• 대한한방내과학회지
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• 제22권4호
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• pp.589-599
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• 2001

Objective: This study was carried out to investigate the effects of Hyangsayukgunja-tang extract on indomethacin-induced gastric mucosal lesions of mice. Methods: To evaluate the effects of Hyangsayukgunja-tang extract and Misoprostol, the morphology of gastric mucosa, and the distribution of mucose cells, PNA(Peanut Agglutinin), ICAM(intercellular adhesion molecule), and apoptotic cells were observed. Hyangsayukgunja-tang extract and Misoprostol were intragastric injected to the test groups at hour 72 before and just before indomethacin treatment(HYT-J, HYT-72, M-J, M-72), while the INDO group was injected only with indomethacin and the control group was subcutaneously injected only with saline. Results: The gastric mucosal lesions incresed in the fundus and body of INDO group, but softened in HYT group and M group, the effects were more excellent in the HYT-72, M-72 groups than the HYT-J, M-J groups and in the HYT group than M group. The disappearance of surface and neck mucose cells were shown in INDO group, but softened in HYT group and M group. The mucosal configuration of HYT-72 group was the same as control group. The numerical increase of PNA positive reaction in cytoplasm of perietal cells were appeared in INDO group. The PNA positive reaction in HYT group and Miso-group were shown in surface mucous cells and microvilli of apical surface in chief cells as control group, and were the same as control group in all mucosa of HYT-72 group. The distribution of ICAM positive cells, increased in INDO group, but decreased in M-72 group, and were the same as control group in HYT-72 group. The apoptotic cells, increased noticeably in gastric mucosa of INDO group, decreased in HYT group and M group, and decreased noticeably in HYT-72 group. Conclusions: Hyangsayukgunja-tang extract had excellent effects on indomethacin-induced gastric mucosal lesions.

• 만화애니메이션 연구
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• 통권19호
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• pp.37-50
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• 2010

본 연구의 목적은 그람시(Antonio Gramsci)가 언급한 대로 지배적 이념이 한 사회에 종속된 이들의 삶에 습관처럼 자리 잡고 있다는 헤게모니(hegemony) 개념을 통해서 디즈니 애니메이션에 나타난 남성성의 유형을 찾는데 있다. 그리고 코넬(R. W. Connell)은 그람시의 개념을 남성성과 연결시켜 헤게모니적 남성성(hegemonic masculinity)으로 발전시켰다. 헤게모니적 남성성은 한 국가나 사회에서 다른 남성과 여성을 종속하고 지배하려는 경향을 의미하는 것으로, 본 연구에서는 디즈니 애니메이션에 재현된 다양한 남성성을 구분하고, 특히 헤게모니적 남성성에 대한 이론적 접근을 다루고 있다. 한편 코넬의 네 가지 남성성의 분류는 남성 그룹이라는 범주에서 지배 그룹과 피지배 그룹으로 분리되어 있으며, 보다 세부적으로 헤게모니적 남성성, 종속적 남성성, 공모적 남성성, 그리고 주변화된 남성성으로 구분할 수 있다. 이러한 이론적 틀을 가지고 <미녀와 야수 Beauty and the Beast>(1991)에 나타난 지배적 남성성과 피지배적 남성성의 관계를 살펴본 결과, 개스턴(Gaston)과 야수는 헤게모니적 남성성을 소유하고 있으며, 그들 주변에 있는 남성들은 모두 공모적 남성성을 지니고 있다. 한편, 모리스(Maurice)는 지배 집단으로부터 거세된 종속적 남성성에 들어가게 되며, 야수는 헤게모니적 남성성과 주변화된 남성성 모두를 지닌 양가적 인물로 그려지고 있다. 이처럼 디즈니 속에 나타난 남성성은 헤게모니적 남성성을 기반으로 소프트바디에 의한 하드바디의 번복을 더디게 만들고 오히려 하드바디의 체제를 더욱 공고히 구축하고 있다.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2001년도 춘계학술발표대회
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• pp.41-41
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• 2001

