• Korean Journal of Clinical Pharmacy
• /
• v.3 no.1
• /
• pp.79-88
• /
• 1993

Bioequivalence(BE) test of commercially available sustained release tablets of diltiazem hydrochloride(DTZ) was performed to give some guidelines to BE test in korea in case of which drugs with low oral bioavaiiability(BA) due to substantial first-pass hepatic loss form pharmacologically active metabolites. In such cases, the pharmacologic activity after oral administration is greater than anticipated from BA data, based on chemical assay of drug alone. Therefore, this paper explores the use and meaning of area under the plasma concentration-time(AUC) data of parent and its metabolites to access BA if sustained release tablets. Normal healthy male volunteers(n=14) were randomly divided into 2 groups, and sustained release reference$(Herbesser^{(R)})$ and test$(Herben^{(R)})$ tablets of DTZ-30mg were given orally by balanced two-period cross-over dosing schedule. The plasma concentration of DTZ and and its active metabolite, desacetyldiitiazem(DAD), were determined by high performance liquid chromatography, and, $AUC_{DTZ},\;AUC_{DAD},\;AUC_{DTZ+DAD},\;C_{max}\;and\;T_{max}$ obtained. Analysis of varlance(ANOVA) showed that $AUC_{DTZ}\;and\;C_{max}$ passed the standard $(\alpha=0.05,\;1-\beta\geq0.8,\;\Delta\leq0.2)$ of BE test of korea, but $AUC_{DAD}$ was not satisfied from the standpoint of power. On the other hand, $AUC_{DTZ\midDAD}$ may be more avaliable than $AUC_{DAD}$ from the standpoint of statistics and pharmacologic equivalence.

• Journal of the Korean Geotechnical Society
• /
• v.18 no.4
• /
• pp.45-53
• /
• 2002

There are some previous studies on the determination wave equation soil constants by SPT. However, methods suggested in previous researches had such analytical defects as the non-uniqueness of solutions, long-time consuming in computation, and lacking of accuracy due to the limit of available point values in time domain. In this paper, a modified procedure is proposed to improve the accuracy of determination of wave equation soil constants. It is based upon the least-error approach which minimizes the sum of errors between the measured and the recalculated wave values in total time domain. Finally, its applicability was verified by analyzing measured data presented on the released references.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2003.06a
• /
• pp.1154-1157
• /
• 2003

The spent fuel slitting device is an equipment developed for the separation of the pellet and hull from the cutting fuel rod with length of 250 mm, and in order to feed UO$_2$ pellet. We have analyzed on the existing technologies for designing and producing of the slitting device in the first year(2001), based on these results, designed and produced the rod slitting device. It has effectively separated the pellet from the hull, but demanded the supplement separation work because of the mixing with pellet and hull in the vessel, and required the condition for the reducing time of the process. In the second year(2002), we have reduced the work time, performed the test and capacity evaluation with the improving device, based these results, and ensured the data demanded for designing of the spent fuel rod slitting device. We have compared with the DUPIC(Direct use of spent PWR fuel in CAND reactors) process, and developed the device for the purpose of reducing over 40 % in comparition with the DUPIC operation time(5 minutes). Based on these results, it will is effectively applied to available data for designing and producing of the hot test facility.

• Steel and Composite Structures
• /
• v.9 no.2
• /
• pp.103-118
• /
• 2009

It has been reported that more than thirty five percent of steel bridges in the USA are structurally deficient because of structural degradations. The degraded structures need either full replacement or rehabilitation such that they are able to provide the required services for a longer period of time. The cost for repair in most cases is far less than the cost of replacement. Moreover, repair method generally takes less time than replacement and also reduces service interruption time. Modern advanced composites have been used in aerospace and automotive fields since World War II. In the recent past, because of the high strength-to-weight ratio and high stiffness-to-weight ratio, these composite materials have been introduced to civil engineering infrastructures primarily for repair and rehabilitation of concrete structures. However, only a few preliminary studies on repair of corroded steel structures using theses composite materials are reported in the literature available in the public domain. Thus, in this study, a series of laboratory tests was undertaken to evaluate the effectiveness of this repair method using carbon fiber reinforced polymer composite. The paper discusses the test method and test results obtained from these tests.

• Geomechanics and Engineering
• /
• v.34 no.1
• /
• pp.51-67
• /
• 2023

In this research, the degradation rate of physical properties of the Angouran pit bedrock (calc-schist) is first investigated under the specific numbers of freeze-thaw (F-T) cycles. Then, the durability of calc-schist specimens against the F-T cycle number (N) is examined considering the mechanical parameters, and using the decay function and half-time techniques. For this purpose, point load strength (I_S(50)), second durability index (I_d2), Brazilian tensile strength (BTS), and compressive (V_P) and shear (V_S) wave velocities of calc-schist specimens are measured after 0, 7, 15, 40, and 75 N. For comparing the degradation rate of mechanical properties of available rock types on the Angouran mine walls, these tests are also carried out on the limestone and amphibolite schist specimens beside the calc-schist. According to test results, the exponential regression models are developed between the mechanical parameters of rock specimen's and N variable. Also, the long-term durability of each rock type versus N is studied using the decay function and half-time techniques. Results indicated that the degradation rate differs for the above rock types in which amphibolite schist and calc-schist specimens have the highest and least resistance against the N, respectively. The obtained results from this study can play a key role in the optimal design of the mine's final walls.

