• 한국약용작물학회지
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• 제16권4호
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• pp.225-230
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• 2008

흰양삼, 황기, 감초, 구기자, 뽕나무잎, 갈근, 하고초, 오갈피,오미자, 황금, 산약, 황정, 작약, 생지를 1 : 0.7 : 0.4 : 0.7 : 0.4 :0.7 : 1.1 : 0.9 : 0.4 : 0.4 : 0.7 : 0.7 : 0.9 : 0.9의 비율로 함유한 한약재 조성물의 혈당 및 지질대사 개선효과를 제2형 당뇨동물 모델인 db/db 마우스에 있어서 조사하였다. In vitro에서 한약 재조성물 메탄올 추출물의 ${\alpha}$-glucosidase 저해활성을 측정한 결과, 경구 혈당강하제로 사용중인 아카보스 (20.7%)에 비해 높은 저해활성 (25.2%)을 나타내었다. 4주령의 수컷 db/db 마우스 (C57BL/KsJ, n = 14)를 1주간의 적응기간이 지난 후 2군으로 나누어 대조군에게는 AIN-93G diet를 기본으로 한 basal diet를, 실험군에게는 동결건조된 한약재조성물 가루를 식이의 10% 수준으로 함유한 식이를 6주간 제공하였다. 한약 재조성물의 섭취는 실험동물의 체중 및 식이 섭취량에 유의적인 영향을 주지 않았으나 공복 혈당 (442.5 ${\pm}$ 36.0mg/dL)을 대조군 (489.8 ${\pm}$ 34.6mg/dL)에 비해 유의적으로 감소시켰다 (p < 0.05). 또한 한약재조성물 섭취군의 혈장 콜레스테롤 (159.2 ${\pm}$ 18.4mg/dL) 농도는 대조군 (185.4 ${\pm}$ 13.7mg/dL)에 비해 유의적으로 감소하였으며 (p < 0.05), 혈장 중성지방 농도는 한약재 조성물 섭취군 (99.4 ${\pm}$ 15.0mg/dL)이 대조군 (108.8 ${\pm}$11.0mg/dL)에 비해 낮아지는 경향을 나타내었다. 따라서 한약 재조성물의 섭취는 당뇨동물모델에 있어서 혈당 및 혈장 콜레스테롤 농도를 감소시켜, 당뇨병 개선 및 당뇨합병증 예방에 기여할 것으로 사료된다.

• 한방안이비인후피부과학회지
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• 제16권1호
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• pp.42-62
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• 2003

Subjects : We tried to analysis dermatosurgical prescriptions including 477 WonBang(元方) prescriptions for SangJungHaTong(上中下統) introduced by HwangDoYeon(黃道淵). Methods : Prescriptions in BangYakHapPyun(方藥合編) is generally categorized into SangTong(上統), JungTong(中統), HaTong(下統) which are called PoJe(補劑), HwaJe(和劑), KongJe(功劑) respectively. This study classified and analyzed major diseases and symptoms appeared in dermatosurgical prescription and composition of medicine, as well as in BangYakHapPyun(方藥合編). Results and conclusions : The results of examining dermatosurgical prescriptions in WonBang(元方) of SangJungHaTong(上中下統) in BangYakHapPyun(方藥合編) are as follows; 1. The proportion of dematosurgical prescriptions was SangTong(上統) $\frac{10}{126}$(7.9$\%$). JungTong(中統) $\frac{22}{181}$(12.1$\%$), and HaTong(下統) $\frac{16}{163}$(9.8$\%$), which means that JungTong(中統)(HwaJe 和劑) takes up relatively the largest portion. 2. As for SangTong(上統), upper level herbs used in medicine are Glycyrrhiza uralensis(甘草), Paeonia japonica(白芍藥), Angelica gigas(當歸). Astragalus membranaceus(황기). Ginseng(人蔘), Poria cocos(복령), Atractylodis macrocephalae rhizoma(白朮). Cinnamon(肉桂), Rehmaniniae radix preparat(熱地黃). And these herbs are the components of Sipjundaebo-tang(十全大補湯), one of the most well-known medicine for weak energy and blood(補氣血). 3. As for JungTong(中統), in addition to medicine for weak energy and blood. Ledebouriella seseloides(防風) that removes ill elements on skin surface and Pung(風) called "wind". Limonium tetragonum(桔梗) that eliminates discharges and sputum, Angelica dahurica(白芷) that removes discharge and suppress tumor are applied. Other herbs are Ostericum koreanum(羌活). Skullcap(황령),Schizonepeta tenuifolia(荊芥), Aurantii fructus(地殼), Cimicifuga heracleifolia(升麻), Bupleurum falcatum(柴胡), Lonicerae flos(金銀花). These herbs are more effective for wind-calming treatment. cooling down fever, clearing skin irritation, detoxication. removal of tumor and discharge than replenishing energy and blood. 4. As for HaTong(下統), Angelica gigas(當歸) and Ledebouriella seseloides(防風), the two major herbs for SangTong(上統) and JungTong(中統), are mostly used. In addition, Skullcap(黃芩), Gardenia jasminoides(梔子), Eisenia bicyclis(大黃) are other major components and their key efficacy is to lower fever and KongHa(功下). 5. Herbs applied for SangTong(上統), JungTong(中統), and HaTong(下統) in large quantity are Glycyrrhiza uralensis(甘草) that harmoniously combine different herbal elements and Poria cocos(복령) that discharges humidity and watery elements out of body, removes humid and hot elements, and strengthen gastrointestinal system. Based on this, it is inferred that prescriptions for this study focus largely on treatment of humid and hot elements. In the composition of this prescription, Angelica gigas(當歸), Paeonia japonica(白芍藥), and Cnidium officinale(川芎) are taking up relatively large proportion, which are basic herbs for Samul-tang(四物湯). Therefore, it is incurred here that the concept of "replenishing blood" bears importance in dermatosurgical treatment. 6. As for herb medicines used for more than two types of prescriptions of SangTong(上統), JungTong(中統), and HaTong(下統), most of them are simultaneously used for SangTong(上統) and JungTong(中統), or for JungTong(中統), and HaTong(下統) except for Atractylodis macrocephalae rhizoma(白朮) and Gleditsia sinensis(조각자). This finding implies that prescription or treatment that are simultaneously applied are replenishing and harmonizing, or harmonizing and attacking while replenishing and attacking never go together.