• Title/Summary/Keyword: Ar-$CO_2$

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Mixture of Corni Fructus and Schisandrae Fructus improves testosterone-induced benign prostatic hyperplasia through regulating 5α-reductase 2 and androgen receptor

  • Hyun Hwangbo;Min Yeong Kim;Seon Yeong Ji ;Beom Su Park;TaeHee Kim;Seonhye Yoon;Hyunjin Kim;Sung Yeon Kim ;Haeun Jung;Taeiung Kim;Hyesook Lee;Gi-Young Kim;Yung Hyun Choi
    • Nutrition Research and Practice
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    • v.17 no.1
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    • pp.32-47
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    • 2023
  • BACKGROUND/OBJECTIVES: Benign prostatic hyperplasia (BPH) characterized by an enlarged prostate gland is common in elderly men. Corni Fructus (CF) and Schisandrae Fructus (SF) are known to have various pharmacological effects, including antioxidant and anti-inflammatory activities. In this study, we evaluated the inhibitory efficacy of CF, SF, and their mixture (MIX) on the development of BPH using an in vivo model of testosterone-induced BPH. MATERIALS/METHODS: Six-week-old male Sprague-Dawley rats were randomly divided into seven groups. To induce BPH, testosterone propionate (TP) was injected to rats except for those in the control group. Finasteride, saw palmetto (SP), CF, SF, and MIX were orally administered along with TP injection. At the end of treatment, histological changes in the prostate and the level of various biomarkers related to BPH were evaluated. RESULTS: Our results showed that BPH induced by TP led to prostate weight and histological changes. Treatment with MIX effectively improved TP-induced BPH by reducing prostate index, lumen area, epithelial thickness, and expression of BPH biomarkers such as 5α-reductase type 2, prostate-specific antigen, androgen receptor, and proliferating cell nuclear antigen compared to treatment with CF or SF alone. Moreover, MIX further reduced levels of elevated serum testosterone, dihydrotestosterone, and prostate-specific antigen in BPH compared to the SP, a positive control. BPH was also improved more by MIX than by CF or SF alone. CONCLUSIONS: Based on the results, MIX is a potential natural therapeutic candidate for BPH by regulating 5α-reductase and AR signaling pathway.

Effects of Process Variables on the Microstructure and Gas Sensing Characteristics of Magnetron Sputtered $\textrm{SnO}_2$Thin Films (마그네트론 스퍼터링 증착 조건에 따른 $\textrm{SnO}_2$ 박막의 미세구조와 가스검지특성 변화)

  • Kim, Jong-Min;Moon, Jong-Ha;Lee, Byung-Teak
    • Korean Journal of Materials Research
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    • v.9 no.11
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    • pp.1083-1087
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    • 1999
  • Microstructures and the gas-sensing characteristics of the $\textrm{SnO}_2$ thin films were studied, which were deposited at various conditions (rf power, sample temperature, $\textrm{O}_2$/Ar ratio) by the rf magnetron sputtering. As a result, six typical microstructures were derived, such as amorphous(A), amorphous mixed with polycrystalline grains (A+P), polycrystalline with random crystalographic orientation (P), fine columnar (FC), coarse columnar (CC) and Zone T (T) with dense fiberous structure. Typically, A, A+ P, and P structures were formed when no $\textrm{O}_2$ was added to the sputter gas, whereas FC, CC, and T structures were obtained when $\textrm{O}_2$ was added. The A structure formed at low rf power and low temperature, the A+P at high rf power and low temperature, and the P at high rf power and high temperature. The FC structure was obtained at low rf power and low temperature. the CC at low rf power and high temperature, and the T at high rf power and low temperature. Results of the gas-sensing test of the sensor chips fabricated from the typical films indicated that the fine columnar microstructure shows the highest sensitivity both at $300^{\circ}C$ and $400^{\circ}C$. It was proposed that this is due to the high specific surface area of the micro-columns.

