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Improved Detection of Helicobacter pylori Infection and Premalignant Gastric Mucosa Using "Site Specific Biopsy": a Randomized Control Clinical Trial

  • Tongtawee, Taweesak;Dechsukhum, Chavaboon;Leeanansaksiri, Wilairat;Kaewpitoon, Soraya;Kaewpitoon, Natthawut;Loyd, Ryan A;Matrakool, Likit;Panpimanmas, Sukij
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.18
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    • pp.8487-8490
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    • 2016
  • Background: Helicobacter pylori infection and premalignant gastric mucosa can be reliably identified using conventional narrow band imaging (C-NBI) gastroscopy. The aim of our study was to compare standard biopsy with site specific biopsy for diagnosis of H. pylori infection and premalignant gastric mucosa in daily clinical practice. Materials and Methods: Of a total of 500 patients who underwent gastroscopy for investigation of dyspeptic symptoms, 250 patients underwent site specific biopsy using C-NBI (Group 1) and 250 standard biopsy (Group 2). Sensitivity, specificity, and positive and negative predictive values were assessed. The efficacy of detecting H. pylori associated gastritis and premalignant gastric mucosa according to the updated Sydney classification was also compared. Results: In group 1 the sensitivity, specificity, positive and negative predictive values for predicting H. pylori positivity were 95.4%, 97.3%, 98.8% and 90.0% respectively, compared to 92.9%, 88.6%, 83.2% and 76.1% in group 2. Site specific biopsy was more effective than standard biopsy in terms of both H. pylori infection status and premalignant gastric mucosa detection (P<0.01). Conclusions: Site specific biopsy using C-NBI can improve detection of H. pylori infection and premalignant gastric mucosa in daily clinical practice.

Efficacy of Quilting Sutures and Fibrin Sealant Together for Prevention of Seroma in Extended Latissimus Dorsi Flap Donor Sites

  • Shin, In Soo;Lee, Dong Won;Lew, Dae Hyun
    • Archives of Plastic Surgery
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    • v.39 no.5
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    • pp.509-513
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    • 2012
  • Background The extended latissimus dorsi flap is important for breast reconstruction. Unfortunately, donor site seroma is the most common complication of extended latissimus dorsi flap for breast reconstruction. Although using fibrin sealant in the donor site reduces the rate of seroma formation, donor site seroma remains a troublesome complication. The purpose of this study was to analyze the effectiveness of the combination of quilting sutures and fibrin sealant in the latissimus dorsi donor site for the prevention of seroma. Methods Forty-six patients who underwent breast reconstruction with extended latissimus flap were enrolled in the study. The patients received either fibrin sealant (group 1, n=25) or a combination of fibrin sealant and quilting sutures (group 2, n=21) in the extended latissimus dorsi donor site. Outcome measures were obtained from the incidence, volume of postoperative seroma, total drainage amount, indwelling period of drainage, and duration of hospital stay. Results The incidence of seroma was 76% in group 1 and 42.9% in group 2 (P=0.022). We also found significant reductions in seroma volume (P=0.043), total drainage amount (P=0.002), indwelling period of drainage (P=0.01), and frequency of aspiration (P=0.043). The quilting sutures did not affect the rate of drainage, tube reinsertion, or hospital stay. Conclusions The use of quilting sutures combined with fibrin sealant on the latissimus dorsi flap donor site is helpful for reducing the overall seroma volume, frequency of aspiration, and total drainage amount.

