• 한방안이비인후피부과학회지
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• 제24권2호
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• pp.35-40
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• 2011

Objective : The aim of this study is to investigate the characteristics of Ryodoraku in the patients with acute and chronic urticaria, and to compare the acute and chronic urticaria. Methods : Subjects were 124 patients with urticaria, acute(<8 weeks) patients were thirty eight and chronic(${\geq}$ 8 weeks) patients were sixty four. We calculated the average Ryodoraku score(RS, ${\mu}A$) and each variation from physiologic range of 12 Ryodoraku points, and compared the acute and chronic urticaria Ryodoraku points pattern. Results : 1. The mean value of F3 and F5 were under 40${\mu}A$ in acute urticaria group. 2. The mean value of H1, H2, H4, H5, H6, F1 and F4 were over 60${\mu}A$ in chronic urticaria group. 3. There were significant difference between acute and chronic urticaria group at H2, H3, H4, F1, F2, F3, F4, F5 and total Ave. Conclusion : These findings suggest that there are significant differences of Ryodoraku pattern between acute and chronic urticaria group, and Ryodoraku reflect the characteristic of urticaria.

• 한국컴퓨터정보학회논문지
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• 제15권12호
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• pp.19-26
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• 2010

본 논문에서는 일상생활 속에서 무자각적으로 생체신호를 측정하고 분석하여 감성을 평가할 수 있는 임베디드 시스템에 관하여 연구하였다. 지속적으로 변화하는 감성을 일관적이며 신뢰성이 높은 생리적인 방법으로 평가하기 위해 심전도(ECG:Electrocardiogram), 맥파(PPG:Photoplethysmography)의 두 가지 생체신호를 측정하고, 무선전송(Bluetooth) 장치를 이용하여 측정한 생체신호를 실시간으로 노트북PC로 전송하여 분석하였다. 생체신호의 분석방법은 고속 퓨리에 변환(FFT:Fast Fourier Transform)과 전력 스펙트럼 밀도(PSD:Power Spectrum Density)를 이용한 주파수 분석방법으로 두 생체신호의 특정 주파수 대역이 가지는 자율신경계의 활성도의 비율을 분석하여 비교 연구하였다. 또한 보다 빠르고 정확한 감성을 평가하기 위하여 분석 알고리즘의 연산을 최소화 하였으며 그래프를 이용한 분석결과의 시각화를 하였다. 본 논문에서는 무자각적인 생체 신호 측정 시스템을 이용하여 다양한 상황에서 생체신호를 측정하고, 개발한 분석 알고리즘으로 분석한 결과의 차이를 연구하여 정확도 및 신뢰도를 기준으로 감성을 평가하기 위한 분석 시스템을 평가하였다.

• 대한한의학회지
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• 제19권2호
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• pp.194-210
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• 1998

The main purpose of this work is the study on the etiology and pathology of the anorexia in oriental and western medicine. An appetite is stimulated by the need of supply of nutrition for life and the physical desire of hunger which appeared as the alternative of taste. In this paper, I investigated the anatomical and the physiological function system, the Piwei functional system and meridian distribution, and the differentiation of the disease according to the Zangfu(internal organs) in association with the anorexia. And conclusion could be summarized as follows : 1. The tongue, one of the Piwei functional system(脾胃機能系), is connected with Pi(脾), Xin(心), Gan(肝) and Shen(腎) meridian. Especially Pi and Xin meridian have the close relations with taste. 2. The appetite has the close relations with Piwei. The appetite and digestion is influenced by the function of smoothing and regulating and bloodflow of Ki(肝主疏泄), warming the Shen to activate the function of Pi(腎主溫養), cleansing the inspired air and keeping the Ki flowing downward(肺主肅降). 3. The cause of anorexia is the insufficiency of Ki of Piwei(脾胃氣虛), the attack of Wei by hyperactive Gan Ki(脾氣犯胃), the insufficiency of Wei Yin(胃陰不足), the declination of the fire from the vital gate(命門火衰) and the retention or stagnancy of undigested food (飮食停滯). Especially, the main cause of anorexia is the insufficiency of Ki of the Piwei(脾胃氣虛). 4. Recently the attack of Wei by hyperactive Gan Ki(脾氣犯胃) is raised by the main cause of anorexia. 5. The mental function of anorexia, which is induced by the unbalance of Pi, is directly associated with Xin(心) and Xin meridia(心經). 6. The goal of the treatment of the anorexia is dependent on the recovery of the weakness of the Pi. And for this goal, the disorders of the other organs is also treated. 7. In the point of the anatomy and physiology, the main cause of anorexia is the loss of function of the autonomic nerve system and the vagus nerve.