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The Gains To Bidding Firms' Stock Returns From Merger (기업합병의 성과에 영향을 주는 요인에 대한 실증적 연구)

  • Kim, Yong-Kap
    • Management & Information Systems Review
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    • v.23
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    • pp.41-74
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    • 2007
  • In Korea, corporate merger activities were activated since 1980, and nowadays(particuarly since 1986) the changes in domestic and international economic circumstances have made corporate managers have strong interests in merger. Korea and America have different business environments and it is easily conceivable that there exists many differences in motives, methods, and effects of mergers between the two countries. According to recent studies on takeover bids in America, takeover bids have information effects, tax implications, and co-insurance effects, and the form of payment(cash versus securities), the relative size of target and bidder, the leverage effect, Tobin's q, number of bidders(single versus multiple bidder), the time period (before 1968, 1968-1980, 1981 and later), and the target firm reaction (hostile versus friendly) are important determinants of the magnitude of takeover gains and their distribution between targets and bidders at the announcement of takeover bids. This study examines the theory of takeover bids, the status quo and problems of merger in Korea, and then investigates how the announcement of merger are reflected in common stock returns of bidding firms, finally explores empirically the factors influencing abnormal returns of bidding firms' stock price. The hypotheses of this study are as follows ; Shareholders of bidding firms benefit from mergers. And common stock returns of bidding firms at the announcement of takeover bids, shows significant differences according to the condition of the ratio of target size relative to bidding firm, whether the target being a member of the conglomerate to which bidding firm belongs, whether the target being a listed company, the time period(before 1986, 1986, and later), the number of bidding firm's stock in exchange for a stock of the target, whether the merger being a horizontal and vertical merger or a conglomerate merger, and the ratios of debt to equity capital of target and bidding firm. The data analyzed in this study were drawn from public announcements of proposals to acquire a target firm by means of merger. The sample contains all bidding firms which were listed in the stock market and also engaged in successful mergers in the period 1980 through 1992 for which there are daily stock returns. A merger bid was considered successful if it resulted in a completed merger and the target firm disappeared as a separate entity. The final sample contains 113 acquiring firms. The research hypotheses examined in this study are tested by applying an event-type methodology similar to that described in Dodd and Warner. The ordinary-least-squares coefficients of the market-model regression were estimated over the period t=-135 to t=-16 relative to the date of the proposal's initial announcement, t=0. Daily abnormal common stock returns were calculated for each firm i over the interval t=-15 to t=+15. A daily average abnormal return(AR) for each day t was computed. Average cumulative abnormal returns($CART_{T_1,T_2}$) were also derived by summing the $AR_t's$ over various intervals. The expected values of $AR_t$ and $CART_{T_1,T_2}$ are zero in the absence of abnormal performance. The test statistics of $AR_t$ and $CAR_{T_1,T_2}$ are based on the average standardized abnormal return($ASAR_t$) and the average standardized cumulative abnormal return ($ASCAR_{T_1,T_2}$), respectively. Assuming that the individual abnormal returns are normal and independent across t and across securities, the statistics $Z_t$ and $Z_{T_1,T_2}$ which follow a unit-normal distribution(Dodd and Warner), are used to test the hypotheses that the average standardized abnormal returns and the average cumulative standardized abnormal returns equal zero.

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Studies on Production and Efficient Utilization of Livestock Embryos by In Vitro Fertilization and Micromanipulation. III. Transfer of Embryo Derived from In Vitro Fertilization of Bovine Follicular Oocytes Matured In Vitro (체외수정 및 미세조작에 의한 가축(胚)의 생산과 효율적 이용에 관한 연구 III. 소에 있어서 난포란의 체외수정과 수정란 이식)

