feeding medium. The fed-batch culture using this medium resulted in a 2.4-fold increase in cell mass and a 1.9-fold enhancement in specific invertase activity compared with those of the batch culture. The increase in cell mass and specific invertase activity led to a marked increase in total invertase activity, 250U/ml, which was 6.3 times higher than that of the batch culture.

• 정보보호학회논문지
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• 제20권1호
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• pp.17-31
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• 2010

VANET(Vehicular Ad hoc NETwork)에서 차량들은 일괄 확인(batch verification) 기법을 이용해 많은 수의 서명 메시지를 효율적으로 검증할 수 있다. 하지만 각 차량에서의 개별적인 일괄 확인은 네트워크 전체적으로 볼 때 불필요한 중복 검증을 발생시킨다. 이 문제를 해결하기 위해 RSU(Road Side Unit)가 노드를 대신해서 일괄 확인을 수행 할 수 있지만, 이 방법은 일괄 확인이 실패했을 경우 유효하지 않은 서명을 효율적으로 찾을 수 있는 방법이 추가적으로 필요하다. 본 논문에서는 분산 일괄 확인 시스템을 설계하기 위해 고려되어야하는 몇 가지 방법론에 대해서 분석하고 참여 차량이 작은 크기의 서명 집합을 분산해서 일괄 확인하는 효율적인 분산 일괄 확인 시스템을 제안한다. 제안하는 시스템에서 각 노드는 RSU에게 단순 일괄 확인 결과만을 보고하거나 식별한 유효하지 않은 서명들을 보고할 수 있으며 이를 수신한 RSU는 노드의 이 일괄 검증 결과 리포트를 이용하여 효율적으로 유효하지 않은 서명을 식별하여 배제할 수 있다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.1826-1829
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• 2003

Fine chemical production must assure high-standard product quality as well as characterized as multi-product production in small volumes. Installing high-precision batch distillation is one of the common elements in the successful manufacturing of fine chemicals, and the importance of the process operation strategy with quality assurance cannot be overemphasized. In this study, we investigate the optimal operation strategy and production planning of a sequential multi-purpose plants consisting of batch processes and batch distillation with unlimited intermediate storage. We formulated this problem as an MILP model. A mixed-integer linear programming model is developed based on the time slot, which is used to determine the production sequence and the production path of each batch. Illustrative examples show the effectiveness of the approach.