• Title/Summary/Keyword: Atypical structure

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공간구문론을 이용한 자하 하디드 뮤지엄 건축의 공간구조 분석 (Analysis of the Spatial Structure of Zaha Hadid's Museum using Space Syntax)

  • 국진선;조자연
    • 한국실내디자인학회논문집
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    • 제22권5호
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    • pp.311-319
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    • 2013
  • Buildings of the de-constructive tendency beyond definite forms are being constructed in countries with economic power, technical skills and open culture because they require social conditions to accommodate those buildings as well as a lot of construction expenses. Frank Gehry and Zaha Hadid can be chosen as the representative architects of de-constructivism series who are currently working hard. Though both of them are architects belonging to the de-constructivism category, their works show different construction due to the differences in architectural philosophy and working ways. Gehry consider Architect as a fine art and enjoy (sculpture) three-dimensional structure work through Rough Model. With increasing demand for landmark atypical buildings, Hadid has been frequently awarded in the recent series of International Competitions and deals with a lot of cultural works. Affected by absolutism, Hadid showed various diagonal lines in her early construction and works based on the theme of dynamics such as lightness, gliding and light contact with the ground etc. Hadid's Architecture which worked under the theme of dynamic contains a variety of diagonal lines that might cause the viewers to have difficulty on spatial awareness, thus It is known that Hadid's Architecture has lower efficiency on the Circulation and difficulty on spatial cognition compared to the typical museum. According to the research findings of the previous paper that space understanding of viewers on Frank Gehry Museum consisting of complicated planes is generally better than that of them on a typical museum, the purpose of this study is to find out the Circulation efficiency and spatial cognition of Hadid Museum by explaining the space structure of dynamic Hadid Museum and the difference compared to typical museum.

Molecular Analysis of Promoter and Intergenic Region Attenuator of the Vibrio vulnificus prx1ahpF Operon

  • Lee, Hyun Sung;Lim, Jong Gyu;Han, Kook;Lee, Younghoon;Choi, Sang Ho
    • Journal of Microbiology and Biotechnology
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    • 제25권8호
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    • pp.1380-1389
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    • 2015
  • Prx1, an AhpF-dependent 2-Cys peroxiredoxin (Prx), was previously identified in Vibrio vulnificus, a facultative aerobic pathogen. In the present study, transcription of the V. vulnificus prx1ahpF genes, which are adjacently located on the chromosome, was evaluated by analyzing the promoter and intergenic region of the two genes. Northern blot analyses revealed that transcription of prx1ahpF results in two transcripts, the prx1 and prx1ahpF transcripts. Primer extension analysis and a point mutational analysis of the promoter region showed that the two transcripts are generated from a single promoter. In addition, the 3' end of the prx1 transcript at the prx1ahpF intergenic region was determined by a 3'RACE assay. These results suggested that the prx1ahpF genes are transcribed as an operon, and the prx1 transcript was produced by transcriptional termination in the intergenic region. RNA secondary structure prediction of the prx1ahpF intergenic region singled out a stem-loop structure without poly(U) tract, and a deletion analysis of the intergenic region showed that the atypical stem-loop structure acts as the transcriptional attenuator to result in the prx1 and prx1ahpF transcripts. The combined results demonstrate that the differential expression of prx1 and ahpF is accomplished by the cis-acting transcriptional attenuator located between the two genes and thereby leads to the production of a high level of Prx1 and a low level of AhpF.

Jean Paul Gaultier 컬렉션에 나타난 헤드드레스의 해체적 특성 (Deconstructive Features of Headdress Found in Jean Paul Gaultier's Collection)

