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Serial Changes in Mannose-Binding Lectin in Patients with Sepsis

  • Huh, Jin Won;Song, Kyuyoung;Kim, Hwa Jung;Yum, Jung-Sun;Hong, Sang-Bum;Lim, Chae-Man;Koh, Younsuck
    • Tuberculosis and Respiratory Diseases
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    • v.81 no.4
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    • pp.305-310
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    • 2018
  • Background: Mannose-binding lectin (MBL) deficiency leads to increased susceptibility to infection. We investigated whether serial changes in MBL levels are associated with the prognosis of patients diagnosed with septic shock, and correlated with cytokine levels. Methods: We enrolled 131 patients with septic shock in the study. We analyzed the serum samples for MBL and cytokine levels at baseline and 7 days later. Samples on day 7 were available in 73 patients. Results: We divided the patients with septic shock into four groups according to serum MBL levels (< $1.3{\mu}g/mL$ or ${\geq}1.3{\mu}g/mL$) on days 1 and 7. Patients with low MBL levels on day 1 and high MBL levels on day 7 showed a favorable prognosis for 28-day survival (odds ratio, 1.96, 95% confidence interval, 1.10-2.87; p=0.087). The high MBL group on day 7 showed a significant decrease in monocyte chemoattractant protein 1, interleukin (IL)-$1{\beta}$, IL-6, IL-8, interferon-${\gamma}$, and granulocyte macrophage colony-stimulating factor levels compared with the low MBL group on day 7. Conclusion: The increase in MBL levels of patients with septic shock may suggest a favorable prognosis and attenuate pro-inflammatory and anti-inflammatory responses.

Clinicopathological observations on the experimental pancreatitis Induced by ligation of pancreatic ducts (췌관 결찰에 의한 실험적 췌장염의 임상병리학적 관찰)

  • Sung, Eun-jue;Lee, Hyun-beom
    • Korean Journal of Veterinary Research
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    • v.34 no.2
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    • pp.407-415
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    • 1994
  • Present experiments were undertaken in order to find out the most available diagnostic method for acute pancreatitis. Experimental dogs were divided into experimental group and control group. The experimental dogs were laparotomized and their pancreatic ducts were ligated for the induction of pancreatitis. The control dogs were laparotomized only for comparison. In addition to the complete blood count, serum amylase and lipase activities, serum glucose, total protein and albumin contents were measured daily for 11 days after the operation. Fecal fat droplet count by Sudan III staining and fecal trypsin activity examination by x-ray film digetion test were also undertaken daily. The results obtained were summarized as follows; 1. Serum amylase activities of the experimental group increased to peak on the third day and returned to the preoperative values on the eighth day. 2. Serum lipase activities of the experimental group increased to peak on the first day and returned to the preopertive values within six to eight days. 3. Serum glucose contents of the experimental group showed significant increse only on the first day. 4. Serum albumin contents of the experimental group decreased significantly during the experimental period. Whereas those of the control group significantly decreased only on the first day. 5. The experimental group showed marked leukocytosis, neutrophilia, and lymphopenia for the first 5 or 8 days. Whereas the control group showed only neutrophilia for the first 3 days. 6. The results of fecal fat droplet count showed some diagnostic value on the third and fourth day in only one experimental dog(No 1). No significant changes in the fecal trypsin activity were noticed in all dogs. 7. Histopathologically. all dogs of experimental group showed changes of pancreatitis. However the degree of the pancreatic lesion was not pararell to the degree of the serum amylase or lipase activity changes.

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Development of a Rotating Biological Contactor(RBC) Process for the Advanced Wastewater Treatment (회전원판(回轉圓板) 생물막(生物膜) 공법(工法)을 이용한 하(下)·폐수(廢水)의 고도처리(高度處理) 공정(工程) 개발(開發))

  • Kim, Eung Ho;Park, Jae Lo;Yoon, Jung Ro
    • Journal of Korean Society of Water and Wastewater
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    • v.8 no.2
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    • pp.1-11
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    • 1994
  • This study was conducted to develop a new RBC process available for the effective removal of organic matters and nitrogen in sewage. The RBC process for the oxidation organic compounds and nitrification was designed to occur at the 1st-stage and next-stage RBC respectively. Then nitrified water was recycled to the denitrifying RBC located at the lower part of the 1st-stage RBC. Some results were summarized as follows. 1. The loading limitation was represented as $60g{\cdot}COD/gm^2/day$ in experiment of simultaneous removal of organic matter and nitrogen. The maxmum COD % removal was 85% at the load $35g{\cdot}COD/m^2/day$. 2. The $NO_3-N$ % removal was approximately 80% at the load $60g{\cdot}COD/m^2/day$ and the maximum $NO_3-N$ remaval rate was $3.9g{\cdot}COD/m^2/day$ and the overall C/N ratio of 11.0 as required to achive 80% of $NO_3-N$% removal. 3.$NO_3-N$ removal rate was rapidly decreased above the load $7g{\cdot}NH_4{^+}-N/m^2/day$ and the maximum $NO_3-N$ removal rate was $3.7g{\cdot}NO_3-N/m^2/day$. 4. Irrespective of the recycle ratio, the COD % removal at the system of 2-stage RBC unit was nearly constant as 89% while the maximum one in the 1st-stage unit was 77% in the case of 50% recycle. 5. The maximum COD % removal in the 3-stage RBC system was 93% while 1st-stage one being 80%, under the $NH_4{^+}-N$ load of $7.4g/m^2{\cdot}d$. Also maximum percentage of nitrification and denitrification was 69% and 41% respectively, under the same $NH_4{^+}-N$ load.

