• 대한암한의학회지
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• 제16권1호
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• pp.15-31
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• 2011

Objective : The study aims to investigate the effect of moxibustion treatments on autonomic nervous system function of cancer patients through the evaluation of heart rate variability (HRV) biofeedback testing. Materials and Methods : Six cancer patients from inpatient care unit of Dunsan Oriental Hospital, Daejeon University were given three moxibustion treatment sessions every other day over one week period on five Oriental Medicine meridian points CV4, CV6, CV12, KD1, and PC8. HRV biofeedback was conducted before and after each treatment sessions. Three areas of analyses were done from the test conducted; Time Domain Analysis, Frequency Domain Analysis and Autonomic Nervous System (ANS) balance analysis. Results : Time Domain Analysis has shown increased Standard Deviation of all Normal R-R Intervals (SDNN), and decreased Mean Heart Rate and Physical Stress Index (PSI) levels, with statistical significance (P<0.05). In Frequency Domain Analysis, series of moxa treatments have increased Total Power (TP), Very Low Frequency Oscillation Power (VLF), High Frequency Oscillation Power (HF), normalized HF values while decreasing Low Frequency Oscillation Power (LF), normalized LF and LF/HF ratio with statistical significance (P<0.05). The values of ANS activity, ANS balance, Stress resistance, Stress index, have also shown significant changes. For cardiac stability stroke volume power (SP) and Blood Vessel Tension (BVT) were followed, which were both increased after treatment. All changes were statistically significant (P<0.05). Conclusion : The results have shown a positive correlation between the moxibustion treatments and autonomic nervous system responses on cancer patients through the HRV biofeedback testing. This study suggests possible application of moxibustion treatments for managing ANS functions of cancer patients, although additional studies with larger population are necessary to confirm the data.

• 한국건강관리협회지
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• 제4권1호
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• pp.28-38
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• 2006

Background : Phentermine classified by "sympathomimmetic amie", is a stimulant of sympatheic tone But there has been no concrete study which presents the influence of phentermine on autonomic nervous system. Analysis of Heart rate variability is reliable, non-invasive and very useful for evaluating function of autonomic nervous system. We tried to elucidate the influence of phentermine on autonomic nervovs system by heart rate variability. MethodsAmong the 70 candidates who participated in the double-blind case control study whichwas designed in purpose of approving whether- Adipekⓓ is effective for treatment of obesity, 45persons were folled up. From April, 2005 to May 2005, HRV of the candidates who takes phentermine or placebo for 1month, was recorded using BFM-5000ⓓ(medi-core) for 5 minutes in resting state. HRV measures were assessed by time-domain and by frequency- domain analysis. Time domain parameters contain SDNN(Standard Deviation of NN intervals) and RMSSD(Root-Mean-Square of Successive Differences), etc and frequency domain Parameters contain Total Power(TP), Low frequency(LF'0.04-0.15Hz) power. High Frequency(HF:0.15-0.4Hz) power and LF/HF ratio etc. Results: Intakes of phentermine reduce HRV significant1y. SDNN & RMSSD, the main tine domain parameters of HRV, were decreased significantly(P=0.007. 0.016). PSI(Physical Stress Index of Pressure Index) was increase significantly(P=0.002)The main frequency domain parameters(TP, LF & VLF), also decreased significantly. (P=0.024,0.033, 0.015)Conclusion: The result showed that intakes of phentermine reduce heart rate variability and influence on most parameters of HRV. So phentermine not only accelerates sympathetic tone, but also inhibit the balance and function of autonomic nervous system.

• 대한통합의학회지
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• 제11권4호
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• pp.27-39
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• 2023

Purpose : The aim of this study was to identify the influence of transient isokinetic exercise on cardiac autonomic modulation and muscle properties in healthy male subjects. Methods : Twenty-eight healthy males underwent isokinetic exercise of both knee joints using a Biodex systems 3 isokinetic dynamometer with an angular velocity of 60 °/sec. The changes in activity of the autonomic nervous system, as determined by heart rate variability (HRV), and in muscle properties were evaluated at three times: pre-exercise, immediately post-exercise, and 10 min post-exercise. Results : The time domain analysis of HRV revealed significant changes in the beat count and mean and minimal heart rate (HR) measured at pre-exercise, immediately post-exercise, and 10 min post-exercise (p<.001). The beat count and mean HR were markedly increased immediately post-exercise compared to pre-exercise, but then significantly decreased at 10 min post-exercise (p<.001). All parameters of the frequency domain were significantly altered by isokinetic exercise (p<.01). The low frequency/high frequency (LF/HF) ratio, as an index for the sympathovagal balance, was elevated by exercise and remained at a similarly high level at 10 min post-exercise (p<.01). The muscle properties of rectus femoris were changed as follows: Muscle tone and stiffness were significantly increased between pre-exercise and immediately post-exercise (p<.001), and between pre-exercise and at 10 min post-exercise (p<.001). Whereas, the elasticity showed no significant change. Conclusion : These results demonstrated that transient isokinetic exercise could induce changes in cardiac autonomic control and muscle properties. In particular, up-regulation of LF/HF ratio after exercise signifies thus enhanced sympathetic modulation by isokinetic exercise. Therefore, it is needed to understand the cardiovascular risks that may arise during isokinetic exercise for providing the basic evidence to establish appropriate isokinetic exercise protocols as effective rehabilitation exercises.

