• 대한인간공학회지
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• 제22권2호
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• pp.15-28
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• 2003

The one of the most important factors is the platoon design on developing AH3(Advanced Highway System), as it is related to traffic efficiency and drivers' safety. This study was evaluated that how much speed is comfortable for drivers and how long distance is appropriate for vehicular gap of platoon by measuring drivers' physiology signal and sensibility. A fixed-based AHS simulator was developed by using a real vehicle cockpit and the restructured part of Korean highway for human factors evaluation. The EEG(electroencephalogram), ECG (electrocardiogram) and GSR(Galvanic Skin Response) were measured for obtaining drivers' physiology signal according to the change of speed and gap. The brain wave(${\alpha},\;{\beta},\;{\delta},\;{\theta}$) by EEG, the response of the autonomic nervous system. the sympathetic and parasympathetic nervous system, by ECG, and relax-arousal situation by GSR were analyzed. The SD(Semantic Differential) method was also applied to evaluate drivers' sensibility by 5-grade evaluation scale with 96 adjectives. SSQ(Simulator Sickness Questionnaire) was used to measure the simulator sickness of pre and post driving, two times. As the results, drivers were comfortable with 120km/h speed of platoon and lam to 15m vehicular distance. The results of this study may differ from the adaption of the reality because of many parameters. However, the purpose of this study is show to significant results of the drivers' safety and the acceptability of human factors evaluation.

• 대한수의학회지
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• 제35권2호
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• pp.237-243
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• 1995

The effects of various autonomic blocking agents to perivascular nerve stimulation were investigated on isolated coronary artery of pig. 1. The magnitude of contractile response to perivascular nerve stimulation increased with increasing frequency(280Hz) of stimulation. 2. The contractions to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1min) were increased by pretreatment of the cholinestrase inhibitor, physostigmine. 3. The contraction to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1min) was antagonised by the muscarinic antagonist, atropine. 4. The contraction to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1min) was blocked by the neural blocker, tetrodotoxin. 5. The contractions to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1min) were not significantly affected by the ${\alpha}$-adrenergic antagonist, phentolamine or ${\beta}$-adrenergic antagonist, propranolol. 6. The contractile response by the acetylcholine was increased by the pretreatment of cholinestrase inhibitor, physostigmine. This findings suggest that the powerful excitatory action by the perivascular nerve stimulation may be linked to muscarinic receptor by cholinergic nerve excitation in coronary artery of pig.

• 산업경영시스템학회지
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• 제25권2호
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• pp.11-18
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• 2002

Psychological and physiological effects of the simulator sickness could be important bias factors for the sensibility evaluation. The purpose of the present study was to clear the differences of psychophysiological responses due to individual sensitivity of simulator sickness. The present experiment tried to investigate the simulator sickness objectively by observing the change of the simulator sickness for the different level of sickness groups (sick and non_sick group). The subjective evaluations using Simulator Sickness Questionnaire (SSQ) and physiological responses were measured every five minutes when they were driving as 60km/h in the driving graphic simulator. Response level of the subjective evaluation for all subjects on the simulator sickness was linearly increased with time for every item, and the response level of sick group was bigger than that of non_sick group. When the analysis on central nervous system was done separately on the sick and the non_sick group, there was significant difference in the parameter $\theta$/total at Fz and Cz. Although the analysis on autonomic nervous system for all subjects showed the increased activation of sympathetic nervous system, there was no significant difference between the sick and non_sick group. In summary, it is necessary to select the subjects who feel less simulator sickness in order to be accurate sensibility evaluation. The parameters to distinguish between the sick and non_sick group were the change on $\theta$/total and subjective evaluation using SSQ.

• 감성과학
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• 제23권3호
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• pp.3-10
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• 2020

본 연구에서는 기존의 신호체계에서 발생하는 황색 신호 딜레마 상황에서 운전자의 상태를 파악하고 새로운 신호체계를 제안하고자 한다. 특히, 생체신호 분석을 통해 운전자 중심의 대처모형을 제안한다. 이를 위해 자동차 그래픽 시뮬레이터를 통해 교차로 도로 주행상황을 구현하여 기존의 신호체계와 본 연구에서 제안하는 신호체계에서 운전자의 생리적 반응을 관찰하여 규명하고자 한다. 따라서 대조군(기존 신호체계)과 새로운 황색 신호체계를 실험군(새로운 신호체계)으로 나누어 20대 초보 운전자를 중심으로 실험을 진행하였다. 그 결과, 대조군보다 실험군에서 교감신경의 출현이 우세하였으며 통계적으로 유의차가 인정되었다(p<0.05). 이를 통해 새로운 신호체계가 운전자가 긴장감을 유발하는 것처럼 보이지만 교감신경과 부교감신경의 비율이 6:4로 이상적인 균형으로 해석할 수 있다. 결론적으로, 본 연구에서 제안하는 대처 신호체계를 교통체계에 적용한다면 운전자가 더욱 안정적인 주행이 가능할 것으로 보인다.

