• Clinical and Experimental Pediatrics
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• 제49권4호
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• pp.446-450
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• 2006

Congenital central hypoventilation syndrome은 혈중 이산화탄소 증가와 저산소에 대한 자율 신경계와 호흡 조절 기능의 선천성 결함으로 호흡의 저환기가 주로 수면시에 발생하는 질환이다. 이는 신경 이주장애 질환(neurocristopathy)에 속한다고 알려져 있으며 선천성 거대결장 등의 질환과 잘 동반된다. 아직까지 확실한 완치법은 없는 상태이고 환아들은 평생을 환기 보조에 의존하여 생존해야 하며 적절한 환기 보조를 통해서 생존 기간을 연장할 수 있다. 저자들은 출생시부터 반복되는 수면시의 무호흡과 청색증이 있는 환아에서 congenital central hypoventilation 및 선천성 거대 결장이 동반된 1례를 경험하였기에 보고하는 바이다.

• Journal of Korean Neurosurgical Society
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• 제58권2호
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• pp.101-106
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• 2015

Objective : The aim of this study was to explore the immunity in rats transplanted with adipose-derived mesenchymal stem cells (ADSCs) and acellular nerve (ACN) for repairing sciatic nerve defects. Methods : ADSCs were isolated from the adipose tissues of Wistar rats. Sprague-Dawley rats were used to establish a sciatic nerve defect model and then divided into four groups, according to the following methods : Group A, allogenic nerve graft; Group B, allograft with ACN; Group C, allograft ADSCs+ACN, and Group D, nerve autograft. Results : At the day before transplantation and 3, 7, 14, and 28 days after transplantation, orbital venous blood of the Sprague-Dawley rats in each group was collected to detect the proportion of $CD3^+$, $CD4^+$, and $CD8^+$ subsets using flow cytometry and to determine the serum concentration of interleukin-2 (IL-2), tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) and $interferon-{\gamma}$ ($IFN-{\gamma}$) using enzyme-linked immunosorbent assay (ELISA). At each postoperative time point, the proportion of $CD3^+$, $CD4^+$, and $CD8^+$ subsets and the serum concentration of IL-2, $TNF-{\alpha}$, and $IFN-{\gamma}$ in group C were all near to those in group B and group D, in which no statistically significant difference was observed. As compared with group A, the proportion of $CD3^+$, $CD4^+$, and $CD8^+$ subsets and the serum concentration of IL-2, $TNF-{\alpha}$, and $IFN-{\gamma}$ were significantly reduced in group C (p<0.05). Conclusion : The artificial nerve established with ADSCs and ACN has no obvious allograft rejection for repairing rat nerve defects.

• 한국지하수토양환경학회지:지하수토양환경
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• 제6권1호
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• pp.53-62
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• 2001

표면결함이 고밀도 폴리에틸렌 지오멤브레인의 열적 안정성과 응력균열저항성에 미치는 영향을 온도와 표면 결함 부여조건을 달리한 환경조건에서 역학적 특성, 화학저항성 및 피로시간을 측정하여, 조사하였다. 특별 고안된 장치를 사용하여 인위적으로 지오멤브레인 표면에 결함을 부여하였다. 표면결함은 표면결함 유도매체의 전단속도 100mm/min에서 표면결함 유도매체의 크기가 작을수록, 표면결함 부여횟수가 커질수록 증가하였다. 또한 이 조건에서 인장강도는 감소하였지만 인장신도는 증가하였다. 표면결함 부여조건이 같을 경우 고온으로 갈수록 그리고 침지시간이 길어질수록 인장강도는 감소되고 인장신도는 증가하여 표면결함이 부여된 지오멤브레인의 화학저항성은 저하되었다. 끝으로 응력균열저항성 시험 결과 온도가 높아질수록 표면결함이 부여된 지오멤브레인의 피로시간은 단시간 영역으로 이동되었다.

