• Asian Pacific Journal of Cancer Prevention
• /
• 제16권17호
• /
• pp.7467-7472
• /
• 2015

Background: Breast cancer is known to be one of the most prevalent cancers among women in both developing and developed countries. The incidence of breast cancer in Pakistan has increased dramatically within the last few years and is the second country after Israel in Asia to have highest proportional cases of breast cancer. However, there are limited data for breast cancer available in the literature from Pakistan. Objectives: The study was conducted to bring to light the common clinical presentation of breast cancer and to evaluate the frequency of established risk factors in breast carcinoma patients and furthermore to compare the findings between premenopausal and postmenopausal women in Pakistan. Materials and Methods: A 6 months (from July 2012 to Dec 2012) cross sectional survey was conducted in Surgical and Oncology Units of Civil Hospital, Karachi. Data were collected though a well developed questionnaire from 105 female patients diagnosed with carcinoma of breast and analyzed using SPSS version 17. Institutional ethical approval was obtained prior to data collection. Results: Out of 105 patients, 43 were premenopausal and 62 were postmenopausal, 99 being married. Mean age at diagnosis was $47.8{\pm}12.4years$. A painless lump was the most frequent symptom, notived by 77.1%(n=81). Some 55.2% (n=58) patients had a lump in the right breast and 44.8%(n=47) in the left breast. In the majority of cases, the lump was present in upper outer quadrant 41.9% (n=44). Mean period of delay from appearance of symptoms to consulting a doctor was $5.13{\pm}4.8months$, from the shortest 1 month to the longest 36 months. Long delay (> 3 months) was the most frequent figure 41.9%. Considering overall risk factors most frequent were first pregnancy after 20 years of age (41%), physical breast trauma (28.6%), lack of breast feeding(21.9%), and early menarche <11 years (19%), followed by null parity (16.2%), consumption of high fat diet (15.2%), family history of breast cancer or any other cancer in first degree relatives (9.5% and 13.3%, respectively). Some of the less common factors were late menopause >54 years (8.6%), use of oral contraceptive pills (10.5%), use of hormone replacement therapy (4.7%),smoking (4.7%) and radiation (0.96%). Significant differences (p<0.005) were observed between pre and post menopausal women regarding history of physical breast trauma, practice of breast feeding and parity. Conclusions: A painless lump was the most frequent clinical presentation noted. Overall age at first child > 20 years, physical breast trauma, lack of breast feeding, early menarche <11 were the most frequent risk factors. Physical breast trauma, lower parity, a trend for less breast feeding had more significant associations with pre-menopausal than post-menopausal onset. Increase opportunity of disease prevention can be obtained through better understanding of clinical presentation and risk factors important in the etiology of breast cancer.

• 한국컴퓨터정보학회논문지
• /
• 제13권4호
• /
• pp.255-262
• /
• 2008

현대사회 최근 정보통신기술의 비약적인 발전과 인터넷 이용의 폭발적인 증가에 따라, 인터넷을 이용한 전자상거래(Electronic Commerce)가 새로운 경제활동의 영역으로 정착되어 가고 있다. 시대의 흐름에 따른 전자거래는 새로운 형태의 거래라는 점에서 법률적인 문제도 많이 야기되고 있는 상황이다. 그러나 전자거래를 규율할 수 있는 법제도적인 정비의 구축과 전자거래의 이용관행이 아직 확립되지 못한 실정이다. 인터넷 전자거래에 있어서 구매계약의 체결은 전자문서교환(EDI)방식에 의하여 체결된다 할지라도 그 성질상 당사자간의 교환약정이 불특정 다수인을 상대로 하는 인터넷 전자거래에 그대로 적용될 수는 없을 것이다. 이러한 인터넷 전자거래계약의 주된 법적 문제 중 하나가 계약의 성립을 들 수 있다. 전자거래기본법에서 송신시기와 수신시기를 논한다는 것은 이미 전자거래가 격지자간의 거래로 볼 필요성이 있음을 전제로 한 것이므로 격지자간의 계약으로 보아야 하기 때문이다. 우리민법은 대화자간의 계약과 격지자간의 계약으로 구분하여 계약의 성립시기를 달리 정하고 있는 민법의 규정은 불합리하다고 할 수 있기 때문에 양자 모두 동일하게 도달주의의 원칙으로 정하여야 할 것이다.

