• Title/Summary/Keyword: Atypia

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Cytologic Findings of Infectious Mononucleosis Lymphadenitis - A Report of Four Cases - (전염성 단핵구중 림프절염의 세침흡인 세포학적 소견 - 4예 보고 -)

  • Sohn, Jin-Hee;Jung, Eun-Ha;Park, Hye-Rim
    • The Korean Journal of Cytopathology
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    • v.9 no.2
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    • pp.227-231
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    • 1998
  • Infectious mononucleosis(IM) Is an acute self-limiting lymphoproliferative disorder associated with infection by the Epstein-Barr Virus(EBV), with the characteristic triad of fever, sore throat, and cervical or generalized lymphadenopathy. And also there are atypical lymphocytes in the peripheral blood. Cytological findings of IM lymphadenitis are characterized by a florid immunoblastic and atypical lymphoid cell proliferation. However, the small number of cases were studied by fineneedle aspiration cytology(FNAC) even though there was a complexity of lymph node pathology. It is important to recognize the reactive pattern of IM that would initiate EBV study and to avoid unnecessary biopsy We studied findings of lymph node FNAC from 4 patients with EBV infection confirmed by EBV-specific serologic studios. All of the cases were positive for viral capsid antigen(VCA) and one case was positive for anti-EBV nuclear antigen(EBNA). Cytologically, all of the cases exhibited high cellularity and atypia with great numbers of large immunoblastic lymphocytes.

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Quality Assuarance on Fine Needle Aspiration Cytology of Malignant Salivary Gland Neoplasms (악성 침샘종양의 세침흡인 세포검사의 정도관리)

  • Oh, Young-Lyun;Ko, Young-Hyeh
    • The Korean Journal of Cytopathology
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    • v.15 no.1
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    • pp.40-44
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    • 2004
  • To evaluate the quality of fine needle aspiration cytology diagnosis on malignant salivary gland neoplasms, cytologic findings were correlated with histologic diagnosis of 56 surgically removed malignant salivary gland tumors. Seven cases (12.5%) were insufficient, 23 cases (41.1%) were diagnosed as malignant, 17 (30.4%) cases were accurately diagnosed by histologic subtype, and 9 cases (16%) were diagnosed as benign. Five out of 9 false negative cases were misdiagnosed as pleomorphic adenomas. Except the cases with insufficient specimen, overall sensitivity was 81.6%, and the sensitivity varied according to the histologic subtype; 91% in salivary duct carcinoma, 100% in carcinoma ex pleomorphic adenoma, 50% in mucoepidermoid carcinoma, 63% in adenoid cystic carcinoma, and 50% in acinic cell carcinoma. The diagnostic accuracy differed among cytopathologists irrespective of periods after acquisition of board of pathologists. These results confirm that salivary gland neoplasm can be easily misdiagnosed in fine needle aspiration cytology and a great caution should be given in diagnosing the benign appearing salivary aspirates to avoid under-diagnosis of malignant neoplasm with low grade cytologic atypia.

Tenosynovial Chondromatosis on Plantar Area (A Case Report) (족저부에 발생한 건활막 연골종증(1예 보고))

  • Hwang, Chung-Soo;Chung, Phil-Hyun;Kang, Suk;Kim, Jong-Pil;Kim, Young-Sung;Yang, Chul-Ho;Lee, Jong-Im
    • Journal of Korean Foot and Ankle Society
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    • v.13 no.2
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    • pp.214-217
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    • 2009
  • Tenosynovial chondromatosis is a multinodular cartilaginous proliferation that arises from the tenosynovial membranes. It is rare, benign neoplasm, most commonly affects the tendon of the wrist and hand. It is clinically important because of its high rate of recurrence with a unique histopathological pattern which not infrequently displays considerable focal cellular atypia and hypercellurality nevertheless it is benign, but it has not been well recognized because of its rarity. We report here a rare case of tenosynovial chondromatosis of the tendon sheath of flexor hallucis longus and flexor digitorum longus in plantar area.

