• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제40권6호
• /
• pp.272-277
• /
• 2014

Objectives: Non-vascularized iliac crest bone graft (NVIBG) is a known treatment option in mandibular reconstruction following jaw resection, but no documented review of patients treated with NVIBG exists for northern Nigeria. The experience and technique from a Nigerian tertiary hospital may serve as baseline data for comparison and improvement of practice for other institutions. Materials and Methods: A retrospective review of medical records and patient case files from January 2012 to December 2013 was undertaken. All case files and other medical records of patients who had reconstruction with NVIBG for benign or malignant lesions with immediate or delayed reconstruction were selected for review. Results: Twenty patients had mandibular reconstruction with NVIBG during the study period. Two patients were excluded because of incomplete medical records. Eighteen patients' (male=14, female=4) records were reviewed. Their ages ranged from 13 to 62 years (mean $26.0{\pm}10.6years$). Indications for NVIBG included jaw tumors (n=16; 88.3%), jaw cyst (n=1; 5.6%) and gunshot injury (n=1; 5.6%). Jaw tumors seen were ameloblastoma (n=15; 83.3%) and osteosarcoma (n=1; 5.6%). Treatments done were mandibular resection with condylar resection (n=7; 38.9%), mandibular segmental resection (n=10; 55.6%) and subtotal mandibulectomy (n=1; 5.6%). Patients' postoperative reviews and radiographs revealed good facial profile and continued bone stability up to 1 year following NVIBG. Conclusion: NVIBGs provide an acceptable alternative to vascularized bone grafts, genetically engineered bone, and distraction osteogenesis for mandibular reconstruction in resource-limited centers.

• Nutrition Research and Practice
• /
• 제13권2호
• /
• pp.105-114
• /
• 2019

BACKGROUND/OBJECTIVES: Several previous studies have investigated whether regular walnut consumption positively changes heart-health-related parameters. The aim of this study was to investigate the effects of daily walnut intake on metabolic syndrome (MetS) status and other metabolic parameters among subjects with MetS. SUBJECTS/METHODS: This study was a two-arm, randomized, controlled crossover study with 16 weeks of each intervention (45 g of walnuts or iso-caloric white bread) with a 6 week washout period between interventions. Korean adults with MetS (n = 119) were randomly assigned to one of two sequences; 84 subjects completed the trial. At each clinic visit (at 0, 16, 22, and 38 weeks), MetS components, metabolic parameters including lipid profile, hemoglobin A1c (HbA1c), adiponectin, leptin, and apolipoprotein B, as well as anthropometric and bioimpedance data were obtained. RESULTS: Daily walnut consumption for 16 weeks improved MetS status, resulting in 28.6%-52.8% reversion rates for individual MetS components and 51.2% of participants with MetS at baseline reverted to a normal status after the walnut intervention. Significant improvements after walnut intake, compared to control intervention, in high-density lipoprotein cholesterol (HDL-C) (P = 0.028), fasting glucose (P = 0.013), HbA1c (P = 0.021), and adiponectin (P = 0.019) were observed after adjustment for gender, age, body mass index, and sequence using a linear mixed model. CONCLUSION: A dietary supplement of 45 g of walnuts for 16 weeks favorably changed MetS status by increasing the concentration of HDL-C and decreasing fasting glucose level. Furthermore, consuming walnuts on a daily basis changed HbA1c and circulating adiponectin levels among the subjects with MetS. This trial is registered at ClinicalTrials.gov as NCT03267901.