• 한국지리정보학회지
• /
• 제10권2호
• /
• pp.152-163
• /
• 2007

현재 시행되고 있는 사전환경성검토는 부분 항목별 수치분석이 이루어지고 있어 종합적인 사전환경성검토가 어려운 실정이다. 또한, 수치자료의 활용이 미흡하여 환경성검토 분석결과의 객관성이 저하되고 있고, 평가비용과 시간도 많이 소요되고 있다. 본 연구에서는 8개 사전환경성 검토요소에 대한 지리정보체계의 공간분석기능을 도입하였으며, 개별 요소들의 평가결과를 통한 종합적인 검토를 수행할 수 있도록 계층분석기법을 활용한 사전환경성검토 GIS 의사결정시스템을 구축하였다. 본 연구에서 개발한 사전환경성 검토 GIS 의사결정 시스템과 기 구축된 GIS 데이터의 활용을 통해 환경성 검토에 객관성의 충족 및 시간 비용 절감이 가능하여 사업초기에 도로노선선정 시 사전환경성 검토에 활용 가능할 것이다. 또한, 본 연구에서 개발된 시스템을 통하여 수치적이고 시각적인 자료를 활용한 평가로 주민의 합의를 보다 용이하게 이끌어 낼 수 있고, 사업초기에 비용과 시간을 절감하면서 도로건설에 따른 환경성을 검토할 수 있을 것으로 기대된다.

• 대한토목학회논문집
• /
• 제26권1D호
• /
• pp.185-193
• /
• 2006

현재 시행되고 있는 사전환경성검토는 부분 항목별 수치분석이 이루어지고 있어 종합적인 사전환경성검토가 어려운 실정이다. 또한, 수치자료의 활용이 미흡하여 환경성검토 분석결과의 객관성이 저하되고 있고, 평가비용과 시간도 많이 소요되고 있다. 본 연구에서는 8개 사전환경성 검토요소에 대한 지리정보체계의 공간분석기능을 도입하였으며, 개별 요소들의 평가결과를 통한 종합적인 검토를 수행할 수 있도록 사전 환경성검토 GIS 의사결정시스템을 구축하였다. 본 연구에서 개발한 사전환경성 검토 GIS 의사결정시스템과 기 구축된 GIS 데이터를 활용을 통해 환경성 검토에 객관성이 충족 및 시간 비용 절감이 가능하여 사업초기에 도로 노선선정 시 사전환경성 검토에 활용 가능할 것이다. 또한, 본 연구 개발된 시스템을 통하여 수치적이고 시각적인 자료를 활용한 평가로 주민의 합의를 보다 용이하게 이끌어 낼 수 있고, 사업초기에 비용과 시간을 절감하면서 도로건설에 따른 환경성을 검토할 수 있을 것으로 기대된다.

• 한국컴퓨터정보학회논문지
• /
• 제22권3호
• /
• pp.147-153
• /
• 2017

The main subject of year 2016 Davos forum was "The 4th Industrial Revolution." Recently, interests and investment in drone market, so called industrial revolution in the sky is growing in many countries around the world. Before, drone was used for military purpose such as reconnaissance or attacking but today, it is used in various private sectors such as unmanned delivery service, agriculture, leisure activities, etc. Presently, many major countries in the world are already involved in the 'war without gunfire' to be dominant in this drone industry. Korean government also has announced an extreme relaxation of regulations for growing drone industry by opening a conference with Ministers related to economics. During the conference, business scope of drone which was limited to agriculture, photographing, and observation was expanded to all the fields except for cases hindering national safety and security. In terms of shooting purpose drone its process of receiving approval for flight and shooting is simplified to online registration. What is more, drone delivery service will be allowed in island areas such as Goheung, Yeongwol, etc from first term of year 2017. Finding the way to apply drone in criminal investigation is also speeding up. Recently, Public Safety Policy Research Center in Korean National Police University has inquired for research service and its result will be out around November. Likewise, although more and stronger foundation for supporting drone industry is made but there are still, some opinions saying that we should take a careful approach in consideration to the side effect such as abuse in crime. One may also try terror by placing a dangerous substance. If drone falls, it may hurt any civilians. Moreover, if shopping purpose drone is hacked, it may result in violation of privacy. Compared to America, Europe, and China, we are at the very beginning stage of drone industry and it is necessary to reorganize legal issues to grow this industry. This can be thought from two perspectives; first, the growth of drone industry is blocked by difficult regulations on Aviation Law and Radio Regulation Law. The second issue is the safety and privacy that are required for operating drone. For the advanced technologies to make human life more profitable, more active and proactive actions are required by criminal law side. In preparation to the second mechanical era where man and machines should go together, I hope that responsible preparation is required in all fields including the criminal law.

