• 한국물환경학회지
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• 제27권5호
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• pp.580-586
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• 2011

Low impact development (LID) technique is recently proposed as new concept to reduce surface runoff and pollutant loading with various best management practices (BMPs). In this study, LIDMOD2, which is one of the model to evaluate LID, was applied at Mohyeon developing area to evaluate the redcution of annual runoff and pollution loading, cost-reduction efficient by LID with design of structural BMPs including bioretention, wet pond, and wetland. As a simulation results, the bioretention had the highest reduction efficiency for runoff (41.43%), and 22% for T-N and 22% for BOD. Wet pont had the highest reduction efficiency for T-P as showing 25% of reduction rate. As a results of cost-reduction efficient, wet pont represented the highest cost-effective for T-N and BOD with showing 0.43 T-P kg/million won and 17.37 BOD kg/million won, respectively, and bioretention represented the highest cost-effective for T-P with showing 2.52 T-P kg/million won. LID technology could reduce effectively surface runoff and nonpoint source pollution and construct sustainable development. LIDMOD2 could be suggested as useful tool to evaluate and design LID.

• BMB Reports
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• 제46권9호
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• pp.465-470
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• 2013

Bone morphogenetic proteins (BMPs) have diverse and important roles in the proliferation and differentiation of adult stem cells in our tissues. Especially, BMPs are well known to be the main inducers of bone formation, by facilitating both proliferation and differentiation of bone stem cells. Interestingly, in skin stem cells, BMPs repress their proliferation but are indispensable for the proper differentiation into several lineages of skin cells. Here, we tested whether BMP antagonists have an effect on the prevention of wrinkle formation. For this study we used an in vivo wrinkle-induced mouse model. As a positive control, retinoic acid, one of the top anti-wrinkle effectors, showed a 44% improvement compared to the non-treated control. Surprisingly, bone morphogenetic protein receptor 1a extracellular domain (BMPR1a-ECD) exhibited an anti-wrinkle effect which was 6-fold greater than that of retinoic acid. Our results indicate that BMP antagonists will be good targets for skin or hair diseases.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.927-932
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• 2016

Bone morphogenetic proteins (BMPs), belonging to the transforming growth factor-${\beta}$ superfamily, regulate many cellular activities including cell migration, differentiation, adhesion, proliferation and apoptosis. Use of recombinant human bone morphogenic protein-2 (rhBMP-2) in oral and maxillofacial surgery has seen a tremendous increase. Due to its role in many cellular pathways, the influence of this protein on carcinogenesis in different organs has been intensively studied over the past decade. BMPs also have been detected to have a role in the development and progression of many tumors, particularly disease-specific bone metastasis. In oral squamous cell carcinoma - the tumor type accounting for more than 90% of head and neck malignancies- aberrations of both BMP expression and associated signaling pathways have a certain relation with the development and progression of the disease by regulating a range of biological functions in the altered cells. In the current review, we discuss the influence of BMPs -especially rhBMP-2- in the development and progression of oral squamous cell carcinoma.

• 한국습지학회지
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• 제18권4호
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• pp.448-455
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• 2016

환경부는 비점오염원 관리를 위해 시범사업으로 12개의 비점오염 저감시설을 경안천 유역에 설치하였으며, 2006년부터 모니터링이 시작되었다. 본 연구는 비점오염 저감시설의 오염부하량, 저감효율, 유지관리 활동 등의 장기간 수행된 모니터링 결과를 바탕으로 각 시설의 경제성을 평가하기 위해 수행되었으며, 생애주기비용(Lifecycle cost, LCC)을 분석하였다. 비점오염 저감시설의 유지관리는 시설경관을 향상시키기 위한 심미적 관리가 중점적으로 수행된 것으로 나타났으며, 저류형 시설(Retention Pond, RP)이 년간 8,483$, 침투형 시설(Infiltration System, IS)이 8,888$로 대부분 비슷한 비용이 발생한 것으로 분석되었다. LCC는 인공습지(Constructed Wetland, CW)가 가장 높은 것($418,324)으로 나타났으며, 반면에 식생형 시설(Vegetated System, VS)이 가장 낮은 것($210,418)으로 분석되었다. 본 연구에서 조사된 비점오염 저감시설의 LCC와 하수처리장 등 수질처리시설의 LCC를 비교한 결과 비점오염 저감시설이 낮은 것으로 나타났다. 한편, 처리용량 대비 생애주기비용이 높아질수록 TSS와 TN의 저감효율은 높아지는 것으로 나타났다. 이러한 연구결과는 비용효율적인 비점오염 저감시설을 설계하는데 유용하게 활용될 것으로 기대되며, 향후 LCC 모델의 기초자료에도 활용될 수 있을 것으로 판단된다.

