• Title/Summary/Keyword: Apparent Diffusion Coefficient

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Mobility of Water and Solute Intluenced by PHYSICAL PROCESSES in field Soils (포장에서 물리적 진행과정에 의해 영향을 받은 물질과 수분의 이동성)

  • Doug Young Chung
    • Journal of Korea Soil Environment Society
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    • v.1 no.2
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    • pp.73-81
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    • 1996
  • The self-diffusion coefficients of chloride and tritiated water ranged from 4.8 $\times$ 10-7 to 7.2 $\times$ 10-7 cm2/sec and 5.5 $\times$ 10-5 to 1.6 $\times$ 10-4 cm2/sec for three different depths of soil constituents at about 50% water content by volume, respectively Mobility of solute and water was conducted under steady-state flow conditions in a field soil consisting of 70 cm of clay to silty clay over a medium sand. A steady-state water flow conditions was maintained by applying irrigation water at a constant flux of 2cm per day. The water labeled with chloride and tritium was leached into the plot during the steady-state condition for 87 days. The positions of tritium and chloride as a function of soil depth and the time was measured by extracting samples of the soil solution with suction probes. Extremes in solute displacement occurred at equal and different depths within the plot. An analysis of these measurements indicated the observations of the pore-water velocity and the apparent diffusion coefficient were log normally disturbed. Twenty-four soil suction probes, used to identify the rate at which a solute was displaced in the soil, will yield an estimate of the mean pore-water velocity of this soils within a range of approximately 5% of its true value providing the effects of potential solute-soil interaction are taken into account.

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Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

  • Usuda, Katsuo;Sagawa, Motoyasu;Motono, Nozomu;Ueno, Masakatsu;Tanaka, Makoto;Machida, Yuichiro;Maeda, Sumiko;Matoba, Munetaka;Kuginuki, Yasuaki;Taniguchi, Mitsuru;Tonami, Hisao;Ueda, Yoshimichi;Sakuma, Tsutomu
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.11
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    • pp.4629-4635
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    • 2014
  • Background: Diffusion-weighted imaging (DWI) makes it possible to detect malignant tumors based on the diffusion of water molecules. However, it is uncertain whether DWI has advantages over FDG-PET for distinguishing malignant from benign pulmonary nodules and masses. Materials and Methods: One hundred-forty-three lung cancers, 17 metastatic lung tumors, and 29 benign pulmonary nodules and masses were assessed in this study. DWI and FDG-PET were performed. Results: The apparent diffusion coefficient (ADC) value ($1.27{\pm}0.35{\times}10^{-3}mm^2/sec$) of malignant pulmonary nodules and masses was significantly lower than that ($1.66{\pm}0.58{\times}10^{-3}mm^2/sec$) of benign pulmonary nodules and masses. The maximum standardized uptake value (SUVmax: $7.47{\pm}6.10$) of malignant pulmonary nodules and masses were also significantly higher than that ($3.89{\pm}4.04$) of benign nodules and masses. By using optimal cutoff values for ADC ($1.44{\times}10^{-3}mm^2/sec$) and for SUVmax (3.43), which were determined with receiver operating characteristics curves (ROC curves), the sensitivity (80.0%) of DWI was significantly higher than that (70.0%) of FDG-PET. The specificity (65.5%) of DWI was equal to that (65.5%) of FDG-PET. The accuracy (77.8%) of DWI was not significantly higher than that (69.3%) of FDG-PET for pulmonary nodules and masses. As the percentage of bronchioloalveolar carcinoma (BAC) component in adenocarcinoma increased, the sensitivity of FDG-PET decreased. DWI could not help in the diagnosis of mucinous adenocarcinomas as malignant, and FDG-PET could help in the correct diagnosis of 5 out of 6 mucinous adenocarcinomas as malignant. Conclusions: DWI has higher potential than PET in assessing pulmonary nodules and masses. Both diagnostic approaches have their specific strengths and weaknesses which are determined by the underlying pathology of pulmonary nodules and masses.