• 벤처혁신연구
• /
• 제6권4호
• /
• pp.23-40
• /
• 2023

본 연구는 빠른 속도로 디지털화 및 모바일화되는 리테일 산업에서 전통적인 오프라인 리테일러인 백화점을 대상으로 고객 가치 이론을 기반으로 백화점의 모바일 앱 지속 이용 의도에 영향을 미치는 고객 가치 요인을 조사한다. 본 연구에서는 다차원적인 고객 가치를 기능적 가치, 편의적 가치, 그리고 사회적 가치의 세 가지 차원으로 분류하였다. 기능적 가치는 옴니채널 리테일 환경에서의 채널 간 통합과 일관된 고객 경험 제공을 의미하며, 편의적 가치는 고객이 모바일 앱 이용 시 절약할 수 있는 시간과 노력의 절약인 편의성이다. 사회적 가치는 백화점의 모바일 앱 내 친환경 마케팅과 관련하여 제품 또는 서비스 사용으로 인해 발생하는 사회적 승인 또는 사회적 자아 개념의 향상을 뜻한다. 이렇게 세 가지 차원의 고객 가치를 선행변수로 하여 종속변수인 모바일 앱 지속 이용 의도에 미치는 각 영향력을 분석하였다. 국내 신세계 백화점의 모바일 앱 사용 이력이 있는 고객을 대상으로 데이터 수집 후 Smart PLS 4.0을 사용하여 실증 분석하였다. 분석 결과 고객 가치의 세 가지 차원인 기능적 가치, 편의적 가치, 사회적 가치가 모두 고객의 모바일 앱 지속 이용 의도에 정(+)의 영향을 미치는 것으로 나타났으며 기능적 가치의 영향력이 가장 큰 영향을 미친다. 기술의 발전으로인한 옴니채널 리테일 트렌드에서 기능적 가치가 가장 중요한 영향 요인으로 나타남에 따라 오프라인 리테일러인 백화점의 통합된 채널 제공이 중요하다는 점을 시사한다. 백화점 모바일 앱 활성화를 위한 고객 중심 전략 수립 방향에 대한 통찰력을 제공하며, 백화점이 기존 오프라인 채널이 아닌 신규 모바일 채널을 통해 변화하는 고객의 기대 및 요구를 효과적으로 충족할 수 있는 맞춤화된 서비스와 마케팅 활동을 위한 기초적인 분석자료를 시사한다.

• 대한수의학회지
• /
• 제47권4호
• /
• pp.449-456
• /
• 2007

The approval of use of certain food-grade phosphates as food additives in a wide variety of meat products greatly stimulated research on the applications of phosphates in foods. Although phosphates have never been classified as antimicrobial agents, a number of investigators have reported that phosphates have antimicrobial activities. Phytic acid is a natural plant inositol hexaphosphate constituting 1-5% of most cereals, nuts, legumes, oil seeds, pollen, and spores. In this study, we investigated antibacterial activities of sodium phytate (SPT), sodium pyrophosphate (SPP), sodium tripolyphosphate (STPP) on Salmonella typhimurium in tryptic soy broth and in row meat media including chicken, pork and beef. SPY, SPP and STPP at the concentrations of 0.5 and 1% dose-dependently inhibited the growth of S. typhimurium in tryptic soy broth at various pHs. The antibacterial activities of SPT and STPP were the stronger than that of SPP. In chicken, pork, and beef, SPT, SPP and STPP at the concentrations of 0.1, 0.5 and 1.0% significantly inhibited the bacterial growth in a dose-dependant manner (p < 0.05). The antibacterial activities of SPT, SPP, and STPP were more effective in chicken than beef. SPT and STPP at the concentration of 1% reduced the bacterial count by about 2 log units. The addition of SPT, SPP and STPP at the concentration of 0.5% in meats increased the meat pHs by 0.28-0.48 units in chicken, pork, and beef. These results suggest that SPT and STPP were equally effective for the inhibition of bacterial growth both in TSB and meat media and that SPT can be used as an animal food additive for increasing shelf-life and functions of meats.

