• Journal of Ginseng Research
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• 제48권4호
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• pp.395-404
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• 2024

Background: Ginsenoside Rg₁ (Rg₁) is one of the main active components in Chinese medicines, Panax ginseng and Panax notoginseng. Research has shown that Rg₁ has a protective effect on the cardiovascular system, including anti-myocardial ischemia-reperfusion injury, anti-apoptosis, and promotion of myocardial angiogenesis, suggesting it a potential cardiovascular agent. However, the protective mechanism involved is still not fully understood. Methods: Based on network pharmacology, ligand-based protein docking, proteomics, Western blot, protein recombination and spectroscopic analysis (UV-Vis and fluorescence spectra) techniques, potential targets and pathways for Rg₁ against myocardial ischemia (MI) were screened and explored. Results: An important target set containing 19 proteins was constructed. Two target proteins with more favorable binding activity for Rg₁ against MI were further identified by molecular docking, including mitogen-activated protein kinase 1 (MAPK1) and adenosine kinase (ADK). Meanwhile, Rg₁ intervention on H9c2 cells injured by H₂O₂ showed an inhibitory oxidative phosphorylation (OXPHOS) pathway. The inhibition of Rg₁ on MAPK1 and OXPHOS pathway was confirmed by Western blot assay. By protein recombination and spectroscopic analysis, the binding reaction between ADK and Rg₁ was also evaluated. Conclusion: Rg₁ can effectively alleviate cardiomyocytes oxidative stress injury via targeting MAPK1 and ADK, and inhibiting oxidative phosphorylation (OXPHOS) pathway. The present study provides scientific basis for the clinical application of the natural active ingredient, Rg₁, and also gives rise to a methodological reference to the searching of action targets and pathways of other natural active ingredients.

• 한국환경기술학회지
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• 제19권6호
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• pp.503-513
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• 2018

영산강 수계의 오염총량관리 이행사항 평가 및 원활한 제도 운영을 위해 단위유역 내 행정구역경계에 해당되는 소하천에 대해 지속적으로 시행하는 있는 모니터링 자료를 토대로 특성을 분석하였다. 모니터링 해당기간(2011~2016년) 내 모니터링은 1분기에 비해 2분기 측정 횟수가 많아 목표수질 설정 및 평가 시 측정횟수 등을 고려해야 하며, 일반적 하천처럼 상류지역 보다 하류지역의 하천이 수질이 악화되어 있는 것으로 분석되었다. 더불어 모니터링 지점의 오염부하량을 산정한 결과 풍영정천, 삼포천 등에서 수질이 매우 악화되어 있는 것으로 분석되었다. 이는 유량 및 BOD, T-P의 농도가 높아 영산강 본류의 수질에 미치는 영향이 크므로 수질개선을 위해서는 각종 오염원의 관리가 필요한 것으로 분석되었다. 또한, 목표수질 대상항목인 BOD 및 T-P의 측정항목간의 연관성을 평가하기 위해 지점별로 상관분석을 한 결과 BOD는 COD, TOC와 연관성이 높게 나타나 유기물과 관련된 오염원의 배출에 의한 영향을 받는 것으로, T-P는 SS, COD와의 연관성이 높게 나타나 강우에 의한 유입의 영향을 받는 것으로 나타났다. 본 연구에서의 장기간 모니터링을 수행하여 축적된 수질자료를 분석하고 특성을 파악함으로써 해당수계의 수질관리에 효율적이고 과학적인 방안을 설계함에 있어 기초자료 및 방향을 제시할 수 있을 것으로 판단된다.

