• Title/Summary/Keyword: Baek-Kyung

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In Vitro Anti-Helicobacter pylori Activity of Panaxytriol Isolated from Ginseng

  • Bae, Eun-Ah;Han, Myung-Joo;Baek, Nam-In;Kim, Dong-Hyun
    • Archives of Pharmacal Research
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    • v.24 no.4
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    • pp.297-299
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    • 2001
  • This study investigated the effect that some polyacetylenes and protopanaxatriol, which were isolated from heated ginseng (family Araliaceae), have on inhibiting Helicobacter pylori (HP) growth. Among the compounds tested, panaxytriol was quite effective in inhibiting HP growth with an MIC of 50 ${\mu}g/ml$. Cinsenoside Rhl and protopanaxatriol weakly inhibited $H^{+}/K^{+}$-ATPase from a rat stomach.

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cDNA Microarray Analysis of Transcriptional Response to Hyperin in Human Gastric Cancer Cells

  • Jeoung, Dooil;Kim, Jae-Hwan;Lee, Youn-Hyung;Myungin Baek;Lee, Seongeun;Baek, Nam-In;Kim, Hae-Yeong
    • Journal of Microbiology and Biotechnology
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    • v.12 no.4
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    • pp.664-668
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    • 2002
  • Antioxidants either scavenge superoxide and free radicals or stimulate the detoxification mechanisms within cells, resulting in increased detoxification of free radicals formation. Hyperin, isolated from the stem of Uncaria rhynchophylla, prevented oxygen radical formation and inhibited lipid oxidation. The effective concentrations were 31.3 $\mu$M for a radical scavenging assay and 2.2 $\mu$M for a microsome assay. cDNA microarray analysis to determine which genes were modulated by hyperin found that 50 genes were upregulated and 37 genes were downregulated in SNU-668 human gastric cancer cells. Among these genes, thirteen genes that were significantly affected by hyperin were verified by RT-PCR for their effect of genetic reprogramming.

The bibliographical study on Poong-On(風溫) (풍온(風溫)에 관(關)한 문헌적(文獻的) 고찰(考察))

  • Han, Jae-Soo;Oh, Tae-Hwan;Jung, Sung-Gi;Rhee, Hyung-Koo
    • The Journal of Internal Korean Medicine
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    • v.13 no.2
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    • pp.141-155
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    • 1992
  • This study has been carried out to investigate the cause symptom and treatment of Poong-On(風溫) by referring to 29 leteratures. The results were obtained as follows; 1. The factors causing Poong-On(風溫) is wind and heat. 2. The symptom of Poong-On(風溫) is as follows. fever, chilling, cough, sweating sign, chest discomfort, thirst, Doo Chang Wan Bi(頭脹脘痺), Yang Maeg Boo Hwal(陽脈浮滑), Eum Maeg Yoo Yak(陰脈濡弱), Seol Tae Baek Bak(舌苔白薄). 3. The treatment-method of Poong-On(風溫) is as follows. Sin Ryang Hae Pyo(辛凉解表), San Poong Han Ii Rae Pyo(散風寒以解表), Seol Yeol Hwa Eum(泄熱和陰), So Sul Ii Hae Pyo(疏泄以解表). 4. The treatment-herbs of Poong-On(風溫) is as follows, Eun Gyo San(銀翹散), Ma Haeng Gam Sug Tang(麻杏甘石湯), Jo Wee Sung Gi Tang(調胃承氣湯), An Goong Woo Hwang Hwan(安宮牛黃丸), Seo Gag Ji Hwang Tang(犀角地黃湯), Baek Ho Tang(白虎湯), Sa Sam Maeg Moon Dong Tang(沙蔘麥門冬湯), Ga Gam Bok Maeg Tang(加減伏脈湯), Saeng Maeg San(生脈散).

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Isoprenylated flavonoids from the root bark of Morus alba L. and their inhibition effect on NO production in LPS-induced RAW 264.7 cells

  • Jung, Jae-Woo;Ko, Jung-Hwan;Ko, Won-Min;Park, Ji-Hae;Baek, Yun-Su;Kim, Youn-Chul;Baek, Nam-In
    • Journal of Applied Biological Chemistry
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    • v.60 no.2
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    • pp.109-111
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    • 2017
  • The root bark of Morus alba L. were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH, and $H_2O$ fractions. The repeated silica gel ($SiO_2$), octadecyl $SiO_2$ (ODS), and Sephadex LH-20 column chromatographies of the EtOAc fraction led to isolation of 12 phenolic compounds. The chemical structures of the compounds were determined as sanggenol Q (1), sanggenol A (2), sanggenol L (3), kuwanon T (4), cyclomorusin (5), sanggenon F (6), sanggenol O (7), sanggenon N (8), sanggenon G (9), mulberrofuran G (10), mulberrofuran C (11), and moracin E (12). All isolated compounds were evaluated for inhibit lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages.