• 제목/요약/키워드: As22U

검색결과 879건 처리시간 0.025초

A 24 kDa Excretory-Secretory Protein of Anisakis simplex Larvae Could Elicit Allergic Airway Inflammation in Mice

  • Park, Hye-Kyung;Cho, Min-Kyoung;Park, Mi-Kyung;Kang, Shin-Ae;Kim, Yun-Seong;Kim, Ki-Uk;Lee, Min-Ki;Ock, Mee-Sun;Cha, Hee-Jae;Yu, Hak-Sun
    • Parasites, Hosts and Diseases
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    • 제49권4호
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    • pp.373-380
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    • 2011
  • We have reported that a 24 kDa protein (22U homologous; As22U) of Anisakis simplex larvae could elicit several Th2-related chemokine gene expressions in the intestinal epithelial cell line which means that As22U may play a role as an allergen. In order to determine the contribution of As22U to allergic reactions, we treated mice with 6 times intra-nasal application of recombinant As22U (rAs22U). In the group challenged with rAs22U and ovalbumin (OVA), the number of eosinophils in the bronchial alveolar lavage fluid (BALF) was significantly increased, as compared to the group receiving only OVA. In addition, mice treated with rAs22U and OVA showed significantly increased airway hyperresponsiveness. Thus, severe inflammation around the airway and immune cell recruitment was observed in mice treated with rAs22U plus OVA. The levels of IL-4, IL-5, and IL-13 cytokines in the BALF increased significantly after treatment with rAs22U and OVA. Similarly, the levels of anti-OVA specific lgE and lgG1 increased in mice treated with rAs22U and OVA, compared to those treated only with OVA. The Gro-${\alpha}$ (CXCL1) gene expression in mouse lung epithelial cells increased instantly after treatment with rAs22U, and allergy-specific chemokines eotaxin (CCL11) and thymus-and-activation-regulated-chemokine (CCL17) gene expressions significantly increased at 6 hr after treatment. In conclusion, rAs22U may induce airway allergic inflammation, as the result of enhanced Th2 and Th17 responses.

Effect of Refrigeration Oil on the Condensation Heat Transfer for R-22 and R-407C Refrigerations in Microfin Tube with a U-bend

  • Cho, Keum-Nam;Tae, Sang-Jin
    • International Journal of Air-Conditioning and Refrigeration
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    • 제9권2호
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    • pp.85-93
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    • 2001
  • The present study experimentally investigated the effect of refrigeration oil on the condensation heat transfer for R-22 and R-407C in a microfin tube with a U-bend. Mineral oil and POE oil were used for R-22 and R-407C respectively. Experimental parameters were an oil concentration from 0 to 5%, a mass flux from 100 to 400 $kg/m^2s$ and an inlet quality from 0.5 to 0.9. The enhancement factors for both R-22 and R-407C refrigerants at the first straight section decreased continuously as the oil concentration increased. The decreased rapidly as the mass flux decreased and the inlet quality increased. The heat transfer coefficients in the U-bend showed the maximum at the 90$^{\circ}$position. the heat transfer coefficients at the second straight section within the dimensionless length of 48 were larger by a maximum of 33% than the average heat transfer coefficient at the first straight section.

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Species Diversity and Seasonal Changes of Dominant Ulva Species (Ulvales, Ulvophyceae) in Mikawa Bay, Japan, Deduced from ITS2 rDNA Region Sequences