• IE interfaces
• /
• v.24 no.1
• /
• pp.1-7
• /
• 2011

The purpose of this research was to develop an integrated interface for the usability test of systems or products in the design process. It is capable of automatically creating GOMS models which can predict human task performances. It can generate GOMS models to be interacted with the prototype interfaces. It can also effectively manage various design information and various usability test results to be implemented into the new product and/or system design. Thus we can perform usability test for products or system prototypes more effectively and also reduce time and effort required for this test. For usability tests, we established an integrated interface based on GOMS model by the LabVIEW program. We constructed the system that the linkage to GOMS model is available. Using this integrated interface, the menu structure of mobile phone can be constructed easily. User can design a depth and a breath that he want. The size of button and the label of the button is changable. The path to the goal can be defined by the user. Using a designed menu structure, the experiment could be performed. The results of GOMS model and the actual time are presented. Besides, values of operators of GOMS model can be defined as the value that user wants. Using the integrated interface that we developed, the optimal menu structure deducted. The menu structure that user wants can be established easily. The optimal layout and button size can be decided by comparison of numerous menu structures. User can choose the method of usability test among GOMS model and empirical data. Using this integrated interface, the time and costs can be saved and the optimal menu structure can be found easily.

• Smart Structures and Systems
• /
• v.11 no.3
• /
• pp.299-314
• /
• 2013

This paper presents a nonlinear time series analysis technique for evaluating machine defect severity, based on the Recurrence Plot (RP) entropy. The RP entropy is calculated from the probability distribution of the diagonal line length in the recurrence plot, which graphically depicts a system's dynamics and provides a global picture of the autocorrelation in a time series over all available time-scales. Results of experimental studies conducted on a spindle-bearing test bed have demonstrated that, as the working condition of the bearing deteriorates due to the initiation and/or progression of structural damages, the frequency information contained in the vibration signal becomes increasingly complex, leading to the increase of the RP entropy. As a result, RP entropy can serve as an effective indicator for defect severity assessment of rolling bearings.

• Journal of Internet Computing and Services
• /
• v.17 no.5
• /
• pp.89-95
• /
• 2016

In a software testing domain, test case prioritization techniques improve the performance of regression testing, and arrange test cases in such a way that maximum available faults be detected in a shorter time. User-sessions and cookies are unique features of web applications that are useful in regression testing because they have precious information about the application state before and after making changes to software code. This approach is in fact a user-session based technique. The user session will collect from the database on the server side, and test cases are released by the small change configuration of a user session data. The main challenges are the effectiveness of Average Percentage Fault Detection rate (APFD) and time constraint in the existing techniques, so in this paper developed an intelligent framework which has three new techniques use to manage and put test cases in group by applying useful criteria for test case prioritization in web application regression testing. In dynamic weighting approach the hybrid criteria which set the initial weight to each criterion determines optimal weight of combination criteria by evolutionary algorithms. The weight of each criterion is based on the effectiveness of finding faults in the application. In this research the priority is given to test cases that are performed based on most common http requests in pages, the length of http request chains, and the dependency of http requests. To verify the new technique some fault has been seeded in subject application, then applying the prioritization criteria on test cases for comparing the effectiveness of APFD rate with existing techniques.

• Wind and Structures
• /
• v.14 no.5
• /
• pp.383-411
• /
• 2011

Roof is an integral part of building envelope. It protects occupants from environmental forces such as wind, rain, snow and others. Among those environmental forces, wind is a major factor that can cause structural roof damages. Roof due to wind actions can exhibit either flexible or rigid system responses. At present, a dynamic test procedure available is CSA A123.21-04 for the wind uplift resistance evaluation of flexible membrane-roofing systems and there is no dynamic test procedure available in North America for wind uplift resistance evaluation of rigid membrane-roofing system. In order to incorporate rigid membrane-roofing systems into the CSA A123.21-04 testing procedure, this paper presents the development of a load cycle. For this process, the present study compared the wind performance of rigid systems with the flexible systems. Analysis of the pressure time histories data using probability distribution function and power spectral density verified that these two roofs types exhibit different system responses under wind forces. Rain flow counting method was applied on the wind tunnel time histories data. Calculated wind load cycles were compared with the existing load cycle of CSA A123.21-04. With the input from the roof manufacturers and roofing associations, the developed load cycles had been generalized and extended to evaluate the ultimate wind uplift resistance capacity of rigid roofs. This new knowledge is integrated into the new edition of CSA A123.21-10 so that the standard can be used to evaluate wind uplift resistance capacity of membrane roofing systems.

• Nuclear Engineering and Technology
• /
• v.52 no.9
• /
• pp.1926-1938
• /
• 2020

We validated the performance of RELAP MOD3.3 code regarding the hybrid SIT with available experimental data. The concept of the hybrid SIT is to connect the pressurizer to SIT to utilize the water inside SIT in the case of SBO or SB-LOCA combined with TLOFW. We investigated how well RELAP5 code predicts the physical phenomena in terms of the equilibrium time, stratification, condensation against Separate Effect Test (SET) data. We also conducted the validation of RELAP5 code against Integrated Effect Test (IET) experimental data produced by the ATLAS facility. We followed conventional approach for code validation of IET data, which are pre-test and post-test calculation. RELAP5 code shows substantial difference with changing number of nodes. The increase of the number of nodes tends to reduce the condensation rate at the interface between liquid and vapor inside the hybrid SIT. The environmental heat loss also contributes to the large discrepancy between the simulation results of RELAP5 and the experimental data.