• Journal of East-Asian Urban History
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• v.2 no.2
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• pp.272-296
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• 2020

The study will first pay attention to the conflict between Kyoto Animation Co. and residents over establishing memorial facilities after the "Kyoto Animation 1^st Studio arson and Murder Incident," which occurred in Kyoto, Japan on the morning of July 18, 2019. And through on-site coverage and review of related TV program "Summer of Prayer, Voice of the Holy Land" aired by Mainichi Broadcasting System on August 17, 2019. We reviewed what this conflict means by Japanese animation fans to set a "Holy Land" of specific regions and the resulting content tourism business model. The conflict between Kyoto Animation Co. and the residents resulted in a lengthy confrontation which did not get solved until late July 2020. It proves the cooperation of residents is essential for the success of content tourism, especially the cooperation model for development of Holy Land.

• Nuclear Engineering and Technology
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• v.56 no.5
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• pp.1738-1746
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• 2024

The effect of europium-driven corrosion behavior of Alloy 709 in FLiNaK molten salt was investigated by static immersion tests at 700 ℃. It was found that the corrosion of Alloy 709 increased after the addition of EuF₃, even though the standard reduction potential of Eu(III)/Eu(II) was negative than those of Fe(II)/Fe, Ni(II)/Ni and Cr (II)/Cr. The presence of Eu(III) led to deeper corrosion attack layers and more pits on the steel surface in comparison with corrosion in blank FLiNaK. However, the addition of Eu(III) seemed to have a role in reducing surface cracking that was explored in corrosion by blank FLiNaK, which depended on Eu(III) concentration.

• 대한생식의학회:학술대회논문집
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• 2000.06a
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• pp.13-28
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• 2000

Human spermatozoa exhibit a capacity to generate ROS and initiate peroxidation of the unsaturated fatty acids in the sperm plasma membrane, which plays a key role in the etiology of male infertility. The short half-life and limited diffusion of these molecules is consistent with their physiologic role in key biological events such as acrosome reaction and hyperactivation. The intrinsic reactivity of these metabolites in peroxidative damage induced by ROS, particularly $H_2O_2$ and the superoxide anion, has been proposed as a major cause of defective sperm function in cases of male infertility. The number of antioxidants known to attack different stages of peroxidative damage is growing, and it will be of interest to compare alpha-tocopherol and ascorbic acid with these for their therapeutic potential in vitro and in vivo. Both spermatozoa and leukocytes generate ROS, although leukocytes produce much higher levels. The clinical significance of leukocyte presence in semen is controversial. Seminal plasma confers some protection against ROS damage because it contains enzymes that scavenge ROS, such as catalase and superoxide dismutase. A variety of defense mechanisms comprising a number of antioxidants can be employed to reduce or overcome oxidative stress caused by excessive ROS. Determination of male infertility etiology is important, as it will help us develop effective therapies to overcome excessive ROS generation. ROS can have both beneficial and detrimental effects on the spermatozoa and the balancing between the amounts of ROS produced and the amounts scavenged at any moment will determine whether a given sperm function will be promoted or jeopardized. Accurate assessment of ROS levels and, subsequently, OS is Vital, as this will help clinicians both elucidate the fertility status and identify the subgroups of patients that respond or do not respond to these therapeutic strategies. The overt commercial claims of antioxidant benefits and supplements for fertility purposes must be cautiously looked into, until proper multicentered clinical trials are studied. From the current data it appears that no Single adjuvant will be able to enhance the fertilizing capacity of sperm in infertile men, and a combination of the possible strategies that are not toxic at the dosage used would be a feasible approach.