• Nutrition Research and Practice
• /
• 제16권2호
• /
• pp.217-232
• /
• 2022

BACKGROUND/OBJECTIVES: Filipino children aged 6-10 yrs are consuming poor quantities and quality of food based on the 2013 Philippine National Nutrition Survey. During these years healthy eating habits must be formed through family influence. Within this background, a complete package of nutrition intervention-feeding and nutrition classes, was pilot tested in selected schools to determine 1) changes in nutrition attitude and behavior and 2) food intake of schoolchildren after the intervention. SUBJECTS/METHODS: A quasi-experimental design was used in the study. School children aged 7-9 yrs enrolled in selected Philippine public elementary schools and their mothers/caregivers were the study participants. Profile and socio-demographic data were collected from each participant at baseline. The nutrition behavior and food intake of children were determined using the modified Child and Diet Evaluation Tool (CADET) and the 24-h food recall form, respectively. Data were analyzed using Stata version 15. RESULTS: No significant differences in characteristics were found among the 339 child-mother pairs in the 4 study groups. The modified CADET recorded improved mean attitude scores of children ranging from 22 to 24 points at endline in the group receiving both lunch feeding and nutrition education classes (group 3). The perceived better behavior of children was reported by their mothers in terms of increased intake of milk and vegetables and decreased consumption of sugar. These improvements were supported by the actual food intake of children obtained from the 24-h food recall. CONCLUSIONS: Family involvement, particularly of mothers/caregivers, appeared to be an important factor in shaping the children's eating behavior. An intervention package with lunch feeding and nutrition classes resulted in a substantial improvement in children's behavior and actual food intake with increased levels of vegetables and milk while lowering sugar consumption. The adoption of the intervention package in public elementary schools should therefore be pursued.

• Safety and Health at Work
• /
• 제13권1호
• /
• pp.112-116
• /
• 2022

Background/Aims: The Gachon Regional Occupational Cohort Study (GROCS) is a large-scale longitudinal study of occupational safety and health data (covering Work Environment Monitoring, Workers' Health Surveillance, and Occupational Health Service) conducted by the Gachon University Gil Medical Center (GUGMC) in Incheon, Republic of Korea. We conducted GROCS to identify the health effects of workers' occupational risks, behavior, socioeconomic status, and life style. Methods: The GROCS includes data from Work Environment Monitoring, Workers' Health Surveillance, and Occupational Health Service. The baseline year for all data collection was 2018. Work Environment Monitoring was conducted in 240 companies located in Incheon. General Health Examination and Special Health Examination were performed on 32,725 and 9,504 workers, respectively. Occupational Health Services were provided to 16,883 workers in 171 companies. These data have been collected and operated at an external data management institution and were provided as a retrospective cohort after removing personal identification information. Results: In 2018, the total number of companies was 2,854, among which which 488 special Health Examination, 171 Work Environment Monitoring, and 240 Occupational Health Service. The proportion of companies undergoing Special Health Examination was 17.1%, the proportion of companies undergoing Work Environment Monitoring was 8.4%, and the proportion of Companies undergoing Occupational Health Service was 6.0%. Conclusion: GROCS expects researchers to utilize its useful and reliable resource for occupational health and surveillance with for academic or political purposes to lead to improved workers' health and working environment.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제26권5호
• /
• pp.266-276
• /
• 2023

Purpose: Human milk oligosaccharides (HMOs) may be genetically determined based on the secretor and Lewis status of the mother. This study aims to determine the HMO profile and the secretor and Lewis gene status of Indonesian lactating mothers. Methods: Baseline data of 120 mother-infant pairs between 0-4 months post-partum obtained from a prospective longitudinal study was used. The concentrations of 2'-fucosyllactose (2'FL), lacto-N-fucopentaose I (LNFP I), lacto-N-tetraose (LNT), lacto-N-neotetraose (LNnT), 3'-sialyllactose (3'SL), and 6'-sialyllactose (6'SL) were measured. Genetic analysis was performed for mothers using targeted next-generation sequencing and Sanger sequencing. Wild-type AA with the rs1047781 (A385T) polymorphism was categorized as secretor positive, while heterozygous mutant AT was classified as a weak secretor. The presence of rs28362459 (T59G) heterozygous mutant AC and rs3745635 (G508A) heterozygous mutant CT genes indicated a Lewis negative status, and the absence of these genes indicated a positive status. Subsequently, breast milk was classified into various groups, namely Group 1: Secretor+Lewis+ (Se+Le+), Group 2: Secretor-Lewis+ (Se-Le+), Group 3: Secretor+Lewis-(Se+Le-), and Group 4: Secretor-Lewis- (Se-Le-). Data were analyzed using the Mann-Whitney and Kruskal-Wallis rank tests, and a p-value of 0.05 indicated statistical significance. Results: A total of 58.3% and 41.7% of the samples had positive and weak secretor statuses, respectively. The proportion of those in Group 1 was 85%, while 15% were Group 3. The results showed that only 2'FL significantly differed according to the secretor status (p-value=0.018). Conclusion: All Indonesian lactating mothers in this study were secretor positive, and most of them had a Lewis-positive status.

