• Title/Summary/Keyword: BIOLOGICAL PUSH

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Interfacial bonding Energy between Laser Surface Treated HA layer and Ti alloy (레이저 표면처리에 의한 수산화아파타이트 코팅된 타이타니움합금 경계면의 결합에너지)

  • Moon, D.S.;Kim, Y.K.;Nam, S.Y.;Cho, H.S.;Huh, E.J.;Kim, S.Y.;Lee, J.H.
    • Proceedings of the KOSOMBE Conference
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    • v.1997 no.05
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    • pp.35-38
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    • 1997
  • The interfacial bonding energy between laser surface treated HA layer and Ti alloy substrate was investigated using a mechanical push-out tester. The initial slope of shear-stress and reduced displacement curves, maximum interfacial bond strength and bonding energy were calculated from results of the push-out test. The calculated initial slpoes are 38 MPa for the Ti alloy(A), 65 MPa for the sandblast finished specimen(B), 95 MPa for the HA plasma spray coated specimen and 49 MPa for the laser surface treated specimen(D). The maximum interfacial bonding strength are 3 MPa for the A, 19 MPa for the B, 20 MPa for the C, 10 MPa for the D. The interfacial bonding energies are $3.3\times10^{-9}J/mm^2$ for the A, $15.5\times10^{-9}J/mm^2$ for the B, $15.6\times10^{-9}J/mm^2$ for the C and $18.3\times10^{-9}J/mm^2$ for the D. Microscopic observation shows that the breaking of the laser treated specimen had been occured through the boundary between HA layer and polymer resin, but the untreated specimen had been occured through the inside of HA coating layer.

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Systematical Analysis of Cutaneous Squamous Cell Carcinoma Network of microRNAs, Transcription Factors, and Target and Host Genes

  • Wang, Ning;Xu, Zhi-Wen;Wang, Kun-Hao
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.23
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    • pp.10355-10361
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    • 2015
  • Background: MicroRNAs (miRNAs) are small non-coding RNA molecules found in multicellular eukaryotes which are implicated in development of cancer, including cutaneous squamous cell carcinoma (cSCC). Expression is controlled by transcription factors (TFs) that bind to specific DNA sequences, thereby controlling the flow (or transcription) of genetic information from DNA to messenger RNA. Interactions result in biological signal control networks. Materials and Methods: Molecular components involved in cSCC were here assembled at abnormally expressed, related and global levels. Networks at these three levels were constructed with corresponding biological factors in term of interactions between miRNAs and target genes, TFs and miRNAs, and host genes and miRNAs. Up/down regulation or mutation of the factors were considered in the context of the regulation and significant patterns were extracted. Results: Participants of the networks were evaluated based on their expression and regulation of other factors. Sub-networks with two core TFs, TP53 and EIF2C2, as the centers are identified. These share self-adapt feedback regulation in which a mutual restraint exists. Up or down regulation of certain genes and miRNAs are discussed. Some, for example the expression of MMP13, were in line with expectation while others, including FGFR3, need further investigation of their unexpected behavior. Conclusions: The present research suggests that dozens of components, miRNAs, TFs, target genes and host genes included, unite as networks through their regulation to function systematically in human cSCC. Networks built under the currently available sources provide critical signal controlling pathways and frequent patterns. Inappropriate controlling signal flow from abnormal expression of key TFs may push the system into an incontrollable situation and therefore contributes to cSCC development.

New Fluid Flow System for Simulation of Mechanical Loading to Bone Cells During Human Gait Cycle

  • Ahn, Jae-Mok
    • Journal of Biomedical Engineering Research
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    • v.28 no.3
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    • pp.377-386
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    • 2007
  • Mechanical loading to bone cells using simple sine wave or constant wave fluid flow has been widely used for in vitro experiments. Human gait is characterized by a complex loading to bones of lower extremities which results from a series of events consisting of heel strike, foot flat and push-off during the stance phase of the gait cycle. Telemetric force analyses have shown that human femora are subject to multiphasic loading. Therefore, it would be ideal if the physiologic loading conditions during human walking can be used for in vitro mechanotransduction studies. Here, for a mechanotransduction study, we develop it fluid flow system (FFS) in order to simulate human physiologic mechanicalloading on bone cells. The development methods of the FFS including the COR (Center for Orthopedic Research), monitor program are presented. The FFS could generate various multiphasic loading conditions of human gaits with output flow. Wall shear distribution was very uniform, with 81 % of the effective loading area of the culture on a glass slide. Our results demonstrated that the FFS, provide a new translational approach for unveiling molecular mechanotransduction pathways in bone cells.

