• The Korean Journal of Physiology and Pharmacology
• /
• v.22 no.1
• /
• pp.53-61
• /
• 2018

Ethyl linoleate is an unsaturated fatty acid used in many cosmetics for its various attributes, such as antibacterial and anti-inflammatory properties and clinically proven to be an effective anti-acne agent. In this study, we investigated the effect of ethyl linoleate on the melanogenesis and the mechanism underlying its action on melanogenesis in B16F10 murine melanoma cells. Our results revealed that ethyl linoleate significantly inhibited melanin content and intracellular tyrosinase activity in ${\alpha}$-MSH-induced B16F10 cells, but it did not directly inhibit activity of mushroom tyrosinase. Ethyl linoleate inhibited the expression of microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase related protein 1 (TRP1) in governing melanin pigment synthesis. We observed that ethyl linoleate inhibited phosphorylation of Akt and glycogen synthase kinase $3{\beta}$ ($GSK3{\beta}$) and reduced the level of ${\beta}-catenin$, suggesting that ethyl linoleate inhibits melanogenesis through $Akt/GSK3{\beta}/{\beta}-catenin$ signal pathway. Therefore, we propose that ethyl linoleate may be useful as a safe whitening agent in cosmetic and a potential therapeutic agent for reducing skin hyperpigmentation in clinics.

• The Pure and Applied Mathematics
• /
• v.9 no.1
• /
• pp.57-61
• /
• 2002

Let G be a connected graph. A pebbling move on a graph G is the movement of taking two pebbles off from a vertex and placing one of them onto an adjacent vertex. The pebbling number f(G) of a connected graph G is the least n such that any distribution of n pebbles on the vertices of G allows one pebble to be moved to any specified, but arbitrary vertex by a sequence of pebbling moves. In this paper, the pebbling numbers of the compositions of two graphs are computed.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.46 no.1
• /
• pp.34-38
• /
• 2017

Myelophycus simplex Papenfuss, a type of brown algae, is known to be majorly distributed in along the southern coast of Korea and Japan. The purpose of this study was to investigate the effects of M. simplex Papenfuss methanol extract (MSPME) on melanogenesis in ${\alpha}$-melanocyte-stimulating hormone-stimulated B16F10 melanoma cells. Melanin contents of B16F10 melanoma cells were decreased by 27, 41, and 59% in a dose-dependent manner, upon MSPME treatment at 100, 300, and $500{\mu}g/mL$, respectively. Tyrosinase activities in B16F10 melanoma cells were decreased by 18, 49, and 61% in a dose-dependent manner, upon MSPME treatment at 100, 300, and $500{\mu}g/mL$, respectively. MSPME suppressed expression of tyrosinase, tyrosinase-related protein-1, tyrosinase-related protein-2, and melanocyte-inducing transcription factor in B16F10 melanoma cells. Concentration of $50{\mu}g/mL$ of MSPME especially induced greater decreases in tyrosinase activity, melanin contents, and melanogenic enzyme protein expressions. This results indicate that MSPME inhibits melanin synthesis and tyrosinase activity, and M. simplex Papenfuss extract may be an ideal candidate as a skin whitening agent.

• Solar Energy
• /
• v.20 no.4
• /
• pp.61-67
• /
• 2000

The purpose of this study is to improve heat transfer by attaching rectangular fins to tube. Experiments were carried out under the following conditions - Aspect ratio$(W_f/R_f)$ is 0.7, 1.2 and 1.8. Temperature conversion between high and low positions of water in the thermal storage appeared because maximum density point of water is about $4^{\circ}C$ and inlet direction of working fluid influenced conductive heat transfer Compared with the unfinned tube(bare tube), the rectangular tube increased the ice thermal storage energy and the ice thermal storage energy was increased as aspect ratio was increased.

• Korean Journal of Microbiology
• /
• v.12 no.2
• /
• pp.59-68
• /
• 1974

With an aim to disclose causal factors scably grains intoxications, the screening of toxic Fusaria and the detection of toxic priniciples were performed in respect of cultured cells bioassay with HeLa cells, skin-necrotizing effect, histopathological investigation and also chromatographic analysis sith following results ; 1. Among the fungi, Fusarium sp. F-27, F-63 and F-61 were highly toxic to mice, causing liver injury characterized necrosis and inflammation. 2. HeLa cell culture bioassay demonstrated that the cell of the isolated strains of Fusaria were suspected to produce toxic material (Fusarenon-X). 3. The culture filtrates of Fusarium nivale Fn-2B, F-27, and F-63, were injected subcutaneously, and caused inflammation followed by crust on the skin ICR-mice. 4. The observation method of skin-necrotizing effect to the mice can be used to the screening to the toxin-producing fungi isolated from many fusarial contaminations.

