• Title/Summary/Keyword: Barrier factors

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The Effects of Baekho-tang Extracts on Regulating Th2 Differentiation through Improving Skin Fat Barrier Damage (백호탕 추출물의 지방장벽 손상 개선을 통한 상피 내 Th2 분화 조절 효과)

  • Ahn, Sang Hyun;Kim, Ki Bong;Jeong, Aram
    • The Journal of Pediatrics of Korean Medicine
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    • v.35 no.4
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    • pp.156-166
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    • 2021
  • Objectives The purpose of this study is to confirm the regulate effect of T helper (Th) 2 differentiation that Baekho-tang extract may produce to improves skin lipid barrier damages. Methods Four-weeks-old NC/Nga mice were divided into four groups: control group (Ctrl, n=10), lipid barrier eliminated group (LBE, n=10), Dexamethasone treatment after lipid barrier elimination group (DxT, n=10), and Baekho-tang extract treatment group after lipid barrier elimination group (BHTT, n=10). Baeko-tang extract was administered for 3 days after removal of the skin fat barrier in BHTT group. Then, we identified changes in external symptoms of the skin, factors affecting skin barrier such as potential of hydrogen (pH), filaggrin (FLG), transepidermal water loss (TEWL) and Th2 differentiation factors like Interleukin (IL)-4, Kallikrein Related Peptidase 7 (KLK7) and protease activated receptor 2 (PAR-2) through our immunohistochemistry. Results After lipid barrier elimination, the reduction of morphological skin inflammations was less in BHTT group than in LBE group and DxT group. Also, pH and TEWL were significantly decreased with BHTT group. However, FLG was significantly increased in BHTT group compared to LBE, DxT, and Ctrl group. All kinds of Th2 differentiation factors (IL-4, KLK7 and PAR-2) were also decreased in BHTT compared to the LBE and DxT. Conclusions As a result of this study, BHT administration decreased pH, TEWL, and increased FLG, thus participating in recovering damaged skin barrier. Since Th2 differentiation factors were decreased as well, BHT's regulatory effect in sequential immune reactions may be a possible explanation of how it enhances recovery of the damaged lipid barrier.

Th2 Differentiation Control through Formation of Skin Fat Barrier of Sabaek-san extract (사백산 추출물의 지방장벽 생성을 통한 Th2 분화 조절)

  • Ahn, Sang Hyun;Jeong, A Ram;Kim, Ki Bong
    • The Journal of Pediatrics of Korean Medicine
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    • v.36 no.1
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    • pp.57-64
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    • 2022
  • Objectives The purpose of this study is to confirm the regulate effect of T helper (Th) 2 differentiation that Sabaek-san extract may produce to improves skin lipid barrier damage. Methods Four-weeks-old NC/Nga mice were divided into four groups: control group (Ctrl, n=10), lipid barrier eliminated group (LBE, n=10), Dexamethasone treatment after lipid barrier elimination group (DXT, n=10), and Sabaek-san extract treatment group after lipid barrier elimination (SBT, n=10). Sabaek-san extract was administered for 3 d after removal of the skin fat barrier in SBT group. Then, we identified changes in external symptoms of the skin, factors affecting skin barrier such as potential of hydrogen (pH), filaggrin, transepidermal water loss (TEWL) and Th2 differentiation factors like Interleukin (IL)-4, Kallikrein Related Peptidase 7 (KLK7), and protease activated receptor 2 (PAR-2) through our immunohistochemistry. Results After lipid barrier elimination, the reduction of morphological skin inflammations was less in SBT group than in LBE and DXT group. Also, pH and TEWL were significantly decreased with SBT group. However, filaggrin was significantly increased in SBT group compared to LBE, DXT, and Ctrl group. All kinds of Th2 differentiation factors (IL-4, KLK7 and PAR-2) were also decreased in SBT compared to the LBE and DXT. Conclusions As a result of this study, SBT administration decreased pH, TEWL, and increased filaggrin, thus participating in recovering damaged skin barrier. Since Th2 differentiation factors were decreased as well, SBT's regulatory effect in sequential immune reactions may be a possible explanation of how it enhances recovery of the damaged lipid barrier.

The Effect of Consumer’s Switching Barrier Perception on Store Loyalty in Apparel Product Purchasing (의류제품 구매시 소비자의 전환장벽지각이 점포충성도에 미치는 영향)

  • 김수진;정명선
    • Journal of the Korean Society of Clothing and Textiles
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    • v.25 no.8
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    • pp.1512-1523
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    • 2001
  • The purposes of this study were to examine the effect of switching barrier perception on store loyalty in apparel product purchasing to classify the factors of switching barrier perception, and additionally ot identify differences of store loyalty and switching barrier perception according to demographic characteristics. The questionnaire was administered to 300 women shopped in a department store in Gwang-ju city during February 10-23, 2001. Data collected from 261 women were analyzed by using frequency, factor analysis, ANOVA, Duncan-test, regression analysis by SPSS for windows PC program. The results were as follows; 1. The consumer’s perceived switching barrier was composed of three factors; economic psychological, time factor. 2. There was significant difference in store loyalty according to consumer’s age, occupation, education level. and income. 3. There was significant differences in economic. time switching barrier perception according to consumers’age, occupation education level, and income. There was significant difference in psychological switching barrier perception according to consumers’ occupation education level, and income. 4. The swiching barrier perception significantly infulenced on the store loyalty.