Diffusion Weighted Imaging Can Distinguish Benign from Malignant Mediastinal Tumors and Mass Lesions: Comparison with Positron Emission Tomography

  • Usuda, Katsuo;Maeda, Sumiko;Motono, Nozomu;Ueno, Masakatsu;Tanaka, Makoto;Machida, Yuichiro;Matoba, Munetaka;Watanabe, Naoto;Tonami, Hisao;Ueda, Yoshimichi;Sagawa, Motoyasu
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.15
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    • pp.6469-6475
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    • 2015
  • Background: Diffusion-weighted magnetic resonance imaging (DWI) makes it possible to detect malignant tumors based on the diffusion of water molecules. It is uncertain whether DWI is more useful than positron emission tomography-computed tomography (PET-CT) for distinguishing benign from malignant mediastinal tumors and mass lesions. Materials and Methods: Sixteen malignant mediastinal tumors (thymomas 7, thymic cancers 3, malignant lymphomas 3, malignant germ cell tumors 2, and thymic carcinoid 1) and 12 benign mediastinal tumors or mass lesions were assessed in this study. DWI and PET-CT were performed before biopsy or surgery. Results: The apparent diffusion coefficient (ADC) value ($1.51{\pm}0.46{\times}10^{-3}mm^2/sec$) of malignant mediastinal tumors was significantly lower than that ($2.96{\pm}0.86{\times}10^{-3}mm^2/sec$) of benign mediastinal tumors and mass lesions (P<0.0001). Maximum standardized uptake value (SUVmax) ($11.30{\pm}11.22$) of malignant mediastinal tumors was significantly higher than that ($2.53{\pm}3.92$) of benign mediastinal tumors and mass lesions (P=0.0159). Using the optimal cutoff value (OCV) $2.21{\times}10^{-3}mm^2/sec$ for ADC and 2.93 for SUVmax, the sensitivity (100%) by DWI was not significantly higher than that (93.8%) by PET-CT for malignant mediastinal tumors. The specificity (83.3%) by DWI was not significantly higher than that (66.7%) for benign mediastinal tumors and mass lesions. The accuracy (92.9%) by DWI was not significantly higher than that (82.1%) by PET-CT for mediastinal tumors and mass lesions. Conclusions: There was no significant difference between diagnostic capability of DWI and that of PET-CT for distinguishing mediastinal tumors and mass lesions. DWI is useful in distinguishing benign from malignant mediastinal tumors and mass lesions.

Kinetic Modeling of Dewatering of Potato Slice When Soaked in Concentrated Solution (고농도 용액에 침지시 감자 절편의 동력학적 탈수 모델링에 관한 연구)

  • 최동원;신해헌
    • The Korean Journal of Food And Nutrition
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    • v.13 no.5
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    • pp.477-482
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    • 2000
  • For the purpose of explaining the dewatering phenomena of potato slice soaked in concentrated solution three models were proposed. Earlier model cannot explain the dewatering phenomena of potato slice in concentrated solution because of limiting its condition which is necessary to build a model. Therefore other three models were suggested and a model based on Fick\`s second law of mass transport at infinite plate conditions and numerical analysis was test model for explaining dewatering phenomena of potato soaked in concentrated solution. Apparent diffusion coefficient of water could be readily estimated from model III, and it could explain adequately the difference of the dewatering phenomena of various soaking conditions.

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\Transport Phenomena of Alkali Metal Chlorides theough Poly(2-Hydroxyethyl Methacrylate) Hydrogel Membrane (Poly(2-Hydroxyethyl Methacrylate) 수화겔 막에 대한 알카리 금속 염화물의 수송현상)

  • Seong, Yong-Gil;Lee, Chun-Gi;Jeon, Mu-Sik
    • Journal of Biomedical Engineering Research
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    • v.8 no.2
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    • pp.123-134
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    • 1987
  • The transport phenomena of alkali metal chlorides through poly(2 hydroxyethyl methacrylate) hydrogel membrane have been studied using electrodialysis. The hydrogel membranes were prepared by the polymerization of 2-hydroxvethyl methacrylate in the presence of 45%(V/V) H2O and ethyleneglycodimethacrylate. The initiator used in the polymerization was azobismethylisobutyrate (AMIB) prepared from azobisiobtyronitrile (AIBN) using Mortimer method. The permeability of alkali metal chlorides such LiCl, NaCl and KCI at 50 voltage was obtained. The permeability of NaCl was also observed at 30, 40, 50, and 60 voltages respectively. The concentration of solutes permeated through the membrane was measurer by flame photometry. The experimental results have been discussed with the comparison of apparent solute molecular size, the self-diffusion coefficient of solutes, the transport number of cations in aqueous solution. These indic aloes that poly(2 hydroxyethyl methacrylate) hydrogel membrane shows a specific selectivity for sodium ion.

