Purpose: This study predicted the flow of chemical, biological, and radiological materials in chemical, biological, and radiological defense facilities within the base during a chemical, biological, and radiological attack based on the conditions of the facility before the existing improvement, analyzed the flow of pollutants and the human impact of toxic substances, and identified the occurrence of leakage. Method: Assuming that the simple chemical, biological, and radiological defense facility improvement plan, which reflects the characteristics of the building, has been improved to the facility standard, the flow of chemical, biological, and radiological materials in the chemical, biological, and radiological defense facility within the base was predicted in the event of a chemical, biological, and radiological attack under the same conditions, and the flow of contaminants and the impact on occupants by toxic substances were analyzed to determine spatial safety. Result: In the case of Plan 1, it was found that leakage occurred after approximately 250 seconds in spaces where existing flat-panel chemical, biological, and radiological defense facilities were not installed. In the cases of Plans 2 and 3, it was found that leakage occurred in spaces where existing flat-panel chemical, biological, and radiological defense facilities were not installed. Conclusion: n the case of plans 1, 2, and 3, it was found that airtightness was maintained because no leakage occurred in the improved plane. In the case of plan 4, airtightness was not maintained due to leakage in the space where the existing plane simple chemical, biological, and radiological protection facilities were not installed.