• Journal of the Korean Ceramic Society
• /
• v.39 no.9
• /
• pp.857-862
• /
• 2002

Porous ceramic supports with immobilized microorganisms for the water purifier were synthesized by firing green compacts of mixed powder comprising of fly ash, bentonite and an additive of yeast powder at 800∼1,000$^{\circ}C$ for 1h and the pore and mechanical properties of specimens were investigated. The compressive strength was increased in FB (Fly Ash + Bentonite) specimens while pore properties was decreased with increasing the bentonite content and sintering temperature. The compressive strength, bulk density, apparent density, porosity, mean pore size, pore volume and specific surface area of FB specimens at 800∼1,000$^{\circ}C$ were 89.6∼128.9 kgf/$cm^2$, 1.25∼1.43, 1.61∼1.78, 27.2∼62.2%, 7.9∼25.6 ${\mu}m$, 8.9∼$22.2{\times}10^{-5}\;cm^3/g$ and 35.2∼134.3 $m^2/g$, respectively. The pore properties of FBY (FB+yeast powder) specimens were superior to that of FB specimens, however compressive strength was decreased with increasing yeast powder content. The overall properties of 9F1B1Y (9F1B+10% of yeast powder) specimens at 900$^{\circ}C$ for 1 h were 98.7 kgf/$cm^2$, 1.20, 1.67, 68.1%, 48.9 ${\mu}m$, $29.5{\times}10^{-5}\;cm^3/g$ and 152.2 $m^2/g$, respectively. In this study, it was revealed that 9F1B1Y specimen demonstrated better S. saprophyticus adherence properties n their surface pores. Consequently, the microorganisms immobilized on porous ceramic supports showed better water purifying performance with many pores and adequate strength.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.29 no.6
• /
• pp.473-476
• /
• 2018

Herein, a $2{\times}2$ subarray antenna is designed to implement a VHF band active electronically scanned array. The Yagi-Uda antenna is used as a radiating element. The bandwidth enhancement and miniaturization of the Yagi-Uda antenna are achieved by optimizing the diameter of a driven element and the length of a director. In addition, the grid reflector is utilized to improve the front-to-back ratio(FBR) and to reduce both the wind resistance and overall system weight. The fabricated $2{\times}2$ subarray antenna fully covers the VHF target band($0.98{\sim}1.02f_c$). The measured maximum gain is 10.61 dBi and the FBR is larger than 26 dB.

• The Journal of Information Systems
• /
• v.32 no.4
• /
• pp.149-162
• /
• 2023

Purpose In the textile industry, fabric defects significantly impact product quality and consumer satisfaction. This research seeks to enhance defect detection by developing a transformer-based deep learning image segmentation model for learning high-dimensional image features, overcoming the limitations of traditional image classification methods. Design/methodology/approach This study utilizes the ZJU-Leaper dataset to develop a model for detecting defects in fabrics. The ZJU-Leaper dataset includes defects such as presses, stains, warps, and scratches across various fabric patterns. The dataset was built using the defect labeling and image files from ZJU-Leaper, and experiments were conducted with deep learning image segmentation models including Deeplabv3, SegformerB0, SegformerB1, and Dinov2. Findings The experimental results of this study indicate that the SegformerB1 model achieved the highest performance with an mIOU of 83.61% and a Pixel F1 Score of 81.84%. The SegformerB1 model excelled in sensitivity for detecting fabric defect areas compared to other models. Detailed analysis of its inferences showed accurate predictions of diverse defects, such as stains and fine scratches, within intricated fabric designs.

• Sleep Medicine and Psychophysiology
• /
• v.10 no.1
• /
• pp.61-66
• /
• 2003

Objectives: The purpose of this study is to investigate the relationship between the extent of prolongation in P300 latency by sleep deprivation and personality variables. Methods: Eighteen healthy male college students participated in this study. Subjects remained awake for 37 hours under continuous surveillance. In the morning and evening of two consecutive study days, P300 was checked four times. MMPI and STAI-T were checked in the morning of the first day. The 18 subjects were divided into two groups according to their extent of P300 prolongation by sleep deprivation: Group A consisted of short P300 latency prolonged subjects, and group B of long latency prolonged subjects. The MMPI profiles and STAI-T scores of these two groups were compared. Results: Group B showed significantly higher scores in the Mf subscale (t=-2.16, df=16, p=0.046) and Pa subscale (t=-2.61, df=16, p=0.019) than group A. Group B also showed higher F subscale scores at a marginally significant level (t=-2.11, df=16, p=0.052). Conclusion: These results suggest that subjects with higher scores in F, Mf, and Pa subscales tend to have delayed cognitive process and decreased efficiency of mental process by sleep deprivation. It can be hypothesized that individuals who are sensitive, passive, dependent, and easily projecting are susceptible to the deterioration of cognitive function by total sleep deprivation.

• The Pure and Applied Mathematics
• /
• v.4 no.1
• /
• pp.61-69
• /
• 1997

In this paper, we study the dynamics of a two-parameter unfolding system $\chi$' = y, y' = $\beta$y＋$\alpha$f($\chi\alpha\pm\chiy$＋yg($\chi$), where f($\chi$,$\alpha$) is a second order polynomial in $\chi$ and g($\chi$) is strictly nonlinear in $\chi$. We show that the higher order term yg($\chi$) in the system does not change qulitative structure of the Hopf bifurcations near the fixed points for small $\alpha$ and $\beta$ if the nontrivial fixed point approaches to the origin as $\alpha$ approaches zero.