Chromatin configuration and microtubule assembly were determined in porcine maturing and activated oocytes following intracytoplasmic sperm injection. Microtubule localization was confirmed using a mouse monoclonal antibody to $\alpha$-tubulin and detected using a fluorescent labeled goat anti-mouse secondary antibody. DNA was stained with propidium iodide. The image of microtubules and chromatin was captured using laser scanning confocal microscope. In germinal vesicle stage oocyte, sperm chromatin remained condensation and sperm derived microtubules were not observed at 8 to 12 h after sperm injection. At 24 h after injection, the sperm nucleus developed to the metaphase chromatin along the metaphase structure of female nucleus. In some metaphase I stage oocytes, sperm chromatin decondensed at 8 h to 12 h after injection, sperm aster was seen soon after sperm injection. At 24 h after sperm injection into metaphase I stage oocyte, male chromatin developed to the metaphase chromatin while female chromatin extruded first polar body and formed the metaphase chromatin. At 12 to 15 h after sperm injection into preactivated oocytes, condensed sperm nucleus was located in close proximity of female pronucleus. However, the condensed nucleus did not fuse with female pronucleus. In preactivated ocytes, injected sperm remained condensation, a few sperm organized small microtubular aster. Instead, maternal derived microtubules were organized near the female chromatin, which seem to move condensed male chromatin near to the female pronucleus. These results suggest that sperm nuclear decondensing activity and nucleation activity of centrosome during fertilization are cell cycle dependent. In absence of male functional centrosome, female origin centrosome takes over the role of microtubule nucleation for nuclear movement.

• 한국산학기술학회논문지
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• 제11권6호
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• pp.2124-2128
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• 2010

본 연구에서는 MAPK 저해제인 U0126이 난자성숙과정에서 특히 감수분열, 미세소관 형성 그리고 액틴 필 라먼트 형성에 미치는 영향을 조사하였다. 그 결과 MAPK 단백질은 12시간째에 인산화되기 시작하여, 24시간째에 대부분 인산화 되었고 metaphase II에 이르기 까지 유지되었다. 배포단계(GV)에 있는 난자를 U0126의 $20{\mu}M$ 농도로 처리하였을 때 MAPK의 인산화가 완전히 억제되었으나 배포의 파열 단계(GVBD)로의 성숙에는 진행하였으나, metaphase I까지는 발달하지 못하였다. 또한 MAPK 저해제로 인해 비정상적인 방추사의 형성을 초래하였다. 난자를 배포의 파열단계(GVBD) 이후에 U0126을 처리하였을 때 극체의 방출은 정상 이였으나 중기 판의 배열과 염색체의 분열은 비정상적 이였다. 결론적으로, 유사분열 활성화 효소단백질인 MAPK의 활성은 돼지 난자의 체외성숙과정에서 배포단계(GV)의 염색체의 배열과 감수분열의 완성에 중요한 조절 인자임을 이번 연구를 통해 알 수 있었다.

• 상하수도학회지
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• 제31권6호
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• pp.599-609
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• 2017

Desalination plants have been recently constructed in many parts of the world due to water scarcity caused by population growth, industrialization and climate change. Most seawater desalination plants are designed with a submarine pipeline for intake and discharge. Submarine pipelines are installed directly on the bottom of the water body if the bottom is sandy and flat. Intake is located on a low-energy shoreline with minimal exposure to beach erosion, heavy storms, typhoons, tsunamis, or strong underwater currents. Typically, HDPE (High Density Polyethylene) pipes are used in such a configuration. Submarine pipelines cause many problems when they are not properly designed; HDPE pipelines can be floated or exposed to strong currents and wind or tidal action. This study examines the optimal design method for the trench depth of pipeline, analysis of on-bottom stability and dilution of the concentrate based on the desalination plant conducted at the Pacific coast of Peru, Chilca. As a result of this study, the submarine pipeline should be trenched at least below 1.8 m. The same direction of pipeline with the main wind is a key factor to achieve economic stability. The concentrate should be discharged as much as high position to yield high dilution rate.

• Wind and Structures
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• 제21권2호
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• pp.223-239
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• 2015

Open decks are a widely used deck configuration in long-span cable-stayed bridges; however, incorporating aerodynamic countermeasures are advisable to achieve better aerodynamic performance than a bluff body deck alone. A sectional model of an open deck cable-stayed bridge with a main span of 400 m was selected to conduct a series of wind tunnel tests. The influences of five practical aerodynamic countermeasures on flutter and vortex-induced vibration (VIV) performance were investigated and are presented in this paper. The results show that an aerodynamic shape selection procedure can be used to evaluate the flutter stability of decks with respect to different terrain types and structural parameters. In addition, the VIV performance of $\prod$-shaped girders for driving comfortableness and safety requirements were evaluated. Among these aerodynamic countermeasures, apron boards and wind fairings can improve the aerodynamic performance to some extent, while horizontal guide plates with 5% of the total deck width show a significant influence on the flutter stability and VIV. A wind fairing with an angle of $55^{\circ}C$ showed the best overall control effect but led to more lock-in regions of VIV. The combination of vertical stabilisers and airflow-depressing boards was found to be superior to other countermeasures and effectively boosted aerodynamic performance; specifically, vertical stabilisers significantly contribute to improving flutter stability and suppressing vertical VIV, while airflow-depressing boards are helpful in reducing torsional VIV.

