• 셀메드
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• 제5권3호
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• pp.20.1-20.4
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• 2015

Ayurveda is often criticized for having empirical and non-evidence based approach to treat the patients. At the same time, modern medicine is also being criticized for having a non-holistic, reductionist and mechanistic approach of treating the patients which do not help in many real clinical situations. An open minded deduction of treatment approaches in both of these systems for a common patient however makes us to rethink that ideally both systems are similar with a common objective of offering a cure although in a manner which is better understood through their own methods of learning. The differences therefore, are more superficial rather than being deeply rooted in the understanding. A more tolerant viewpoint towards the competitive medical systems may therefore be a better approach to offer optimal health care to our people through a genuine amalgamation of these two health care sciences through an integrated approach. Once this tolerance is developed, it will give us an opportunity to think for a focused selection of type of health care depending upon the type of the disease and strength of the particular system in that area.

• Natural Product Sciences
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• 제29권2호
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• pp.104-112
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• 2023

COVID-19 caused a catastrophe in human health. People infected with COVID-19 also suffer from various clinical illnesses during and after the infection. The Boerhavia diffusa plant is well known for its antihypertensive activity. ACE-II inhibitors and calcium channel blockers are reported as mechanisms for the antihypertensive activity of B. diffusa phytoconstituents. Various studies have said ACE-II is the virus's binding site to attack host cells. COVID-19 treatment commonly employs a variety of synthetic antiviral and steroidal drugs. As a result, other clinical illnesses, such as hypertension and hyperglycemia, emerge as serious complications. Safe and effective drug delivery is a prime objective of the drug development process. COVID-19 is treated with various herbal treatments; however, they are not widely used due to their low potency. Many herbal plants and formulations are used to treat COVID-19 infection, in which B. diffusa is the most widely used plant. The current study relies on discovering active phytoconstituents with ACE-II inhibitory activity in the B. diffusa plant. As a result, it can be used as a treatment option for patients with COVID-19 and related diseases. Different phytoconstituents of the B. diffusa plant were selected from the reported literature. The activity of phytoconstituents against ACE-II proteins has been studied. Molecular docking and ligand-protein interaction computation tools are used in the in-silico experiment. Physicochemical, drug-likeness, water solubility, lipophilicity, and pharmacokinetic parameters are used to evaluate phytoconstituents. Liriodenine has the best drug-likeness, bioactivity, and binding score characteristics among the selected ligands. The in-silico study aims to find the therapeutic potential of B. diffusa phytoconstituents against ACE-II. Targeting ACE-II also shows an effect against SARS-CoV-2. It can serve as a rationale for designing a drug for patient infected with COVID-19 and associated diseases.

• 대한한의학회지
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• 제29권4호
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• pp.161-170
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• 2008

Objectives: This study aimed at comparing Sasang constitutional medicine(SCM) with other constitutional theories of the world. Methods: From PubMed database, we first searched all papers using the term 'constitution', then filtered those having really constitution-focused papers. Then, they were analyzed to compare each constitutional theory and medicinal practice. Results: There were five constitution-related medicines which have been practiced in medical field: Sasang, iridology, somatotype, dermatoglyphics and Ayurveda. There was the largest number of scientific researches for dermatoglyphics while the smallest number of papers was for SCM. The other three constitutional theories were based on anatomic/histologic difference between types in contrast to SCM and Ayurveda, which relied on inherited functional differences of four or three internal organs. Conclusions: This study simultaneously compared five major constitutional theories currently practiced as medicines in the world. We found that even as SCM seems to have the most potential as therapeutic medicine it should be studied more using scientific methodologies to be a world-wide medicine.

• Advances in Traditional Medicine
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• 제9권1호
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• pp.1-13
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• 2009

Medicinal herbs are significant source of synthetic and herbal drugs. In the commercial market, medicinal herbs are used as raw drugs, extracts or tinctures. Isolated active constituents are used for applied research. For the last few decades, phytochemistry (study of plants) has been making rapid progress and herbal products are becoming popular. According to Ayurveda, the ancient healing system of India, the classical texts of Ayurveda, Charaka Samhita and Sushruta Samhita were written around 1000 B.C. The Ayurvedic Materia Medica includes 600 medicinal plants along with therapeutics. Herbs like turmeric, fenugreek, ginger, garlic and holy basil are integral part of Ayurvedic formulations. The formulations incorporate single herb or more than two herbs (poly-herbal formulations). Medicinal herb contains multitude of chemical compounds like alkaloids, glycosides, saponins, resins, oleoresins, sesquiterpene, lactones and oils (essential and fixed). Today there is growing interest in chemical composition of plant based medicines. Several bioactive constituents have been isolated and studied for pharmacological activity. R. cordifolia is an important medicinal plant commonly used in the traditional and Ayurvedic system of medicine for treatment of different ailments. This review illustrates its major constituents, pharmacological actions substantiating the claims made about this plant in the traditional system of medicine and its clinical applications.