A Study of the Dynamic Amplification Characteristics of the Domestic Seismic Observation Sites Using Coda Wave (Coda파를 이용한 국내 관측소지반의 동적 증폭특성에 관한 연구)

  • Kim, Junkyoung;Lee, Jundae
    • Journal of the Korean GEO-environmental Society
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    • v.10 no.7
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    • pp.135-141
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    • 2009
  • For more reliable estimation of soil-structure interaction and seismic source and attenuation properties, site amplification function should be considered. This study use the Nakamura's method (1989) for estimating site amplification though various methods for the same purpose have been proposed. This method was originally applied to the surface waves of background noise and therefore there are some limitation for applications to general wave energy. However, recently this method has been extended and applied to the S wave energy successfully. This study applied the method to the coda wave energy which is equivalent to the backscattered S wave energy. We used more than 60 observed ground motions from 5 earthquakes which occurred recently, with magnitude range from 3.6 to 5.1 Each station showed characteristic site amplification property in low-, high- and resonance frequency ranges. In the case of comparing these results to those from S wave energy, lots of information to the site classification work can be gained. Moreover, removal of site amplification can give us more reliable seismic source parameters.

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Additive Properties of Crude, Age Specific and Age Adjusted Rates for Cancer Incidence and Mortality

  • Takiar, Ramnath;Shrivastava, Atul
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.13
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    • pp.5407-5409
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    • 2014
  • Background: In National Cancer Registry Programme (NCRP) reports, various rates are routinely provided for 50 cancer sites of males and 54 cancer sites of females. Very often, depending on our interest, we wish to see these rates for group of cancers like head and neck cancers, oral cancers, and reproductive cancers. In such a situation, the desired rates are calculated independently from the actual data and reported. The question is can we derive the rates for groups of cancers from the published reports when the data is provided only for the individual sites? Objective: In the present paper, an attempt is made to explore the mathematical properties of various rates to derive them directly for the group of cancer sites from the published data when the rates are provided only for the individual sites. Source of data: The cancer incidence data collected by two urban Population Based Cancer Registries (PBCRs), under the network of NCRP for the period of 2006-08 was considered for the study purposes. The Registries included were: Bangalore and Bhopal. Results: In the present communication, we have shown that the crude rate (CR), age specific rates and age-adjuste rates (AAR) all possess additive properties. This means, given the above rates for individual sites, the above rates can be calculated for groups of sites by simply adding them. In terms of formula it can be stated that CR(Site1+Site2+++ SiteN) = CR(Site1)+CR(Site2) +++ CR(SiteN). This formula holds good for age specific rates as well as for AAR. This property facilitates the calculation of various rates for defined groups of cancers by simply adding the above rates for individual sites from which they are made up.

Acellular dermal matrix (Insuregraf) in the prevention of Frey's syndrome and surgical site depression after parotidectomy

  • Choi, Jangyoun;Park, Song I;Rha, Eun Young;Seo, Bommie Florence;Kwon, Ho;Jung, Sung-No
    • Archives of Craniofacial Surgery
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    • v.20 no.3
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    • pp.176-180
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    • 2019
  • Background: Parotidectomy is the treatment of choice in many parotid tumors. Due to the extensive nature of the procedure, unfavorable complications such as gustatory sweating, surgical site depression are common. Various techniques using fascia, muscle or AlloDerm have been developed but debate still remains regarding its availability and affordability. We applied a newly developed acellular dermal matrix (Insuregraf) to the parotidectomy field to act as a physical barrier and to provide adequate filling effect for prevention of functional and aesthetic complications. Methods: From March 2010 to March 2017, 30 patients with parotid tumors underwent superficial parotidectomy. Twenty patients underwent only superficial parotidectomy. Ten patients had Insuregraf applied to the surgical site after superficial parotidectomy. We evaluated the incidence of Frey's syndrome, surgical site depression, and patient satisfaction rate in both groups. Results: The incidence of Frey's syndrome was lower in the Insuregraf group (0 vs. 2). Surgical site depression was also lower in the Insuregraf group (2 vs. 20). Satisfaction score for facial contour in Insuregraf group was 9.2 out of 10, which was comparable to 6.2 out of 10 in the control group. Conclusion: Application of Insuregraf after superficial parotidectomy is an effective surgical procedure to prevent complications such as Frey's syndrome and surgical site depression. This technique is affordable and safe with no immune reactions. Above all this surgical method should be considered as an option for patients who are concerned about the contour of the face after surgery.