• Journal of Acupuncture Research
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• 제27권3호
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• pp.147-157
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• 2010

Objectives : The purpose of this study was to propose appropriate strategic directions and road maps for successful achievement of programs preventing winter disease in the summer. Methods : Details on programs preventing winter disease in the summer such as clear concept, theoretical basis, current status, intervention or available prescriptions and indication/contraindication/caution were prepared through the related journal review, upon which an observational study was devised and done for simulation to find out even a trivial problem and to guarantee the safety beforehand. The experimental group was divided into 5 groups by the size of pill and the way ginger is treated; 1cm pill with ginger group, 3cm pill group without ginger, 3cm pill group dipped into ginger, 3cm pill group applying ginger to acupoints and 3cm pill group with ginger Results 1. program preventing winter disease in the summer was defined as representative winter diseases such as common cold, influenza, chronic asthma, chronic bronchitis, allergic rhinitis, emphysema, chronic gastritis and rheumatoid arthritis, and preventive care in the summer, reinforcing deficient yang qi of five viscera by using exuberant yang qi from summer heat. 2. It was based upon historically established theories which is 'nourishing yang qi in the spring and summer', 'long summer, namely rainy spell in the summer overwhelms the winter, because of earth winning water according to the five phases theory' and 'To replenish yang qi is major principle to treat winter diseases, which can be most appropriately and timely applied to the patient with deficient yang qi of five viscera inherently, especially in the three dog days of the summer, because of exuberant exterior yang qi and deficient interior yang qi in the five viscera'. 3. In the adjacent China and Taiwan, acupoint applying method in the three dog days named 'San Fu Tie' have been stirring a boom throughout the nation, in which Xiaochuan Gao was used as a basic prescription and it mainly was applied at bilateral $BL_{13}$, $_{15}$ and $_{17}$ for about 4 hours. As far as domestic current status, the necessity of adopting the above method prior to Herbal formula was also recognised, because not a few koreans have apprehension for the safety of it including medicinal herbs and are reluctant to take it any more due to negative advertisement of narrow minded doctors' association. 4. Indication of acupoint applying method in the three dog days included most of winter diseases such as common cold, influenza, chronic asthma, chronic bronchitis, allergic rhinitis, emphysema, chronic gastritis. contraindication was pregnant woman and the weak such as infants and the old. More attention was paid to grasp firmly the normal reaction following the treatment for preventing side effect and teasing blister. recommendation was also given to abstain from food inducing phlegm and dampness such as meat, shrimp and crab as well as cold drinks and foods 5. In the simulation observational study based upon the above findings following review the related articles, no blister was shown on the acupoints icluding bilateral $BL_{13}$, $_{15}$ and $_{17}$ in every experimental group during 24hr observation following the acupoint applying treatment with pills made by modified and devised prescription. At 4 hr, the effectiveness of it reached a peak showing redness and mild tenderness and there is little difference between groups 3cm pills groups regardless of the way ginger was treated. abdominal distention and growling was found in all the volunteers during the treatment at CV 8. Strategic directions and road maps : Through successful fulfillment of the program preventing winter disease in the summer, Korean traditional medicine should be integrated into mainstream national health care services. Cultural access was thought to be as important as Scientific EBM approach. First of all, To evoke potential cultural homogeneity from campaigns and press advertisement was needed for promoting public awareness about preventing winter disease in the summer by enhancing immunity via acupoint applying treatment in the three dog days, and then indigenous name as Sambokcheop, protocol, Clinical Research Form for data collection of it should be developed and prepared. Once the first step was taken this summer, through a thorough data collection and scrutinized scientific evaluation, drawbacks should be compensted for and the efficacy and safety should be substantiated.

• 대한간호학회지
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• 제4권2호
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• pp.1-16
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• 1974