• Toxicological Research
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• 제11권1호
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• pp.15-21
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• 1995

Several populations of lymphocytes possess receptors for autonomic neurotransmitter, which make lymphocytes susceptible to autonomic stimulation. This study was to evaluate the functional alternation of effector cells of the immune system. Female Balb/C mice, 15-20 g, were injected with MA subcutaneously under various conditions. Mixed lymphocyte reaction (MLR) showed certain T cell subsets were affected by MA. The level of interleukin-2 (IL-2) production was inhibited due to a defect in expression of the IL-2 receptor. In mice injected with 20 mg MA/kg, 1 day before assay, phagocytosis of peritoneal macrophages showed $14.07\pm3%$, which was similar degree to 5 mg MA/kg treatment for 4 consecutive days. Phagocytosis was almost recovered to that of control after 4 day in 20 mg/kg injected mice. Maximum inhibition of plaque forming cell (PFC) occurred when MA was given early, indicating the inductive time point of antibody production was affected. The cortisol level increased in the MA treated group (0.05, 0.20, and $0.08{\mu}g$/dl for control, low, and high dose-MA treated mice, respectively). Based on these results, MA has general suppression effects on the immune systems by functional alteration of effector cells. Considering the increment of serum cortisol levels, MA partially impacts the neuroendocrine system to lead to failure of immune response.

• 동의신경정신과학회지
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• 제16권2호
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• pp.259-266
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• 2005

상기 환자는 25세 여환으로 유학 준비 중 경제적 이유로 유학이 좌절되면서 취업과 유학 준비의 문제로 부모님과 마찰이 있던 상태에서 2005년 7월 19일 두통(頭痛)이 발생하여 양방 내과 및 신경정신과 치료를 받으나 별무호전하고 2005년 7월 23일 악심(惡心) 및 구토(嘔吐)가 추가 발생하여 2005년 7윌 25일부터 2005년 8월 3일까지 동서한방병원 한방신경정신과로 입원한 환자로 한방적으로는 간기울결(肝氣鬱結)로 인한 두통(頭痛)으로, 양방적으로는 긴장형(緊張型) 두통(頭痛)으로 진단받고 한방치료를 통해 호전된 환자이다. 내원당시 다양한 양방적 검사를 시행하여 기질성 질환 여부를 배제하였고, 두통(頭痛)과 겸발한 구토(嘔吐)에 초점을 두고 향묘평위산(香妙平胃散)을 투여하여 빠른 치료효과를 나타낼 수 있었다. 이러한 자율신경계의 균형 이상에서 발생하는 증상의 경우 환자 및 보호자와의 면담 도구로서 HRV의 사용이 상당한 설득력을 보였으나, 보편성의 확보를 위해서는 많은 임상연구 및 치험례의 보고가 필요할 것으로 사려된다

• 대한한의학회지
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• 제22권2호
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• pp.31-40
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• 2001

This experimental studies was to investigate location of labeled neurons in CNS following injection of pseudorabies virus(PRV), Bartha strain, into the uterus and Sanyinjiao(Sp6) of rats. After survival times of 4-5 days following the injection of PRV, the rats were perfused, and their brain and spinal cord were frozen sectioned($30\mu\textrm{m}$). These sections were stained by PRV immunohistochemical staining methods, and observed with light microscope. The results were as follows: 1. In the spinal cord, overlap areas of PRV labeled neurons projecting to uterus and Sp6 were observed in lamina VII, IX and X areas of cervical segments. In thoracic segments, overlap areas were observed in lamina IV, VII, X and intermediolateral n.. In lumbar segments, overlap area of PRV labeled neurons were observed in lamina I, V-VII, IX, X and intermediolateral n.. In sacral segments, overlap areas of PRY labeled neurons were observed in lamina N, V, VII, X and sacral parasympathetic n.. 2. In the brain, overlap areas of PR V labeled neurons projecting to the uterus and Sp6 were observed in lateral paragigantocellular n., rostroventrolateral reticular n., raphe obscurus n., raphe pallidus n., raphe magnus n., locus coeruleus n., Barrington's n., A5 cell group, central gray n., paraventricular hypothalamic n. and arcuate n. This results suggest that overlap areas of PRV labeled neurons of the spinal cord projecting to the uterus and Sp6 might be the first-order neurons related to the viscera-somatic sensory and sympathetic preganglionic neurons. PRV labeled neurons of the brain may be the second and third-order neurons response to the movement of smooth muscle of uterus. These PRV labeled neurons may be central autonomic center related to the integration and modulation of reflex control linked to the sensory and motor system monitoring the internal environment. These overlap areas of spinal cord and brainmay be related to autonomic centers related to regulation of uterus.