• 사상체질의학회지
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• 제19권3호
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• pp.176-187
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• 2007

1. Objectives The purpose of this research is to find out the Sasang Constitutional difference in Heart Rate Variability. 2. Methods We enrolled 8498 workers who tested for Heart Rate Variability(HRV) from September 1, 2005 to November 28, 2005 except works whose body constitusions were undetermined according to QSCCII. 3. Results & Conclusions The result of HRV of autonomic activity and stress resistance were arranged in the order of Soeumin, Soyangin and Taeumin. On the other hand Stress Index and Fatigue Index were arranged in the order of Taeumin, Soyangin and Soeumin. But autonomic balance was no significance relationship between Sasang Constitutions. This research has shown that there is a statistical significance between the HRV and Sasang Constitutions. The findings indicated that HRV could be useful mean to make a diagnosis of Sasang Constitution or apprehended Constitutional differences.

• 대한통합의학회지
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• 제4권4호
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• pp.77-82
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• 2016

Purpose: The purpose of this study was to investigate the therapeutic effect of non-invasive vagus nerve stimulation by transcutaneous electrical nerve stimulation application on the autonomic nervous system of human body. Methods: Participants were seventeen healthy adults. Standard deviation of all normal N-N intervals(SDNN), root mean square of successive differences(RMSSD), low frequency(LF), high frequency(HF) were compared in pre and post Mean values after intervention. Data were analyzed in Wilcoxon's signed-ranks test. Results: The results of this study is that sistolic blood pressure and pulse rate decreased mean value after non-invasive vagus nerve stimulation by transcutaneous electrical nerve stimulation. High frequency, low frequency, SDNN, RMSSD increased mean value in heart rate variability after intervention. But that is not significant except for SDNN. Conclusion: Non-invasive vagus stimulation by transcutaneous electrical nerve stimulation effect on parasympathetic nerve stimulation, and then it might be effective method for autonomic nerve balance control.

• 대한물리의학회지
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• 제9권1호
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• pp.63-68
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• 2014

PURPOSE: The purpose of this study was to examine the position changes with tilt table on autonomic nervous system using heart rate variability analysis. METHODS: Fourty healthy adult males volunteered in this study. The low frequency, high frequency and low frequency/high frequency ratio and mean heart rate, standard deviation of all normal R-R intervals, root mean square of successive differences, heart rate variability index were measured at the tilt table angle of $0^{\circ}$, $45^{\circ}$ and $90^{\circ}$ with pulsoximeter. Data were analyzed one-way ANOVA and LSD post hoc test. RESULTS: The mean heart rate, low frequency and low frequency/high frequency ratio increased significantly at higher angle of tilt table(p<.05). The root mean square of successive differences, heart rate variability index decreased significantly at lower angle of tilt table(p<.05). The standard deviation of all normal R-R intervals, high frequency decreased at higher angle of tilt table did not show significant difference. CONCLUSION: The symphathetic activity increased significantly at higher angle of tilt table. The parasymphathetic activity decreased at higher angle of tilt table, but the difference were not significant. The autonomic adaptation, balance and heart rate variability decreased significantly at higher angle of tilt table. Based on these results, in the treatment of patients with a change in posture precedence should be carefully treated. Further studies are necessary to determine the most safety and effective methods.

• 대한약침학회지
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• 제17권3호
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• pp.62-69
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• 2014

Objectives: The purpose of this study is to report a case series of advanced cancer patients whose cancer pain was relieved by using autonomic nerve pharmacopuncture (ANP) treatment. ANP is a subcutaneous injection therapy of mountain ginseng pharmacopuncture (MGP) along the acupoints on the spine (Hua-Tuo-Jia-Ji-Xue; 0.5 cun lateral to the lower border of the spinous processes of vertebrae) to enhance the immune system and to balance autonomic nerve function. Methods: Patients with three different types of cancer (gastric cancer, lung cancer, colon cancer with distant metastases) with cancer pain were treated with ANP. 1 mL of MGP was injected into the bilateral Hua-Tuo-Jia-Ji-Xue on the T1-L5 sites (total 12-20 mL injection) of each patient's dorsum by using the principle of symptom differentiation. During ANP treatment, the visual analogue scale (VAS) for pain was used to assess their levels of cancer pain; also, the dosage and the frequency of analgesic use were measured. Results: The cancer pain levels of all three patients improved with treatment using ANP. The VAS scores of the three patients decreased as the treatment progressed. The dosage and the frequency of analgesics also gradually decreased during the treatment period. Significantly, no related adverse events were found. Conclusion: ANP has shown benefit in controlling cancer pain for the three different types of cancer investigated in this study and in reducing the dosage and the frequency of analgesics. ANP is expected to be beneficial for reducing cancer pain and, thus, to be a promising new treatment for cancer pain.

