• Progress in Medical Physics
• /
• v.29 no.1
• /
• pp.29-41
• /
• 2018

The objective of this study was to evaluate the chemical exchange saturation transfer (CEST) effect of amino acids and neurotransmitters, which exist in the human brain, depending on the concentration, pH, and amplitude of the saturation radiofrequency field. Phantoms were developed with asparagine (Asn), ${\gamma}-aminobutyric$ acid (GABA), glutamate (Glu), glycine (Gly), and myoinositol (MI). Each chemical had three different concentrations of 10, 30, and 50 mM and three different pH values of 5.6, 6.2, and 7.4. Full Z-spectrum CEST images for each phantom were acquired with a continuous-wave radiofrequency (RF) saturation pulse with two different $B_1$ amplitudes of $2{\mu}T$ and $4{\mu}T$ using an animal 9.4T MRI system. A voxel-based CEST asymmetry was mapped to evaluate exchangeable protons based on amide (-NH), amine ($-NH_2$), and hydroxyl (-OH) groups for the five target molecules. For all target molecules, the CEST effect was increased with increasing concentration and B1 amplitude; however, the CEST effect with varying pH displayed a different trend depending on the characteristics of the molecule. On CEST asymmetric maps, Glu and MI were well visualized around 3.0 and 0.9 ppm, respectively, and were well separated macroscopically at a pH of 7.4. The exchange rates of Asn, Glu, BABA, and Gly usually decreased with increasing pH. The CEST effect was dependent on the concentration, acidity of the target molecules, and B1 amplitude of the saturation RF pulse. The CEST effect for Asn can be observed in a 9.4T MRI system. The results of this study are based on applying the CEST technique in patients with neurodegenerative diseases when proteins in the brain are increased with disease progression.

• The Korean Journal of Financial Management
• /
• v.23 no.1
• /
• pp.49-67
• /
• 2006

This study examines whether won/dollar futures have price discovery function and volatility spillover effect or not, using intraday won/dollar futures prices, volumes, and spot rates for the interval from March 2, 2005 through May 30, 2005. Futures prices and spot rates are non-stationary, but there is the cointegration relationship between two time series. Futures returns, spot returns, and volumes are stationary. Asymmetric effects on volatility in futures returns and spot returns does not exist. Analytical results of mean equations of the BGARCH-EC (bivariate GARCH-error correction) model show that the increase of futures returns raise spot returns after 5 minutes, which implies that futures returns lead spot returns and won/dollar futures have price discovery function. In addition, the long-run equilibrium relationship between the two returns could help forecast spot returns. Analytical results of variance equations indicate that short-run innovations in the futures market positively affect the conditional variances of spot returns, that is, there is the volatility spillover effect in the won/dollar futures market. A dummy variable of volumes does not have an effect on two returns but influences significantly on two conditional variances.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.40 no.1
• /
• pp.65-71
• /
• 2016

In recent years, 3D printing has received increasing attention due to releases of low-cost 3D printers based on open-source platform. 3D printing is expected to reduce the barrier to entry in the traditional manufacturing processes by increasing flexibility and creating an advantage to manufacture customized products at low costs. In this study, a unique eyeglass frame was designed to have a snake shape, which has an asymmetric geometry unlike traditional frames. The eyeglass frame was designed in a customized manner by reflecting dimensional characteristics of a customer's face. Finite element analysis was performed to investigate the structural safety of the 3D printed frames during the assembly process. The analysis also considered the effect of anisotropic material properties as determined by tensile tests. The eyeglass frame was then printed using the customized sizes and the best building process. The eyeglass frame was successfully assembled with lenses and without structural failure during its assembly procedure.