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Analysis on the Factors Affecting the Results of Full Frontal Barrier Impact Test (고정벽 정면충돌시험 결과에 미치는 요인 분석)

  • Lim, Jaemoon
    • Journal of Auto-vehicle Safety Association
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    • v.8 no.3
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    • pp.5-9
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    • 2016
  • The objective of this study was to find the factors affecting the results of full frontal barrier impact test for the NCAP (New Car Assessment Program). To find the factors, the frontal NCAP test results of the NHTSA (National Highway Traffic Safety Administration) were utilized. The three tested vehicle were same model year. It was observed the second peak value of barrier force affected the occupant injury risk. As the second peak value of the barrier force increases, the injury risk of the driver side occupant increases as well.

Prediction of the Effect of Quiet Pavement on Reducing Barrier Height (저소음 포장도로 시공에 따른 방음벽 높이 저감효과 예측)

  • Yang, Hong-Seok;Cho, Hyun-Min;Jeong, Jong-Seok;Kim, Myung-Jun
    • International Journal of Highway Engineering
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    • v.18 no.5
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    • pp.31-37
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    • 2016
  • PURPOSES : The purpose of this study is to evaluate the effect of the quiet pavement on reducing a barrier height by using a prediction tool called SoundPLAN. METHODS : Firstly, the prediction was carried out to evaluate the difference in the maximum noise level at a building facade between the normal and the quiet pavements without a barrier. After calculating the noise reduction effect by the quiet pavement, a comparable barrier height to obtain the same noise reduction effect with it was predicted according to designable factors including road-building distance(10 m, 20 m, 40 m) and road-barrier distance(5 m, 10 m, 20 m, 30 m). RESULTS : The result showed that within the considered designable factors, the maximum barrier height was 37 m, 52 m, and 55 m to have the same noise reduction effect by the quiet pavement reducing 1 dBA, 3 dBA, and 5 dBA, respectively. It was evaluated that the barrier height increased with the increase of the road-building and road-barrier distances. To simulate the real situation in urban areas and to evaluate the combined effect of the normal/quiet pavement and barrier, the barrier height was fixed as 6 m. It was predicted that the noise level would reduce to as low as 0.2 dBA by the combination of normal pavement and barrier. On the other hand, the combination of the quiet pavement and barrier reduced 1.2 dBA, 3.2 dBA, and 5.2 dBA, respectively, for quiet pavement reducing 1 dBA, 3 dBA, and 5 dBA. CONCLUSIONS : A guideline needs to be suggested to select appropriate noise abatement schemes by considering factors such as the roadbuilding and road-barrier distances.

Exercise Pattern and Influencing Factor of Exercise Barrier in Patients with Osteoarthritis (골관절염 환자의 운동양상과 운동장애 영향요인)

  • Kim, Jong-Im;Kim, In-Ja;Kang, Hyun-Sook;Bae, Sang-Chul;Lee, Eun-Ok
    • Journal of muscle and joint health
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    • v.9 no.2
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    • pp.135-143
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    • 2002
  • Exercise is an important strategy for health promotion in patients having osteoarthritis. But, lots of patients with osteoarthritis were underexercised. Exercise pattern and influencing factors of exercise barrier are not well-known. To address this issue, we studied the exercise pattern and influencing factors of exercise barrier in patients with osteoarthritis. The subjects of the study were 463 adult osteoarthritis (Mean age = 61.63 years) who had diagnosed osteoarthritis by rheumatologist. Data were gathered from May 1999 to February 2000 using a questionnaire and exercise barrier(Sallis et al, 1989), exercise pattern(Lee et al., 2000), physical status by WOMAC(Bellamy, 1989), socail support(Sallis et al., 1989), fatigue and pain using graphic rating scale, depression by CES-D(Radloff,1977). Data were analyzed with the SPSS win 6.0 using frequency, ANOVA, Stepwise multiple regression. The results of this study were as follows; 1) 56.4% of sample was 'do not exercise at all', 'longer rest than exercise', was 15.9%, 'longer exercise than rest' was 7.2%, 'exercise regularly' was 20.5%. 2) Social support (F=10.349, p=0.000) and exercise barrier(F=4.455, p=0.004) were showed significantly difference by exercise pattern. 3) Influencing factors of exercise barrier were depression and social support. Thoses explained 13.3% of exercise barrier. In conclusion, half of osteoarthritis patient did not do exercise and it was shown that depression and social support were major influencing factors to exercise barrier. The results of this study can be applied to develop the health promoting educational program for patients with osteoarthritis.

