• IMMUNE NETWORK
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• 제3권1호
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• pp.38-46
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• 2003

Background: Platelet-activating factor (PAF) induces nuclear factor $(NF)-{\kappa}B$ activation and angiogenesis and increases tumor growth and pulmonary tumor metastasis in vivo. The role of $NF-{\kappa}B$ activation in PAF-induced angiogenesis in a mouse model of Matrigel implantation, and in PAF-mediated pulmonary tumor metastasis were investigated. Methods: Angiogenesis using Matrigel and experimental pulmonary tumor metastasis were tested in a mouse model. Electrophoretic mobility shift assay was done for the assessment of $NF-{\kappa}B$ translocation to the nucleus. Expression of angiogenic factors, such as tumor necrosis factor $(TNF)-{\alpha}$, interleukin $(IL)-1{\alpha}$, basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) were tested by RT-PCR and ELISA. Results: PAF induced a dose- and time-dependent angiogenic response. PAF-induced angiogenesis was significantly blocked by PAF antagonist, CV6209, and inhibitors of $NF-{\kappa}B$ expression or action, including antisense oligonucleotides to p65 subunit of $NF-{\kappa}B$ (p65 AS) and antioxidants such as ${\alpha}$-tocopherol and N-acetyl-L-cysteine. In vitro, PAF activated the transcription factor, $NF-{\kappa}B$ and induced mRNA expression of $TNF-{\alpha}$, $IL-1{\alpha}$, bFGF, VEGF, and its receptor, KDR. The PAF-induced expression of the above mentioned factors was inhibited by p65 AS or antioxidants. Also, protein synthesis of VEGF was increased by PAF and inhibited by p65 AS or antioxidants. The angiogenic effect of PAF was blocked when anti-VEGF antibodies was treated or antibodies against $TNF-{\alpha}$, $IL-1{\alpha}$, and bFGF was co-administrated, but not by antibodies against $TNF-{\alpha}$, $IL-1{\alpha}$, and bFGF each alone. PAF-augmented pulmonary tumor metastasis was inhibited by p65 AS or antioxidants. Conclusion: These data indicate that PAF increases angiogenesis and pulmonary tumor metastasis through $NF-{\kappa}B$ activation and expression of $NF-{\kappa}B$-dependent angiogenic factors.

• International Journal of Contents
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• 제1권2호
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• pp.26-30
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• 2005

According to the fast growth of information on the Internet, it is becoming increasingly difficult to find and organize useful information. To reduce information overload, it needs to exploit automatic text classification for handling enormous documents. Support Vector Machine (SVM) is a model that is calculated as a weighted sum of kernel function outputs. This paper describes a document classifier for web documents in the fields of Information Technology and uses SVM to learn a model, which is constructed from the training sets and its representative terms. The basic idea is to exploit the representative terms meaning distribution in coherent thematic texts of each category by simple statistics methods. Vector-space model is applied to represent documents in the categories by using feature selection scheme based on TFiDF. We apply a category factor which represents effects in category of any term to the feature selection. Experiments show the results of categorization and the correlation of vector length.

• Journal of Acupuncture Research
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• 제24권2호
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• pp.113-123
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• 2007

목적 : 황기가 혈관 신생 작용이 있는지에 관하여 관찰한다. 황기는 상처의 치유나 허혈성 질환에 효과를 나타내는 것으로 알려져있다. 이러한 효과가 황기의 혈관 신생작용과의 관련성을 이해하며 향후 임상에 쓰일 수 있는 황기 약침액 개발을 위한 기초 자료를 목표로 한다. 방법 : 황기의 혈관 신생 작용의 관찰을 위하여 human umbilical vein endothelial cells(HUVECs)와 Matrigel angiogenesis model을 이용하여 연구하였다. 결과 : 황기는 용량에 따라서 HUVECs의 증식을 나타내었다. 또한 혈관 내피 세포의 이동과 관형 형성을 보였다. 혈관 신생 물질인 basic fibroblast growth factor(bFGF)가 황기에 의해 증가하였다. Matrigel angiogenesis model에서 황기는 조직학적으로 혈관 형성을 촉진하였으며，헤모글로빈의 증가를 나타내었다.