A Study of Local Ventilation Design on PC Programm (국소환기 설계의 전산화에 관한 연구)

  • Yoon, Myong Cho
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.3 no.2
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    • pp.213-226
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    • 1993
  • The purpose of this study is to computerize the design of single source for a duct work system which is essential for the improvement of working places. There are different types of hood, such as general hood, push pull hood and canopy hood. And out of these three types, general hood and canopy hood were used as subjects of this study. The software used here was Quattro Pro 123 programm, and the hardware was IBM PS/SX(type 5510-SK4 S/N 83-05164). And the results are tabulated in

    and
    . All of the hazardous factors of working places, except for physical factors, such as noise, vibration, illumination and etc, are control measurement related. In order words, workiong places that have problems with toxic gas, mist, fume, dust, odors, biological factors or wetness can be improved by means of the local ventilation design. However, the reqires very complicate processes, and in the case of canopy hood, particularly, one runs into difficulties due to frequent discrepancies generated from calculations through many processes. Recently, progress of the computer hardware technics has been dazzling, and also the software is development rapidly. As proven in the results of this study, it is good that designs for industrial ventilation systems are readily available for easy use. It is hopeful that young scholars will develop easier and quicker methods for local ventilation designs in the future.

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  • Comparative gait characteristics of infant and adults (유아와 성인의 보행 특성 비교)

    • Chang, Y.H.;Yang, G.T.;Im, S.H.;Mun, M.S.;Lee, K.O.;Kim, M.Y.
      • Proceedings of the KOSOMBE Conference
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      • v.1998 no.11
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      • pp.86-87
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      • 1998
    • To understand the developmental process of the gait pattern from infancy to the adult, a gait analysis for a 14 months female infant has been performed for ten weeks. The gait parameters has been measured every other week since the week when she was able to walk without aid. The infant gait data at the tenth week of the test shows a similar pattern to the adult gait in many aspects including initial knee flexion, initial ankle dorsiflexion, the push-off pattern, etc. There is not a significant change in the hip flexion angle from week to week from the two weeks after the test started. To check the individuality in the collected data, more infant subjects are being tested presently.

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    Development of a Patient Monitoring System Overall Architecture and Specifications (환자모니터링시스템의 개발 : 전체구조 및 기본사양)

    • 우응제;박승훈
      • Journal of Biomedical Engineering Research
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      • v.18 no.1
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      • pp.17-24
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      • 1997
    • We have developed a patient monitoring system including module-based bedside monitors, interbed network, central stations, clinical workstations, and DB servers. A bedside monitor with a color LCD can accommodate up to 3 module cases and 21 different modules. Six different physiological parameters of ECG, respiration, invasive blood pressure, noninvasive blood pressure, body temperature, and arterial pulse oximetry with plethysmoyaph are provided as parameter modules. In a single bedside monitor, modules and a module controller communicate with IMbps data rate through an intrabed network based on RS-485 and HDU protocol. At the same time, it communicates with other bedside monitors and central stations through interbed network based on 1 OMbps Ethernet and TCP/IP protocol. Central stations using 20" color CRT monitors can be connected with many bedside monitors and they display 18 channels of waveforms simultaneously. Clinical workstations are used mainly for the review of patient datE In order to accommodate more advanced data management capabilities such as 24-hour full disclosure, we have developed a relational database server dedicated to the patient monitoring system. Software for bedside monitor, central station, and clinical workstation fully utilizes graphical user interface techniques and all functions are controlled by a rotate/push button on the bedside monitor arid a mouse on the central station and clinical workstation. The entire system satisfies the requirements of AAMI and ANSI standards in terms of electrical safety and performances.nces.

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    Comparison of Muscular Endurance Limit of the Thumb with Repetitive Using Between Adults and Children (성인 및 청소년의 엄지손가락 반복사용에 따른 근 피로한계 비교)

    • Park, J.H.;Kim, G.H.;Son, K.
      • Journal of Biomedical Engineering Research
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      • v.34 no.1
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      • pp.1-7
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      • 2013
    • According to the frequent use of mobile devices, risk of repetitive strain injury for the finger joints was increasing recently. The purpose of this study was to investigate the difference of muscular endurance limit of the thumb between adults and children. A total of thirty subjects (15 adults: $41.0{\pm}7.9$ years and 15 children: $9.5{\pm}2.7$ years) was recruited for this experiment. Maximum voluntary contraction (MVC) of the thumb was measured for 100 trials for each subject by using a push-pull gauge. From the maximum peak value obtained, three main factors (MVC, endurance limit, and fatigue index) were defined to quantify fatigue characteristics of the thumb flexor muscle. The experimental results showed that the mean of MVC, endurance limit, and fatigue index of the children were approximately 50% compared to the adults (p < 0.001). From the results of Pearson correlation test, the endurance limit was highly correlated with weight, age, hand length rather than height. Based on this study, children are more vulnerable to repetitive task using the thumb such as text/SNS messaging, gaming, and scrolling.