This Study involved the development of a survey form and the collection of data in an effort-to provide information which can be used in the improvement of nursing curricula. The data examined were the kinds courses currently being taught in the curricula of nursing education institutions throughout Korea, credits required for course completion, and year in-which courses are taken. For the purposes of this study, curricula were classified into college, nursing school and vocational school categories. Courses were directed into the 3 major categories of general education courses, supporting science courses and professional education course, and further subdirector as. follows: 1) General education (following the classification of Philip H. phoenix): a) Symbolics, b) Empirics, c) Aesthetics. 4) Synthetics, e) Ethics, f) Synoptic. 2) Supporting science: a) physical science, b) biological science, c) social science, d) behavioral science, e) Health science, f) Educations 3) Professional Education; a) basic courses, b) courses in each of the respective fields of nursing. Ⅰ. General Education aimed at developing the individual as a person and as a member of society is relatively strong in college curricula compared with the other two. a) Courses included in the category of symbolics included Korean language, English, German. Chines. Mathematics. Statics: Economics and Computer most college curricula included 20 credits. of courses in this sub-category, while nursing schools required 12 credits and vocational school 10 units. English ordinarily receives particularly heavy emphasis. b) Research methodology, Domestic affair and women & courtney was included under the category of empirics in the college curricula, nursing and vocational school do not offer this at all. c) Courses classified under aesthetics were physical education, drill, music, recreation and fine arts. Most college curricula had 4 credits in these areas, nursing school provided for 2 credits, and most vocational schools offered 10 units. d) Synoptic included leadership, interpersonal relationship, and communications, Most schools did not offer courses of this nature. e) The category of ethics included citizenship. 2 credits are provided in college curricula, while vocational schools require 4 units. Nursing schools do not offer these courses. f) Courses included under synoptic were Korean history, cultural history, philosophy, Logics, and religion. Most college curricular 5 credits in these areas, nursing schools 4 credits. and vocational schools 2 units. g) Only physical education was given every Year in college curricula and only English was given in nursing schools and vocational schools in every of the curriculum. Most of the other courses were given during the first year of the curriculum. Ⅱ. Supporting science courses are fundamental to the practice and application of nursing theory. a) Physical science course include physics, chemistry and natural science. most colleges and nursing schools provided for 2 credits of physical science courses in their curricula, while most vocational schools did not offer t me. b) Courses included under biological science were anatomy, physiologic, biology and biochemistry. Most college curricula provided for 15 credits of biological science, nursing schools for the most part provided for 11 credits, and most vocational schools provided for 8 units. c) Courses included under social science were sociology and anthropology. Most colleges provided for 1 credit in courses of this category, which most nursing schools provided for 2 creates Most vocational school did not provide courses of this type. d) Courses included under behavioral science were general and clinical psychology, developmental psychology. mental hygiene and guidance. Most schools did not provide for these courses. e) Courses included under health science included pharmacy and pharmacology, microbiology, pathology, nutrition and dietetics, parasitology, and Chinese medicine. Most college curricula provided for 11 credits, while most nursing schools provide for 12 credits, most part provided 20 units of medical courses. f) Courses included under education included educational psychology, principles of education, philosophy of education, history of education, social education, educational evaluation, educational curricula, class management, guidance techniques and school & community. Host college softer 3 credits in courses in this category, while nursing schools provide 8 credits and vocational schools provide for 6 units, 50% of the colleges prepare these students to qualify as regular teachers of the second level, while 91% of the nursing schools and 60% of the vocational schools prepare their of the vocational schools prepare their students to qualify as school nurse. g) The majority of colleges start supporting science courses in the first year and complete them by the second year. Nursing schools and vocational schools usually complete them in the first year. Ⅲ. Professional Education courses are designed to develop professional nursing knowledge, attitudes and skills in the students. a) Basic courses include social nursing, nursing ethics, history of nursing professional control, nursing administration, social medicine, social welfare, introductory nursing, advanced nursing, medical regulations, efficient nursing, nursing english and basic nursing, College curricula devoted 13 credits to these subjects, nursing schools 14 credits, and vocational schools 26 units indicating a severe difference in the scope of education provided. b) There was noticeable tendency for the colleges to take a unified approach to the branches of nursing. 60% of the schools had courses in public health nursing, 80% in pediatric nursing, 60% in obstetric nursing, 90% in psychiatric nursing and 80% in medical-surgical nursing. The greatest number of schools provided 48 crudites in all of these fields combined. in most of the nursing schools, 52 credits were provided for courses divided according to disease. in the vocational schools, unified courses are provided in public health nursing, child nursing, maternal nursing, psychiatric nursing and adult nursing. In addition, one unit is provided for one hour a week of practice. The total number of units provided in the greatest number of vocational schools is thus Ⅲ units double the number provided in nursing schools and colleges. c) In th leges, the second year is devoted mainly to basic nursing courses, while the third and fourth years are used for advanced nursing courses. In nursing schools and vocational schools, the first year deals primarily with basic nursing and the second and third years are used to cover advanced nursing courses. The study yielded the following conclusions. 1. Instructional goals should be established for each courses in line with the idea of nursing, and curriculum improvements should be made accordingly. 2. Course that fall under the synthetics category should be strengthened and ways should be sought to develop the ability to cooperate with those who work for human welfare and health. 3. The ability to solve problems on the basis of scientific principles and knowledge and understanding of man society should be fostered through a strengthening of courses dealing with physical sciences, social sciences and behavioral sciences and redistribution of courses emphasizing biological and health sciences. 4. There should be more balanced curricula with less emphasis on courses in the major There is a need to establish courses necessary for the individual nurse by doing away with courses centered around specific diseases and combining them in unified courses. In addition it is possible to develop skill in dealing with people by using the social setting in comprehensive training. The most efficient ratio of the study experience should be studied to provide more effective, interesting education Elective course should be initiated to insure a man flexible, responsive educational program. 5. The curriculum stipulated in the education law should be examined.