  • 정영채;김창근;윤종택;이종완;최선호
    • Journal of Embryo Transfer
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    • v.9 no.3
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    • pp.261-268
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    • 1994
  • Immatured bovine follicular oocytes added with serum, hormones, granulosa cells and bovine oviduct epithelium cells were fertilized in vitro after in vitro maturation. In vitro maturation and early development capacity were examined and IVF-derived embryos were transferred and to recipients and effects of sperm treatment on in vitro capacitation were investigated. The rate of in vitro maturation was improved when they were co-culutred with granulosa cells in the TCM199 medium added with 10% FCS and hormones. The percentage of acrosome reaction was not differed between sperm treatments and sperm of above 25% under-went AR during 30 min preincubation with caffeine and heparin. The cleavage rate of oocytes in vitro fertilized in TCM199 medium added with 10% FCS and hormones, GC or BOEG higher than that in medium with 10% FCS and GC. But the rate was not significantly different between GC and BOEG The cleavage of rate oocytes cultured in medium containing serum, hormones and BOEG was 80.2% and more embryos were developed to Blastocyst (17.3%). The selected embryos were transferred to 9 recipients by surgical or nonsurgical method but did not result in pregnancy.

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Development of High Efficiency CIGS Thin Film Solar Cells by co-evaporation process (동시진공증발법을 이용한 고효율 CIGS 박막 태양전지 개발)

  • Yun, Jae-Ho;Ahn, Se-Jin;Ahn, Byung-Tae;Pak, Hi-Sun;Yoon, Kyung-Hoon
    • 한국신재생에너지학회:학술대회논문집
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    • 2009.06a
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    • pp.23-23
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    • 2009
  • CIGS 박막 태양전지는 제조단가가 낮고 박막 태양전지 중에서 변환효율이 가장 높아 발전 가능성이 큰 태양전지로 인식되고 있다. 이미 일본, 독일, 미국을 비롯한 선진국에서는 30-50 MW 급의 양산 라인이 구축되고 있어 2010년 이후에는 본격적인 상용화가 진행될 것으로 보인다. CIGS 광흡수층은 진공증발, 셀렌화, 나노입자, 전기도금등 다양한 방식으로 제조가 가능한데 이 중에서도 동시진공증발공정은 고효율 CIGS 박막 태양전지 제조에 적합하다. 본 연구에서는 동시진공증발법을 이용하여 CIGS 박막을 증착하였으며 소다회유리/Mo/CIGS/CdS/i-ZnO/n-ZnO/Al/AR 구조의 태양전지를 제조하였다. 기판온도 모니터링을 통한 Cu 이차상 조절 기술을 이용하여 결정립이 매우 큰 CIGS 박막을 증착하였으며 Ga/(In+Ga) 조성비의 조절을 통하여 밴드갭 에너지를 최적화하였다. 또한 QCM 장치를 활용하여 용액 속에서 성장되는 CdS 박막의 두께와 특성을 조절하였다. 이러한 공정최적화를 통하여 개방전압 0.65 V, 단락전류밀도 38.8 $mA/cm^2$, 충실도 0.74 그리고 변환효율 18.8% 의 CIGS 박막 태양전지를 얻었다.

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Study on an Enhanced Manufacturing Process for Mobile Camera Window Glass (Mobile용 Camera Window의 공정 개선에 관한 연구)

  • Ahn, Hae Won;Shin, Ki Hoon;Oh, Jae Ho;Kim, Hak Chul;Kwon, Soo Kun;Choi, Seong Dae
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.14 no.5
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    • pp.15-21
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    • 2015
  • The glass used for Mobile Camera Window is required to have high strength. Cell type manufacturing by means of CNC is widely used for camera window. Individual loading and unloading is needed for each process, such as painting and PVD, in cell type manufacturing. The purpose of this study is to search the enhanced manufacturing process with sheet type throughout bulk unit production in painting and PVD. This study includes sheet type manufacturing processes such as laser cutting, wet etching, 2nd tempering, printing, and AF/AR coating.