• 한국음향학회지
• /
• 제28권7호
• /
• pp.646-652
• /
• 2009

본 논문에서는 점용접 너깃의 피로수명을 고려한 차량 서브프레임의 용접간격 최적화 설계기법이 제안된다. 주파수영역 피로해석기법에 의해 점용접 너깃의 피로수명이 평가된다. 피로해석에서 사용되는 입력 데이터는 벨지안로 프로파일을 통과하는 차량동역학 해석과 차량 서브프레임 유한요소모델의 모드 주파수 해석을 통해 얻는다. 주파수 영역 피로해석으로 부터 얻은 피로수명 결과로부터 용접간격 최적화를 수행 할 설계점들이 선정된다. 점용접 너깃의 피로수명을 최대화시키는 용접간격을 얻기 위하여 4-요인, 3-수준 직교배열 실험계획법이 사용된다. 본 연구를 통하여 최적화된 서브프레임은 초기모델에 비하여 최소 피로수명을 갖는 용접 너깃의 피로수명이 약 65.8 % 증대되는 것을 알 수 있다.

• Korean Journal of Radiology
• /
• 제25권3호
• /
• pp.301-313
• /
• 2024

Objective: The current body of evidence lacks clarity regarding the comparative efficacy and safety of radiofrequency ablation (RFA) and microwave ablation (MWA) as minimally invasive treatments for benign thyroid nodules. The primary objective of this study is to clarify these concerns. Materials and Methods: A comprehensive search was conducted using the Cochrane Library, Scopus, Europe PMC, and Medline databases until October 10th, 2023, using a combination of relevant keywords. This study incorporated literature that compared RFA and MWA for benign thyroid nodules. The primary outcome was the volume reduction ratio (VRR) from baseline to follow-up. Secondary outcomes were symptom score, cosmetic score, ablation time, major complications rate, hemorrhage, hoarseness, skin burn, cough, and sympathetic nerve injury. We used Risk of Bias in Non-randomized Studies - of Interventions (ROBINS-I) tool to assess the risk of bias in the included studies. We employed random effects models to analyze the standardized mean difference (SMD) and odds ratio for the presentation of outcomes. Results: Nine studies with 2707 nodules were included. The results of our meta-analysis indicated similar efficacy between RFA and MWA in terms of VRR during the 1 (SMD 0.06; 95% confidence interval [CI]: -0.13 to 0.26; P = 0.52) and 3 (SMD 0.11; 95% CI: -0.03 to 0.25; P = 0.12) months of follow-up. VRR was significantly higher in RFA than in MWA at the 6 (SMD 0.25; 95% CI: 0.06-0.43; P = 0.008) and 12 month of follow-up (SMD 0.38; 95% CI: 0.17 to 0.59; P < 0.001). There were no significant differences between RFA and MWA in symptom scores, cosmetic scores, or the incidence of complications, including hemorrhage, hoarseness, skin burn, cough, and sympathetic nerve injury. Conclusion: RFA showed a higher VRR than MWA at 6 and 12-month follow-ups, with a comparable safety profile.

• 대한전자공학회논문지SD
• /
• 제45권11호
• /
• pp.71-76
• /
• 2008

H.264(또는 MPEG-4/AVC pt.10) 압축 표준은 고성능 영상 압축 알고리즘으로 그 적용 범위를 넓혀 가고 있다. H.264 압축 표준의 가변길이 코드(Variable Length Code)는 데이터의 통계적 중복성의 특성을 이용하여 압축을 한다. 이러한 압축된 비트 스트림은 복호기에서 연속된 비트 스트림을 잘라내는 작업과 테이블에서 비트 스트림과 비교하는 작업을 진행하는데 순수 하드웨어 구현이 까다로운 연산부이다. 본 논문에서는 HD 영상을 실시간으로 복호 가능한 가변길이 복호기 구조를 제안한다. Exp-Golomb 복호기는 연산기로 구성되어 있으며, CAVLD는 테이블과 연산기를 혼합하여 최적화된 하드웨어로 설계하였다. 비트 스트림의 분할(parsing) 작업은 배럴 쉬프터(Barrel shifter)와 1값 감지기(First 1's detector)에서 진행되며, 이 두 유닛은 Exp-Golomb 복호기와 CAVLD가 공유하는 구조로 설계하여 불필요한 하드웨어를 제거하였다. CAVLD와 재정렬(Reorder) 유닛간의 병목현상으로 가변길이 복호기 뿐만 아니라 H.264 디코더 전체의 성능 저하가 나타나는 단점을 제거하기 위해서 CAVLD와 재정렬 유닛간 FIFO와 재정렬 유닛의 최종 출력에 메모리를 두어 병목현상을 제거하였다. 제안된 가변길이 복호기는 Verilog-HDL을 이용하여 설계하고 FPGA를 통해 검증하였다. 0.18um 표준 CMOS 공정을 사용한 합성 결과는 22,604 게이트 수이며, 동작 주파수 120MHz에서 HD 영상이 복호됨을 확인하였다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제28권2호
• /
• pp.132-140
• /
• 2017