• Journal of Oral Medicine and Pain
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• 제20권2호
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• pp.317-325
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• 1995

This study was performed to investigate the mean life expectancy of dental prosthetic restorations. The author has examined 352 dental prosthesis clinically and radiologically, and decided the success(survival) and failure(mortality) of the dental prosthesis. The dental prosthesis which had been treated in the Seoul National University Dental Hospital, two private clinics in Seoul, one university dental hospital, and two private clinics in local province were included in this study. The survival analysis using product limit estimator was used and the mean life expectancy of each type of dental prosthesis was calculated. The results were as follows : 1. The life expectancies were 10.5 years in gold crown and bridge, 8.5 years in porcelain fused to metal crown and bridge, 8.3 years in nonprecious metal crown and bridge, 8.1 years in removal partial denture, and 7.7 years in full denture. 2. The causes of mortality were in the order of dental caries(24.6%), fracture of dental prosthesis(19.2%), periodontal problems(18.6%), chronic chewing difficulty and dysfunction due to dental prosthesis(15.0%), excessive exposure of abutments due to the marginal defect of dental prosthesis(14.4%), abnormal occlusion due to severe attrition of artificial teeth in dentures(3.0%), periapical problems(2.4%), perforation of dental prosthesis(1.8%), and loose contacts with neighboring tooth(1.2%). 3. Among survival cases, 66.5% showed normal chewing ability and 31.9% showed partial chewing ability. However, 1.6% of them complained loss of chewing ability. 4. Among failure cases, 6.6% showed normal chewing ability and 38.9% showed partial chewing ability. However, 54.5% of them complained loss of chewing ability.

• Structural Monitoring and Maintenance
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• 제2권1호
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• pp.19-34
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• 2015

One of the main causes of a limited use of nondestructive evaluation (NDE) technologies in bridge deck assessment is the speed of data collection and analysis. The paper describes development and implementation of the RABIT (Robotics Assisted Bridge Inspection Tool) for data collection using multiple NDE technologies. The system is designed to characterize three most common deterioration types in concrete bridge decks: rebar corrosion, delamination, and concrete degradation. It implements four NDE technologies: electrical resistivity (ER), impact echo (IE), ground-penetrating radar (GPR), and ultrasonic surface waves (USW) method. The technologies are used in a complementary way to enhance the interpretation. In addition, the system utilizes advanced vision to complement traditional visual inspection. Finally, the RABIT collects data at a significantly higher speed than it is done using traditional NDE equipment. The robotic system is complemented by an advanced data interpretation. The associated platform for the enhanced interpretation of condition assessment in concrete bridge decks utilizes data integration, fusion, and deterioration and defect visualization. This paper concentrates on the validation and field implementation of two NDE technologies. The first one is IE used in the delamination detection and characterization, while the second one is the USW method used in the assessment of concrete quality. The validation of performance of the two methods was conducted on a 9 m long and 3.6 m wide fabricated bridge structure with numerous artificial defects embedded in the deck.

• Archives of Plastic Surgery
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• 제33권4호
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• pp.413-422
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• 2006

Purpose: This study was designed to compare the wound healing effect of silk fibroin, alginate and fibroin/ alginate blend sponge with clinically used Nu gauze in a rat skin defect model. Methods: Two full thickness excisions were made on the back of Sprague-Dawley rat. The excised wound was covered with either of the silk fibroin(SF), alginate (SA), or fibroin/alginate blend sponge(SF/SA). On the postoperative days of 3, 7, 10 and 14, the wound area was calculated by image analysis software. At the same time, a skin wound tissue was biopsied. Results: Healing time 50% ($HT_{50}$) of SF/SA sponge treated group was dramatically reduced as compared with that of control treatment. We also found that the $HT_{50}$ of SF/SA sponge was significantly decreased as compared with either those of SF or SA treatment. Furthermore, SF/SA treatment significantly increased the size of epithelialization and collagen deposition as well as the number of PCNA positive cells on epidermal basement membrane as comapred with those of control treatment. Conclusion: Our results suggest that the wound healing effect of SF/SA blend sponge is the best among other treatments including SF and SA during the whole wound healing period.

• Archives of Plastic Surgery
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• 제43권5호
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• pp.418-423
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• 2016

Background Skin grafting is a relatively simple and thus widely used procedure. However, the elastic and structural quality of grafted skin is poor. Recently, various dermal substitutes have been developed to overcome this disadvantage of split-thickness skin grafts. The present study aims to determine the feasibility of RapiGraft as a new dermal substitute. Methods This prospective study included 20 patients with partial- or full-thickness skin defects; the patients were enrolled between January 2013 and March 2014. After skin defect debridement, the wound was divided into two parts by an imaginary line. Split-thickness skin grafting alone was performed on one side (group A), and RapiGraft and split-thickness skin grafting were used on the other side (group B). All patients were evaluated using photographs and self-questionnaires. The Manchester scar scale (MSS), a chromameter, and a durometer were used for the scar evaluation. The average follow-up period was 6 months. Results The skin graft take rates were 93% in group A and 89% in group B, a non-significant difference (P=0.082). Statistically, group B had significantly lower MSS, vascularity, and pigmentation results than group A (P<0.05 for all). However, the groups did not differ significantly in pliability (P=0.155). Conclusions The present study indicates that a simultaneous application of RapiGraft and a split-thickness skin graft is safe and yields improved results. Therefore, we conclude that the use of RapiGraft along with skin grafting will be beneficial for patients requiring reconstructive surgery.