  • 김선영
    • 한국의류학회지
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    • 제36권5호
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    • pp.489-500
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    • 2012
  • This work surveys the trend and dissolution characteristics in headdress that appear in Jean Paul Gaultier's collection. Along with a related literature review, a total of 903 headdress pieces shown in collections 40 times (excluding the common caps and hats) were analyzed, covering from 2001S/S to 2010 F/W of Jean Paul Gaultier's Haute Couture and Pret-a-Porter. The headdress trend indicated in his collections was divided into such subgroup forms of folklore, usage of natural things, usage of artificial things, religion, retro, scarf, variations in headgear, mask and veil, atypical type and abstract. Such an expression tendency was so unique and mixed characteristic that it was hard to define its form and structure thanks to enlargement and exaggeration, extremity in ornaments, and use of foreign materials, which led to creative dynamics. Gaultier's headdress also reflected the following characteristics: first, expression of difference indicative of time deconstruction; second, uncertainty of meanings via deconstruction; third, text interactivity via deconstruction of gender and material adopted; fourth, decentralization through dissolution of the Orient and the Occident.

Distinct Repressive Properties of the Mammalian and Fish Orphan Nuclear Receptors SHP and DAX-1

  • Park, Yun-Yong;Teyssier, Catherine;Vanacker, Jean-Marc;Choi, Hueng-Sik
    • Molecules and Cells
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    • 제23권3호
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    • pp.331-339
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    • 2007
  • It has been suggested that the structure and function of nuclear receptors are evolutionally conserved. Here, we compare the molecular functions of the nile tilapia (Oreochromis niloticus) small heterodimer partner (nSHP/NR0B2) and the Dosage-sensitive sex reversal AHC critical region on X chromosome gene 1 (nDAX-1/NR0B1) with those of human SHP and DAX-1 (hSHP and hDAX-1, respectively). We found that, upon transient cotransfection of human cells, nDAX-1 repressed the activity of tilapia SF-1 (nSF-1) but not that of human SF-1, although the physical interaction with human SF-1 was retained. Similarly, nSHP repressed the activity of nSF-1, whereas hSHP did not, pointing to divergent evolution of SHP/SF-1 in fish and human. We thus propose that the repressive functions of SHP and DAX-1 have been conserved in fish and mammals although with different transcriptional targets and mechanisms. These differences provide new insights into the physiological diversification of atypical orphan nuclear receptors during vertebrate evolution.

바이오모픽 건축의 유기체 철학 배경에 관한 연구 (Organic Philosophy Background of Biomorphic Architecture)

  • 김정신
    • 한국콘텐츠학회논문지
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    • 제14권5호
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    • pp.436-443
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    • 2014
  • 불확정성의 도시 사회구조에서도 생존을 위한 뚜렷한 성향을 가지고 특성화를 구축하는 건축을 바이오모픽 건축이라고 본 연구에서 전제하고 연구를 시작하였다. 본 연구의 목적은 현대건축의 비정형적이고 새로운 형상의 건축으로 전개되어 가고 있는 바이오모픽 건축에 내재되어 있는 의미를 해석하여 바이오모픽 건축 발생의 유기체 철학적 배경을 분석하는 것이다. 바이오모픽 건축은 자율적 생존구조를 지닌 생명체 형상으로 생명체가 지닌 생명현상의 잠재력을 형태로 구체화한 건축이라고 정의하였다. 이론적 고찰을 통해 바이오모픽 건축의 특성은 유동적 생명현상의 형상화와 상호관계적 자기조직화와 사용자 경험의 활성화 지원으로 분석되었다. 바이오모픽 건축의 특성을 분석하여 바이오모픽 건축의 발생요인으로 유기체 철학을 도출하는 연구분석의 객관적 기준을 구체적 사유로서의 '생성'과 복잡성의 과학과 창발적 시스템을 중심으로 정리하였다. 바이오모픽 건축의 발생요인으로 유기체 철학을 중심으로 분석하였다. 새로운 건축의 유기체 철학을 중심으로 하는 발생배경에는 건축 관련 구성요소와 환경과의 유기체적인 통합의 특성이 작용되는 현상을 확인할 수 있다.