  • Kawai, Hiroshi;Shimada, Satoshi;Hanyuda, Takeaki;Suzuki, Teruaki;Gamagori City Office, Gamagori City Office
    • ALGAE
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    • 제22권3호
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    • pp.221-228
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    • 2007
  • Frequent occurrences of green tides caused by Ulva species (Ulvales, Ulvophyceae) associated with eutrophication along enclosed coasts are currently causing environmental problems in coastal ecosystems. In addition, increasing intercontinental introductions of coastal marine organisms, including Ulva, are also a serious issue. However, due to the considerable morphological plasticity of this genus, the taxonomy of Ulva species based on morphological studies is problematic. Therefore, in order to elucidate the species diversity and seasonal changes of the dominant Ulva species in Mikawa Bay, central Honshu, Japan, we made seasonal collections of Ulva species at seven localities, and identified the dominant species using the ITS2 rDNA region sequences. We identified the following nine taxa as common Ulva species in the area: 1) Ulva pertusa Kjellman; 2) U. ohnoi Hiraoka et Shimada; 3) U. linza L.; 4) U. californica Wille; 5) U. flexuosa Wulfen; 6) U. fasciata Delile; 7) U. compressa L.; 8) U. armoricana Dion et al.; 9) U. scandinavica Bliding. Among the species, U. pertusa was most common and dominant from spring to summer, and U. ohnoi from autumn to winter. Ulva californica and U. scandinavica have not been reported before from Japan.

전립선암의 정확한 진단을 위한 질감 특성 분석 및 등급 분류 (Analysis of Texture Features and Classifications for the Accurate Diagnosis of Prostate Cancer)

  • 김초희;소재홍;박현균;;;;최흥국
    • 한국멀티미디어학회논문지
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    • 제22권8호
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    • pp.832-843
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    • 2019
  • Prostate cancer is a high-risk with a high incidence and is a disease that occurs only in men. Accurate diagnosis of cancer is necessary as the incidence of cancer patients is increasing. Prostate cancer is also a disease that is difficult to predict progress, so it is necessary to predict in advance through prognosis. Therefore, in this paper, grade classification is attempted based on texture feature extraction. There are two main methods of classification: Uses One-way Analysis of Variance (ANOVA) to determine whether texture features are significant values, compares them with all texture features and then uses only one classification i.e. Benign versus. The second method consisted of more detailed classifications without using ANOVA for better analysis between different grades. Results of both these methods are compared and analyzed through the machine learning models such as Support Vector Machine and K-Nearest Neighbor. The accuracy of Benign versus Grade 4&5 using the second method with the best results was 90.0 percentage.

중공철근으로 보강한 U-플랜지 트러스 복합보의 구조 내력에 관한 실험연구 (Experimental Study on the Structural Capacity of the U-flanged Truss Hybrid Beam with Hollow Rebars)

  • 이성민;오명호;김영호
    • 한국공간구조학회논문집
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    • 제22권3호
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    • pp.65-72
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    • 2022
  • A typical low and medium-sized neighborhood living facility in reinforced concrete building secures a high floor and pursues an efficient module plan(long span). Accordingly, research on the development of new hybrid beams that can innovatively reduce labor costs such as on-site installation and assembly while securing strength and rigidity is ongoing. In order to verify the structural performance of the U-flanged truss composite beam with newly developed shape, Experiments with various variables are required. Based on the results, this study is to evaluate the strength of U-flanged truss hybrid beam through the flexural strength of the Korea Design Code and experimental values. It was evaluated that nominal flexural strength was 110% to 135% higher than the experimental value.

마이크로핀관 곡관부내 대체 냉매의 응축 열전달에 미치는 냉동기유의 영향 (Effect of Refrigeration Oil on the Condensation Heat Transfer for Alternative Refrigerant in Microfin Tube with a U-bend)

  • 태상진;조금남
    • 설비공학논문집
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    • 제12권6호
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    • pp.541-549
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    • 2000
  • The present study experimentally investigated the effect of refrigeration oil on the condensation heat transfer for R-407C and R-22 in a microfin tube with a U-bend. POE oil ($74.1\;\textrm{mm}^2/s,\;40^{\circ}C$,) and mineral oil $62.5\;\textrm{mm}^2/s,\;40^{\circ}C$,) were used for R-407C and R-22 respectively Experimental parameters were an oil concentration from 0 to 5%, a mass flux from 100 to $400kg/m^{2}s sand an inlet quality from 0.5 to 0.9. The enhancement factors for both R-22 and R-407C refrigerants at the first straight section decreased continuously as the oil concentration increased. They decreased rapidly as the mass flux decreased and the inlet quality increased. The heat transfer coefficients in the U-bend showed the maximum at the $90^{\circ}$/TEX> position. The heat transfer coefficients at the second straight section within the dimensionless length of 48 were larger by a maximum of 33% than the average heat transfer coefficient at the first straight section.