• 대한소아치과학회지
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• 제29권3호
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• pp.345-353
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• 2002

Bone morphogenetic proteins(BMPs)는 형태형성 및 세포 분화동안 다양한 조절 역할을 담당하는 신호전달 인자이다. 시상두개봉합부 발생시 BMPs와 그 수용체의 역할을 분석하기 위해, in situ hybridization방법을 이용하여 태생 15일에서 18일 시상두개봉합부에서 그 발현 양상을 분석하였다. BMP-2와 BMP-3은 태생 15일부터 osteogenic front와 두정골에서 발현을 보였으며 태생 16일부터 모낭에서 발현이 시작되었다. BMP-4는 osteogenic front에서 강하게 발현되었으며, 간엽조직 및 두정골에서 약하게 발현되었다. BMP-5는 모낭에서 발현되었다. 이전 연구에서 BMP-6는 비후된 연골세포에서 발현된다고 보고되었으나 본 연구에서는 발현되지 않았다. BMP-7은 태생기에 두정골에서 발현되었다. BMPR-IB는 osteogenic front의 외측 가장자리에서 발현되었으나, BMPR-IA는 발현되지 않았다. 이런 결과를 종합해 볼 때, 두개봉합부 초기 형태발생시 BMP-4는 미분화 간엽세포로부터 골아세포로 commit되는 초기단계에 중요한 역할을 하며, BMP-2와 BMP-3는 전구 골아세포에서 골아세포로의 분화과정에, BMP-7은 좀 더 분화가 진행된 골아세포 및 골의 분화 유지에 중요하며, type I 수용체 중 BMPR-IB가 BMP들의 신호전달에 중요한 역할을 함을 예측 할 수 있다. 결론적으로 BMP 신호전달은 다양한 BMP 리간드들과 그 수용체들에 의해 골아세포 분화 전반에 걸쳐 관여하고 있음을 시사한다.

• 대한생식의학회:학술대회논문집
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• 대한불임학회 2004년도 제46차 춘계학술대회
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• pp.19-20
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• 2004

• 한국환경과학회지
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• 제12권8호
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• pp.891-896
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• 2003

The objectives of this study wre to investigate the effects of two synthetic pyrethroids, bifenthrin(BF) and permethrin(PM), in runoff and to evaluate the effects of suspended solids (SS) in the transport of pyrethroid along the drainage channel. Monitoring of BF and PM was conducted with the runoffs as well as in sediments existing along the drainage channel at a nursery site located in southern California, USA. This study also suggests Best Management Practices (BMPs) to alleviage the pollution caused by heavy usage of pyrethroid insecticides at nursery sites. Due to a high affinity to solid particles of pyrethroid insecticides, the concentrations of BF and PM were proportional to the SS contents along the drainage channel. This study suggests that alleviation of pyrethroids existing in runoffs could be controlled by the removal of suspended solids in runoffs and potential implications of current drainage channels for mitigation of pesticides associated with runoffs.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2007년도 학술발표회 논문집
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• pp.1008-1013
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• 2007

The objectives of the paper were to identify appropriate best management practices (BMPs) for reducing nonpoint source (NPS) pollutant loadings and to simulate the effects of the application of the several BMP scenarios on the study watershed using Agricultural Nonpoint Source (AGNPS) model. AGNPS model was calibrated and validated for runoff, sediment yield, and nutrient components using the observed hydrologic and water quality data. The simulated runoff, sediment, and nutrient components were well agreed with observed data. The validated AGNPS was applied to estimate the NPS pollution removal efficiency for BMP scenarios which were selected considering the pollutant characteristics of the study watershed.

• 대한의생명과학회지
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• 제24권4호
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• pp.285-291
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• 2018

Gremlin-1 (GREM1) has been defined as an antagonist of bone morphogenetic proteins (BMPs), particularly during embryonic development and tissue differentiation. However, recent studies have shown that GREM1 has BMPs-dependent or -independent functions in diverse human diseases. GREM1 plays a key role in the process of organ fibrosis, including lungs, kidneys, and so on. The GREM1-induced fibrosis typically promotes the development of other diseases, such as pulmonary hypertension, renal inflammation, and diabetic nephropathy. More recently, considerable evidence has been reported showing that GREM1 is involved in the promotion and/or progression of tumors in vitro and in vivo. It also performs an oncogenic role in the maintenance of cancer stem cells. Although GREM1 is known to function in a variety of diseases, here we focus on the role of GREM1 in cancer, and suggest GREM1 as a potential therapeutic target in certain types of cancer.

• 대한치주과학회:학술대회논문집
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• 대한치주과학회 2005년도 제45회 종합학술대회 연제초록
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• pp.24-25
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• 2005