Experimental study on the compressive stress dependency of full scale low hardness lead rubber bearing

  • Lee, Hong-Pyo;Cho, Myung-Sug;Kim, Sunyong;Park, Jin-Young;Jang, Kwang-Seok
    • Structural Engineering and Mechanics
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    • 제50권1호
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    • pp.89-103
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    • 2014
  • According to experimental studies made so far, design formula of shear characteristics suggested by ISO 22762 and JEAG 4614, representative design code for Lead Rubber Bearing(LRB) shows dependence caused by changes in compressive stress. Especially, in the case of atypical special structure, such as a nuclear power structure, placement of seismic isolation bearing is more limited compared to that of existing structures and design compressive stress is various in sizes. As a result, there is a difference between design factor and real behavior with regards to shear characteristics of base isolation device, depending on compressive stress. In this study, a full-scale low hardness device of LRB, representative base isolation device was manufactured, analyzed, and then evaluated through an experiment on shear characteristics related to various compressive stresses. With design compressive stress of the full-scale LRB (13MPa) being a basis, changes in shear characteristics were analyzed for compressive stress of 5 MPa, 10 MPa, 13 MPa, 15 MPa, and 20 MPa based on characteristics test specified by ISO 22762:2010 and based on the test result, a regression analysis was made to offer an empirical formula. With application of proposed design formula which reflected the existing design formula and empirical formula, trend of horizontal characteristics was analyzed.

The Terminal and Internal Hairpin Loops of the ctRNA of Plasmid pJB01 Play Critical Roles in Regulating Copy Number

  • Kim, Sam Woong;Jeong, In Sil;Jeong, Eun Ju;Tak, Je Il;Lee, John Hwa;Eo, Seong Kug;Kang, Ho Young;Bahk, Jeong Dong
    • Molecules and Cells
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    • 제26권1호
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    • pp.26-33
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    • 2008
  • The plasmid pJB01, a member of the pMV158 family isolated from Enterococcus faecium JC1, contains three open reading frames, copA, repB, and repC. Plasmids included in this family produce counter-transcribed RNA (ctRNA) that contributes to copy number control. The pJB01 ctRNA, a transcript which consists of 54 nucleotides (nts), is encoded on the opposite strand from the copA/repB intergenic region and partially overlaps an atypical ribosome binding site (ARBS) for repB. The ARBS is integrated by the two underlined conserved regions: 5'-TTTTTGTNNNNTAANNNNNNNNNATG-3', and the ctRNA is complementary only to the 5' conserved sequence 5'-TTTTTGT-3'. This complementary sequence is located at a distance from the terminal loop of the ctRNA secondary structure. The ctRNA structure predicted by the mfold program suggests the possible generation of a terminal and an internal hairpin loop. The amount of in vitro translation product of repB mRNA was inversely proportional to the ctRNA concentration. Mutations in the terminal and internal hairpin loops of the ctRNA had inhibitory effects on its binding to the target mRNA. We propose that the intact structures of the terminal and internal hairpin loops, respectively, play important roles in forming the initial kissing and extending complexes between the ctRNA and target mRNA and that these regulate the copy number of this plasmid.

FSI 해석에 의한 비정형 초고층 빌딩의 풍응답 특성에 관한 연구 (A Study on the Wind-Induced Response Characteristics of Freeform Shaped Tall Building using FSI Analysis)

  • 박성철;김효진;한상을
    • 한국전산구조공학회논문집
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    • 제27권4호
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    • pp.223-230
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    • 2014
  • 본 논문에서는 FSI해석을 이용하여 비정형 초고층 빌딩의 풍응답 특성을 연구하였다. 해석모델은 Twist모델이며, 뒤틀림 각도와 풍가속도의 상관관계에 대해 연구 중점을 두었다. 먼저 단방향 해석을 수행하여 100년 재현주기 풍속에 대한 최대 횡 변위를 구하고, 제한조건을 만족하는 탄성계수를 산출한다. 그리고 양방향 해석을 수행, 시간이력해석을 통해 산출된 탄성계수와 임의의 밀도를 가지는 풍가속도를 예측하게 된다. 정방형 모델은 높이 400m, 변장비 1:1, 세장비 8로 설정, 뒤틀림 모델은 0도에서 90도까지 15도 간격으로, 90도에서 360도까지 90도 간격으로 비틀어 회전시켰다. 형상에 따른 풍가속도 예측 결과, 정방형 모델이 뒤틀림 모델보다 크게 산출되어 풍진동 영향에 더 민감한 것을 검증하였다.

