• The korean journal of orthodontics
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• v.52 no.5
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• pp.354-361
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• 2022

Objective: To analyze the overall treatment effects in terms of the amount of uprighting with changes in the three-dimensional positions of the mandibular posterior teeth after applying the biocreative reverse curve (BRC) system. Methods: Thirty-four patients (mean age, 20.5 ± 8.56 years) were treated using the BRC system (mean period, 8.17 ± 2.19 months). Cone-beam computed tomography was performed before treatment and after treatment with the BRC system. The three-dimensional movement of each tooth was analyzed in the coordinate system at points on the crown and root apex. A paired t-test was used to analyze the treatment effects of the BRC system. Results: The application of the BRC system spanning from the first premolar to the second molar resulted not only in buccal and distal uprighting, but also in increased buccal and distal tipping of the teeth. The premolars and the first molar were extruded, and the second molar was intruded. Conclusions: When the BRC system is applied, simultaneous distal and buccal uprighting of the premolars and molars can be achieved bilaterally using a temporary skeletal anchorage device without unnecessary movement of the anterior teeth.

• The korean journal of orthodontics
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• v.51 no.3
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• pp.179-188
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• 2021

Objective: To evaluate the overall treatment effects in terms of the amount of uprighting with changes in the sagittal and vertical positions of mandibular molars after applying an orthodontic miniplate with a nickel-titanium (NiTi) reverse curve arch wire (biocreative reverse curve [BRC] system). Methods: A total of 30 female patients (mean age, 25.99 ± 8.96 years) were treated with the BRC system (mean BRC time, 10.3 ± 4.07 months). An I-shaped C-tube miniplate (Jin Biomed) was placed at the labial aspect for the alveolar bone of the mandibular incisors. A 0.017 × 0.025-inch NiTi reverse curve arch wire was engaged at the C-tube mini-plate anteriorly and the first and second premolars and molars posteriorly in the mandibular arch. Pre- and post-BRC lateral cephalograms were analyzed. A paired t-test was used to analyze the treatment effects of BRC. Results: The mandibular second molars were intrusively uprighted successfully by the BRC system. Distal uprighting with a controlled vertical dimension was noted on the first molars when they remained engaged in the BRC and the distal ends of the arch wire were laid on the second molars. The mandibular first and second premolars showed a slight extrusion. The changes in the mandibular incisors were unremarkable, while the mandibular molar angulation improved significantly. The lower occlusal plane rotated counterclockwise (MP-LOP: 1.13° ± 2.60°). Conclusions: The BRC system can provide very effective molar uprighting without compromising the position of the mandibular anterior teeth.

• BMB Reports
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• v.52 no.2
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• pp.139-144
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• 2019

Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems, development of novel therapeutic targets for inhibition of BRC proliferation, metastasis and recurrence have been constantly needed. Thus, in this study, we identified overexpression of SETDB1 (SET Domain Bifurcated 1), a histone methyltransferase, in RNA-seq data of BRC derived from TCGA portal. In Gene Ontology (GO) analysis, cell migration-related GO terms were enriched, and we confirmed down-regulation of cell migration/invasion and alteration of EMT /MET markers after knockdown of SETDB1. Moreover, gene network analysis showed that SMAD7 expression is regulated by SETDB1 levels, indicating that up-regulation of SMAD7 by SETDB1 knockdown inhibited BRC metastasis. Therefore, development of SETDB1 inhibitors and functional studies may help develop more effective clinical guidelines for BRC treatment.

• Journal of the Korean Wood Science and Technology
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• v.40 no.2
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• pp.61-70
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• 2012

In this study the effect of heartwood-coating (HCO), vapor-dam (VD), bark-remaing (BR) and bark-remaining- coating (BRC) treatments were evaluated during air circulating oven-drying of hollowed round-post of Korean red pine. Hollowed round-post could be dried from the green condition to approximately 6% MC within 84 to 156 hours for the UC, HCO and VD specimens and it took 72 to 240 hours to about 8% MC, which is recommended as the indoor in-use MC. The temperatures in the hole of the Control (UC) and HCO specimens constantly showed a higher-leveled distribution pattern than those inside wood. The vapor pressure in the hole of the UC, HCO and BR specimens was higher than that inside wood and showed difference as highest value of about 20 mbar. The surface checks of all specimens were mild and were observed in increasing order of BRC, BR, UC, VD and HCO specimens.

• Journal of the Korean Wood Science and Technology
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• v.42 no.2
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• pp.101-111
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• 2014

In this study the effect of heartwood-coating (HCO), vapor-dam (VD), bark-remaining (BR) and bark-remaining-coating (BRC) treatments on the air circulating oven-drying characteristics of Japanese larch hollowed round-post was evaluated. The drying times of the hollowed round-posts for control, VD, HCO and BR specimens were 72, 168, 204 and 240 hours, respectively, from the initial MC to about 8% MC, which was recommended as the indoor in-use MC. The temperature in the hole of the VD specimen was lower than that of wood and the difference between air temperature in the hole and wood temperature became large during drying period. The vapor pressure of air in the hole was higher than that of inside wood for all specimens except VD specimen. The surface checks on all specimens were observed in increasing order of BR, BRC, UC, HCO and VD specimens.