• The Korean Journal of Pain
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• v.21 no.3
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• pp.173-178
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• 2008

Background: The intrathecal (IT) $GABA_A$ receptor antagonist, bicuculline (BIC), results in tactile allodynia (TA) through disinhibition in the spinal cord. Such disinhibition is considered to be an important mechanism for neuropathic pain. Agmatine, an endogenous polyamine, has a neuro-protective effect in the central nervous system. We investigated the analgesic effects and mechanisms of agmatine action on BIC-induced TA. Methods: Male Sprague-Dawley rats, weighting 250-300 g, were subjected to implantations of PE-10 into the lumbar subarachnoid space for IT drug injection. Five days after surgery, either $10{\mu}l$ of normal saline (NS) or agmatine ($30{\mu}g$ or $10{\mu}g$) in $10{\mu}l$ NS were injected 10 min prior to BIC ($10{\mu}g$) or NMDA ($5{\mu}g$). We assessed the degree of TA (graded 0: no response, 1: mild response, 2: moderate response, 3: strong response) every 5 min for 30 min. Areas under curves and degree of TA were expressed as mean ${\pm}$ SEM. Results were analyzed using one-way ANOVA followed by a Tukey test for multiple comparisons. P < 0.05 was considered significant. Results: IT BIC-induced strong TA reached its peak and plateaued between 10 to 15 min. IT NS-NMDA induced mild transient TA for up to 15 min. Preemptive IT AG attenuated IT BIC-induced TA dose dependently and preemptive IT AG10 completely abolished the IT NMDA-induced TA. Conclusions: Preemptive IT AG attenuated the IT BIC-induced TA through inhibitory actions on postsynaptic NMDA receptor activation. AG might be a viable therapeutic option in the treatment of neuropathic pain.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.2B
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• pp.124-132
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• 2007

Where a wireless LAN and a cellular network coexist, a mobile node has to experience vertical handoffs to move between them. Immediately after the vertical handoffs, TCP must need adaptation latency to adjust its congestion window to the proper size at a newly arrived network to use full of a new end-to-end available bandwidth. Even though SACK TCP has the best performance among other regular TCPs in the previous studies, it still cannot use full of the new available bandwidth quickly due to its inefficient increasing way of congestion window. BIC TCP, that becomes a popular TCP in long fat networks, has great feature working well against vertical handoffs by increasing congestion window exponentially with TCP connection sustained. In this paper, we derive adaptation latency of SACK TCP and BIC TCP numerically, and verify them by simulations. We also find that the shorter adaptation latency of BIC TCP produces higher throughput than SACK TCP on vertical handoffs. Consequently, to get higher performance on vertical handoff situations, we propose to use BIC TCP.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.7
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• pp.678-685
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• 2013

In this paper, we propose a design of dual-band patch antennas for Global Positioning System(GPS) applications, and the designed antenna is used as an individual element of GPS arrays. A low distortion and a high isolation of the array are achieved by adjusting rotating angles of each array element. The antenna consists of two radiating patches that operate in the GPS $L_1$ and $L_2$ bands, and the two ports feeding network with a hybrid chip coupler is adopted to achieve a broad circular polarization(CP) bandwidth. The rotating angles of each antenna element are varied with four directions(${\phi}=0^{\circ}$, ${\phi}=90^{\circ}$, ${\phi}=180^{\circ}$, ${\phi}=270^{\circ}$) in order to minimize the pattern distortion and maximize the isolation among array elements. The measurement shows bore-sight gains of 0.3 dBic($L_1$) and -1.0 dBic($L_2$) for the center element. Bore-sight gains of 1.6 dBic($L_1$) and 1.0 dBic($L_2$) are observed for the edge element. This results demonstrate that the proposed antenna is suitable for GPS array applications.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2003.10b
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• pp.15-16
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• 2003

• Journal of Periodontal and Implant Science
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• v.53 no.2
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• pp.157-169
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• 2023

Purpose: The aim of this study was to evaluate the impact of polydeoxyribonucleotide (PDRN) on histologic outcomes when implant placement and lateral sinus floor elevation are performed simultaneously. Methods: Three bimaxillary premolars (P2, P3, and P4) were extracted from 4 beagle dogs 2 months before lateral sinus floor elevation. After lateral elevation of the sinus membrane, each sinus was allocated to either the test or control group. Sinuses underwent either 1) collagenated synthetic bone graft with PDRN following lateral sinus floor elevation (test group) or 2) collagenated synthetic bone graft without PDRN after lateral sinus floor elevation (control group). Eight weeks after the surgical procedure, all animals were euthanised for a histologic and histomorphometric assessment. Augmented height (AH), protruding height (PH), and bone-to-implant contact in pristine (BIC_p) and augmented (BIC_a) bone were measured. The composition of the augmented area, which was divided into 3 areas of interest located in coronal, middle and apical areas (AOI_C, AOI_M, and AOI_A), was calculated with 3 parameters: the area percentage of new bone (pNB), residual bone graft particle (pRBP), and fibrovascular connective tissue (pFVT). Results: AH, PH, BIC_p, BIC_a total, BIC_a coronal, and BIC_a middle values were not significantly different between sinuses in the control and test groups (all P>0.05). The BIC_a apical of sinuses in the test group (76.7%±9.3%) showed statistically higher values than those of sinuses in the control group (55.6%±22.1%) (P=0.038). pNB, pRBP, and pFVT showed statistically significant differences between the 2 groups in AOI_A (P=0.038, P=0.028, and P=0.007, respectively). pNB, pRBP, and pFVT in AOI_C and AOI_M were not significantly different between samples in the control and test groups (all P>0.05). Conclusions: The histologic findings revealed that lateral sinus floor elevation with PDRN might improve early new bone formation and enable higher bone-to-implant contact.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.42 no.4
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• pp.187-192
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• 2016

