• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.04a
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• pp.139-149
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• 2006

Amyloid beta (A$\beta$) is believed one of the major pathogens of Alzheimer's disease (AD), and the reduction of A$\beta$ is considered a primary therapeutic target. Immunization with A$\beta$ can reduce A$\beta$ burden and pathological features in transgenic AD model mouse. This means anti-A$\beta$ autoantibodies may have a role in AD pathology. Recent findings suggest anti-A$\beta$ autoantibodies level decrease in AD patients. The early detection of AD is important for treatment of this disease. However, diagnosis on AD has only been possible through limited methods such as neuropsychological examination or MRI. To investigate whether it was possible to detect the presence and different levels of naturally occurring anti-A$\beta$ autoantibodies in the plasma of patients with AD and age-matched controls. An advanced ELISA was performed to detect levels of naturally occurring anti-A$\beta$ autoantibodies in the plasma. The level of anti-A$\beta$ auto-antibodies from patients with idiopathic Parkinson's disease or stroke and from normal controls were compared to that of AD patients. Our results showed a significantly lower anti-A$\beta$ autoantibodies level in AD compared to those with other neurological diseases or control. The level of anti-A$\beta$ autoantibodies in the serum may be used to diagnose the presence of AD.

• Journal of Korean Society of Water and Wastewater
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• v.24 no.4
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• pp.377-386
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• 2010

To identify operating parameters of the up-flow filtering system, which is available to discharge filtering residue after the rain, developed for treatment of urban storm runoff, lab scale test was carried out. Removal efficiency of SS was 68.7%, 62.2%, and 58.6% at the area roading rate of 2.46m/h, 4.68m/h, and 10m/h, respectively, filtering device is desirable to operate at the lower than 4.68m/h of area roading rate to get higher level of 60% SS removal efficiency. The removal efficiency of SS was 57.1% ~ 68.7% at the raw water SS of 100mg/L ~ 600mg/L, and the SS in treated water was maintained at the constant level through the elapsed time. It is indicate that filtering device can guarantee a certain level of effluent water quality at various raw water quality. The removal efficiency of SS to the depth of filter media was 68.3%, 78.6% at the filter depth of 10 cm, 20cm respectively. The final treated water quality was showed 30.2mg/L of CODMn, 1.60mg/L of TN and 0.25mg/L of TP. The average removal efficiencies by filtering device developed in this research were recorded slightly lower levels than other research. The main reason of these results were the first, the filter depth of the media used in this test was shallow, the second, the kind of filter media in discharge port of residue. More research to kind of filter media, filter packing rate, select of media for residue discharge port should be go on to produce optimum operating condition. The result of this study would be valuable for the application of filtration device to control of urban storm water.

• Journal of the Institute of Electronics and Information Engineers
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• v.54 no.7
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• pp.93-102
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• 2017

Recently increasing usage of smartphones makes the Internet of Things (IoT) a leading technology that can collect and share data through sensor networks and wireless communication such as low-power Bluetooth (BLE). BLE-based application can provide operators more precise information on Automatic Door system by remotely diagnosing the system faults through wireless sensor networks and sensors around the Automatic Door. In this paper, a smart device with extended BLE module is implemented which can monitor and Control the system states and faults remotely without on-site diagnostic. while maintaining system integrity so that increase efficiency of time and costs for system management. We can use the results of this research as a basis in evaluating reliability of data between devices, extending communication module in Controller of obsolete Door systems, and establishing centralized monitoring systems in near future with multi-channel Door Controls.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.20 no.11
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• pp.1121-1129
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• 2009

In this paper, the UWB(Ultra-Wide Band) modules such as a pulse generator and the LNA(Low-Noise Amplifier) with AGC(Auto Gain Control) are designed to construct a cross-borehole pulse radar system, of which performance is compared with the existing system. The budget and specification of the radar system are determined by calculating the total path loss of the underground medium including an empty cavity. The pulse generator is fabricated to have the repeatation frequency 40 kHz, the pulse width lower than 5 ns and the peak signal level +73 dBm. The UWB LNA is designed to have the noise figure 3.77 dB, the variable gain range 100 dB and the frequency range of 20 MHz to 200 MHz. Compared with the existing system in an actual test site, the implemented system renders it possible to detect the blind area due to the UWB LNA with low noise figure.