• 한국항공우주학회지
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• 제48권6호
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• pp.455-466
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• 2020

본 연구에서는 다수의 우주 환경 관측용 탑재체를 장착한 6U급 초소형위성에 대한 열모델을 구축하여 이를 기반으로 수행된 열설계에 대해 기술하였으며, 궤도 열해석을 통해 적용된 열설계의 유효성을 입증하였다. 초소형위성의 특성을 고려하여 표면 처리 및 절연체, 열전도체 등의 수동 열제어 기법 위주로 열설계를 진행하였지만, 배터리 및 추력기 등과 같이 작동 온도의 범위가 좁고 궤도 열환경에 직접적으로 노출되는 부품들에 대해서는 능동 열제어 기법 중 하나인 히터를 적용하였다. 궤도 열해석 조건은 기본적으로 위성의 궤도 조건을 바탕으로 하며, 임무 시나리오에 따른 발열량 및 위성의 자세에 따라 임무 모드, 초기 운용 모드, 비상운용 모드, 편대 비행 모드로 분류하여 궤도 열해석을 수행하였다. 각 모드 별 해석 결과를 통해 모든 부품들이 작동 온도 조건을 만족하는 것을 확인하였고, 비상운용 모드의 해석 결과를 통해 배터리 및 추력기의 히터 용량과 작동 주기를 산출하였다.

• 생명과학회지
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• 제30권9호
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• pp.813-818
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• 2020

고세균 유전체들 사이의 공통적 유전자를 파악하는 archaeal clusters of orthologous genes (arCOG) 알고리즘으로, 168 균주의 고세균들에 공통적인 보존적 유전자를 파악하고자 하였다. 보존된 ortholog의 수는 168, 167, 166 및 165 균주에서 각각 14, 10, 9 및 8개였다. 이들 41개의 arCOG 중에서 번역, 리보솜 구성 및 생합성에 관련된 arCOG가 13개로 가장 많았고 DNA의 복제와 재조합 및 수복에 관련된 arCOG가 10개로 다음으로 많았다. 168개의 고세균 균주들에 보존적인 14개의 arCOG들은 tRNA synthetase가 6개로 가장 많았다. 리보솜과 반응, tRNA 합성, DNA 복제, 전사와 관련한 arCOG가 각 2개씩으로 고세균에서 단백질 발현의 중요성을 알 수 있었다. 보존적 arCOG 구성원들의 distance value의 평균으로 3개 이상의 구성원을 가지는 강(class)과 목(order) 수준에서 유전체를 분석한 결과, Euryarchaeota 문의 Archaeoglobi 강과 Thermoplasmata 강이 각각 최저치와 최고치를 나타내었다. 본 연구는 기초과학 연구와 함께 항균제 개발 및 종양 제어 등에 필요한 자료를 제공할 수 있을 것이다.

