• Mycobiology
• /
• 제39권4호
• /
• pp.257-265
• /
• 2011

L-Phenylalanine is one of the essential amino acids that cannot be synthesized in mammals in adequate amounts to meet the requirements for protein synthesis. Fungi and plants are able to synthesize phenylalanine via the shikimic acid pathway. L-Phenylalanine, derived from the shikimic acid pathway, is used directly for protein synthesis in plants or metabolized through the phenylpropanoid pathway. This phenylpropanoid metabolism leads to the biosynthesis of a wide array of phenylpropanoid secondary products. The first step in this metabolic sequence involves the action of phenylalanine ammonialyase (PAL). The discovery of PAL enzyme in fungi and the detection of $^{14}CO_2$ production from $^{14}C$-ring-labeled phenylalanine and cinnamic acid demonstrated that certain fungi can degrade phenylalanine by a pathway involving an initial deamination to cinnamic acid, as happens in plants. In this review, we provide background information on PAL and a recent update on the presence of PAL genes in fungi.

• 한국정보처리학회:학술대회논문집
• /
• 한국정보처리학회 2002년도 추계학술발표논문집 (상)
• /
• pp.715-718
• /
• 2002

실시간 동영상에서 객체의 추적은 배경영상에서 움직이는 객체를 추출하고 추출된 객체의 이동을 추적하는 것으로 컴퓨터 비전 및 여러 실용적 응용 분야에서 관심을 가지는 주제중 하나이다. 본 논문에서는 실시간 객체의 추적에서 배경영상과 입력영상의 차영상을 이용하는 방법의 전 처리로 시간의 흐름에 따라 변화되는 배경영상의 잡음을 최소화하기 위하여 입력영상의 일부분을 배경영상으로 대체함으로 최신의 배경영상을 유지 할 수 있는 방법을 제안하고자 한다. 실시간 동영상의 객체추적은 배경영상과 입력영상의 차를 이용하는데 최초의 배경영상은 시간의 흐름에 의해 빛의 양이나 주위환경에 의해 많은 변화를 가져오게 된다. 또한 실시간으로 처리해야 하는 시간성으로 인해 최신의 배경영상을 획득하는데 많은 처리시간을 할애할 수 없다. 따라서 전체 영상의 일부분을 대상으로 점진적으로 누적영상을 배경영상에 적용함으로 실시간 환경에서의 배경영상의 변화에 의한 잡음을 최소화 하도록 하였다.

• 정보처리학회논문지B
• /
• 제18B권3호
• /
• pp.117-130
• /
• 2011

본 논문에서는 객체이동을 고려한 배경영상 생성과 사고 후보영역의 보존 및 검증하는 방법을 포함하는 개선된 교차로 교통사고 감지 방법을 제안한다. 교차로 내 신호등 주기를 이용한 교차로 사고감지 방법이 제안된 바 있는데 이는 사고 객체의 가려짐이 발생할 경우 사고를 감지하지 못하는 문제가 발생할 수 있다. 본 논문에서는 역원근변환을 수행하여 객체의 크기를 일정하게 하였으며, 환경잡음에 강건한 배경영상 생성, 객체의 이동정보를 이용한 사고 후보영역의 생성, 에지 정보를 이용한 사고 후보영역의 보존 및 삭제 방법 등을 제안한다. 제안한 알고리즘의 성능을 알아보기 위하여 교차로에 설치된 DVR을 통해 출퇴근 시간대의 영상, 야간 및 주간의 우천 시의 다양한 사고 영상, 조명 및 그림자의 환경적 잡음이 포함된 영상을 저장하여 실험하였다. 실험 결과 실험에 포함된 20건의 사고를 모두 감지하였으며 실제 사고 유효 획득률은 76.9%로 나타났다. 또한 검지영역의 면적에 따라 초당 10~14프레임의 처리속도를 나타내어 실시간 처리에 문제가 없을 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권9호
• /
• pp.3945-3949
• /
• 2014

Background: A cancer registry program has been established in East Azerbaijan and this has emphasized the importance of cancers of gastrointestinal tract in this region. The aim of the present pathology-based cancer registry report is to renew epidemiologic aspects of gastrointestinal tract cancers and estimate recent trends. Materials and Methods: A survey team reviewed and collected all records of cancer cases from all referral and valid pathology laboratories of East Azerbaijan province during September 2007-2011. Crude rates, age-specific rates of cancer incidence and annual percent change were calculated. Results: The total newly diagnosed cancer cases (n=6,889)comprised 4,341 males (63.0%) and 2,540 females (36.9%). Gastric cancer was the most common GI tract cancer with an ASR (per $10^5$) of 23.1 for males and 7.69 for females. The ASRs for esophageal and colorectal cancers were 9.69 and 11.2 in males and 7.35 and 8.93 in females. Trend analysis showed a significant decline for esophageal cancer and increasing incidence for colorectal cancer in females. Conclusions: The prevalence of gastric cancer is high in East Azerbaijan province of Iran. This pathology based cancer registry showed an ascending trend for colorectal cancer and decreasing trend for esophageal cancer in females during 2007-2011.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권1호
• /
• pp.367-370
• /
• 2012

