• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2297-2301
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• 2015

Background: Despite widely adopted standard methods for follow-up including cystoscopy plus cytology, recurrence rates of non muscle-invasive bladder cancer (NMIBC) have not improved over the past decades, still ranging from 60% through 70%. Hence, widely acceptable surveillance strategies with excellent sensitivity are needed. Early recurrence has led to the development of a novel cystoscopy technique utilizing photodynamic diagnosis (PDD). Although, no studies have evaluated the efficacy of PDD for patients of MIBC, BCG failure or 2nd-transurethelial resection (TUR). Materials and Methods: The present study was performed from October 2012 through May 2013. IRB approved 25 patients initially underwent a cystoscopy examination of white light and blue light followed by the resection of tumors identified. Resections were performed from bladder mucosa areas considered suspicious at PDD, along with PDD negative normal bladder mucosa area resected by random biopsy. Specimens were divided into two groups, PDD positive and negative. Primary endpoints were sensitivity and specificity. Results: A total of 147 specimens extracted from 25 patients were included in the analysis. Some 45 out of 92 PDD-positive specimens were confirmed to have bladder cancer, and 51 out of PDD-negative 55 specimens were confirmed to be cancer negative. The sensitivity of PDD was 91.8% (45/49) and specificity was 52.0% (51/98). The sensitivity:specificity was 89.5% (17/19) : 47.6% (30/63) in 12 2nd-TUR patients, 90.5% (19/21) : 61.1% (11/18) in seven MIBC patients, and 95.0% (19/20) : 48.5% (16/33) in eight failed BCG cases. Conclusions: PDD-TURBT has high sensitivity to diagnose BC even for 2nd-TUR, MIBC or BCG failure cases.

• 대한수의학회지
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• 제41권2호
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• pp.211-218
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• 2001

병원성 내장리슈만편모충(Leishmania donovani)에서 추출한 GP63 또는 LPG 항원을 liposome으로 캡슐화하고 보강제로서 BCG를 조합하여 DBA-2N 마우스에 면역접종을 한 후, 내장리슈만편모충의 병원성 amastigote를 접종하여 이들 물질의 방어면역 효과를 관찰하였다. 그 결과 GP63 과 LPG, 그리고 BCG를 모두 첨가하여 접종한 마우스의 간 조직에서 유의성 있는 내장리슈만편모충의 감소가 관찰되었으나 감소율은 27.4%에 불과하였다. 실험적 피부리슈만편모충증에 대하여 성공적인 방어면역성을 나타낸 GP63이 내장리슈만편모충 감염에 대하여 방어면역성을 상실한 원인을 분석하기 위한 실험에서 C3H 마우스에 GP63-GST 단백질과 BCG를 혼합하여 면역접종하고 내장리슈만편모충의 병원성 amastigote로 접종한 후, 혈청 내 특이항체와 비장세포에서의 감마인터페론 및 IL-5의 생산을 관찰하였다. 그 결과 GP63-GST와 BCG를 혼합하여 면역 접종한 마우스의 간 조직에서도 유의성 있는 amastigote의 감소는 관찰되지 않았다. 한편 이들 마우스의 비장세포에서는 BCG 만을 접종한 군에 비해 10배 이상의 감마인터페론과 3배의 IL-5가 생산되었다. 이와 같은 사실은 GP63-GST 단백질과 BCG를 혼합하여 접종한 마우스에서 Th1 및 Th2 타입 면역반응이 모두 활성화되었음을 시사하며, Th1 뿐만 아니라 Th2 타입 면역 반응도 함께 활성화된 것이 실험적 내장리슈만편모충 감염에 대한 방어면역에 실패한 원인 중의 하나일 것으로 사료되었다.

• 농촌의학ㆍ지역보건
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• 제32권3호
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• pp.125-138
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• 2007

Objectives: This retrospective study is to identify related factors of treatment success of patients with tuberculosis at community health centers. Methods: The subjects of this study were 1,417 patients with tuberculosis treated in 28 community health centers. The predictors of tuberculosis treatment success were analyzed in terms of 2 areas, which were characteristics of patients and health centers(TB control program). The characteristics of patients consist of 2 factors, such as demographic & diagnosis and treatment. The present conditions of health centers consist of 3 factors, location of centers, resources, and community activities. Data were analysed using X2- test and logistic regression methods. Results: The significant differences between success group and failure group were sex(p=0.003), age(p=0.013), job(p=0.000), type of patients(p=0.001), past history(p=0.029), BCG injection(p=0.009), sputum culture examination(p=0.017), period of treatment(p=0.000), location of center(p=0.001), population per staff(p=0.015), FTE(p=0.027), education days of staff(p=0.005), BCG injection rate(p=0.001), case detection rate (p=0.003), and health education provision rate(p=0.044). Then these variables were analysed using logistic regression analysis. Significant positive factors of treatment success were occupation(95% CI:1.3-6.1), periods of treatment(95% CI:1.5-2.2), center in large city(95% CI:1.2-16.7), center in middle city(95% CI:2.1-24.3), job education related TB(95% CI:1.02-1.3), and BCG injection rate(95% CI:1.1-303.4). Significant negative factors of treatment success were male(95% CI:0.1-0.5) and treatment after default(95% CI:0.005-0.5). Conclusions: Tuberculosis is still one of serious diseases in Korea, because it causes highest mortality rate among OECD countries. This study may provide information to improve treatment effectiveness of tuberculosis at community health centers.