• Asian-Australasian Journal of Animal Sciences
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• v.24 no.3
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• pp.400-406
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• 2011

An experiment was carried out to assess the effects of xylanase supplementation on the performance, net energy and gut microflora of broilers fed a wheat-based diet. Day-old male broiler chicks were allocated to two dietary treatments. Each treatment was composed of six replicate cages of seven broilers per cage. The diets were wheat-based and offered as mash. The treatments included i) basal diet deficient in metabolizable energy; and ii) basal diet supplemented with a commercial xylanase added at 4,000 U/kg feed. Bird performance, nutrient utilization and gut microbial populations were measured. Heat production and net energy were determined using an auto-control, open circuit respiration calorimetry apparatus. Results showed that exogenous xylanase supplementation improved feed conversion efficiency (p<0.05) and increased diet AME (+4.2%; p<0.05), as well as heat production (HP), net energy for production (NEp), production of $CO_2$, and consumption of $O_2$. The respiratory quotient (RQ) was also increased (p<0.01) by the addition of xylanase. NEp value was increased by 26.1% while daily heat production per kg metabolizable body weight was decreased by 26.2% when the xylanase was added. Xylanase supplementation numerically increased the ileal digestibility of protein and energy by 3 and 6 percentage units respectively (p>0.05). The ileal digestibility of hemicellulose was significantly improved by xylanase addition (p<0.05).

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1787-1791
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• 2012

Objective: The p53 tumor suppressor pathway plays an important role in gastric cancer (GC) development. Auto-regulatory feedback control of p53 expression is critical to maintaining proper tumor suppressor function. So far, several studies between p53 Arg72Pro polymorphism and GC have generated controversial and inconclusive results. Methods: To better assess the purported relationship, we performed a meta-analysis of 19 publications. Eligible studies were identified by searching the Pubmed database. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess any link. Results: Overall, a significant association was detected between the p53 Arg72Pro polymorphism and GC risk (Pro-allele vs. Arg-allele: OR = 1.05, 95%CI = 1.01-1.08; Pro/Pro vs. Arg/Arg: OR = 1.13, 95%CI = 1.04-1.22). Moreover, on stratified analysis by race, significantly increased risk was found for Asian populations (Pro-allele vs. Arg-allele: OR = 1.06, 95%CI = 1.02-1.10; Pro/Pro vs. Arg/Arg: OR = 1.16, 95%CI = 1.07-1.26; Pro/Pro+Pro/Arg vs. Arg/Arg: OR = 1.58, 95%CI = 1.09-2.27). Conclusions: Our study provided evidence that the p53 72Pro allele may increase GC risk in Asians. Future studies with larger sample size are warranted to further confirm this association in more detail.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.1
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• pp.80-85
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• 2018