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운영비 절감을 고려한 u-City 구축 모델 개발 (A Development of u-City Construction Model Considering the Reducing of Operating Cost)

  • 박광호;김대영;김윤형
    • 산업경영시스템학회지
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    • 제33권4호
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    • pp.10-22
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    • 2010
  • The first full-scale u-City operation has started in Dongtan u-City. As local cities take over and operate the u-City, unexpected issues arise such as securing the budget of operating costs and self-providing the costs with business models utilizing the u-City assets. The paper presents a strategy for solving these issues. The strategy provides a foundation(infrastructure) for long-term operation models which may reduce the long-term operating costs. In order to establish the economic operating framework of u-City, suggested are some cost-reduction models based on the operating costs structure. For each model, a base framework with comparative analysis of operating costs is provided. With these models, each u-City may select a relevant model according to the characteristics of it. We hope that the framework provides the foundation for efficient and sustainable u-City operations.

건강정보 교환 표준에 기반한 유비쿼터스 헬스케어 시스템 개발 (Development of an Ubiquitous Healthcare System based on Health Information Exchange Standards)

  • 이인근;김화선;조훈
    • 한국지능시스템학회논문지
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    • 제22권3호
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    • pp.273-280
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    • 2012
  • 의료 환경의 변화로 인해 개인의 건강관리를 위한 유비쿼터스 헬스케어(u-헬스케어) 서비스 및 시스템에 관한 관심이 증대되고 있다. u-헬스케어 시스템은 기본적으로 생체신호를 측정하기 위한 개인건강기기, 무선통신을 통해 개인건강기기로부터 전송되는 정보를 수집하는 정보수집기, 그리고 정보수집기로부터 전송되는 개인건강정보를 저장하고 관리하기 위한 건강정보시스템 등과 같은 다양한 기기와 시스템이 결합된 복합적인 환경으로 구성되어 있다. 이러한 기기 및 시스템 사이의 상호운용성을 위해 국제적으로 IEEE 11073이나 HL7과 같은 건강정보 교환 표준들이 발표되었으나, 국내에서는 이러한 표준을 적용한 u-헬스케어 시스템의 개발하여 실제 환경에 적용한 연구가 많지 않다. 따라서 본 논문에서는 건강정보 교환을 위한 국제 표준에 기반하여 혈당, 혈압, 체성분과 같은 건강정보를 관리할 수 있는 u-헬스케어 시스템을 개발한다. 또한 경북대학교병원 내분비계 질환자 대상의 임상시험을 통해 개발한 시스템의 안정성을 검증하고, 운영 과정에서의 문제점 및 개선 방안을 찾는다.

u-City 수출 모델 개발을 위한 마스터플랜 수립 방안에 관한 연구 (A Study on the Master Plan for Development of u-City Export Model)

  • 김윤형;박광호
    • 한국전자거래학회지
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    • 제17권2호
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    • pp.1-22
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    • 2012
  • 본 연구에서는 u-City 해외 선점을 위한 일환으로 u-City 수출 모델 개발을 위한 마스터플랜 수립 방안에 대한 연구를 진행하였다. 본 논문에서 제안하는 마스터플랜 수립을 위해 u-City 수출 관련 정부의 정책 방향 및 u-City 해외 진출에 관련된 선행연구를 조사하여 성공적인 u-City의 해외 진출을 위한 구상 계획, 구축 계획, 운영 계획, 평가 계획 단계를 가지는 마스터플랜 프레임워크를 설계하였다. 또한, 현재 국토부에서 진행 중인 u-City 수출 모델 개발을 위한 프로젝트에 적용하여 해외 맞춤형 u-City 마스터플랜 사례를 제시하였다. 본 연구는 u-City 해외 선점을 위한 정부의 정책을 구체화하는데 도움을 줄 수 있으며, u-City를 기반으로 해외에 진출하고자 하는 민간기업들의 U-City 수출 모델 개발에 기여할 수 있을 것으로 기대된다.