• 동의생리병리학회지
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• 제23권4호
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• pp.805-817
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• 2009

This study was to investigate central localization of neurons projecting to the urinary bladder and urinary bladder-related acupoints(Wijung, $BL_{40}$) and neurons of immunoreactive to hormones and hormone receptors regulating urinary bladder function by using peudorabies virus(PRV). In this experiment, Bartha's strain of pseudorabies virus was used in rats to trace central localization of urinary bladder-related neurons and urinary bladder-related acupoints($BL_{40}$) which can regulate urinary system. PRV was injected into the urinary bladder and acupoints($BL_{40}$) related urinary system. After six days survival of rats, mainly common labeled neurons projecting to the urinary bladder and urinary bladder-related acupoints were identified in spinal cord, medulla, pons and diencephalon by PRV immunohistochemical staining method. First-order PRV labeled neurons projecting to urinary bladder and urinary bladder-related acupoints were found in the cervical, thoracic, lumbar and sacral spinal cord. Commonly labeled preganglionic neurons were labeled in the lumbosacral spinal cord and thoracic spinal cord. They were found in the lateral horn area(sacral parasympathetic nucleus and intermediolateral nucleus), lamina V-X, intermediomedial nucleus and dorsal column area. The area of sensory neurons projecting to urinary bladder and Wijung($BL_{40}$) was L5-S2 spinal ganglia and T12-L1 spinal ganglia, respectively. In the brainstem, the neurons were labeled most evidently and consistently in the nucleus of tractus solitarius, area postrema, dorsal motor nucleus of vagus nerve, reticular nucleus, raphe nuclei(obscurus, magnus and pallidus), C3 adrenalin cells, parapyramidal area(lateral paragigantocellular nucleus), locus coeruleus, subcoeruleus nucleus, A5 cell group, Barrington's nucleus and periaqueductal gray matter. In the diencephalon, PRV labeled neurons were marked mostly in the paraventricular nucleus and a few ones were in the lateral hypothalamic nucleus, posterior hypothalamic nucleus, ventromedial hypothalamic nucleus, arcuate nucleus, median eminence, perifornical nucleus, periventricular nucleus and suprachiasmatic nucleus. In cerebral cortex, PRV labeled neurons were marked mostly in the frontal cortex, 1,2 area, hind limb area, agranular insular cortex. Immunoreactive neurons to Corticotropin releasiing factor(CRF), Corticotropin releasiing factor-receptor(CRF-R), c-fos and serotonin were a part of labeled areas among the virus-labeled neurons of urinary bladder and Wijung($BL_{40}$). The commonly labeled areas were nucleus tractus solitarius, area postrema, reticular nucleus, raphe nuclei(obscurus, magnus and pallidus), locus coeruleus, A5 cell group, Barrington,s nucleus, arcuate nucleus, paraventricular nucleus, frontal cortex 1, 2 area, hind limb, and perirhinal(agranular insular) cortex. These results suggest that overlapped CNS locations are related with autonomic nuclei which regulate the functions of urinary bladder-relate organs and it was revealed by tracing PRV labeled neurons projecting urinary bladder and urinary bladder-related acupoints. These commonly labeled areas often overlap with the neurons connected with hormones and hormone receptors related to urination.

• 대한약침학회지
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• 제19권2호
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• pp.101-108
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• 2016