• Journal of the Korean Chemical Society
• /
• v.48 no.1
• /
• pp.85-93
• /
• 2004

The purpose of this research was to investigate the change of argumentation of middle school students when they participated in argument tasks with CASE(Cognitive acceleration through science education) programs. Students argumentations were divided into two categories; 'explanatory argumentation' and 'dialogic argumentation'. Several argumentation components were used in their argumentation. Among argumentation components, claim and ground took place more than half of argumentation components. The percentage of 'dialogic argumentation' was lower than the percentage of 'explanatory argumentation'. The percentage of 'dialogic argumentation' was getting higher during CASE intervention. CASE programs had more effect on symmetric group than asymmetric group, however it was unstable. In general, participation ratio in argumentation of the formal operational student was high and the ratio in argumentation of the transitional student was getting higher.

• Physical Therapy Rehabilitation Science
• /
• v.5 no.4
• /
• pp.205-209
• /
• 2016

Objective: Children with spastic diplegic cerebral palsy show weakness especially in the lower-extremity rather than upper-extremity muscles and display characteristics such as asymmetric alignment, deficits in postural control or balance ability, and slow walking speed. Various therapeutic interventions are applied to children with cerebral palsy, of which taping is widely used in the field of rehabilitation, however, there are few studies of the effects of kinesio taping on gait patterns of children with cerebral palsy. The present study investigated the effects of kinesio taping on gait parameters of children with cerebral palsy. Design: Cross-sectional study. Methods: Four children with spastic diplegia participated in this study. The participants' gait parameters while walking 10 m with and without kinesio taping (tibialis anterior, quadriceps femoris, and gluteus maximus) were recorded. Gait parameters including gait velocity, cadence, step length, stride length, single support time, and double support time were evaluated using the GAITRite. Mean values were obtained after having the subjects walk three times in each condition with a 5-minute rest period between each condition. The order of each condition was assigned randomly. Results: There were significant improvements in gait velocity, step length, stride length, and single support time of the right leg with kinesio taping condition compared to the without kinesio taping condition taping (p<0.05). However, there were no significant differences in cadence, single support time of the left leg, or double support time. Conclusions: The results show that kinesio taping may have a positive effect for improving gait parameters of children with spastic diplegia. However, its usefulness in the rehabilitation of children with cerebral palsy needs to be further investigated.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.30 no.2 s.245
• /
• pp.126-135
• /
• 2006

The pressure drop characteristics in a rotating two-pass duct with rib turbulators are investigated in the present study. The square duct has a hydraulic diameter $(D_h)$ of 26.7 mm, and $1.5mm{\times}1.5mm$ square $90^{\circ}-rib$ turbulators are attached on the leading and trailing walls. The pitch-to-rib height ratio (p/e) is 10. The distance between the tip of the divider and the outer wall of the duct is $1.0D_h$ and the width of divider wall is 6.0mm or $0.225D_h$. The Reynolds number (Re) based on the hydraulic diameter is kept constant at 10,000 to exclude the Reynolds effect, and the rotation number (Ro) is varied from 0.0 to 0.20. The pressure drop distribution, the friction factor and thermal performance are presented for the leading, trailing and the outer surfaces. It is found that the curvature of the $180^{\circ}$-turn produces Dean vortices that cause high pressure drop in the turn. The channel rotation results in pressure drop discrepancy between leading and trailing surfaces so that non-dimensional pressure drops are higher on the trailing surface in the first-pass and on the leading and side surfaces in the second-pass. In the turning region, Dean vortices shown in the stationary case transform into one large asymmetric vortex cell, and subsequent pressure drop characteristics also change. As the rotation number increases, the pressure drop discrepancy enlarges.

• Korean Journal of Applied Biomechanics
• /
• v.18 no.1
• /
• pp.169-178
• /
• 2008

The goals of this study were to provide data of 3 dimensional ground reaction force(GRF) parameters during stair ascent and descent on three different stair runs and to investigate variability and asymmetry index of them. 10 healthy adults participated in this study and performed 7 different types of gait with 10 trials each. After data analysis, following results were found. Firstly, stair run did not affect on the pattern of GRF parameters, coefficient of variation and asymmetry index. Secondly, a significant different GRF pattern was found between level walking and stair walking. Especially, ascending stair walking has only large Fz1 and small Fz3 while level walking and descending stair walking have a "M" shape connected by Fz1, Fz2 and Fz3. Thirdly, only vertical GRF parameters of stair walking revealed acceptable coefficient of variation and asymmetry index.