• 셀메드
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• 제7권2호
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• pp.9.1-9.6
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• 2017

Recurrent Acute Pancreatitis/ Chronic Pancreatitis (RAP/ CP) is generally marked by sudden onset of symptoms like severe abdominal pain, vomiting and weight loss that needs emergency hospitalization. Owing to irreversible and progressive nature of the disease and limitations of conventional treatment, many patients look for an alternative solution. Here, we report data of 250 well diagnosed cases of acute recurring/ chronic pancreatitis, enrolled in between January 1997 to August 2016, in our Ayurvedic clinical practice in Northern part of India. Ayurveda is well recognized as an independent medical system parallel to conventional medicines in India and a subject is free to opt for any system of medicine for the prevention and treatment of any ailment. The subjects were treated with a complex herbo-mineral formulation based on the principles of Rasa Shastra in Ayurveda that deals with the therapeutics of processed metals in the prevention and treatment of diseases. They were also prescribed a regulated balanced diet and lifestyle. Significant improvement has been noted in subjects who have completed the treatment.

• Advances in Traditional Medicine
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• 제5권4호
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• pp.272-282
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• 2005

Piper betle Linn. (PB), which belongs to the family Piperaceae, is used traditionally in many Asian countries for treatment of a variety of aliments. It has also been used in Ayurveda and Unani systems of medicine. PB leaves are also used as a masticatory in the form of quid. The basic preparation of PB leaves for chewing purposes (PB quid) is known as Paan in India. It is recommended in ancient scripture of Ayurveda and is closely associated with Indian culture. PB is reported to have several therapeutic potentials as well as to produce some untoward effects. The review deals with phytoconstituents present, therapeutic potentials and untoward effects of PB.

• Natural Product Sciences
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• 제14권2호
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• pp.122-126
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• 2008

Chronic oral toxicity studies (90 days) on aqueous and methanol extracts of the whole plant of Peristrophe paniculata (Forssk) Brummitt were carried out in Wistar rats. The dosage was 200 mg/kg/day, p.o. for both the extracts. All external morphological and biochemical changes, in addition to body weight and vital organ weights were recorded. During this investigation, no significant mortality was observed. The results showed that both the extracts were devoid of any toxicity at the dose level studied as compared to the control group.

• Natural Product Sciences
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• 제12권1호
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• pp.50-54
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• 2006

The wound healing activity of plumbagin and the chloroform extract of Plumbago rosea Linn. (Yoot), incorporated into ointments with yellow soft paraffin, have been investigated on rats. Wound healing activity was studied using excision and incision wound models in rats following topical application. Both plumbagin and the Plumbago rosea root extract produced a significant response in both of the wound models studied. The wound contracted in 14 days in the case of plumbagin (0.1%) and 16 days in case of Plumbago rosea root extract (0.5%), as against in 22 days in the case of control animals. The results were also comparable to those of a standard drug, framycetin sulphate cream (1% w/w) in terms of wound contracting ability, wound closure time, tensile strength of wound and regeneration of tissues at the wound site. Histological studies revealed evidences for the healing process by formation of fibrovascular tissue, epithelization and increased collagenization when compared to control.

• Advances in Traditional Medicine
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• 제9권2호
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• pp.101-105
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• 2009

Morinda tinctoria Roxb. (Family: Rubiaceae) is commonly known as Indian mulberry or Aal in India. This plant is very well known for its therapeutic benefit in Indian systems of medicine including Ayurveda and Siddha and in other forms of traditional Medicine worldwide for the treatment of several ailments. Almost all parts of this plant have been explored for its medicinal uses. Several reports on the phytochemical and therapeutic benefits of this plant have been reported. In this article an attempt has been made to review the traditional uses, phytochemical profiles and therapeutic potentials of Indian mulberry.

• 셀메드
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• 제2권2호
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• pp.17.1-17.5
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• 2012

Ayurveda is a nearly 3000 years old traditional medical system of India. Most of the time, people turn to ayurvedic physicians in desperate conditions. Here clinical practices of Ayurveda were initially found effective in the management of migraine among few patients. Later, it was developed as an ayurvedic treatment protocol (ATP) which consists of four herbo-mineral formulations (HMF), three meals and three snacks in a day with eight hours sleep at night. ATP brought significant relief in reducing the frequency, intensity of pain and associated symptoms in the migraine patients. IHS diagnostic criteria was followed to establish the diagnosis of migraine and uniform ATP was prescribed to each patient who were primarily treated by the ayurvedic physicians at their respective clinics. Such observations were presented at appropriate international forums. In an effort to validate the above, the present study carries the details of nine migraine patients who were first diagnosed and treated for migraine by a leading headache expert at Mumbai in India and were then referred to receive ATP. A total number of nine subjects volunteered to this program. Out of those, seven subjects completed 120 days of ATP. Five subjects reported significant improvement in overall symptoms of migraine. All subjects were followed up periodically for four years. No Grade II side effects were observed in any treated case. HMF has also been proved to be safe in experimental studies. Further pharmacological and randomized controlled clinical studies are in progress at the respective departments of a premier medical institute in India.