Objectives: This study introduces the history and types of Korean pharmacopuncture and reports trends of research on Korean pharmacopuncture. Methods: Pharmacopuncture studies were searched from the first year of each search engine to 2014 by using seven domestic and foreign search databases. Selected studies were divided into the history of pharmacopuncture, kinds and features of pharmacopuncture, research types, and experimental and clinic studies and were then classified by year of publication, type of pharmacopuncture, disease, and topic. Results: Pharmacopuncture can be classified into four large groups: meridian field pharmacopuncture (MFP), eight-principles pharmacopuncture (EPP), animal-based pharmacopuncture (ABP) and mountain-ginseng pharmacopuncture, which is a single-compound pharmacopuncture (SCP). The largest numbers of studies were reported from 1997 to 2006, after which the numbers decreased until 2014. Of experimental studies, 51.9%, 18.7%. 14.3%, 9% and 3.4% were on SCP, ABP, MFP, formula pharmacopuncture (FP), and EPP, respectively. Of clinical studies, 54.7%, 15.3%. 14.9% 10.0% and 1.5% were on ABP, MFP, EPP, SCP, and FP (1.5%), respectively. Among clinical studies, case reports and case series accounted for 76.5%, followed by randomized controlled trials (RCTs, 16.4%) and non-RCT (13.9%). Musculoskeletal diseases, toxicity and safety tests, anti-cancer effects, and nervous system diseases were mainly treated in experimental studies while musculoskeletal diseases, nervous system diseases, toxicity and safety tests, and autonomic nerve function tests were addressed in clinical studies. Bee venom (BV) was the most frequently-used pharmacopuncture in mechanism studies. Pharmacopuncture was mainly used to treat musculoskeletal diseases. Conclusion: Pharmacopuncture and studies of it have made great progress in Korea. Studies on BV pharmacopuncture and musculoskeletal diseases accounted for most of the studies reported during the review period. Research on the types of pharmacopuncture and diseases has to be expanded. Especially, studies on the use of MFP and EPP for treating patients with various diseases are needed.

• 한국게임학회 논문지
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• 제15권2호
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• pp.105-114
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• 2015

뇌파 및 심전도 생체신호를 복합적으로 이용한 감정인식을 통한 실시간 사용자 인터페이스를 제안한다. 기존에 뇌파를 통한 감정인식의 문제점이었던 낮은 정확도를 개선하기 위해 뇌파의 Theta, Alpha, Beta, Gamma의 상대파워 값과 심전도의 자율신경계 비율을 혼합하는 복합 생체신호 감정 인식 시스템을 개발했다. 기쁨, 공포, 슬픔, 즐거움, 화남, 혐오에 해당하는 6가지 감정을 인식하기 위해 사용자별 확률 값을 저장하는 데이터 맵을 생성하고, 채널에 대응하는 감정 인식의 정확도를 향상시키기 위해 가중치를 갱신하는 알고리즘을 제안한다. 또한 뇌파로 구성된 단일 데이터와 뇌파/심전도 생체신호 복합 데이터의 실험 결과를 비교한 결과 23.77%의 정확도 증가를 보였다. 제안된 인터페이스 시스템은 높은 정확도를 통해 게임 및 스마트 공간의 제어에 필요한 인터페이스로 기기에 활용이 가능할 것이다.

• BMB Reports
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• 제35권4호
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• pp.420-427
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• 2002

Partial nerve injury is the main cause of neuropathic pain disorders in humans. Acupuncture has long been used to relieve pain. It is known to relieve pain by controlling the activities of the autonomic nervous system. Although the mechanism of neuropathic pain and analgesic effects of electroacupuncture (EA) have been studied in a rat model system, its detailed mechanism at the molecular level remains unclear. To identify genes that might serve as either markers or explain these distinct biological functions, a cDNA microarray analysis was used to compare the expression of 8,400 genes among three sample groups. Messenger RNAs that were pooled from the spinal nerves of 7 normal. 7 neuropathic pain, and 7 EA treatment rat models were compared. Sixty-eight genes were differentially expressed more than 2-fold in the neuropathic rat model when compared to the normal, and restored to the normal expression level after the EA treatment. These genes are involved in a number of biological processes, including the signal transduction, gene expression, and nociceptive pathways. Confirmation of the differential gene expression was performed by a dot-blot analysis. Dot-blotting results showed that the opioid receptor sigma was among those genes. This indicates that opioid-signaling events are involved in neuropathic pain and the analgesic effects of EA. The potential application of these data include the identification and characterization of signaling pathways that are involved in the EA treatment, studies on the role of the opioid receptor in neuropathic pain, and further exploration on the role of selected identified genes in animal models.