• Journal of the Korea Fashion and Costume Design Association
• /
• v.18 no.1
• /
• pp.61-78
• /
• 2016

This study through the literature research to understand the most representative art trend - the definition and evolution of the Cubism in the early 20th century, and through the analysis on the representative painter's works, such as works of Pablo Ruiz Picasso and Georges Braque, This article raises the unique characteristics of the Cubist painting, such as geometry modeling, simultaneity, transparency, collage, deconstruction and reconstruction, etc. On the basis of theoretical research in this study, in order to meet the novelty and originality of clothing design requirements in the field, this research uses the modeling characteristics of the Cubist painting, designs and makes five sets of works in costume designing. Research findings are as follows, 1) According to the geometry modeling, split garment surface into triangle or irregular polygon shaped. 2) Show front and side images of the characters in the same garment surface. 3) Overlapping the images of the characters in the same garment surface. 4) Make use of composite materials to express the characters. 5) Disassemble the characters recombine them in an abstract painting way. These works mainly completed by adopting some techniques like Patchwork and Figurative painting. The colors consist of red, yellow and blue caused "Three primary colors series" to achieve the goal of expanding visual effect. Additionally, for the sake of the formal beauty-deformation distortion, symmetric and asymmetric, for instance the structure of the costume adopts formal beauty technique.

• Composites Research
• /
• v.13 no.3
• /
• pp.9-20
• /
• 2000

Free vibration characteristics of a cantilevered laminated composite beam with multiple non-propagating transverse open cracks are investigated. In the present analysis a special ply-angle distribution referred to as asymmetric stiffness configuration inducing the elastic coupling between chord-wise bending and extension is considered. The multiple open cracks are modelled as equivalent rotational springs whose spring constants are calculated based on the fracture mechanics of composite material structures. Governing equations of a composite beam with open cracks are derived via Hamilton's Principle and Timoshenko beam theory encompassing transverse shear and rotary inertia effect is adopted. The effects of various parameters such as the ply angle, fiber volume fraction, crack numbers, crack positions and crack depthes on the free vibration characteristics of the beam with multiple cracks are highlighted. The numerical results show that the existence of the multiple cracks in an anisotropic composite beam affects the free vibration characteristics in a more complex fashion compared with the beam with a single crack.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.28 no.8 s.227
• /
• pp.910-920
• /
• 2004

The heat/mass transfer characteristics in a rotating two-pass duct with and without rib turbulators are investigated in the present study. The square duct has a hydraulic diameter ($D_h$) of 26.7 mm, and $1.5\;mm{\times}1.5\;mm$ square $90^{\circ}$-rib turbulators are attached on the leading and trailing walls. The pitch-to-rib height ratio (p/e) is 10. The Reynolds number based on the hydraulic diameter is kept constant at 10,000 to exclude the Reynolds effect, and the rotation number is varied from 0.0 to 0.20. In the smooth duct, the curvature of the $180^{\circ}$-turn produces Dean vortices that enhance heat/mass transfer in the post-turn region. When rib turbulators are installed, heat/mass transfer is augmented 2.5 times higher than that of the smooth duct since the main flow is turbulated by reattaching and separating in the vicinity of the duct surfaces. The duct rotation results in heat/mass transfer discrepancy so that Sherwood number ratios are higher on the trailing surface in the first-pass and on the leading surface in the second-pass. In the turning region, Dean vortices shown in the stationary case transform into one large asymmetric vortex cell, and subsequent heat/mass transfer characteristics also change. As the rotation number increases, the heat/mass transfer discrepancy enlarges.