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Evapotranspiration of Soybean-Barley Cropping as a Function of Evaporation and Available Soil Water in the Root Zone (콩 보리 작부체계하(作付體系下)에서 대기증발요구(大氣蒸發要求) 및 토양수분(土壤水分)의 함수(函數)로서의 증발산량(蒸發散量))

  • Im, Jeong-Nam;Jung, Yeong-Sang;Ryu, Kwan-Shig;Yoo, Sun-Ho
    • Korean Journal of Soil Science and Fertilizer
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    • v.15 no.4
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    • pp.213-220
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    • 1982
  • Soil water changes in lysimeters with four different soils and two different available soil depths were monitored during the growing seasons of the soybean-barley cropping from 1977 to 1980 in Suweon to evaluate evapotranspiration (ET) as a function of available soil water and evaporative demand of the atmosphere. ET was calculated with soil water profile and water balance. Soil water content was measured with a neutron moisture depth gauage and The evaporative demand of the atmosphere was estimated with a class A pan evaporation. Rainfall. solar radiation, and wind speed were observed to examine heat and water balances. The average ET of soybeans ranged from 1.6 mm/day at seedling to 6.5 mm/day at flowering, and that of barley ranged from 0.5 mm/day at the regrowth stage to 4.6 mm/day at heading; however, a large variability was observed. The ratio of ET to pan evaporation ($ET/E_o$) ranged from 0.5 to 1.1 for soybeans and 0.4 to 1.2 for barley. The soil evaporation factor ($K_e$) of the $ET/E_o$ component decreased as the soil water depleted and the canopy developed. The crop transpiration factor ($K_t$), another component of $ET/E_o$, also was a function of time and the soil water. $K_t$ was constant when the available soil water fraction (f) in the root zone was greater than a threshold value, and $K_e$ was decreased linearly when f was lower than this threshold. The threshold was 0.7 for the moderate evaporative demand days, 0.4 to 0.5 for the low evaporative demand days, and 0.9 to 0.96 for the high evaporative demand days. Conclusively, the ET can be estimated from the evaporative demand of the atmosphere, $E_o$, $K_e$ and $K_t$, and the available soil water content in the root zone.

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Nephrotoxicity of Acetaminophen and Gentamicin in Combination in Rats

  • Yoon, Sang-Don;Lim, Chae-Woong;Rim, Byung-Moo
    • Toxicological Research
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    • v.14 no.2
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    • pp.151-156
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    • 1998
  • Acetaminophen (APAP) and gentamicin are widely used for many patients, but little in-formation is available regarding the combined effects of APAP and gentamicin. This study was aimed to investigate the potent nephrotoxicity following combined-treatment with APAP and gentamicin. Serum biochemical parameters and histopathological changes in the kidney were observed in female SD rats after continuous daily treatment with either 600 mg/kg/day APAP, and/or 300 mg/kg/day gentamicin for 3 days, and compared with saline sham-treated control animals. APAP and gentamicin combination-treated rats exhibited inconsistent increasing tendency in blood urea nitrogen (BUN) by 96 hours after the last treatment, compared to control or the animals treated with each drug. The relative kidney weights were also increased. Histopathological findings of kidneys revealed that necrosis of proximal convoluted tubules were higher in rats treated with APAP and gentamicin combination than the rats treated with each drug alone. These results suggest that combination use of both drugs have more severe nephrotoxicity than treating each drug alone.

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Forecast of Influent Characteristics in Wastewater Treatment Plant with Time Series Model (시계열모델을 이용한 하수처리장 유입수 성상 예측)

  • Kim, Byung-Goon;Moon, Yong-Taik;Kim, Hong-Suck;Kim, Jong-Rack
    • Journal of Korean Society of Water and Wastewater
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    • v.21 no.6
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    • pp.701-707
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    • 2007
  • The information on the incoming load to wastewater treatment plants is not often available to apply to evaluate effects of control actions on the field plant. In this study, a time series model was developed to forecast influent flow rate, BOD, COD, SS, TN and TP concentrations using field operating data. The developed time series model could predict 1 day ahead forecasting results accurately. The coefficient of determination between measured data and 1 day ahead forecasting results has a range from 0.8898 to 0.9971. So, the corelation is relatively high. We made forecasting program based on the time series model developed and hope that the program will assist the operators in the stable operation in wastewater treatment plants.

