• Natural Product Sciences
• /
• v.13 no.3
• /
• pp.195-198
• /
• 2007

Hepatoprotective action of alcoholic extract of Bacopa monniera (BME) was evaluated on Dgalactosamine (D-GalN) induced rat liver toxicity. Bacopa monniera extract reduced the elevated serum enzyme activities of ALT, AST, ALP, LDH, ${\gamma}-GT$ and the formation of hepatic malondialdehyde induced by D-GalN. The alcholic extract of Bacopa monniera also significantly restored the decreased levels of glutathione and the decreased activities of glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase and glucose-6-phosphatase. Therefore these results suggest that Bacopa monniera has hepatoprotective effect against D-GalN induced hepatotoxicity.

• Natural Product Sciences
• /
• v.13 no.1
• /
• pp.46-53
• /
• 2007

The effects of the alcoholic extract of Bacopa monniera (BMA) on morphine-induced pharmacological activities were studied in mice. Oral administration of the extract (40 mg/kg) significantly inhibited morphine-induced analgesic tolerance, withdrawal symptoms, hyperactivity, reverse tolerance, Dopamine receptor supersensitivity and apo-morphine-induced climbing behaviour in mice. The results of this study showed that, alcoholic extract of Bacopa monniera (BMA) exerted inhibitory effect against morphine-induced pharmacological effects, suggesting that the extract could be useful in the treatment of morphine toxicity.

• Advances in Traditional Medicine
• /
• v.6 no.4
• /
• pp.253-263
• /
• 2006

The plant is used in India as well as several countries since several centuries for treating different types of ailments. The plant is an important constituent of the Ayurvedic Materia Medica and finds mention in several ancient texts including Caraka Sanhita ($6^{th}$ century A.D.) and the Bhavprakasa ($16^{th}$ century A.D.). The scientific studies on this plant have reported several activities of this plant. Though the plant has cardiotonic, vasoconstrictor, sedative, neuro-muscular blocking, and anticancer activities, it is more popular as memory enhancer. Traditionally, a poultice made of the boiled plant is placed on the chest in acute bronchitis and coughs of children. The plant contains saponins: bacosides A and B, hersaponin, sapogenins: bacogenin $A_{1}$, $A_{2}$, and $A_{3}$ stigmasterol, and flavonoids: luteolin and luteolin-7 glucoside, nicotine, brahmine, and herpestine. This review focuses on the scientific data published since 1931.