• Molecules and Cells
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• v.37 no.4
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• pp.322-329
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• 2014

N-acetylglucosamine kinase (GlcNAc kinase or NAGK; EC 2.7.1.59) is highly expressed and plays a critical role in the development of dendrites in brain neurons. In this study, the authors conducted structure-function analysis to verify the previously proposed 3D model structure of GlcNAc/ATP-bound NAGK. Three point NAGK mutants with different substrate binding capacities and reaction velocities were produced. Wild-type (WT) NAGK showed strong substrate preference for GlcNAc. Conversion of Cys143, which does not make direct hydrogen bonds with GlcNAc, to Ser (i.e., C143S) had the least affect on the enzymatic activity of NAGK. Conversion of Asn36, which plays a role in domain closure by making a hydrogen bond with GlcNAc, to Ala (i.e., N36A) mildly reduced NAGK enzyme activity. Conversion of Asp107, which makes hydrogen bonds with GlcNAc and would act as a proton acceptor during nucleophilic attack on the ${\gamma}$-phosphate of ATP, to Ala (i.e., D107A), caused a total loss in enzyme activity. The overexpression of EGFP-tagged WT or any of the mutant NAGKs in rat hippocampal neurons (DIV 5-9) increased dendritic architectural complexity. Finally, the overexpression of the small, but not of the large, domain of NAGK resulted in dendrite degeneration. Our data show the effect of structure on the functional aspects of NAGK, and in particular, that the small domain of NAGK, and not its NAGK kinase activity, plays a critical role in the upregulation of dendritogenesis.

• Molecules and Cells
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• v.42 no.7
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• pp.503-511
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• 2019

As sessile organisms, plants have developed sophisticated system to defend themselves against microbial attack. Since plants do not have specialized immune cells, all plant cells appear to have the innate ability to recognize pathogens and turn on an appropriate defense response. The plant innate immune system has two major branches: PAMPs (pathogen associated molecular patterns)-triggered immunity (PTI) and effector-triggered immunity (ETI). The ability to discriminate between self and non-self is a fundamental feature of living organisms, and it is a prerequisite for the activation of plant defenses specific to microbial infection. Arabidopsis cells express receptors that detect extracellular molecules or structures of the microbes, which are called collectively PAMPs and activate PTI. However, nucleotidebinding site leucine-rich repeats (NB-LRR) proteins mediated ETI is induced by direct or indirect recognition of effector molecules encoded by avr genes. In Arabidopsis, plasmamembrane localized multifunctional protein RIN4 (RPM1-interacting protein 4) plays important role in both PTI and ETI. Previous studies have suggested that RIN4 functions as a negative regulator of PTI. In addition, many different bacterial effector proteins modify RIN4 to destabilize plant immunity and several NB-LRR proteins, including RPM1 (resistance to Pseudomonas syringae pv. maculicola 1), RPS2 (resistance to P. syringae 2) guard RIN4. This review summarizes the current studies that have described signaling mechanism of RIN4 function, modification of RIN4 by bacterial effectors and different interacting partner of RIN4 in defense related pathway. In addition, the emerging role of the RIN4 in plant physiology and intercellular signaling as it presents in exosomes will be discussed.

• Korean journal of aerospace and environmental medicine
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• v.30 no.3
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• pp.83-85
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• 2020

In commemoration of Vol. 30, Issue 3, our journal prepared five review articles and one original paper. The global outbreak of COVID-19 in 2020 has impacted our society, and especially the aviation and travel industries have been severely damaged. Kwon presented the aviation medical examination regulations related to COVID-19 announced by the Ministry of Land, Infrastructure, and Transport of the Republic of Korea. Lim summarized various efforts of airlines to overcome the crisis in the aviation industry. He also discussed the management of these aircraft as the number of airplanes landing for long periods increased. Finally, he suggested various quarantine guidelines at airports and onboard aircraft. COVID-19 has had a profound impact on mental health as well as physical effects. Kim investigated the impact of COVID-19 on mental health and suggested ways to manage the stress caused by it. The Internet of Things (IoT) refers to a technology in which devices communicate with each other through wired or wireless communication. Hyun explained the current state of the technology of the IoT and how it could be used, especially in the aviation field. In the area of airline service, various situations arise between passengers and crew. Therefore, role-playing is useful in performing education to prepare and respond to passengers' different needs appropriately. Ra introduced the conceptual background and general concepts of role-playing and presented the actual role-play's preparation process, implementation, evaluation, and feedback process. For a fighter to fly for a long time and perform a rapid air attack, air refueling is essential, which serves refueling from the air rather than from the aircraft base. Koo developed a questionnaire based on the HFACS (Human Factors Analysis and Classification System) model and used it to conduct a fighter pilot survey and analyze the results.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.05a
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• pp.143-146
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• 2008

In this paper, It presents the method the player will be able to confront when the NPC approach to the player, the NPC which have the property which is similar form grouping. The property of the NPC follows in quality of Game and it decides with separate way. To attribute of the NPC it is composed of conduct pattern, an attack pattern and the weapon pattern back. It considers a priority on the group wild middle which is formed and it judges the attack yes or no of the player. The method that proposed will play an important role in development of a 3D FPS games.

