• Bulletin of the Korean Chemical Society
• /
• 제27권9호
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• pp.1466-1468
• /
• 2006

• Bulletin of the Korean Chemical Society
• /
• 제16권12호
• /
• pp.1212-1218
• /
• 1995

An efficient synthesis of 6,8-dioxa-1,4-diazacyclopenta[b]phenanthren-5-one (Pyrazinopsoralen) (4) has been carried out by the Suzuki coupling reaction as a key step starting from 5-bromo-6-methoxybenzofuran (6) and methyl 2-iodo-3-pyrazinecarboxylate (8).

• Bulletin of the Korean Chemical Society
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• 제27권4호
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• pp.484-488
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• 2006

The solid-phase synthesis of new series of 1,6,8-trisubstituted tetrahydro-2H-pyrazino[1,2-a]pyrimidine-4,7-diones as bicyclic $\beta$-turn mimetics is described. Their NF-kB inhibition activities were tested and the effect of substituents on bicyclic ring was investigated. Among the prepared compounds, the fluorobenzyl and methoxybenzyl group substituted compounds 26 and 27 at C-1 and C-8 position showed more inhibitory activities than the others. Tested at a concentration of 10 uM, these two compounds showed a 60% inhibition against the target NF kB 549.

• Bulletin of the Korean Chemical Society
• /
• 제20권6호
• /
• pp.744-746
• /
• 1999

• Bulletin of the Korean Chemical Society
• /
• 제21권4호
• /
• pp.371-372
• /
• 2000

• Bulletin of the Korean Chemical Society
• /
• 제19권3호
• /
• pp.386-390
• /
• 1998

• Bulletin of the Korean Chemical Society
• /
• 제21권4호
• /
• pp.449-450
• /
• 2000

• Bulletin of the Korean Chemical Society
• /
• 제18권10호
• /
• pp.1128-1130
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• 1997

• Bulletin of the Korean Chemical Society
• /
• 제17권3호
• /
• pp.212-214
• /
• 1996

• Bulletin of the Korean Chemical Society
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• 제34권1호
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• pp.54-58
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• 2013

Licochalcones, derived from the dried roots of Glycyrrhiza inflata, have been reported to show various biological activities including antitumor, antiparasitic, antileishmanial, antioxidative, superoxide scavenging, antibacterial, and PTP1B activity. Licochalcone D has an allyl group on ring A instead of ring B, however, most other natural licochalcones possess the group on ring B. Total synthesis of licochalcone D has not been reported even possessing the strongest anti-inflammatory activity. Therefore, the first total synthesis of licochalcone D has been developed by using water-accelerated [3,3]-sigmatropic rearrangement method.