Objectives: Very early-onset schizophrenia (VEOS) is a type of psychosis having a low frequency, insidious onset, and devastating clinical outcome. In this study, the demographic features, information on medication, clinical outcomes, and intellectual capability of patients diagnosed with VEOS in a hospital were analyzed to provide therapeutic strategies for this type of schizophrenia. Methods: Using the electronic medical records of the National Center for Mental Health, 69 patients with VEOS were identified based on the DSM-5 criteria of schizophrenia. The data were summarized and analyzed according to the demographic characteristics, medications used, intellectual strength measured by the full intelligence quotient (FIQ) score, and current clinical status measured by the Clinical Global Impression-Severity (CGI-S) and various combinations of these parameters. Results: The screened study group contained similar numbers of males and females. The younger the onset of psychosis, the lower the frequency. The study population included a significantly higher proportion of births in the winter season than that of the general population. The 3 most frequently used antipsychotic medications were risperidone and its derivatives, clozapine and olanzapine. Valproic acid and divalproex sodium were the most commonly added drugs for outcome augmentation. 53.5% of the study population had received benzodiazepines and/or hypnotics. The average FIQ of the study population was 69.4, which is quite low compared to previous Korean studies with similar populations. There was a weak negative correlation between FIQ and CGI-S, but it was not statistically significant. The average CGI-S score was 4.2, which meant that the patients were moderately ill. Conclusion: This study demonstrated that patients with VEOS showed more frequent intellectual deficits at baseline and poorer outcomes than the control group. Risperidone, clozapine, valproic acid and their combinations were the most preferred medications for the treatment of psychosis. Benzodiazepines were quite commonly added for various reasons.

• 전자공학회논문지CI
• /
• 제45권2호
• /
• pp.26-32
• /
• 2008

동영상 압축 기술은 오랜 기간 동안 연구되었으며 H.264/AVC는 최근에 사용되고 있는 동영상 압축 표준 중 가장 효율적인 동영상 압축 표준으로 알려져 있다. H.264/AVC의 베이스 프로파일에서는 무손실 압축과정으로 기존의 VLC(Variable Length Coding) 방식 대신에 압축 효율을 향상시킨 CAVLC(Context-Adaptive Variable Length Coding)라는 압축 방식을 사용한다. CAVLC 복호기는 기존의 VLC 보다 많은 VLC 표가 필요하기 때문에 하드웨어로 구현하기에는 많은 면적을 요구하게 되며 소프트웨어로 구현 시에는 표 탐색에 의해서 성능이 저하된다. 본 논문에서는 이러한 CAVLC 복호기의 소프트웨어에서의 성능 저하를 막기 위해서 VLC 표를 계층적으로 집단화하여 코드만으로 주소를 정하고 정해진 VLC 표를 한번만 참조하여 성능을 향상시키는 방법을 제안한다. 제안된 알고리즘은 C 언어로 모델링하였으며 ARM ADS1.2에서 컴파일하고 ARM9TDMI 프로세서 시스템을 Armulator를 이용하여 시뮬레이션하였다. 실험 결과, H.264/AVC 표준 참조 프로그램인 JM(Joint Model) 10.2 보다 약 80%의 수행 시간 단축을 보였으며 최근 논문에서의 산술연산 알고리즘보다 15%의 성능 향상을 보였다.