Background: Breast cancer is the most commonly diagnosed cancer in women worldwide In Iran, it ranks first among cancers diagnosed in women and is the fifth most common cause of death. The aim of this study was to present the mortality trends from breast cancer for Iranian women during a period of almost a decade, in order to provide update information regarding the likely future. Methods: We analyzed National death Statistic reported by the Iranian Ministry of Health and Medical Education from 1995 to 2004 to generate annual mortality rates/100,000, overall, by age group (<15, 15-49 and ${\geq}50$ years of age) and age standardized rate (ASR). Results: The age standardized mortality rate of breast cancer increased dramatically during these years from 1.40 to 3.52 per 100,000 and its mortality was increasing 151.4% for Iranian women, although it seemed that the rate leveled off from 2002 to 2004. Moreover the increasing rate was higher for those aged between 15-49 compared to age >50 years old. Conclusion: There is an increasing trend for breast cancer mortality in Iran. Thus, health education programs to rectify the lack of women awareness about breast cancer signs and effective screening are urgently needed.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권5호
• /
• pp.2513-2518
• /
• 2016

Background: In 2008, non-Hodgkin lymphoma ranked tenth among other malignancies worldwide with an incidence of around 5 cases per 100,000 in both genders. The latest available rates in Tunisia are from 2006. Materials and Methods: This study aimed to provide an update about NHL incidence for 2009 and its trend between 1998 and 2009 as well as a projection until 2024, using data from the Salah Azaiz Institute hospital registry and the Noth Tunisia cancer registry. Results: In 2009, the NHL incidence in the north of Tunisia was 4.03 cases per 100,000, 4.97 for men and 3.10 for women. Diffuse large B-cell lymphoma (DLBCL) accounted for 63.2% of all NHL subtypes. Between 1998 and 2009, the overall trend showed no significant change. When we compared the trend between two periods (1998-2005 and 2005-2009), joinpoint regression showed a significant decrease of NHL incidence in the first period with an annual percentage change (APC) of -6.7% (95% CI:[-11.2%;-2%]), then the incidence significantly increased from 2005 to 2009 with an APC of 30.5% (95% CI: [16.1%; 46.6%]. The analyses of the different subtype trends showed a significant decrease in DLBCL incidence between 1998 and 2000 (APC:-21.5; 95% CI: [-31.4%;-10.2%]) then the incidence significantly increased between 2004 and 2007 (APC: 18.5; 95% CI: [3,6%;35.5%]). Joint point analysis of the age-period-cohort model projection showed a significant increase between 2002 and 2024 with an APC of 4.5% (%95 CI: [1.5%; 7.5%]). The estimated ASR for 2024 was 4.55/100 000 (95% CI: [3.37; 6.15]). Conclusions: This study revealed an overall steady trend in the incidence of NHL in northern Tunisia between 1998 and 2009. Projection showed an increase in the incidence in NHL in both genders which draw the attention to the national and worldwide burden of this malignancy.

• 인지과학
• /
• 제14권3호
• /
• pp.13-21
• /
• 2003

이 연구에서는 기존의 지능형 교수기계와 또래 튜터링의 단점을 보완하여 '가르치기를 통한 학습'을 위한 교수가능 에이전트(Teachable Agent, 이하 TA) 의 이론적 배경 및 설계방안을 제시하고자 한다. TA는 학습자가 컴퓨터 에이전트를 가르치는 과정을 통해 학습하는 시스템으로 교수 Module, 묻고 답하기 Module, 테스트 Module, 학습자료 Module 등의 4 가지 Module로 구성된다. 교수 Module에서는 개념도(concept map)의 구성을 통해 튜터 역할을 하는 학습자가 TA 의 심성모형 (mental model)을 수정하고 update하게 되며, 묻고 답하기 Module에서는 인터렉티브 창을 통해 튜터와 TA가 제한된 방식으로 학습내용에 관한 질문과 응답을 함으로써 개념도를 수정보완하게 된다. 테스트 Module에서는 튜터가 가르친 TA가 미리 정해놓은 학습목표에 도달하였는지를 평가하게 된다. 테스트 결과 TA가 일정 수준에 도달하지 못한 경우에는 개념도의 재수정 과정을 통해 계속적인 학습이 이루어지도록 한다. 학습자료 Module은 튜터가 참고할 자료를 제공해 주는 Module이다. 이러한 TA는 튜터의 역할을 담당하는 학습자에게 깊이 있는 인지적 처리와 능동적인 학습동기를 경험하도록 함으로써 실제 교육현장에서의 유용한 교수/학습도구로 활용될 수 있을 것으로 기대된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권18호
• /
• pp.8595-8598
• /
• 2016