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Physical Properties and Dyeing Behaviors of Cellulosic Fabrics Treated with Liquid Ammonia (액체암모니아 처리한 셀룰로오스계 직물의 물성 및 염색성)

  • 배소영;이문철;김경환;일본명
    • Textile Coloration and Finishing
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    • v.7 no.1
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    • pp.10-22
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    • 1995
  • Cellulosic fabrics, i.e. rayon, polynosic, and linen were treated with liquid ammonia at -33.4$^{\circ}C$. The fine structures, bending properties, tensile strength, wrinkle recoveries, and dyeing properties of the treated fabrics were studied. Dyeing was carried out with two direct dyes, C. I. Direct Red 2 and Blue 1. The liquid ammonia treatment for three fabrics brought about the transition of crystal lattices and the decrease of crystallinity; transforming cellulose I structure of original linen to cellulose I and III structure, and cellulose II structure of original rayon and polynosic to cellulose II and III structure. Moisture regain of liquid ammonia- treated polynosic and linen was higher than that for untreated, and water absorbency of liquid ammonia-traeated fabrics was all lower than that of untreated. Also, bending properties of treated fabrics were not improved compared with those of untreated ones. The rayon treated with liquid ammonia was increased not only the apparent diffusion coefficient and the rate of dyeing but also equilibrium dye adsortion, whereas polynosic and linen were increased only equilibrium dye adsortion. It is suggested that the pore sizes of liquid ammonia-treated rayon, polynosic, and linen are much smaller than that of liquid ammonia-treated cotton.

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Vasogenic Edema in Experimental Cerebral Fat Embolism

  • Park Byung-Rae;Koo Bong-Oh
    • Biomedical Science Letters
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    • v.11 no.1
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    • pp.31-36
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    • 2005
  • To evaluate the magnetic resonance imaging and electron microscopic findings of the hyperacute stage of cerebral fat embolism in cats and the time needed for the development of vasogenic edema. Magnetic resonance imaging was performed at 30 minutes (group 1, n=9) and at 30 minutes and 1, 2, 4, and 6 hours after embolization with triolein (group 2, n= 10). As a control for group 2, the same acquisition was obtained after embolization with polyvinyl alcohol particles (group 3, n=5). Electron microscopic examination was done in all cats. In group 1, the lesions were iso- or slightly hyperintense on T2-weighted (T2W) and diffusion-weighted (DWIs) images, hypointense on the apparent diffusion coefficient (ADC) map image, and markedly enhanced on the gadolinium-enhanced T1-weighted images (Gd-T1WIs). In group 2 at 30 minutes, the lesions were similar to those in group 1. Thereafter, the lesions became more hyperintense on T2WIs and DWIs and more hypoinfense on the ADC map image. In group 3, the lesions showed mild hyperintensity on T2WIs at 6 hours but hypointensity on the ADC map image from 30 minutes, with a tendency toward a greater decrease over time. Electron microscopic findings revealed discontinuity of the capillary endothelial wall, perivascular and interstitial edema, and swelling of glial and neuronal cells in groups 1 and 2. The lesions were hyperintense on T2WIs and DWIs, hypointense on the ADC map image, and enhanced on Gd-T1WIs. On electron microscopy, the lesions showed cytotoxic and vasogenic edema with disruption of the blood-brain barrier.