Early wound healing of the hard-palate mucosal harvest site using artificial dermis fixation by a transparent plate

  • Suzuki, Yushi;Tanaka, Ichiro;Sakai, Shigeki;Yamauchi, Tomohiro
    • Archives of Plastic Surgery
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    • v.48 no.2
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    • pp.208-212
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    • 2021
  • Background There are currently no guidelines for the postoperative wound management of the hard-palate donor site in cases involving mucosal harvesting. This study describes our experiences with the use of an artificial dermis for early epithelialization and transparent plate fixation in cases involving hard-palate mucosal harvesting. Methods A transparent palatal plate was custom-fabricated using a thermoplastic resin board. After mucosal harvesting, an alginic acid-containing wound dressing (Sorbsan) was applied to the donor site, which was then covered with the plate. After confirming hemostasis, the dressing was changed to artificial dermis a few days later, and the plate was fixed to the artificial dermis. The size of the mucosal defect ranged from 8×25 to 20×40 mm. Results Plate fixation was adequate, with no postoperative slippage or infection of the artificial dermis. There was no pain at the harvest site, but a slight sense of incongruity during eating was reported. Although the fabrication and application of the palatal plate required extra steps before and after harvesting, the combination of the artificial dermis and palatal plate was found to be very useful for protecting the mucosal harvest site, and resulted in decreased pain and earlier epithelialization. Conclusions The combination of artificial dermis and a transparent palatal plate for wound management at the hard-palate mucosal donor site resolved some of the limitations of conventional methods.

Quantification of Heterogenous Background Fractures in Bedrocks of Gyeongju LILW Disposal Site (경주 방폐장의 불균질 배경 단열의 정량화)

  • Cho, Hyunjin;Cheong, Jae-Yeol;Lim, Doo-hyun;Hamm, Se-Yeong
    • The Journal of Engineering Geology
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    • v.27 no.4
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    • pp.463-474
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    • 2017
  • Heterogeneous background fractures of granite and sedimentary rocks in Gyeongju LILW (low-intermediate level radioactive waste) facility area have been characterized quantitatively by analyzing fracture parameters (orientation, intensity, and size). Surface geological survey, electrical resistivity survey, and acoustic televiewer log data were used to characterize the heterogeneity of background fractures. Bootstrap method was applied to represent spatial anisotropy of variably oriented background fractures in the study area. As a result, the fracture intensity was correlated to the inverse distance from the faults weighted by nearest fault size and the mean value of electrical resistivity and the average volumetric fracture intensity ($P_{32}$) was estimated as $3.1m^2/m^3$. Size (or equivalent radius) of the background fractures ranged from 1.5 m to 86 m and followed to power-law distribution based on the fractal property of fracture size, using fractures measured on underground silos and identified surface faults.

A CLINICAL STUDY ON THE ANATOMICAL SITE SURVIVAL RATE IN INTRAORAL SQUAMOUS CELL CARCINOMA (구강내 부위별 편평 상피암종의 생존율에 관한 임상 연구)