• 유통과학연구
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• 제11권8호
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• pp.5-14
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• 2013

Purpose - We live in a world of constant change and competition. Many airports have specific competitiveness goals and strategies for achieving and maintaining them. The global economic recession, financial crises, and rising oil prices have resulted in an increasingly important role for facility investment and renewal and the implementation of appropriate policies in ensuring the competitive advantage for airports. It is thus important to analyze the factors that enhance efficiency and productivity for an airport. This study aims to determine the efficiency levels of 20 major airports in East Asia, Europe, and North America. Further, this study also suggests suitable policies and strategies for their development. Research design, data, and methodology - This paper employs the DEA-CCR, DEA-BCC, and DEA-Malmquist production index analysis models to determine airport efficiency. The study uses data on the efficiency and productivity of the world's leading airports between 2006 and 2010. The input variables include the airport size, the number of runways, the size of passenger terminals, and the size of cargo terminals. The output variables include the annual number of passengers and the annual cargo volume. The study uses basic data from the 2010 World Airport Traffic Report (ACI). The world's top 20 airports (as rated by the ACI report) are investigated. The study uses the expanded DEA Model and the Super Efficiency Model to identify the most effective airports among the top 20. The Malmquist productivity index analysis is used to measure airport effectiveness. Results - This study analyzes longitudinal and cross-sectional data on the world's top 20 airports covering 2006 to 2010. A CCR analysis shows that the most efficient airports in 2010 were Gatwick Airport (LGW), Zurich Airport (ZRH), Vienna Airport (VIE), Leonardo da Vinci Fiumicino Airport (FCO), Los Angeles International Airport (LAX), Seattle-Tacoma Airport (SEA), San Francisco Airport (SFO), HongKong Airport (HKG), Beijing Capital International Airport (PEK), and Shanghai Pudong Airport (PVG). We find that changes in airport productivity are affected more by technical factors than by airport efficiency. Conclusions - Based on the study results, we offer four airport development proposals. First, a benchmark airport needs to be identified. Second, inefficiency must be reduced and high-cost factors need to be managed. Third, airport operations should be enhanced through technical innovation. Finally, scientific demand forecasting and facility preparation must become the focus of attention. This paper has some limitations. Because the Malmquist productivity index is based on the hypothesis of the, the identified production change could be over- or under-estimated. Further, as DEA estimates the relative efficiency. It also cannot generalize to include all airport conditions because the variables are limited. To measure airport productivity more accurately, other input variables and environmental variables such as financial and policy factors should be included.

• 대한간호
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• 제29권3호
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• pp.36-48
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• 1990