• 대한한의진단학회지
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• 제12권1호
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• pp.63-79
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• 2008

Background: The consequences of disordered breathing patterns are not only distressing to the patient but also expensive to our health care systems if they are not diagnosed and treated. So we performed this study to investigate clinical significants trough gigong, yoga and hyperventilation in oriental medicine and westen medicine Method: Voluntary control of respiration is one of the main methods of physical and mental training such as meditation, qigong meditation or Yoga. So, this study focuses on breathing in qigong and yoga. This study appreciates a role that a control of respiration has in physical, mental aspects and searches side-effects in qigong and yoga Conclusions: A control of respiration has a function that manages Jung(精), Qi(氣), Shin(神) in Oriental Medicine. It manages Autonomic Nerve system, Endocrine system and induces natural awareness. So Briging the body and mind work through a control of breathing. Breathing pattern disorder has Damum and Qiher pattern in Oriental Medicine pattern. This disease pattern concearnes ATP metabolism. Qiher is concearned with a mitochondria disorder and Damum is concearned with a products of lactate. we guess that Lactate analysis may be utilized as a diagonostic criteria of Breathing pattern disorder. After this, It needs a study that Lactate analysis is concearned with Breathing pattern disorder as Damum pattern. Result: A control of respiration is related not only breathing but also spiritual and physical state. Joo-hwa-ip-ma as Breathing pattern disorder is smiliar to hyperventilation. HVS is patternated Damum and Qi-Weakness pattern in oriental medicine. Lactate is an important complement that diagonates HVS and will be concearned with Damum.

• 대한한방내과학회지
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• 제15권1호
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• pp.80-98
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• 1994

According to the original documents, Sagungsan is considered as an effective drug for controlling the hypertensive epistaxis induced by tension of autonomic nerve and it's hyperfunction. The present experiment was designed to understand the effect of Sagungsan extract on the hemostatic action, intracranial pressure, blood pressure and cardiovascular system in experimental animals. And thus the bleeding time, prothrombin time, capillary dilation, blood pressure, Intracranial pressure, and enzymatic analysis of the ATPase activities were studied. The result obtained here were as followings: 1. Sagungsan water extract reduced the bleeding time in mouse, and prolonged the prothrombin time in rabbits. 2. The drug extract increased the tail volume by capillary dilation in rats. 3. The drug extract inhibited the increase of intracranial pressure and arterial blood pressure in rabbits. 4. At the early time, the increase of arterial blood pressure by the drug extract significantly inhibited by pretreated atropin and regitine in rabbits. 5. The drug extract relaxed the smooth muscle by stimulating the Mg2+-Ca2+-ATPase activities of gastric sarcoplasmic reticulum isolated from rabbit stomach. 6. The drug extract stimulated the heart contraction by inhibiting the $Mg^{2+}-Ca^{2+}-ATPase$ activities of cardiac sarcoplasmic reticulum isolated from rabbit heart. The inhibitory mechanism was reversible and noncompatitive. 7. The drug extract increased the hepatic blood volume by stimulating the hepatic total ATPase activities and hepatic metabolism. 8. The drug extract acted as a tranquilizer by inhibiting the neural Na+-K+-ATPase activity. According to the results, Sagungsan water extract dilated the capillaries, stimulated the heart beat, and thus increased the blood flow with decreasing the intracranial pressure and blood pressure. These effects stanches the epistaxis collectively.

• 한국엔터테인먼트산업학회논문지
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• 제13권4호
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• pp.185-194
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• 2019

본 연구는 단기간 숲 체험자들의 뇌파와 맥파의 변화를 측정하여 정신적인 효능을 확인하는 데 목적이 있다. 이를 위해 경기도 청평에 위치한 자연휴양림에 방문한 484명의 체험자를 대상으로 숲 체험 전·후 뇌파와 맥파를 측정하여 다음과 같은 결과를 도출하였다. 첫째, 숲 체험자들은 집중도, 두뇌활동정도 및 두뇌스트레스에 효과가 있는 것으로 나타났다. 둘째, 숲 체험자들은 심장건강도 및 자율신경건강도 모두 긍정적인 효과가 있는 것으로 확인되었다. 즉, 산림에서 방출되는 여러 가지 물질들이 우리 신체에 호흡기를 통해 들어오게 되면 먼저 심장활동에 긍정적인 영향을 주고, 이는 곧 정서적인 측면인 두뇌에도 작용하여 다양한 호전을 기대할 수 있게 하는 것으로 보인다. 그러므로 숲 체험에 대한 과학적인 근거에 기인한 효능을 바탕으로 많은 사람들이 참여할 수 있는 여건을 만들어 건강한 삶을 위한 하나의 지침으로 숲 체험이 널리 활용되기를 기대한다. 아울러 호흡과 심박 그리고 두뇌의 상호작용에 대한 기전 역시 이를 통해 가능할 것으로 보여 향후 숲 체험에 대한 다양한 실험 연구가 중요하다 하겠다.