On-line Fussy Performance Management of Profibus Networks

  • Lee, Kyung-Chang;Song Kang;Kim, Dong-Wook;Lee, Suk
    • International Journal of Precision Engineering and Manufacturing
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    • v.1 no.2
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    • pp.5-13
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    • 2000
  • Most networks for automation are tuned to an expected traffic condition ar their design stage. During their actual operations, however, the networks experience considerable changes in traffic from time to time. These traffic changes caused by common events like machine failure and production schedule change may adversely affect th network performance and, in turn , the performance of the connected devices. This paper presents experimental results for performance management of a Profibus-FMS network. The performance management aims to maintain a uniform level of network performance at all stations under changing network traffic. The performance management algorithm monitors the performance of individual network stations and commands the stations to change their timer values in order to have comparable performance at all stations. In order to determine the amount of timer change, the algorithm employs a set of fuzzy rules. The algorithm has been evaluated on a Profibus network.

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A Study on the Radiograph Inspection of Specimen in Welding Pass Using ATOS 80 High-strength Steel (ATOS 80 고장력강의 용접 패스에 따른 용접부 방사선검사에 관한 연구)

  • Baek, Jung-Hwan;Choi, Byung-Ky
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.21 no.6
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    • pp.915-919
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    • 2012
  • In constructing all kinds of equipment and steel structure, parts with discontinuities such as weld defects formed in the welded structure can generate fatigue cracks that results in damage or accidents. In this study, weld zones are investigated with X-rays and the latent images are put on film. Weld zone defects can be verified by developing the film. As weld defects are investigated by radiographic testing and correlated with the welding condition, more appropriate welding conditions can be found. According to the result of X-ray radiographic inspection of butt welding ATOS 80 high-strength steel with a thickness of 12mm, the best conditions for welding without creating weld defects are 4 weld-passes, a protective gas of 20% $CO_2$ and 80% Ar, a protective gas flow of 20L/min, a welding current of 200A, an arc voltage of 24V, a welding speed of 14.4cm/min, a welding rod angle of $50^{\circ}$, a welding gap of 5 mm with a ceramic base, and sand pre-heating to $160^{\circ}$ Celsius prior to welding.

Effect of Si on Spatter Generation and Droplet Transfer Phenomena of MAG Wwlding (MAG 용접의 스패터 발생 및 용적이행현상에 미치는 Si의 영향)

  • 안영호;이종봉;엄동석
    • Journal of Welding and Joining
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    • v.17 no.3
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    • pp.36-43
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    • 1999
  • The effect of Si content in welding wires on spattering characteristics and droplet transfer phenomena was studied. In MAG welding using 80% Ar-20% $CO_2$ shielding gas, spattering characteristics and droplet transfer phenomena were varied with Si content of wire. With increasing Si content, the spattering ratio and the ratio of large size spatter $(d\geq1.0mm)$ were increased. The increase of Si content in molten metal made surface tension increase due to reduction of oxygen content, which resulted from deoxidizing action of silicon. The increase of surface tension resulted in unstable transfer phenomena and arc instability in both short circuit and spray region. With changing Si content of wire, spattering characteristics and droplet transfer phenomena was directly influenced by the variation of surface tension, compared with the effect of arc stability.

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Electromigration Characteristics Stduy DCV Interconnect Structures in Cu Dual-Damascene Process (Cu Dual Damascene 배선 공정에서의 DCV 배선구조의 EM 특성 연구)

  • Lee, Hyun-Ki;Choi, Min-Ho;Kim, Nam-Hoon;Kim, Sang-Yong;Chang, Eui-Goo
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2005.07a
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    • pp.123-124
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    • 2005
  • We investigated the effect of a Ta/TaN Cu diffusion barrier existence on the reliability and the electrical performance of Cu dual-damascene interconnects. A high EM performance in Cu dual-damascene structure was observed the BCV(barrier contact via) interconnect structure to remain Ta/TaN barrier layer. Via resistance was decreased DCV interconnect structure by bottomless process. This structure considers that DCV interconnect structure has lower activation energy and higher current density than BCV interconnect structure. The EM failures by BCV via structure were formed at via hole, but DCV via structure was formed EM fail at the D2 line. In order to improve the EM characteristic of DCV interconnect structure by bottomless process, after Ta/TaN diffusion barrier layer in via bottom is removed by Ar+ resputtering process, it is desirable that Ta thickness is thickly made by Ta flash process.

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