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Fine Needle Aspiration Cytology of Intracystic Papillary Carcinoma of the Breast - A Case Report - (유방의 낭내 유두상 암종의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Lee, Ah-Won;Choi, Yeong-Jin;Lee, Kyo-Young;Kim, Byung-Kee;Kim, Sun-Moo;Shim, Sang-In
    • The Korean Journal of Cytopathology
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    • v.8 no.2
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    • pp.179-184
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    • 1997
  • Intracystic papillary carcinoma(IPC) of the breast is a distinctive and very rare variant of intrductal carcinoma. The cytologic features of IPC have been rarely reported, and there are difficulties in distinguishing between benign and malignant papillary breast lesions. Herein we report a IPC of the breast in a 80 year-old female. Fine needle aspiration cytology revealed monotonous cuboidal epithelial cells in small clusters and individually scattered on bloody background. The tumor cells did not show overt cytologic atypia. With the histologic features of this case and review of the literature, the cytologic differential points are discussed.

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Diagnostic importance of Ultrasound-Guided Fine Needle Aspiration in Diagnosing Hepatic Lesions among Sudanese Patients 2015

  • Edris, Ali Mahmoud Mohammed;Ali, Imtithal Mohamed;Bakeit, Shaimaa Bushra;Abashar, Mohamed;Siddig, Emmanuel Edwar
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.2
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    • pp.553-555
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    • 2016
  • Background: Liver cytology is indicated and requested for evaluating hepatic masses in symptomatic or serendipitous cryptic discovered lesions. Objective: To determine the cytomorphological patterns of hepatic lesions identified among a group of Sudanese patients. Materials and Methods: This is an analytical descriptive hospital-based study included 165 patients undergoing ultrasound-guided fine needle is an aspiration cytology (FNAC)for hepatic lesions, at Al-Amal Military Hospital & Khartoum Teaching Hospital in Khartoum, Sudan. Clinical data were reviewed. Air dried Diff Quick stained smears were grouped into unsatisfactory samples, benign lesions, and malignant neoplasms. Results: Our population were consisted of 35 (21.2%) females and 130 (78.8%) males, with a male to female ratio 3.7:1 and an age ranged between 47 to 80, and a mean age $57{\pm}7$. Of 165 cases, 57 (34.5%) were benign, no atypia were noticed, 101 (61.2%) were malignant. Most investigated patients were found to have metastatic lesions. Conclusion: FNAC is a useful tool for investigating hepatic lesions.

Proximal-type Epithelioid Sarcoma Involving Perineum - Case Report - (회음부를 침범한 근위형 유상피육종 - 증례보고 -)

  • Park, Yong-Koo;Park, Ho-Chul
    • The Journal of the Korean bone and joint tumor society
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    • v.7 no.2
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    • pp.64-67
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    • 2001
  • Epithelioid sarcoma has been well characterized as a distincitve entity. In the classic form, it occurs in the distal extremities of young adults. However, in the proximal form, it was found mostly in the pelvis, perineum, and genital tract of young to middle-aged adults. Morphologically, the tumor cells had promient epithelioid or rhabdoid features with marked cytologic atypia, and grew in a multinodular pattern. Immunohistochemically, cytokeratin, epithelial membrane antigen, and vimentin were positive in the tumor cells. This reports dealt with 32-year-old male lesion on his perineum. The tumor shows typical features of proximal type epithelioid sarcoma. We also discussed pathological differential diagnosis and prognosis on this particular disease.

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Cytologic Findings of Fine Needle Aspiration Biopsy of Ancient Schwannoma (퇴행성 신경초종의 세침흡인 생검에 대한 세포학적 소견)

  • Joo, Hee-Jae;Lee, Kwang-Gil
    • The Korean Journal of Cytopathology
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    • v.1 no.2
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    • pp.158-163
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    • 1990
  • Ancient (degenerated) schwannomas are benign tumors that display pronounced degenerative changes including cyst formation, calcification, hemorrhage, and hyalinization. The tumors are usually infiltrated by large numbers of inflammatory cells such as neutrophils, lymphocytes, siderophages, and histiocytes. They are located in deep locations such as the retroperitoneum and must be differentiated from malignant soft tissue tumors because spindle cells with nuclear atypia may be present. In the fine needle aspiration biopsy. The cytologic findings of two cases of ancient schwannoma occurring in posterior mediastinum and retroperitoneum, respectively, are described. Computerized tomographic findings of both cases showed changes of cystic degeneration or necrosis. A case occurred in retroperitoneum revealed features of destruction of vertebral body to suggest a malignant soft tussue tumor radiologically. The cytologic findings of aspiration biopsy of both tumors revealed that the tumor cells were spindle in shape with elongated nuclei. Some of tumor cells were arranged in a palisading fashion. Cell structures that resemble the Verocay bodies were observed. Some of the tumor cells showed pleomorphic bizarre nuclei, but no mitotic activity or chromatin clumping was seen. Inflammatory cells, siderophages and histiocytes were scattered in fibrillar material. These cytologic findings are important in the diagnosis of ancient schwannoma and in the differentiation of this tumor from the malignant spindle cell tumor.