• 감성과학
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• 제3권2호
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• pp.17-28
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• 2000

Psychoacoustic characteristics of automobile horns play significant role in resulting subjective evaluation and psychphysiological reactions. However, comparison and differentiation of physiological responses to commercially available horns is a complicated task due to the small contrast in technical features of horns and the influence of such processes as habituation on physiological outcome with the increased number of auditory stimulation trials. In a study on 10 college students, there was performed comparative analysis of reactivity of physiological responses mediated by central and autonomic nervous systems in order to identify the role of habituation on decrement of psychophysiological responsivity and assess the ability to differentiate subjectively most and least preferred, as well as most and least appropriate horns according to physiological manifestations. The EEG and autonomic responses to 7 automobile horns were analyzed during 3 blocks of trials, with varying order of stimuli and changed acoustic parameters of horns in each block. Thus, responses were analyzed for totally 21 trials of auditory stimulation. It was shown that electrodermal and cardiovascular responses have different reactivity patterns to repeated stimulation: skin conductance measures habituated, cardiac reactivity showed no signs of habituation, and the vascular response demonstrated sensitization. The temporal EEG exhibited marked habituation of fast beta band power, while alpha-blocking effect did not habituate during the course of experiment. Differentiation of physiological responses of most and least preferred and appropriate horns was possible in our study, however, some cardiovascular reactivity measures differentiated during the entire course of the experiment, while EEG and electrodermal parameters showed significant differences only during first block of trials, and were later affected by the habituation.

• 한국정보과학회논문지:시스템및이론
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• 제32권7호
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• pp.333-340
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• 2005

네트워크 기반 컴퓨터 시스템이 외부 침입이나 혹은 내부 침입에 의해 부분적으로 손상 (Partially Compromised)이 되더라도 최소한의 필수 서비스를 지속적으로 제공할 수 있게 해주는 침입감내시스템(Intrusion Tolerance System) 설계에 요구되는 중요한 요소 기술 중의 하나는 컴퓨터 시스템의 정량적 신인도(Dependability) 분석이라 할 수 있다. 본 논문에서는 침입감내시스템의 방어능력을 확보하기 위해 자율컴퓨팅(Autonomic Computing)의 핵심 기술인 자가 치유(Self-healing) 메커니즘을 적용하였다. 주 서버와 보조서버로 구성된 침입감내시스템의 상태천이(State Transition)를 자가치유 메커니즘의 두 가지 요소(결함모델 및 시스템반응)를 활용하여 분석하였으며, 시뮬레이션 실험을 통해 침입감내시스템의 가용도(Availability)를 계산한 후, 두 가지 경우의 취약성(Vulnerability) 공격에 대한 사례 연구를 진행하였다.

• Journal of Pharmaceutical Investigation
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• 제15권1호
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• pp.22-31
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• 1985

The influence of some sympathetic blocking agents on pressor actions of norepinephrine and angiotensin was investigated in rabbits. 1. Phentolamine, sympathetic ${\alpha}-blocking$ agent, blocked the pressor action of norepinephrine, but did not affect the pressor action of angiotensin 2. Chlorisondamine, autonomic ganglionic blocking agent, potentiated the both actions of norepinephrine and angiotensin. 3. Guanethidine, bethanidine and debrisoquine, sympathetic neuronal blocking agents, potentiated the action of norepinephrine, while diminished that of angiotensin. 4. Reserpine, norepinephrine depleting agent, increased the pressor response of norepinephrine, but did not influence the pressor action of angiotensin.