• 한국해양공학회지
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• 제4권2호
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• pp.250-250
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• 1990

In this paper, fatigue tests were carried out at stress test levels of 461 MPa, 441 MPa, and 431 MPa by using smooth specimen of$2_{1/4}$ Cr-1 Mo steel with the stress ratio(R) of 0.05. The initiation, growth and coalescense process of the major cracks and sub-cracks among the fatigue cracks on the smooth specimen are investigated and measured under each stress level at a constant cycle ratio by the replica technique with optical microscope. Some of the important results are as follows: In spite of the difference of stress levels, the major crack data gather into a small band in the curve of surface crack length and crack depth against cycle ratio N/Nf. The sub-crack data, however, deviate from the band of the major crack. The growth rates, da/dN, of major and sub-crack plotted against the stress intensity factor range, ${\Delta}K$, have the tendency to be compressed on a relatively small band. But it is more effective to predict fatigue life through major cracks. The propagation behavior of surface microcracks on the smooth specimens coincides with that of the specimen having an artificial small surface defect or through crack.

• 재활복지공학회논문지
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• 제4권1호
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• pp.29-34
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• 2010

완전 이식형 보청기는 기존 보청기가 가지고 있는 여러 문제점들을 해결하기 위해 연구 개발되고 있다. 이러한 완전이식형 보청기에 사용되는 이식형 마이크로폰은 일반적으로 측두부의 피부아래 이식된다. 그런데 이식된 마이크로폰의 특성은 음식을 먹거나 치아의 마찰, 생체동잡음에 의해 영향을 받을 수 있다. 본 논문에서는 이식된 마이크로폰에 골전도를 통해 전달된 생체잡음신호가 미치는 영향을 조사하기 위하여, 사람의 측두부 및 피부의 특성이 유사한 물리모델을 제작하여, 이식된 마이크로폰의 감도측정실험을 수행하였다. 1 kHz의 순음신호를 이식된 마이크로폰에 인가하고, 동시에 여러 주파수대의 정현파진동을 인공뼈에 인가하여 측정되었다. 그 결과 마이크로폰의 출력은 골전도를 통한 신호의 영향을 받아 왜곡될 수 있으며, 그 영향은 주파수대역에 따라 달라짐을 확인하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 하계학술대회 논문집 C
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• pp.1770-1772
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• 2003

본 연구는 국내에서 최초로 제안되고 적용가능성이 입증되어 설계, 제작된 Probe-type Pockets sensor(HY-Pockets Sensor)를 GIS등의 고전압 장비들에 응용한 레이저 부분방전 진단 시스템 개발을 목표로 하고 있다. 이러한 목적으로, 170kV 급 실 규모 GIS내부의 전류 도체에 다양한 곡률 반경의 침 전극을 부착시켜 부분 방전에 기인된 불평등 전계를 형성시켜 개발된 센서의 실규모 적용 가능성을 고찰하였다. 본 레이저 계측 시스템은 He-Ne laser, single multi-mode optical fiber, $2{\times}2$ 50/50 laser to single mode fiber coupler, probe-type Pockets sensor, photo detector 등으로 구성하여 레이저의 진행을 유도하고, 신호의 특성을 분석하였다. probe-type Pockets sensor로부터 의 출력 신호는 photo detector를 통해 전기적 신호로 변환되어 digital oscilloscope에 의해 측정되고, 또한 PC를 통해 데이터의 저장과 통계적, 분석적 처리 과정을 수행하게 된다. 본 연구의 결과로서 부분방전원에서 생성된 방전 신호에 대한 거리에 따른 센서 감도 결정, 그에 대한 센서 감도의 보정 향상, 전계의 세기의 변화에 따른 센서의 선형성 등이 도출되었고, 이러한 실험결과를 통해 실 GIS(170kv급) 내부에서 발생하는 부분방전의 검출에 본 레이저 부분방전 진단 시스템의 적용 가능성이 제시 되었다.