• 환경영향평가
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• 제2권1호
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• pp.39-55
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• 1993

The importance of urban and regional natural park increases because of the needs for preserving the natural resources and providing with natural recreation space in nature. This planning of natural park management should be established based on the research of the various natural resources in the park. But for the lack of effective data synthesizing methods and concepts, only some restricted factors for zoning plan are considered even though GIS computer system for large complex simulation is used. Therefore, in this study three ecological zoning models such as Basic Factor Model (BFM), Visual Landscape Model (VLM) and Comprehensive Ecological Model (CEM) are proposed and applied to Byounsan Peninsula Nature Park(BPNP) for comparison with the current natural park zoning. The BFM has three components -elevation, slope and vegetation. The VLM has applied with six components -elevation, slope, vegetation, road type, and the visual distance. Finally the CEM's modelling factors have included all of BFM, VLM components are added with the land use type, nature and historic resource factors. The zoning concept of BPNP was based on "Minimization" focused on the specific factors. But introduced modelling concept is "Optimization" based on the total ecological environment. So the result of the modelling has larger area for preservation and development zoning compared with the current zoning whose characteristics are ambiguous which allows the environmental destruction. The future study issues will be the determination of the weighting factor, component reconsideration based on the ground truth data and the agriculture residential area zoning.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2003년도 봄 학술발표회 논문집
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• pp.1071-1076
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• 2003

Basic creep of concrete during very early ages is an important factor on the behavior of young concrete and a great deal of research has been executed. However, in recent studies, it was revealed that the basic creep measured by sealed concrete was inaccurate, especially for high strength concrete because of autogenous shrinkage at early age. This paper presents the results from experimental study that investigate to explore the effect of autogenous shrinkage in basic creep. More specifically, four different mix proportions were casted and the primary variables were water-cement ratios. Through this research, it was found that the differences between apparent specific creep and real specific creep were remarkable in low water-cement ratio at early age. Therefore, it is recommended to modify existing creep model by considering autogenous shrinkage

• International Journal of Vascular Biomedical Engineering
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• 제2권1호
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• pp.17-24
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• 2004

Tumor angiogenesis was simulated using a two-dimensional computational model. The equation that governed angiogenesis comprised a tumor angiogenesis factor (TAF) conservation equation in time and space, which was solved numerically using the Galerkin finite element method. The time derivative in the equation was approximated by a forward Euler scheme. A stochastic process model was used to simulate vessel formation and vessel elongation towards a paracrine site, i.e., tumor-secreted basic fibroblast growth factor (bFGF). In this study, we assumed a two-dimensional model that represented a thin (1.0 mm) slice of the tumor. The growth of the tumor over time was modeled according to the dynamic value of bFGF secreted within the tumor. The data used for the model were based on a previously reported model of a brain tumor in which four distinct stages (namely multicellular spherical, first detectable lesion, diagnosis, and death of the virtual patient) were modeled. In our study, computation was not continued beyond the 'diagnosis' time point to avoid the computational complexity of analyzing numerous vascular branches. The numerical solutions revealed that no bFGF remained within the region in which vessels developed, owing to the uptake of bFGF by endothelial cells. Consequently, a sharp, declining gradient of bFGF existed near the surface of the tumor. The vascular architecture developed numerous branches close to the tumor surface (the brush-border effect). Asymmetrical tumor growth was associated with a greater degree of branching at the tumor surface.