Background: Decision making modalities for screening for many cancer conditions and different stages have become increasingly complex. Computer-based risk assessment systems facilitate scheduling and decision making and support the delivery of cancer screening services. The aim of this article was to survey electronic risk assessment system as an appropriate tool for the prevention of cancer. Materials and Methods: A qualitative design was used involving 21 face-to-face interviews. Interviewing involved asking questions and getting answers from exclusive managers of cancer screening. Of the participants 6 were female and 15 were male, and ages ranged from 32 to 78 years. The study was based on a grounded theory approach and the tool was a semi-structured interview. Results: Researchers studied 5 dimensions, comprising electronic guideline standards of colorectal cancer screening, work flow of clinical and genetic activities, pathways of colorectal cancer screening and functionality of computer based guidelines and barriers. Electronic guideline standards of colorectal cancer screening were described in the s3 categories of content standard, telecommunications and technical standards and nomenclature and classification standards. According to the participations' views, workflow and genetic pathways of colorectal cancer screening were identified. Conclusions: The study demonstrated an effective role of computer-guided consultation for screening management. Electronic based systems facilitate real-time decision making during a clinical interaction. Electronic pathways have been applied for clinical and genetic decision support, workflow management, update recommendation and resource estimates. A suitable technical and clinical infrastructure is an integral part of clinical practice guidline of screening. As a conclusion, it is recommended to consider the necessity of architecture assessment and also integration standards.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권8호
• /
• pp.3997-4001
• /
• 2016

Background: Cancer is a worldwide health problem and pain is among the most common and unpleasant effects affecting well-being of cancer patients. Accurate description of pain can help physicians to improve its management. Many English tools have been developed to assess pain. Onkly a limited number of these are applied in Arab countries. Our aim was to assess the quality, the nature and the severity of pain using the short McGill Pain Questionnaire (SF-MPQ) on cancer patients in the National Institute of Oncology (NIO) in Rabat, Morocco. Materials and Methods: The tool used is the SF-MPQ inspired from the Arabic version of the MPQ. The subjects were cancer patients (N=182) attending the NIO, from 24th October 2015 to 8th January 2016, aging ${\geq}18$ years old, experiencing pain and coming to have or to update their pain medication. Results: The rate of participation was 96.3%. Eight patients had difficulties to express their pain using descriptors, but could use the Visual Analogue Scale (VAS) and the body diagram. The most frequent sensory descriptors were 'Throbbing', 'Shooting', 'Hot-Burning'. The most used affective descriptor was 'Tiring-Exhausting'. The mean VAS was 6.6 (2.4). The mean score of all items was 11.9 (7.8). The patients were suffering from severe pain. The internal consistency of the form was s acceptable. Conclusions: The findings indicate that most of the patients attending the pain center of the NIO could use the descriptors of the SF-MPQ to describe their pain. They indicate the usefulness of the SF-MPQ to assess the nature and the severity of pain in cancer patients. This tool should be tested in other Moroccan and Arabic contexts associated with other tools in clinical trials.

• Safety and Health at Work
• /
• 제8권2호
• /
• pp.169-174
• /
• 2017

Background: We assessed the cancer risks of four different Finnish asbestos-exposed cohorts. We also explored if the cohorts with varying profiles of asbestos exposure exhibited varying relative risks of cancer. Methods: The incident cancer cases for the asbestos-exposed worker cohorts were updated to the end of 2012 using the files of the Finnish Cancer Registry. The previously formed cohorts consisted of asbestos mine workers, asbestosis patients, asbestos sprayers, and workers who had taken part in a screening study based on asbestos exposure at work. Results: The standardized incidence ratio (SIR) for mesothelioma varied from about threefold to > 100-fold in the different cohorts. In the screening cohort the SIR for mesothelioma was highest in 2003-2007, In other cohorts it was more constant in 5-year period inspection. The SIR for lung cancer was about twofold to tenfold in all except the screening cohort. Asbestos sprayers were at the highest risk of mesothelioma and lung cancer. Conclusion: The SIR for mesothelioma is high in all of the cohorts that represent different kinds of asbestos exposure. The smaller SIR for mesothelioma in the screening cohort with lowest level of asbestos exposure might suggest dose-responsiveness between asbestos exposure and mesothelioma. It does seem that the highest risk of lung cancer in these cohorts except in the youngest of the cohorts, the screening cohort, is over. The highest SIR for lung cancer of the asbestosis patient and sprayers cohort is explained by their heavy asbestos exposure.