• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.19 no.1
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• pp.29-34
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• 2006

The effects of $B_2O_3$ addition on the low-temperature sintering behavior and microwave dielectric properties of $(Zn_{0.8}Mg_{0.2})TiO_3$ ceramic system were investigated. Highly dense samples were obtained at the sintering temperatures below $900^{\circ}C$. The $Q{\times}f_o$ values were determined by the microstructures and sintering shrinkages which are affected by the amount of $B_2O_3$ and sintering temperature. Temperature coefficient of resonance frequency($T_f$) changes to a positive value with increasing the amount of $B_2O_3$ due to the increased amount of rutile phase which is one of the reaction products between $(Zn_{0.8}Mg_{0.2})TiO_3$ and $B_2O_3$. For $6.19 moi.{\%}B_2O_3$-added $(Zn_{0.8}Mg_{0.2})TiO_3$ system, it exhibits ${\epsilon}_r$ = 23.5, $Q{\times}f_o$ = 53,000 GHz, and $T_f$ = 0 ppm/$^{\circ}C$ when sintered at $900^{\circ}C$ for 5 h.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.5
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• pp.63-68
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• 2018

In this paper, We intended to design various things for the realization of SoS(System on Substrate) with SIW in 24GHz ISM 밴드(24-24.25GHz). As part of them, We integrated SIW, transition and MPAA as SoS on the same substrate and investigated its characteristics. We used Rogers Ro4350 with relative permittivity of 3.48 and thickness of 20mil. As results of optimal design, insertion loss of the SIW with 11.55mm length showed 0.32dB and insertion loss of 0.19dB occurred in transition to $50{\Omega}$ microstrip. Characteristics of the MPAA integrated on the same substrate as SoS are very similar to those of stand-alone MPAA. But the integrated MPAA decreased by 0.58dB in gain, which is the sum of SIW insertion loss and transition insertion loss, and by 0.7dB in SLL compared that of stand-alone MPAA. However, the bandwidth was increased by 19.4% as it changed from 670MHz to 800Mhz.

• Clinical and Experimental Vaccine Research
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• v.12 no.4
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• pp.319-327
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• 2023

Purpose: Patients with hematological malignancies are at an increased risk of severe infection with coronavirus disease 2019 (COVID-19). However, developing an adequate immune response after vaccination is difficult, especially in patients with lymphoid neoplasms. Since the long-term effects of the BNT162b2 vaccine are unclear, the humoral immune response 5 months after the two vaccinations in patients with hematological disorders was analyzed. Materials and Methods: Samples were collected from 96 patients vaccinated twice with BNT162b2 and treated with at least one line of an antitumor or immunosuppressive drug in our hospital from November 2021 to February 2022. Serum anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) spike (S) antibody titers were analyzed. Patients were age- and sex-matched using propensity matching and compared with a healthy control group. Patients with serum anti-SARS-CoV-2 S antibodies were defined as 'responder' if >50 U/mL. The patients had B-cell non-Hodgkin lymphoma (B-NHL), multiple myeloma, chronic myeloid leukemia, etc. Results: Patients had significantly low antibody levels (median, 55.3 U/mL vs. 809.8 U/mL; p<0.001) and a significantly low response rate (p<0.001). Multivariate analysis showed that patients with B-NHL, aged >72 years, were associated with a low response to vaccination. There were no significant differences between patients with chronic myeloid leukemia and healthy controls. Conclusion: Our study shows that patients with hematological disorders are at risk of developing severe COVID-19 infections because of low responsiveness to vaccination. Moreover, the rate of antibody positivity differed between the disease groups. Further studies are warranted to determine an appropriate preventive method for these patients, especially those with B-NHL.

• Molecules and Cells
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• v.42 no.2
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• pp.135-142
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• 2019

OCT4, also known as POU5F1 (POU domain class 5 transcription factor 1), is a transcription factor that acts as a master regulator of pluripotency in embryonic stem cells and is one of the reprogramming factors required for generating induced pluripotent stem cells. The human OCT4 encodes three isoforms, OCT4A, OCT4B, and OCT4B1, which are generated by alternative splicing. Currently, the functions and expression patterns of OCT4B remain largely unknown in malignancies, especially in human glioblastomas. Here, we demonstrated the function of OCT4B in human glioblastomas. Among the isoform of OCT4B, OCT4B-190 ($OCT4B^{19kDa}$) was highly expressed in human glioblastoma stem cells and glioblastoma cells and was mainly detected in the cytoplasm rather than the nucleus. Overexpression of $OCT4B^{19kDa}$ promoted colony formation of glioblastoma cells when grown in soft agar culture conditions. Clinical data analysis revealed that patients with gliomas that expressed OCT4B at high levels had a poorer prognosis than patients with gliomas that expressed OCT4B at low levels. Thus, $OCT4B^{19kDa}$ may play a crucial role in regulating cancer cell survival and adaption in a rigid environment.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2565-2570
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• 2014