    Socket Pressure Distribution of the Uni-Lateral Trans-Femoral Amputee with a Suction Socket (흡착식 소켓을 착용한 일측 대퇴절단환자의 소켓내부압력분포)

    • Jang, Yun-Hui;Yang, Gil-Tae;Im, Song-Hak;Mun, Mu-Seong;Kim, Yeong-Ho
      • Journal of Biomedical Engineering Research
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      • v.19 no.4
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      • pp.417-422
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      • 1998
    • The study was explored socket pressure distributions on a trans-femoral amputee with a suction socket in static and dynamic situations. Even when the amputee stood in the anatomically neutral position, significant pressure concentrations were observed in the lateral, medial, and posterior planes of the socket. During free level walking, a significant shifting pattern of pressure concentration areas was observed. High socket pressure was observed in the lateral, medial-anterior and posterior walls during mid-stance or push-off period. Socket pressure measurement will be one of the good tool to determine the optimal socket-limb interface.

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    Characteristics of Remote Sensors on KOMPSAT-I (다목적 실용위성 1호 탑재 센서의 특성)

    • 조영민;백홍렬
      • Korean Journal of Remote Sensing
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      • v.12 no.1
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      • pp.1-16
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      • 1996
    • Korea Aerospace Research Institute(KARI) is developing a Korea Multi-Purpose Satellite I(KOMPSAT-I) which accommodates Electro-Optical Camera(EOC), Ocean Color Imager(OCI), Space Physics Sensor(SPS) for cartography, ocean color monitoring, and space environment monitoring respectively. The satellite has the weight of about 500 kg and is operated on the sun synchronized orbit with the altitude of 685km, the orbit period of 98 minutes, and the orbit revisit time of 28days. The satellite will be launched in the third quarter of 1999 and its lifetime is more than 3 years. EOC has cartography mission to provide images for the production of scale maps, including digital elevation models, of Korea from a remote earth view in the KOMPSAT orbit. EOC collects panchromatic imagery with the ground sample distance(GSD) of 6.6m and the swath width of 15km at nadir through the visible spectral band of 510-730 nm. EOC scans the ground track of 800km per orbit by push-broom and body pointed method. OCI mission is worldwide ocean color monitoring for the study of biological oceanography. OCI is a multispectral imager generating 6 color ocean images with and <1km GSD by whisk-broom scanning method. OCI is designed to provide on-orbit spectral band selectability in the spectral range from 400nm to 900nm. The color images are collected through 6 primary spectral bands centered at 443, 490, 510, 555, 670, 865nm or 6 spectral bands selected in the spectral range via ground commands after launch. SPS consists of High Energy Particle Detector(HEPD) and Ionosphere Measurement Sensor(IMS). HEPD has mission to characterize the low altitude high energy particle environment and to study the effects of radiation environment on microelectronics. IMS measures densities and temperature of electrons in the ionosphere and monitors the ionospheric irregularities in KOMPSAT orbit.

    Synthesis and properties of indole based chemosensor

    • Lee, Jun-Hee;Wang, Sheng;Yu, Hyung-Wook;Kim, Hyung-Joo;Son, Young-A
      • Proceedings of the Korean Society of Dyers and Finishers Conference
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      • 2011.03a
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      • pp.36-36
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      • 2011
    • We synthesized new dye sensor based on indole compound. Through the UV-vis absorptions, we analyzed chemosensing properties to explain metal binding properties. The peak absorptions increased at 472 nm when added metal cations($Cd^{2+}$, $Cu^{2+}$, $Hg^{2+}$, $Fe^{2+}$, $Zn^{2+}$, $Ni^{2+}$ and $Cr^{3+}$) and gradually decreased the peak at 516 nm. Thus, this UV-Vis absorption behavior clearly showed the metal binding reaction. To measure energy level of used dye sensor, HOMO/LUMO energy value was calculated with cyclovaltagramm(CV) and using computational calculation method, in which we estimated the optimum structure of dye sensor. CV and computational calculation method, both compared to find suitable geometric structure. (with almost same energy values.) From the computational calculation, dye sensor has plane structure. So, Amine and ketone in the dye sensor faced each other and makes position to bind metal cations. In addition, these positions was supported pull-push electron system and generated MLCT process, when the dye sensor was bonded with the metal cations and resulted chemosensing properties. Through the electrochemical and computational calculation method analyze, we proposed the chemosensing principles that the dye sensor bind the metal cation between ketone and amine. Finally, the formation type of metal ion bindings was determined by Job's plot measurements.

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