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Ischemic Infarcion Model by Middle Cerebral Artery Occlusion using Allogenic Blood Clot in Beagle Dogs (비글견에서 동종혈전 색전술을 이용한 중간대뇌동맥의 허혈성 뇌경색 모델)

  • Kim, Younghwan;Choi, Sooyoung;Lee, Kija;Han, Woosok;Choi, Hojung;Lee, Youngwon
    • Journal of Veterinary Clinics
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    • v.33 no.1
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    • pp.10-15
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    • 2016
  • The purpose of this study was to establish reproducible ischemic infarction model using allogenic blood clot in beagle dogs and identify induced ischemic lesion after middle cerebral artery occlusion using magnetic resonance imaging (MRI) and histopathologic findings. Twenty eight male beagle dogs with no evidence of neurologic disease were experimented. Allogenic embolus was made using a healthy beagle dog. After internal carotid artery (ICA) was exposure, 16G catheter was introduced through the ICA. The dog was administered 0.3 ml blood clot for 15 seconds followed by 3 ml of saline for 15 seconds. MRI scans were performed with 1.5T to evaluate ischemic lesion at 7 days after middle cerebral artery occlusion procedure. Evaluation parameters of MRI include location, distribution, infarction type, margin, shape, mass effect and intensity of T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), fluid attenuated inversion recovery (FLAIR) sequence, diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC). On MRI, all dogs (28/28) showed focal or multifocal lesion including telencephalon and thalamus lesions, especially caudate nucleus (24/28). These lesions had well-defined margin from adjacent brain parenchyma, none or mild mass effect and various shape. Most of dogs appeared hyperintensity on T1WI, T2WI, FLAIR, and DWI/ADC, corresponding to chronic infarction. These lesions were histopathologically confirmed atrophic changes and unstained lesion. In conclusion, MRI is the useful method to provide information about ischemic infarction in dogs and the best reproducible ischemic infarction model was developed by using allogenic blood clot.

Magnetic Resonance Characteristics of Ischemic Brain Infarction in Three Dogs (자기공명영상을 이용한 개의 허혈성 뇌경색의 진단 3례)

  • Lee, Ki-Ja;Kim, Young-Whan;Choi, Sung-Jin;Choi, Soo-Young;Jeong, In-Seong;Choi, Ho-Jung;Lee, Young-Won
    • Journal of Veterinary Clinics
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    • v.31 no.5
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    • pp.457-460
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    • 2014
  • This case study describes the magnetic resonance characteristics of brain infarction in three dogs. Locations of the brain infarcts were cerebella, thalamus, and multifocal. The infarcts were sharply demarcated from adjacent brain parenchyma, homogeneous, T1-hypointense, T2-hyperintense with/without contrast enhancement, and minimal or no mass effect. Diffusion-weighted imaging (DWI) sequences were available in a dog and the infarcts were hyperintense on DWI and were hypointense on the apparent diffusion coefficient map.

Diffusion-hydraulic properties of grouting geological rough fractures with power-law slurry

  • Mu, Wenqiang;Li, Lianchong;Liu, Xige;Zhang, Liaoyuan;Zhang, Zilin;Huang, Bo;Chen, Yong
    • Geomechanics and Engineering
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    • v.21 no.4
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    • pp.357-369
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    • 2020
  • Different from the conventional planar fracture and simplified Newton model, for power-law slurries with a lower water-cement ratio commonly used in grouting engineering, flow model in geological rough fractures is built based on ten standard profiles from Barton (1977) in this study. The numerical algorithm is validated by experimental results. The flow mechanism, grout superiority, and water plugging of pseudo plastic slurry are revealed. The representations of hydraulic grouting properties for JRCs are obtained. The results show that effective plugging is based on the mechanical mechanisms of the fluctuant structural surface and higher viscosity at the middle of the fissure. The formulas of grouting parameters are always variable with the roughness and shear movement, which play a key role in grouting. The roughness can only be neglected after reaching a threshold. Grouting pressure increases with increasing roughness and has variable responses for different apertures within standard profiles. The whole process can be divided into three stationary zones and three transition zones, and there is a mutation region (10 < JRCs < 14) in smaller geological fractures. The fitting equations of different JRCs are obtained of power-law models satisfying the condition of -2 < coefficient < 0. The effects of small apertures and moderate to larger roughness (JRCs > 10.8) on the permeability of surfaces cannot be underestimated. The determination of grouting parameters depends on the slurry groutability in terms of its weakest link with discontinuous streamlines. For grouting water plugging, the water-cement ratio, grouting pressure and grouting additives should be determined by combining the flow conditions and the apparent widths of the main fracture and rough surface. This study provides a calculation method of grouting parameters for variable cement-based slurries. And the findings can help for better understanding of fluid flow and diffusion in geological fractures.