• Journal of The Korean Society of Agricultural Engineers
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• v.57 no.4
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• pp.11-19
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• 2015

The important properties of EVA (ethylene vinyl acetate) redispersible polymer was waterproof, densification of internal pore space of concrete and ball bearing and micro filler. Also, the significant role of polypropylene(PP) fiber was crack control and blockade of movement for deterioration factors. The most studies for EVA were limited in the field of mortar and PP fiber reinforced concrete had been studied in the state of being restricted unit water content, rich mix and mixing much of the fiber without considering construction site. Therefore, the control mix design were applied in ready mixed concrete using 10 % fly ash of total cement weight used in batch plant. On the basis of control mix design, EVA contents ranging from 0 % to 10 % of total cement weight and PP fiber contents ranging from 0 % to 0.5 % of EVA concrete volume were used in the mix designs. The results showed the maximum compressive strength value was measured at EVA 5.0 % and PP fiber 0.1 %, the minimum water absorption ratio was at EVA 10 % and PP fiber 0 %, the durability factor for freezing and thawing resistance was at EVA 5.0 % and PP fiber 0.3 % and the minimum weight reduction ratio of resistance to sulfuric acid attack was at EVA 10 % and PP fiber 0.5 % after curing age 42days. Meanwhile, From these results, PP fiber reinforced EVA concrete would be very benefit, if each optimal mix types were used in hydraulic structures, underground utilities and agricultural structures.

• Wind and Structures
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• v.23 no.6
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• pp.595-613
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• 2016

Large amplitude oscillation of steepled main cables usually presents during construction of a long-span bridge. To study this phenomenon, six typical main cables with different cross sections during construction are investigated. Two main foci have been conducted. Firstly, aerodynamic coefficients of a main cable are obtained and compared through simulation and wind tunnel test: (1) to ensure the simulation accuracy, influences of the numerical model's grid size, and the jaggy edges of main cable's cross section on main cable's aerodynamic coefficients are investigated; (2) aerodynamic coefficients of main cables at different wind attack angles are obtained based on the wind tunnel test in which the experimental model is made by rigid plastic using the 3D Printing Technology; (3) then numerical results are compared with wind tunnel test results, and they are in good agreement. Secondly, aerodynamic coefficients of the six main cables at different wind attack angles are obtained through numerical simulation. Then Den Hartog criterion is used to analyze the transverse galloping of main cables during construction. Results show all the six main cables may undergo galloping, which may be an important reason for the large amplitude oscillation of steepled main cables during construction. The flow structures around the main cables indicate that the characteristic of the airflow trajectory over a steepled main cable may play an important role in the galloping generation. Engineers should take some effective measures to control this harmful phenomenon due to the big possibility of the onset of galloping during the construction period.

• Journal of KIISE:Information Networking
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• v.35 no.1
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• pp.76-90
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• 2008

Wireless sensor networks are expected to play a vital role in the upcoming age of ubiquitous computing such as home environmental, industrial, and military applications. Compared with the vivid utilization of the sensor networks, however, security and privacy issues of the sensor networks are still in their infancy because unique challenges of the sensor networks make it difficult to adopt conventional security policies. Especially, node compromise is a critical threat because a compromised node can drain out the finite amount of energy resources in battery-powered sensor networks by launching various insider attacks such as a false data injection. Even cryptographic authentication mechanisms and key management schemes cannot suggest solutions for the real root of the insider attack from a compromised node. In this paper, we propose a novel trust-based secure aggregation scheme which identifies trustworthiness of sensor nodes and filters out false data of compromised nodes to make resilient sensor networks. The proposed scheme suggests a defensible approach against the insider attack beyond conventional cryptographic solutions. The analysis and simulation results show that our aggregation scheme using trust evaluation is more resilient alternative to median.