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Imprint Cytologic Features of Fibroadenoma of the Breast with Extensive Infarction - A Case Report - (광범위 경색을 동반한 유망의 섬유선종의 압착도말소견 - 1예 보고 -)

  • Choi, Suk-Jin;Lee, Jong-Im;Jang, Tae-Jung;Kim, Ki-Kwon;Kim, Dong-Hoon;Jeoung, Byoung-Ook;Kim, Jung-Ran
    • The Korean Journal of Cytopathology
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    • v.10 no.2
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    • pp.169-174
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    • 1999
  • Spontaneous infarction of fibroadenoma of the breast is very uncommon and may lead to difficulties in clinical and pathological diagnosis. Most reported cases occured in young women during pregnancy or lactation. This report describes imprint cytologic features of an infarcted fibroadenoma in a 19-year-old young woman without evidence of pregnancy. The smears revealed many individually scattered degenerated or necrotic epithelial or spindle stromai cells and naked nuclei on dirty necrotic background. A few sheets of cohesive uniform epithelial cells and a few fragments of stromal cells were also present. Most of the epithelial cells had pyknotic and hyperchromatic nuclei, however, cellular atypism such as pleomorphism, prominent nucleoli or mitosis were not present. Though the necrotic ductular and glandular outline of this case may bear a superficial resemblance to adenocarcinoma, obvious cytologic atypia or mitosis, even in the necrotic areas were not present.

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A Study on Characteristics of Grotesque in Contemporary Fashion Collection -Focus on Damien Hirst's Works- (현대 패션컬렉션에 나타난 그로테스크(Grotesque) 특성 연구 -Damien Hirst의 작품을 중심으로-)

  • Park, Hee Jeong;Kan, Ho-Sup
    • Journal of the Korean Society of Clothing and Textiles
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    • v.37 no.3
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    • pp.399-412
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    • 2013
  • This study introduces a new delivery method for designs as observed in the artwork trends of Damien Hirst and reflected in the unique expression methods of Modern fashion Collections. The study analyzed numerous resources (literature, dissertations, magazines, and the internet) about Damien Hirst and the examination of a modern fashion timeline is limited to after the 2000s. The 'grotesque trend' that appears in Damien Hirst's works can be classified into five categories (fragmented animal, mismatch, excessiveness and exaggeration, comedy and awfulness, and abnormality). Based on this, the study found that heterogeneous, abject abhorrence, double sided of the play, exaggerated atypia and devilishness in Modern fashion. This study suggests a positive direction for the 'grotesque technique' that could be recognized as one of the delivery methods for a unique fashion design based on the attachment of an aesthetic value that supersedes bizarreness and strangeness to expand various methods of expression.

Fine Needle Aspiration Cytology of Mucinous Cystic Carcinoma of the Pancreas - A Case Report - (췌장의 점액 낭샘암종의 세침흡인 세포소견 -1예 보고-)

  • Lee,, Kyung-Ji;Lee, Kyo-Young;Kang, Chang-Suk;Shim, Sang-In;Lee, Ah-Won
    • The Korean Journal of Cytopathology
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    • v.16 no.2
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    • pp.88-92
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    • 2005
  • Mucious cystic neoplasm of pancreas is a cystic neoplasm composed of columnar, mucin-producing epithelium and is supported by ovarian-type stroma. The key to the cytologic evaluation of pancreatic cystic lesions is to recognize the cytologic components as being diagnostic of a mucin-producing cystic neoplasm, as all of these neoplasms need to be resected. We report the use of fine needle aspiration cytology in the diagnosis of an invasive mucinous cystic carcinoma confirmed by partial pancreatectomy. The cytologic specimen showed a abundant mucin background and sheets or papillae of neoplastic cells. There are mucin-containing columnar cells that show a variable degree of cytologic atypia.