• 대한약침학회지
• /
• 제18권1호
• /
• pp.56-62
• /
• 2015

Objectives: The purpose of the study is to assess both the approximate lethal dose and the single dose intramuscular injection toxicity of Danggui (Angelica gigantis radix) pharmacopuncture (DGP) in Sprague-Dawley (SD) rats. Methods: The experiments were conducted at the good laboratory practice (GLP) laboratory, Biotoxtech Co., which is a laboratory approved by the ministry of food and drug safety (MFDS). The study was performed according to the GLP regulation and the toxicity test guidelines of the MFDS (2009) after approval of the institutional animal care and use committee of Biotoxtech. Single doses of DGP were injected intramuscularly into the rats in three test groups of 6 week old SD rats (5 male and 5 female rats per groups) in the amounts of 0.1, 0.5, and 1.0 mL/animal for groups 2, 3, and 4, respectively, and normal saline solution in the amount of 1.0 mL/animal was injected intramuscularly into the rats (5 male and 5 female rats) in the control group. Observations of the general symptoms and weight measurements were performed during the 14 day observation period after the injection. Hematologic and serum biochemical examination, necropsy, and a local tolerance test at the injection site were done after the observation period. Results: No death was observed in three test groups (0.1, 0.5 and 1.0 mL/animal group). In addition, the injection of DGP had no effect on general symptoms, weights, hematologic and serum biochemical examination, and necropsy. The results from the local tolerance tests at injection site showed no treatment related effects in the SD rats. Conclusion: The results of single dose intramuscular injection of DGP suggest that the approximate lethal dose is above 1.0 mL/animal for both male and female SD rats and that intramuscular injection of DGP may be safe.

• 한국임상약학회지
• /
• 제26권2호
• /
• pp.121-127
• /
• 2016

Objective: Until now, there is minimal number of research for overall domestic status of orphan drug use in Korea. The purpose of this study is to identify the list of orphan drugs available in Korea and to understand the status of orphan drug usage in tertiary Hospitals and rare incurable disease Hospital. Methods: We made domestic orphan drug lists based on available orphan drugs in Korea. Based on this lists, we conducted e-mail survey from August, 2014 to September, 2014 to identify domestic status of orphan drug usage including the availability and management of orphan drugs. Results: There are three hundred and eighteen orphan drugs (184 ingredients) registered in Ministry of Food and Drug Safety. Among the three hundred and eighteen orphan drugs, Two hundred and twenty-eight drugs (102 ingredients) were selected. Information on each item was collected and documented with generic and brand names, manufacturers, wholesalers, indications, FDA approval status and insurance coverage. Forty-three tertiary hospitals and thirty-two rare incurable hospitals responded to the survey questionnaire (57.3%). According to the survey result, the antineoplastics and immunomodulating agents group has the highest percentage (40%) usage in the hospital. Of fortythree tertiary hospitals, thirteen hospitals manage orphan drugs separately (30.2%). Based on the reply, most of the healthcare professionals commented the drug information related to efficacy and safety including medication counseling of orphan drugs is insufficient. Conclusion: Through this study we anticipate providing an understanding of orphan drug usage status in Korea. We found the limited resources to the information on orphan drugs and this information requires updating on a regular basis. This can be the basis for further studies about preparing drug information, educational resources for rare disease patients.

• 대한치과마취과학회지
• /
• 제14권4호
• /
• pp.213-219
• /
• 2014

Background: Clinical use of propofol along with remifentanil for intravenous sedation is increasing in these days, but there are not enough researches to evaluate proper target concentration when these drugs are infused by using target controlled infusion (TCI) pump in dental treatment cases. In this study, we compared efficacy of TCI conscious sedation and target concentration of propofol when it used with or without remifentanil during conscious sedation with the help of a TCI for the surgical extraction of impacted teeth. Methods: After IRB approval, all the charts of patients who had undergone surgical extraction of impacted teeth under propofol TCI sedation for 6 months were selected and reviewed for this study. After reviewal of charts, we could divide patients in two groups. In one group (group 1), only propofol was selected for sedation and initial effect site concentration of propofol was $1{\mu}g/ml$ (n = 33), and in another group (group 2), both propofol and remifentanil was infused and initial effect site concentration of each drug was $0.6{\mu}g/ml$ and 1 ng/ml respectively (n = 25). For each group, average propofol target concentration was measured. In addition, we compared heart rate, respiratory rate, and systolic and diastolic blood pressure as well as oxygen saturation. Besides, BIS, sedation scores (OAAS/S), and subjective satisfaction scores were compared. Results: Between group 1 and 2, there were no significant differences in demographics (age, weight and height), and total sedation time. However, total infused dose and the effect site target concentration of propofol was $163.8{\pm}74.5mg$ and $1.13{\pm}0.21{\mu}g/ml$ in group 1, and $104.3{\pm}46.5mg$ and $0.72{\pm}0.26{\mu}g/ml$ in the group 2 with $1.02{\pm}0.21ng/l$ of the effect site target concentration of remifentanil, respectively. During sedation, there were no differences between overall vital sign, BIS and OAAS/S in 2 groups (P > 0.05). However, we figured out patients in group 2 had decreased pain sensation during sedation. Conclusions: Co-administration of propofol along with remifentanil via a TCI for the surgical extraction of impacted teeth may be safe and effective compared to propofol only administration.