• 약학회지
• /
• 제37권3호
• /
• pp.270-277
• /
• 1993

It is well known that lipidperoxide, formed in vivo, induced the denaturation of enzyme and destruction of cell membrane to acute injury of tissue. Aralia elata have physiological activates, the improvement of lipid metabolism, antidiabetic activity etc., which was thought to have the relationship to lipid peroxidation. The anti-lipidperoxidative effect of Aralia elata have not yet established. In this study, we examined the anti-lipidperoxidative effects of Aralia elata (Butanol fraction) on CCI$_{4}$ induced lipidperoxidation in rats, and elucidated the anti-lipidperoxidative mechanism. In rat liver homogenate intoxicated with CCI$_{4}$ (0.5 ml/100g), BuOH fraction of Aralia elata (80 mg/Kg/day) exhibited 85.41% anti-lipidperoxidative effect but in serum 69.63% inhibitory effects, respectively. In mitochondrial and microsomal fraction showed inhibition of 55.85% and 69.30%, respectively. In order to elucidate the mechanism of anti-lipidperoxidation effects of Aralia elata, enzymatic (NADPH dependent) and non-enzymatic (Ascorbic acid catalyzed) reaction, in vitro, were performed. In enzymatic reation, Aralia elata exhibited 59.43% anti-lipidperoxidation effects, but in non-enzymatic reaction exhibited 43.27% inhibition. Therefore, it is noteworthy that antioxidative power of them may mainly results from the inhibition by enzymatic reaction.

• 한국식품영양과학회지
• /
• 제33권4호
• /
• pp.653-658
• /
• 2004

Wistar계 흰쥐에게 두릅열수추출물을 7주간 급여하였으며 당뇨유발은 희생 2주전 streptozotocin을 투여하여 혈당이 300 mg/dL 이상인 흰쥐를 대상으로 유해 활성 산소 대사계에 미치는 영향을 구명하였다. 간조직 중의 유해 활성산소 생성계인 P-450 함량과 XO 및 AD 활성은 정상군에 비하여 당뇨대조군에서 유의적으로 감소된 반면, AH 활성은 증가 되었다. 두릅열수추출물 급여로 이들 유해 활성 생성계 효소 활성 변화가 완화되는 것으로 나타났다. 또한 SOD, CAT, GSH-Px 및 GST, GR과 같은 유해 활성산소 제거계와 G6PD 효소들은 당뇨유발로 유의적인 증가를 보였으나, 두릅열수추출물 급여군에서는 이들 효소 활성이 낮았다. 당뇨유발로 항산화물질인 글루타티온 함량은 유의적으로 감소된 반면 지질과산화물 생성은 유의적으로 증가되었다. 그러나 두릅열수추출물 급여는 당뇨대조군의 이들 함량 변화를 유의적으로 억제하는 것으로 나타났다. 이상의 결과에서 두릅열수추출물 급여는 STZ 투여로 인한 유해 활성산소 대사계 변화를 완화시킬 뿐만 아니라 지질과산화물 생성을 억제함으로써 산화적 스트레스로 인한 당뇨합병을 예방할 수 있을 것으로 사료된다.

• 한국지역사회생활과학회지
• /
• 제16권3호
• /
• pp.17-24
• /
• 2005

This study was carried out to investigate the kinds of fresh wild vegetables, the number of street stalsl, seller's age, and the selling list of items of the street stall in the five-day traditional markets of Gyeongnam Tongyoung and Namhae, Jeonnam Naju and Younggwang, Jeonbuk Iksan and Jangsu, from March to May, 2005. The number of street stalls selling fresh wild vegetables was forty nine in Tongyoung, twenty five in Namhae, thirty in Naju, eighteen in Younggwang, one hundred and thirty in Iksan, and seventeen in Jangsu. The selling lists of items totaled forty items; thirty in Tongyoung, seventeen in Namhae, twenty in Naju, sixteen in Younggwang, twenty seven in Iksan, and thirteen in Jangsu. The main kinds were Aster scaber, Aralia elata, Pteridium aquilinum var. latusculum, Artemisia princeps, Sedum sarmentosum, Oenanthe javanica, Pla쇼codon grandiflorum, Petasites japonicus and Allium monanthum. sprouts or woody plants such as Arazia elate, Ailanthus altissima, Meliosma oldhamii, and Kalopanax pictus were also being sold. About $80{\%}$ of the sellers were over fifty one years old. Half of the sellers were at least sixty years old. More thab $77\%$ of the street stalls in the traditional markets sell fewer than four kinds of fresh wild vegetables.