목조주택 모형개발을 위한 평면모듈 설정에 대한 연구 - 기둥-보 방식 구조를 중심으로 - (A study on the Plan Modular Establishment for the Development of Wooden Dwelling Model - Focused on the Post & Beam Structure -)

  • 강만호;주석중;김재덕
    • 한국주거학회논문집
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    • 제18권1호
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    • pp.141-148
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    • 2007
  • In this research, to develope wooden house model with post & beam structure which is commensurate with domestic environment, we analyzed the size and module of a unit space and space organization of existing habitation, then, based on the result, we tried to suggest general wood house modules. For this, we investigated 98 floor plans for 30 pyeong apartment in Seoul, Gyounggi-do, Gwangju, and Jeolla-do. The results are showed as follows. 1) It has shown that 7 posts distances are available in 2 bay floor plan type - 3.0 m, 3.3 m, 3.6 m, 3.9 m, 4.2 m, 4.5 m, and 4.8 m. 2) It has shown that 8 posts distances are available in 3 bay floor plan type - 3.0 m, 3.3 m, 3.6 m, 3.9 m, 4.2 m, 4.5 m, 4.8 m, and 5.1 m. It was concluded as follows, applying the standard of regulations of horizontal modular coordination design, from $\ulcorner$the standard of modular coordination design in architecture(KSF 1525)$\lrcorner$. 1) The available widths are 3.0 m, 3.3 m, 3.6 m, 4.2 m, and 4.8 m, and the available depths are 3.0 m, 3.3 m, 3.6 m, and 4.2 m. 2) To guarantee a space through post module of a room combination, we can use a module of 3.6 m, 4.2 m, 4.8 m except 3.0 m, 3.3 m among available modules. The module investigated in post & beam structure wooden house is applied in basic 6 floor plans as follows. 1) When organize the room on the basis of tile module of 3.6 m, 4.2 m, it was possible to organize the floor plan. 2) After arranging main room, making practical application of variableness which is advantage of post & beam structure, putting to practical use of extra space that becomes the combination of atypical room such as kitchen, dining room, and bathroom, it was possible to organize the floor plan of the residence. 3) It is possible to organize whole rooms through the plan module from 3.6 m to 4.2 m, that decides the floor plan of a wooden house.

흡연 시 인삼, 쑥, 솔잎 추출물이 폐 세포의 구조와 항산화 효소에 미치는 영향 (The Effects of Extracts from Ginseng, Wormwood and Pine needle in Pulmonary Structure and Anti-oxidant Enzyme in Smoking)

  • 정혁;김상기;김상국;성미영;김현정;김범학;김유영
    • KSBB Journal
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    • 제19권2호
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    • pp.138-142
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    • 2004
  • 본 실험에서 메탄올을 추출 용매로 한 인삼, 쑥, 그리고 솔잎 추출물을 수동분무기를 이용하여 호흡을 통해 직접 실험동물에게 투여하였을 경우 그 효과가 폐의 구조를 유지하는 데 도움을 줄뿐만 아니라 항산화 효소에도 길항적인 효과를 나타냄을 알 수 있었다. 즉, 추출물을 흡입시킴으로서 세포막의 지질과산화를 억제하여 세포의 구조와 기능을 유지함으로써 흡연으로 인한 세포의 파괴 및 불규칙적인 구조 이상을 줄일 뿐만 아니라 추출물에 포함되어 있는 인삼의 saponin, 쑥의 sesquiterpene과 cineol, 솔잎의 rutin 등의 항산화제의 작용에 의해 흡연으로 생긴 유해 라디칼의 분해를 촉진시키거나 항산화 효소의 활성을 증가시킴으로써 폐의 정상적인 기능에 도움을 주는 것으로 생각된다. 특히, 지금까지 연구되어진 in vitro나 in vivo에서의 경구투여나 주사를 통한 방법이 아니라 호흡을 통해 직접 폐에 투입함으로써 그 결과가 빠르게 나타날 수 있을 것으로 생각된다.