• 대한한방내과학회지
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• 제27권3호
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• pp.698-705
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• 2006

Objectives : This study was designed to investigate the effect of PC6 and SP4 on autonomic nerve system in healthy adults. Methods : 22 healthy adults were recruited and randomized into the study group or control group. The study group (real acupuncture group) was acupuncturcd on PC6 and SP4. The control group (sham acupuncture group) was acupunctured superficially near PC6 and SP4 but not the exact points. The subjects rested for 10 minutes, and were then acupunctured. After 15 minutes, acupuncture needles were removed and the subjects rested for another 15 minutes. Heart rate variability(HRV) was continuously measured during the study period by FM-150 (digital Holter ECG recorder). Results : In the real acupuncture group. LF(low frequency) significantly decreased during the acupuncture period(p<0.05). LF/HF ratio also had a significant decrease during acupuncture period and the decrease was maintained during the post-treatment period as compared with the pre-treatment period. In the sham acupuncture group. LF significantly increased during the acupuncture period but LF/HF ratio had no significant changes. Conclusions : The results suggest that acupuncture on PC6 and SP4 can increase parasympathetic activity and balance autonomic nervous system.

• Journal of Dental Anesthesia and Pain Medicine
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• 제24권4호
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• pp.273-283
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• 2024

Background: This study evaluated the effect of remimazolam and propofol on changes in autonomic nerve activity caused by surgical stimulation during orthognathic surgery, using power spectrum analysis of blood pressure variability (BPV) and heart rate variability (HRV), and their respective associations with cardiovascular fluctuations. Methods: A total of 34 patients undergoing Le Fort I osteotomy were randomized to the remimazolam (Group R, 17 cases) or propofol (Group P, 17 cases) groups. Observables included the low-frequency component of BPV (BPV LF; index of vasomotor sympathetic nerve activity), high-frequency component of HRV (HRV HF; index of parasympathetic nerve activity), balance index of the low- and high-frequency components of HRV (HRV LF/HF; index of sympathetic nerve activity), heart rate (HR), and systolic blood pressure (SBP). Four observations were made: (1) baseline, (2) immediately before down-fracture, (3) down-fracture, and (4) 5 min after down-fracture. Data from each observation period were compared using a two-way analysis of variance with a mixed model. A Bonferroni multiple comparison test was performed in the absence of any interaction. One-way analysis of variance followed by Tukey's multiple comparisons test was performed when a significant interaction was observed between time and group, with P < 0.05 indicating statistical significance. Results: Evaluation of autonomic nerve activity in comparison with baseline during down-fracture showed a significant increase in BPV LF (P < 0.001), an increasing trend in HRV LF/HF in Group P, and an increasing trend in HRV HF in Group R. There were no significant differences in HR or SBP between the two groups. Conclusion: During down-fracture of Le Fort I osteotomy, sympathetic nerve activity was predominant with propofol anesthesia, and parasympathetic nerve activity was predominant with remimazolam anesthesia.

• Journal of Acupuncture Research
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• 제28권2호
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• pp.13-25
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• 2011

Objectives : This study was accomplished to investigate the effects of acupuncture at Jeonjung($CV_{17}$) on the heart rate variability(HRV) in healthy adults. And based on that, we tried to find out how acupuncture at Jeonjung($CV_{17}$) effects on the activity and balance of the autonomic nervous system. Methods : We investigated on 74 healthy volunteers consisted of 24 subjects in acupuncture group, 24 subjects in sham acupuncture group and 24 subjects in control group. On the other hand, two volunteers were ruled out by standard of elimination. The study was established by randomized trial. Acupuncture was applied at Jeonjung($CV_{17}$) during 10 minutes in acupuncture group and minimal acupuncture was applied at the same area in sham acupuncture group. No treatment was executed in control group. We measured HRV 3 times : baseline measurement and after treatment in acupuncture group and sham acupuncture group (after rest in control group) twise. The SPSS 15.0 for Windows was used to analyze the data by paired t-test, Wilcoxon signed ranks test (in group) and One-Way ANOVA, Kruskal-Wallis test (between the groups). Results: 1. In acupuncture group, Mean HRT, PSI, Normalized HF decreased significantly. SDNN, Ln (TP), Ln (LF), Ln (VLF), Normalized LF and LF/HF ratio increased significantly. RMSSD, Ln(HF) were not affected. 2. In sham acupuncture group, all indicators were not affected. 3. In control group, mean HRT, Ln(TP) decreased significantly. SDNN, RMSSD, PSI, Ln(LF), Ln(HF), Ln(VLF), normalized LF, normalized HF and LF/HF ratio were not affected. Conclusions : We suggest that acupuncture at Jeonjung($CV_{17}$) increases the activity of autonomic nervous system and makes effects on the balance of the autonomic nervous system.