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Study of previous Factors of Switching barrier at Online shop (온라인 쇼핑몰 전환장벽의 선행요인 연구)

  • Park, Soo-Min;Yoo, Chul-Woo;Choe, Young-Chan
    • Journal of Agricultural Extension & Community Development
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    • v.15 no.3
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    • pp.433-460
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    • 2008
  • The objectives of this study were to figure out the relationships of factors, e-quality, interactivity, trust and switching barrier, to affect the online customers loyalty. Moreover, e-quality was considered because of the problem of ssability originated from the environment that a lot of information and products are given at online business. This study employs a survey method to empirically test the proposed research model. A survey questionnaire was developed and 100 responses were collected. The data were analyzed using PLS method, a structural equation modeling method. The results of the study indicate that e-quality, interactivity, and trust influence switching barrier and that the switching barrier affects virtual relationship, which has an positive effect on loyalty. This study provides valuable theoretical and practical perspectives that e-quality is the most influential factor on virtual relationship and that, of the three factors of switching barrier, the virtual relationship is the most effective one to prevent customers online from changing their main online shop for products.

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The study on the factors which improve skin barrier recovery (피부장벽회복에 영향을 미치는 인자에 관한 연구)

  • Cha, Jae-Hoon;Kim, Yoon-Bum
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.21 no.2
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    • pp.39-45
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    • 2008
  • Objective : Skin barrier protects skin against harmful environment. Its function includes antimicrobial barrier as well as physical barrier. But there are few studies about the factors which improve skin barrier recovery after injury. The aim of this study is to investigate the factors which improve skin barrier recovery. Method : Nine hairless mice was anesthetized by inhalation and we tape stripped them. We used thermometer to know temperature one day ago, before anesthesia, before tape stripping, and after tape stripping. Vapometer was used to know transepidermal water loss before tape stripping, after tape stripping. And we used doppler flowmeter to measure blood flow before tape stripping, after tape stripping. Result : After analyzed data, we concluded that temperature was lower after anesthesia than before anesthesia and after tape stripping than before tape stripping. We could know that transepidermal water loss was lower after tape stripping than before tape stripping and more blood flowed after tape stripping. Conclusion : In our study, it was observed that temperature, transepidermal water loss, blood flow changed after tape stripping. But we thought lowered temperature was pathologic situation, more blood flow was to recover after injury. In traditional korean medicine, cold(寒) and imbalance of blood flow(血行) don't only make many skin diseases, but cold(寒) also obstructs blood flow. So we need to study how to warm cold(寒) and improve blood flow.

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Landscape Preference of the Guide Coating in the Median Barrier on the Expressway by Win-Road Simulation (Win-Road Simulation을 활용한 고속도로 중앙분리대 시선유도도장에 대한 경관선호도 분석)

  • Kim, Tae Gyun;Choi, Jae Young;Lee, Mun Young;Kum, Ki Jung
    • International Journal of Highway Engineering
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    • v.15 no.3
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    • pp.117-125
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    • 2013
  • PURPOSES: By conducting the landscape survey that considered landscape factors of the Guide Coating in the Median Barrier that applied of the various level by simulating of the Guide Coating in the Median Barrier on the expressway, they showed the quantitative standard of landscape preference factors that the Guide Coating gives. METHODS: The shape of the Structural Equation Modeling used AMOS program and made a shape that is made of landscape preference for the Guide Coating in the Median Barrier on the expressway a dependent variable. RESULTS: Result in this, they showed that functionality and emotionalism are the factors that affect the landscape preference. CONCLUSIONS: In the main study, not only showing the Guide Coating in the Median Barrier on the expressway landscape valuation but also embodying the Structural Equation Modeling(SEM) of each group, knowing the Guide Coating and unknowing the Guide Coating. By embodying this, they could study that the drivers' quantitative standard is different when the Guide Coating become first applied and being changed after.

A study on the deduction of the barrier factors in the forest trail for the disabled using wheelchairs (휠체어 사용자를 고려한 숲길의 장애요소 도출에 관한 연구)

  • Kweon, Hyeong-Keun;Lee, Joon-Woo;Park, Bum-Jin;Sin, Won-Sop;Yeom, In-Hwan
    • Korean Journal of Agricultural Science
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    • v.38 no.2
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    • pp.235-241
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    • 2011
  • Recently, as people have become more interested in health issues, their demand on forest trails for bush walking exercise has increased. The purpose of the study is to select barrier factors into forest trail for disabled using wheelchairs. As a result this, it has selected 31 barrier factors through the Delphi method. Of all the these factors, the information board of forest trails, showing the location of the trails, has indicated the highest score of importance at 4.50. Next, securing hiker' walking safety space has indicated an importance level of 4.44; both the slope of forest trails and the height of obstacles have indicated an importance level of 4.38; and the effective width of forest trails has indicated the highest score of importance level of 4.33. From these indicated levels of importance, the respondents of the Delphi method consider the safety of users of forest trail' as the most important factor while the physically disables are hiking. That is why these factors have resulted in acquiring relatively higher values.