H19 is an imprinted oncofetal gene, and loss of imprinting at the H19 locus results in over-expression of H19 in cancers. Aflatoxin B1(AFB1) is regarded as one of the most dangerous carcinogens. Exposure to AFB1 would most easily increase susceptibility to diseases such as hepatocellular carcinoma(HCC) but any possible relationship between AFB1 and H19 is not clear. In present study, we found that AFB1 could up-regulate the expression of H19 and promote cell growth and invasion by hepatocellular carcinoma HepG2 cells. Knocking down H19 RNA co ld reverse the effects of AFB1 on cell growth and invasion. In addition, AFB1 induced the expression of E2F1 and its knock-down could down-regulate H19 expression and suppress cell growth and invasion in hepatocellular carcinoma HepG2 cells. Furthermore, E2F1 over-expression could up-regulate H19 expression and promote cell growth and invasion, with binding to the H19 promoter being demonstrated by chromatin immunoprecipitation assays (ChIP). In summary, our results suggested that aflatoxin B1could promote cell growth and invasion in hepatocellular carcinoma HepG2 cells through actions on H19 and E2F1.

• Progress in Superconductivity and Cryogenics
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• v.19 no.2
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• pp.19-24
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• 2017

Cryogenic milling which is a combined process of low-temperature treatment and mechanical milling was applied to fabricate high critical current density $(J_c)MgB_2$ bulk superconductors. Liquid nitrogen was used as a coolant, and no solvent or lubricant was used. Spherical Mg ($6-12{\mu}m$, 99.9 % purity) and plate-like B powder (${\sim}1{\mu}m$, 97 % purity) were milled simultaneously for various time periods (0, 2, 4, 6 h) at a rotating speed of 500 rpm using $ZrO_2$ balls. The (Mg+2B) powders milled were pressed into pellets and heat-treated at $700^{\circ}C$ for 1 h in flowing argon. The use of cryomilled powders as raw materials promoted the formation reaction of superconducting $MgB_2$, reduced the grain size of $MgB_2$, and suppressed the formation of impurity MgO. The superconducting critical temperature ($T_c$) of $MgB_2$ was not influenced as the milling time (t) increased up to 6 h. Meanwhile, the critical current density ($J_c$) of $MgB_2$ increased significantly when t increased to 4 h. When t increased further to 6 h, however, $J_c$ decreased. The $J_c$ enhancement of $MgB_2$ by cryogenic milling is attributed to the formation of the fine grain $MgB_2$ and a suppression of the MgO formation.

• 한국전자현미경학회:학술대회논문집
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• 1999.05a
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• pp.32-33
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• 1999

• Bulletin of the Korean Chemical Society
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• v.19 no.3
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• pp.363-367
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• 1998

• Journal of the Korean Geotechnical Society
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• v.33 no.12
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• pp.35-44
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• 2017

A large amount of recycled aggregates was produced and crushed from old buildings and pavements. In this study, when these aggregates are re-used in subbase or subgrade materials in near construction sites, their engineering characteristics caused by crushing are investigated in terms of permeability and shear strength. Three different sizes of aggregates (31.5-45.0 mm, 19.0-31.5 mm, 9.5-19.0 mm) and their mixtures, a total of 7 types of aggregates were used in compaction tests (modified D and B methods). After compaction tests, aggregates were sieved and analyzed with four different breakage factors ($B_{15}$, $C_c$, $B_{10}$, $B_r$). The D compaction method gave 2.0-8.0 times more crushable than B compaction method. The breakage factors for the largest size aggregate was 1.4-3.0 times higher than those of the smallest size aggregate. For aggregates with 5.6-9.5 mm sizes, the samples were prepared with $B_{15}$ of 1, 3, 10, 20, 30, 50, 60, and 70 for permeability and direct shear tests. As $B_{15}$ increased, the hydraulic conductivity decreased up to 1/22 for $B_{15}=50$. As $B_{15}$ increased from 1 to 50, the peak friction angle increased from $46.1^{\circ}$ to $54.5^{\circ}$. On the other hand, the friction angle decreased after $B_{15}=60$.

• Journal of the Korean Institute of Intelligent Systems
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• v.19 no.4
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• pp.592-594
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• 2009

In this paper we consider voting analysis in the political science in connection with $B_n$(or $M_n${0, 1}), the semigroup of the binary relations on X with n elements. We also consider it in connection with $M_n$(F) (or $B_n$(F)), the semigroup of all fuzzy binary relations on X. Also we establish a possibility theorem and an impossibility theorem in voting analysis based on preferences in $B_n$ and $M_n$(F).