• 한국해양공학회지
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• 제22권4호
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• pp.65-71
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• 2008

In many cases, open-type plate breakwaters use plates with multiple holes; the holes serve as energy dissipaters and weight reducers. Because of the multi-holes configuration, stress concentration should be considered during the design process. Among several design loading conditions, the loads from a possible collision with a man-made vessel or other unexpected events many damage a multi-perforated steel plate. In that case, the structural behavior of a multi-perforated steel plate is quite significant, and is not well understood. This study presents a collision analysis for a multi-perforated steel plate. First, four different perforation topologies (three with circles and one with squares) were selected to investigate the effect of different hole shapes on the structural response. Second, the wave force at a specific site was calculated and loaded onto a steel plate as a static load. The static stresses were used for reference values. Third, two rigid body impacters (cubical & cylindrical) were applied to the steel plates to investigate the transient stress responses. In addition, two different impacting angles ($45^{\circ}\;&\;90^{\circ}$) were selected to investigate the angle effect. From the collision analysis, the significance of the transient stresses was emphasized.

• 한국인터넷방송통신학회논문지
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• 제17권6호
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• pp.83-88
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• 2017

본 논문에서는 유도무기용 탐색기의 송신 시 고 전력 송수신 신호 분리를 위한 Ka-대역 밀리미터파 3-포트 도파관 순환기를 설계, 제작하였으며 상온에서의 S-parameter 시험, 고 전력 시험, 운용 온도 시험을 통해 성능을 검증하였다. 탐색기 안테나와의 인터페이스 설계 및 소형, 경량화를 위한 표준 도파관 높이의 half-size 설계를 적용하였다. 전기적 성능 구현을 위해 시뮬레이션을 통한 구성 부품인 영구자석, 페라이트 최적 형상 설계 및 포트 별 튜닝 유전체 적용을 통해 성능을 최적화 하였다. 설계된 도파관 순환기는 중심 주파수 Fc 기준 ${\pm}1000MHz$의 대역에서 -20 dB 이하 반사 손실, 0.5 dB 이하 삽입 손실, -23 dB 이하 분리도 특성을 가지며, 측정 결과는 설계 결과와 유사함을 확인하였다.

• 한국인터넷방송통신학회논문지
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• 제18권1호
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• pp.91-96
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• 2018

본 논문에서는 고 전력 저 손실 특성을 가지는 소형 레이더용 Ka-대역 밀리미터파 2축 도파관 로터리 조인트 설계 및 제작하였다. 전기적 성능은 상온 S-parameter 시험, 고 전력 시험, 운용 온도 시험을 통해 검증하였다. 로터리 조인트는 기능적으로 구형 도파관에서 원형 도파관으로 변환하는 모드 변환기 구조 및 회전 부분의 초크 구조로 구성된다. 본 구조는 고정된 송신기와 2축으로 회전하는 안테나를 최소 손실을 가지도록 전기적 연결 및 경량화를 고려하여 설계하였다. 설계된 로터리 조인트는 중심 주파수 Fc 기준 ${\pm}500MHz$의 대역에서 VSWR 1.5:1 이하 반사 손실, -2.0 dB 이상 삽입 손실 특성을 가지며, 측정 결과는 설계 결과와 유사함을 확인하였다.

• Interaction and multiscale mechanics
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• 제2권1호
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• pp.45-68
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• 2009

An aim of the study is to develop an efficient numerical simulation technique that can handle the two-scale analysis of fluid permeation filters fabricated by the partial sintering technique of small spherical ceramics. A solid-fluid mixture homogenization method is introduced to predict the mechanical characters such as rigidity and permeability of the porous ceramic filters from the micro-scale geometry and configuration of partially-sintered particles. An extended finite element (X-FE) discretization technique based on the enriched interpolations of respective characteristic functions at fluid-solid interfaces is proposed for the non-interface-fitted mesh solution of the micro-scale analysis that needs non-slip condition at the interface between solid and fluid phases of the unit cell. The homogenization and localization performances of the proposed method are shown in a typical two-dimensional benchmark problem whose model has a hole in center. Three-dimensional applications to the body-centered cubic (BCC) and face-centered cubic (FCC) unit cell models are also shown in the paper. The 3D application is prepared toward the computer-aided optimal design of ceramic filters. The accuracy and stability of the X-FEM based method are comparable to those of the standard interface-fitted FEM, and are superior to those of the voxel type FEM that is often used in such complex micro geometry cases.