• Wind and Structures
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• 제28권6호
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• pp.381-388
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• 2019

This paper described the application of Geospatial Analysis in determining mean wind speed, $V_h$ for wind load calculation imposed to electrical transmission tower structural design. The basic wind speed data on available station obtained from Malaysian Meteorology Department is adjusted by considering terrain and ground roughness factor. The correlation between basic wind speed, terrain factor and ground roughness stated in EN-50341-1 is used to obtain the $V_h$ for overhead transmission line elements 50 m above ground. Terrain factor, $k_r$ and ground roughness, $z_0$ in this study are presented by land use types of study area. Wind load is then calculated by using equation stated in design code EN-50341-1 by using the adjusted mean wind speed. Scatter plots of $V_h$ for different $k_r$and $z_0$ are presented in this paper to see the effect of these parameters to the value of $V_h$. Geospatial analysis is used to represent the model of $V_h$. This model can be used to determine possible area that will subject to wind load which severe to the stability of transmission tower and transmission line.

• 기술혁신연구
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• 제27권4호
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• pp.21-48
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• 2019

기초연구 분야는 정부의 적극적인 지원으로 양적 확대가 큰 폭으로 이루어지는 반면, 체계적인 투자계획이나 데이터에 기반한 재정소요를 제시하는 연구 및 정책자료가 전무하여 관련 연구가 요구되는 시점이다. 이에 본 연구는 시계열 예측모형을 활용하여 기초연구지원사업의 향후 재정소요를 전망하였다. 기초연구분야의 특성을 포함한 다양한 요인들을 종합적으로 고려하기 위하여 시간에 따른 단일 종속변수의 값을 예측하는 ARIMA 모형이 아닌, 다변수의 영향을 반영할 수 있는 ARIMAX 모형을 선택하였다. 모형 적합성 판단을 위해 ARIMAX 모형과 ARIMA 모형의 예측값을 비교한 결과 ARIMAX 모형에서 예측오차율이 개선됨을 확인하였다. ARIMAX 모형에 기반하여 2017년에서 2021년까지 5년 간의 기초연구지원사업 재정소요를 전망하였다. 본 연구는 기초연구지원사업의 재정소요를 통계적 접근방법인 시계열모형을 적용해 전망한 시범적 연구를 수행하였다는 점과, 단변량이 아닌 다변량을 고려하여 예측력을 개선했다는 점에서 의의를 지닌다. 또한 현 정부 국정과제인 '기초연구 예산 2배 확대' 등 기초연구 투자의 중요성이 꾸준히 강조되는 정책기조를 고려할 때 향후 기초연구 투자전략 수립 시 참고자료로 활용 될 수 있다.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2001년도 봄 학술발표회 논문집
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• pp.609-614
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• 2001

This paper is to explain reasonable shear behavior that can apply usually to reinforced concrete beams on the basic concepts of existent analysis and experimental research information. This study is succession $paper^{2) 3) 4) 5)}$ of treatise announced in existing and main control variable of reinforced concrete beams with stirrups used internal force state factor($\alpha$). Shear failure of reinforced concrete beams with stirrups is Influenced greatly because of the actual geometrical shape(a/d) of the concrete and flexural reinforcement steel ratio, stirrup reinforcement ratio and concrete compression strength, size effect etc. Therefore, shear behavior of reinforced concrete beams with stirrups that flexural crack is happened can be explained easily through proper extent proposal of internal force state factor($\alpha$) that express internal force state flowing. Use existent variable truss model by analysis model to explain arch action. Also, wish to compose each failure factors and correlation with internal force state factor by function, and when diagonal cracks happens, internal force state factor($\alpha$) study whether shear stress and some effect are.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2004년도 제5회 압연심포지엄 신 시장 개척을 위한 압연기술
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• pp.145-152
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• 2004

The flow stress value was calculated by comparing predicted and measured roll force. Using basic on-line roll force model and logged mill data the flow stress equation of high strength steel for automobile was derived. The flow stress equation consists of the flow stress equation of carbon steel and flow stress factor calculated by neural network with input parameters not only carbon contents, strip temperature, strain, and strain rate, but also compositions such as Mn, p, Ti, Nb, and Mo. Using the flow stress equation and basic roll force model, precision roll force model of high strength steel for automobile was derived. Using test set of logged mill data the flow stress equation was verified.