This study was attempted to provide us with basic information on how to improve understanding with patients for operation, and to offer then better nursing and treatment. This kind of study will help scientific application to nursing practice and operating room. The data was collected by interviewing 29 patients who underwent the elective surgery under the general anesthesia at Y hospital in Seoul. The interview ran from October 15 to December 15, 1989. The research instrument was a anxiety measurement device (SAAI) originally developed by Spielberger, et al and modified by Jung-Tack Kim. 1. Hypothesis Testing Hypothesis one was that there would be a difference in state anxiety level according to a time difference in watiting for operation. This hypothesis was rejected(state.anxiety level one hour before operation P>.05, r-.747, State anxiety level half an hour before operation P>.05, r-.1550, state anxiety level just before operation, P>.05, r=.1099). However, state anxiety, evel appeared to be associated with a longer watiting period, like one day before operation (P<.05, r-.4628). Hypothesis two was that there would be a difference according to state anxiety level of patients for operation. This was rejected. (Change of blood perssure in systolie P>.05 r=.1082, Change of blood pressure in diastolic P>.05, r=.088, Change of pulse rate, P>.05, r-1.909) 2. Examining trait anxiety and state anxiety levels, the average level of trait anxiety was 42.034, and the average level of state anxiety one day before operation was 43,000. The average level of state anxiety was averaged 42.356 in a waiting room for operation. 3. Examining the state anxiety level by time period, the one hour before was 42.379 the level half an hour before 42.276, and the level just before operation 42.414. The low level of state anxiety was due to the fact that premedication was not eliminated. 4. Age and time period like one day before operation was related to state anxiety level (F=5.271, P<.0.01) and blood pressure in waiting room for operation. That is, state anxiety level and blood pressure of patients one day before operation appeared high. Sex was relation to changes of blood pressure ; the blood pressure of male patients appeard higer than of female patients. A marital status was also related anxiety level one hour before operation the married patient for operation showed a higher state anxiety level than that of the unmarried patient for operation. Education was similarily related to trait anxiety level in which highly educated patients show lower levels of trait anxiety than poorly educated ones. Motive for hospitalization was related to state anxiety level for patient one hour before operation (F=6.464, P<.05) likewise, patients who are supposed to undergo operation hastily showed higher levels of anxiety than patients who expect elective surgeries.

• 박물관보존과학
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• 제22권
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• pp.53-68
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• 2019

성남시 고등동에서 확인된 조선시대 회격묘 2기는 우씨 묘역에서 발굴되어 기록을 통해 묘주와 조성 시기를 유추 할 수 있는 유구이다. 말각방형으로 합장묘인 4호묘는 수습과정 중 외곽벽에서 글씨와 그림이 확인되었으며, 보존처리 및 적외선조사 결과 만사로 판단되었다. 말각장방형 단묘인 6호묘는 파묘되면서 일부 파괴되어 수습 후 야외전시 될 예정이었다. 그러나 보존처리 결과 운아삽과 역청이 확인되고 잔존하는 형태가 조선시대 회격묘의 양상을 잘 보여주고 있어 자문회의를 통하여 실내전시로 보존방향이 변경되었다. 역청은 분석 결과 송진으로 추정되며 이물질의 혼입으로 순도는 높지 않은 것으로 확인되었다. 2기의 회격묘는 조선시대 무덤 양식의 변화 양상 등 학술연구에 있어 중요한 자료로 활용될 것으로 기대된다.

• 수산해양기술연구
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• 제52권3호
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• pp.209-219
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• 2016

The survey was conducted to investigate biomass and distribution of fisheries resources using a quantitative echo sounder and a fixed gillnet around Marado coast of Jeju to obtain the scientific basic data for dispute resolution with a large purse seine fishery and coastal fishing and policy establishment of reasonable fisheries resources. Hydroacoustic surveys were conducted six times (November 28~29, 2015 (night), February 23~24, 2016 (night) and March 3~4, 2016 (night/day), March 30~31, 2016 (night/day)) using a quantitative echo sounder. The pelagic fish densities were relatively higher around Marado in November 2015, February 2016 and March 3~4, 2016. However, demersal fish densities were relatively higher in Jeju coastal waters on March 30~31, 2016. Catch data using fixed gill net were used to calculate biomass. Based on the hydroacoustic data, fish length-weight function and target strength information of dominant fish, the biomass of fishes were estimated as follow: 5.64 ton CV = 70.2% at night on November 28-29 2015, 7.14 ton CV = 35.8% of pelagic fish and 530.77 ton CV = 34.6% of demersal fishes at night on February 23-24 2016, 2.34 ton CV = 56.7% of pelagic fish and 571.93 ton CV = 40.3% of demersal fish at daytime, 1.39 ton CV = 48.4% of pelagic fish and 194.59 ton CV = 54.3% of demersal fish at night on March 3~4 2016, 0.37 ton CV = 72.9% of pelagic fish and 338.79 ton CV = 99.7% of demersal fish at daytime, 0.24 ton CV = 21.3% of pelagic fish and 68.61 ton CV = 53.8% of demersal fish at night on March 30~31 2016.