Small Watershed Peak Flow Prediction

  • Jun, Byong-Ho;Oh, Kyoung-Doo;Park, Young-Ha
    • Korean Journal of Hydrosciences
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    • v.2
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    • pp.1-12
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    • 1991
  • To estimate the peak discharge from the small rural watersheds, 53 storm events of seven small watersheds from 1972 to 1989 were selected and were analyzed by the multiple regression technique. The peak values by the new prediction method developed in this study were also compared to the real data of Banwol Basins and the estimated peaks of the several watersheds which were analyzed by the Korean engineering companies. These values were also compared to the results from the other method, i.e. the Rational Method, the Kajiyama Method, the Nakayasu Unit Hydrograph companies. Through Method, the Area Routing Method, etc., which are favored by the Korean engineering companies. Through these comparisons, it is proved that the proposed method may be used for day-to-day use without any problem. However, there should be some modifications and improvements as more data are available in the future.

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Effect of Packaging on Keeping Quality of Fresh Ginseng (수삼의 저장성에 미치는 포장의 영향)

  • Gwon, Ho-Ryeong;Lee, Seung-Cheol;Lee, Dong-Seon
    • Food Science and Preservation
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    • v.1 no.2
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    • pp.93-98
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    • 1994
  • Fresh ginseng was packed by using available commercial plastic films of polyvinyl chloride (PVC), cast polypropylene (CPP) and low density polyethylene (LDPE). PVC was used as a wrapping on polystyrene tray, and CPP and LDPE were applied as pouch packages. Gas composition of the package and keeping quality of ginseng in the packages were evaluated for 20 day storage at 5$^{\circ}C$. LDPE (27$\mu\textrm{m}$ thick) Package modified the Package atmosphere to 11.7% O2 and 2.1% CO2, gave low microbial growth and good sensory score after 20 day storage.

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Estimation of Daily Per Capita Intake of Total Phenolics, Total Flavonoids, and Antioxidant Capacities from Fruit and Vegetable Juices in the Korean Diet Based on the Korea National Health and Nutrition Examination Survey 2008 (2008년 국민건강영양조사에 근거한 과채류 주스 음용으로부터 한국인의 일인당 하루 총페놀, 총플라보노이드 및 항산화능 섭취량 추정)

  • Lee, Bong-Han;Kim, Sun-Young;Cho, Chi-Heung;Chung, Dae-Kyun;Chun, Ock-K.;Kim, Dae-Ok
    • Korean Journal of Food Science and Technology
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    • v.43 no.4
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    • pp.475-482
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    • 2011
  • From an analysis of the daily consumption per capita (g/capita/day) in the existing dataset of the Korea National Health and Nutrition Examination Survey 2008, the top seven fruit and vegetable juices (apple, grape, mandarin, orange, pineapple, pomegranate and tomato) commercially available on the Korean market were selected and analyzed. These juices showed a wide range of levels of total phenolics, total flavonoids, and antioxidant capacities. The daily per capita intake of total phenolics from juice consumption was 11.70 mg gallic acid equivalents and that of total flavonoids was 1.65 mg catechin equivalents. The daily per capita intakes antioxidant capacities were 10.42 mg vitamin C equivalents (DPPH assay) and 13.21 mg vitamin C equivalents (ABTS assay). Daily per capita intakes of total phenolics, total flavonoids, and antioxidant capacities were influenced by the compositional content and the daily consumption of fruit and vegetable juices.

Feeding behavior of the copepod Temora turbinata: clearance rate and prey preference on the diatom and microbial food web components in coastal area

  • Chang, Kwang-Hyeon;Doi, Hideyuki;Nishibe, Yuichiro;Nam, Gui-Sook;Nakano, Shin-Ichi
    • Journal of Ecology and Environment
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    • v.37 no.4
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    • pp.225-229
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    • 2014
  • Feeding behavior of Temora turbinata was investigated through laboratory experiments with special emphasis on its food preference and consequent clearance rate on diatom and microbial components given as common natural food assemblage of coastal area (Uchiumi, Uwa Sea, Japan). Among available prey items, T. turbinata showed the highest clearance rate for Thalassiosira spp. ($0.23{\pm}0.08L\;Temora^{-1}day^{-1}$) followed by Chaetoceros spp. ($0.11{\pm}0.03L\;Temora^{-1}day^{-1}$), but clearance rates for other diatom, Nitzschia spp. was lower (0.03 to $0.07L\;Temora^{-1}day^{-1}$). Bacterial abundances showed no response against 24-h feeding of T. turbinata. Feeding of T. turbinata on heterotrophic nanoflagellates (HNF) was apparent when clearance rates of T. turbinata on diatoms were relatively low, but T. turbinata did not consume HNF as well as ciliates with Thalassiosira spp. of which clearance rate was highest. The results suggest that HNF and ciliates are possible supplementary prey item for T. turbinata, but their contribution as food sources can be limited by the presence of other prey items such as preferable diatom species.