  • Kim, Kyung-Wook;Lee, Tae-Hee
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.29 no.5
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    • pp.315-322
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    • 2003
  • Background : Important factors to determine treatment method and prognosis of oral cancer are anatomical site, tumor size, metastatic lesion, histologic cell differenciation and microvascular invasion. Anatomical site has great effect to oral cancer patient's survival rate because each site's accessibility and lymph node metastasis is different but this factor was't studied much than other factors. Patients and Methods : 228 patients with squamous cell carcinoma of common primary sites(Mandible, Maxilla, Floor of Mouth and Tongue) in oral cavity who were diagnosed in the Korea Cancer Center Hospital from January 1989 to December 1999, were clinically studied and analyzed on survival rate. Results : 1. Survival rates of each anatomical sites were Tongue(36.8%), Mandible(33.3%), Maxilla(28.7%) and Floor of Mouth(24.5%). Survival rates difference between Tongue and Floor of Mouth has significance(p<0.05). 2. Survival rates for early cancer of each site were Maxilla(100%), Mandible(57.1%), Tongue(54.2%) and Floor of Mouth(46.7%). Survival rates difference between Maxilla and Floor of Mouth has significance(p<0.05). 3. Survival rates by surgery method of each site were Maxilla(60.6%), Tongue(56.9%), Mandible(44.8%) and Floor of Mouth(26.3%). Survival rates difference between Maxilla and Floor of Mouth has significance(p<0.05). 4. Survival rates by radiation or chemo method of each site were Floor of Mouth(23.5%), Mandible(20.0%), Maxilla(9.5%), and Tongue(9.1%). Survival rates difference between each site doesn't have significance(p>0.05). 5. In advance stage, Survival rates by single therapy of each site were Tongue(33.6%), Mandible(23.5%), Floor of Mouth(16.7%), Maxilla(0%), and Survival rates difference between Maxilla and Tongue has significance (p<0.05). Survival rates by combination therapy of each site were Mandible(38.1%), Maxilla(30.0%), Floor of mouth(18.2%), Tongue(12.5%), and Survival rates difference between Mandible and Tongue has significance(p<0.05). Conclusion : Survival rate of tongue is higher than the other sites, early detection of oral cancer can increase survival rate at any site and combination therapy is the most effetive method, especially at maxilla.

A Radionuclides Suite Selection for Site Characterization and Final Status Survey in the U.S. NPPs (미국의 원전 해체관련 부지특성 및 최종상태 조사를 위한 방사성 오염 핵종 결정 방법에 대한 분석)

  • Zhao, Pengfei;Jeon, Yeo Ryeong;Kim, Yongmin;Lee, Jong Seh;Ahn, Seokyoung
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.14 no.3
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    • pp.267-277
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    • 2016
  • For the decommissioning of a nuclear power plant, a site characterization and final status survey require a site-specific suite of radionuclides that could potentially still be present in the site during or after the decontamination processes. The United States Nuclear Regulatory Commission (U.S. NRC) requires a Decommissioning Technical Base Document (DTBD) along with a Site Characterization and Historical Site Assessment (HSA) from the utility for decommissioning to proceed. Both the DTBD and HSA are preliminary components of the Radiological Site Survey investigation process and should be included in the final License Termination Plan (LTP) for site release and reuse consideration from the U.S. NRC and the utility company. This study reviews the United States Nuclear Power Plants (U.S. NPPs) decommissioning cases and is especially focused on the methodologies used for determining a site-specific suite of radionuclides before and during the site characterization and final status surveys. In 2017, Kori-1 will be ready for decommissioning and related preparations are ongoing, this review will help Korea to prepare regulatory guidelines and give technical background for the safe and successful decommissioning of NPPs.

Architectural Tendencies of Public Art Projects in Korea - Focused on Those in Which Korean Architects Participated in Group after 2000 - (국내 공공미술 사업의 건축적 경향 - 국내 건축가가 단체로 참여한 2000년 이후의 사업을 중심으로 -)

  • Park, Seul-Ki;Kim, Ransoo
    • Korean Institute of Interior Design Journal
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    • v.24 no.1
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    • pp.133-143
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    • 2015
  • This study tried to inquire architectural tendencies in public art projects by analyzing projects and public art works designed by Korean architects. First, it described not only the background and the objectives of this study but also the scope and the methods of it. Second, it gave an overview of public art by explaining the concept, the institutions, and the history of it in Korea. Third, it investigated the contents of public art projects in Korea, in which more than two architectural teams participated, analyzing the tendencies of public art works designed by architects. In order to find the architectural tendencies of public art projects, it analyzed the intentions, the contents and the expressions of architects' art works. In conclusion, this study regarded the architectural tendencies as site-specific, space-experiencing, sheltering, multi-purposeful, contextual, recycling, and eco-friendly.