Objectives: In this study, we investigated whether a high-fat diet (HFD) affected the bone implant connection (BIC) in peri-implant bone. Materials and Methods: Four male rabbits were used in this study. Dental implant surgery was introduced into each tibia, and four implants were integrated into each animal. In both the normal diet (ND) group (n=2) and HFD group (n=2), 8 implants were integrated, for a total of 16 integrated implants. The animals continued with their respective diets for 12 weeks post-surgery. Afterward, the rabbits were sacrificed, and the BIC was assessed histomorphometrically. Results: Histologic and histomorphometric analyses demonstrated that BIC was not impaired in the HFD group compared to the ND group. Conclusion: Within the limitations of this study, we found that HFD did not decrease the BIC in rabbit tibias.

• ETRI Journal
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• v.40 no.5
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• pp.561-569
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• 2018

Modern communication systems employ wideband antennas with circular polarization (CP) radiation. In this work, asymmetric modified bow-tie (ABT) and symmetric modified bow-tie (SBT) slotted circularly polarized single-point probe-fed circular patch antennas with dimensions of $40mm{\times}40mm$ for wideband applications are proposed. A 10 dB RL bandwidth of 350 MHz with CP, 3 dB axial ratio (AR) bandwidth of 100 MHz, peak gain of 4.9 dBic, and 10 dB RL bandwidth of 530 MHz with CP, 3 dB AR bandwidth of 140 MHz, peak gain of 5 dBic are obtained for ABT and SBT slotted circular patch antennas, respectively. The proposed SBT slotted patch is scaled up and down to $50mm{\times}50mm$ and $30mm{\times}30mm$, respectively. The proposed scaled-up version offers 10 dB RL and 3 dB AR bandwidths of 340 MHz and 80 MHz, with a peak gain of 5 dBic. The scaled-down version offers 10 dB RL and 3 dB AR bandwidths of 710 MHz and 180 MHz, with a peak gain of 5.25 dBic. These prototypes are suitable to work in IEEE 802.11a WLAN, ISM, and IEEE 802.11ac applications. The measured and simulated results are then discussed and compared.

• Journal of Satellite, Information and Communications
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• v.12 no.2
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• pp.83-88
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• 2017

In this paper, we propose a three-element CRPA array with improved low-elevation gain. The proposed antenna consists of a feed patch and a radiating patch, and the feed patch is connected by a coaxial cable. The radiating patch is electromagnetically coupled to the feed patch, which allows to improve the low-elevation gain of the antenna. To demonstrate the suitability of the proposed antenna, the antenna characteristics are measured in a full anechoic chamber. The resulting bore-sight gain is 2.8 dBic with an axial ratio of 2.7 dB, and the average gain at the low-elevation direction of $75^{\circ}$ is -1.4 dBic. The results verify that the proposed antenna is suitable for CRPA arrays with anti-jamming capability.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.33 no.4
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• pp.312-321
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• 2007

Purpose: Distraction osteogenesis has been applied to the maxillofacial implantology and good experimental and clinical results have been reported. However, histologic studies of implants placement on distraction osteogenesis of atrophic alveolar ridges are scarce. In this study, we compare the bone formation between in the transport part and in the distraction part by histomorphometric analysis. Materials & methods: Three adult beagle dogs were served as experimental subjects. The 2 premolars and 1st molar were extracted on the Lt. side of mandible in each beagle dog. After one month later, osteotomy was performed and distraction device was adapted. Distraction was performed with gradual incremental separation of two bone pieces at a rate of 1.0mm per day for 5 days. During consolidation phase, new bone was formed in the distraction zone between the separated bone pieces. 5 weeks after distraction phase, 3 implants were placed in each beagle dog. The implants were inserted through transport part and distraction part and inferior basal bone. The animals were sacrificed at 2 weeks, 4 weeks, and 12 weeks after implant placement. BIC and BA of implants on distraction part and transport part were measured histomorphometrically. Results: BIC, BA increased after implant placement as time goes by passes and new bone formation was slightly higher in transport part than in distraction part at 2 weeks, 4 weeks after implant placement. At 12 weeks after implant placement, BIC, BA of were 74%, 61% in transport part and 77%, 59% in distraction part, therefore there were no difference in BIC and BA between transport part and distraction part at 12 weeks after implant placement.

• The Journal of the Korea Contents Association
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• v.7 no.6
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• pp.22-30
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• 2007

Most real word systems such as world economy, stock market, and medical applications, contain a series of dynamic and complex phenomena. One of common methods to understand these systems is to build a model and analyze the behavior of the system. In this paper, we investigated methods for best clustering over time series data. As a first step for clustering, BIC (Bayesian Information Criterion) approximation is used to determine the number of clusters. A search technique to improve clustering efficiency is also suggested by analyzing the relationship between data size and BIC values. For clustering, two methods, model-based and similarity based methods, are analyzed and compared. A number of experiments have been performed to check its validity using real data(stock price). BIC approximation measure has been confirmed that it suggests best number of clusters through experiments provided that the number of data is relatively large. It is also confirmed that the model-based clustering produces more reliable clustering than similarity based ones.