Objective: This study was conducted to investigate the effect of corn grain particle size on ruminant fermentation and blood metabolites in Holstein steers fed total mixed ration (TMR) as a basal diet to explain fundamental data of corn grain for cattle in Korea. Methods: Four ruminally cannulated Holstein steers (body weight $592{\pm}29.9kg$) fed TMR as a basal diet were housed individually in an auto temperature and humidity modulated chamber ($24^{\circ}C$ and 60% for 22 h/d). Treatments in a $4{\times}4$ Latin square design were TMR only (control), TMR with whole corn grain (WC), coarsely ground corn grain (CC), and finely ground corn grain (FC), respectively. The corn feeds substituted for 20% energy intake of TMR intake. To measure the ruminal pH, ammonia N, and volatile fatty acids (VFA), ruminal digesta was sampled through ruminal cannula at 1 h intervals after the morning feeding to determine ruminal fermentation characteristics. Blood was sampled via the jugular vein after the ruminal digesta sampling. Results: There was no difference in dry matter (DM) intake between different corn particle size because the DM intake was restricted to 1.66% of body weight. Different corn particle size did not change mean ammonia N and total VFA concentrations whereas lower (p<0.05) ruminal pH and a ratio of acetate to propionate, and higher (p<0.05) propionate concentration were noted when the steers consumed CC compared with WC and FC. Concentration of blood metabolites were not affected by different particle size of corn grain except for blood triglyceride concentration, which was significantly (p<0.05) increased by FC. Conclusion: Results indicate that feeding CC may increase feed digestion in the rumen, whereas the FC group seemed to obtain inadequate corn retention time for microbial degradation in the rumen.

• 한국약용작물학회:학술대회논문집
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• 2006.04a
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• pp.137-149
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• 2006

Amyloid beta ($A{\beta}$) is believed one of the major pathogens of Alzheimer's disease (AD), and the reduction of $A{\beta}$ is considered a primary therapeutic target. Immunization with $A{\beta}$ can reduce $A{\beta}$ burden and pathological features in transgenic AD model mouse. This means $anti-A{\beta}$ autoantibodies may have a role in AD pathology. Recent findings suggest $anti-A{\beta}$ autoantibodies level decrease in AD patients. The early detection of AD is important for treatment of this disease. However, diagnosis on AD has only been possible through limited methods such as neuropsychological examination or MRI. To investigate whether it was possible to detect the presence and different levels of naturally occurring $anti-A{\beta}$ autoantibodies in the plasma of patients with AD and age-matched controls. An advanced ELISA was performed to detect levels of naturally occurring $anti-A{\beta}$ autoantibodies in the plasma. The level of $anti-A{\beta}$ auto-antibodies from patients with idiopathic Parkinson's disease or stroke and from normal controls were compared to that of AD patients. Our results showed a significantly lower $anti-A{\beta}$ autoantibodies level in AD compared to those with other neurological diseases or control. The level of $anti-A{\beta}$ autoantibodies in the serum may be used to diagnose the presence of AD.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.10
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• pp.1957-1963
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• 2017

This paper has proposed a new-type groundwater auto-monitoring system based on Multi-Sensor Device. The system adopted Multi-Sensor Device as host computer of data acquisition, used Windows Mobile which was prevalent operation system of Multi-Sensor Device. It adopted serial port CAN and RS485 as the communication interface between goundwater sensor Device and monitor host machine and utilized serial-linked multi-sensor design to measure effectively according to the depth of groundwater. We present a design for a groundwater monitoring system based on a network of wirelessly linked sensors. The proposed solution will enable groundwater researchers and decision makers to have quick access to the groundwater data with less effort and cost. Though our design is initially meant for groundwater monitoring, it can be easily adapted to other fields of environmental monitoring.

• Asian-Australasian Journal of Animal Sciences
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• v.18 no.7
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• pp.1017-1021
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• 2005

Myostatin is a negative regulator of skeletal muscle growth and a loss of functional myostatin protein increases muscle hypertrophy and hyperplasia in cattle. The present study was conducted to investigate whether maternal passive immunization against myostatin would improve growth performance in chickens. A complete broiler myostatin cDNA was cloned and it was expressed into two transcripts as 1,128 bp and 985 bp by alternative splicing. A conjugated mature myostatin (350 bp) was used to induce autoimmunization and maternal passively immunized chickens was used for the experiment. It was confirmed that there was a maternal passive immunization against myostatin at zero weeks of age, but its effect was reduced by 6 weeks of age. The auto-immunized groups showed smaller body weights than those of control group during the growing period and the difference was getting bigger with time until 6 weeks of age. These results suggest that passive autoimmunization against myostatin used in this study is not potent enough to stimulate growth performance in chickens.