• Journal of Chest Surgery
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• 제25권4호
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• pp.412-417
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• 1992

Pulmonary artery aneurysm is Behcet`s disease is rare and can be fatal due to rupture. We experienced a case of pulmonary artery aneurysm in Behcet`s disease. The patient was 21 year old woman who was adimitted with three month history of dyspnea, fever and cough. On examination, she had aphthous ulcer in the mouth and erythema nodosum on the left popletial fossa and forearm, but didn`t have any lesion at eyes and genitalia. The latex fixation test for rheumatoid factor, VDRL test for syphillis, antinuclear antibody and LE cell test were all negatives. The third and fourth components of complement in the serum, serum immunoglobulin concentrations[IgG, IgM, IgA] were within normal range. The chest radiography revealed a 5x6cm sized radiopaque mass density in the left hilar region. Two months later, the mass was enlarged to 6x7cm. The IV-DSA showed a single aneurysm at the proximal part of left lower lobe artery with lingular segment artery and no distal perfusion by thombotic obstruction. The steroid therapy was done for a month, but symptoms not improved. We performed resection of lingular segment and lower lobe including the aneurysm. The microscopic findings of the operative specimen were intimal hyperplasia and fragmentation of the internal elastic fibers. She was improved without remarkable event, except infection of the operative wound.

• Journal of Chest Surgery
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• 제32권7호
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• pp.660-664
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• 1999

현재 베체트병은 여러 기관을 침범하는 질환으로 인식되고 있으며 구강 및 음부 궤양, 안병변과 피부병변 을 주증상으로 하고 심혈관계, 호흡기계, 소화기계, 중 颯키麗\ulcorner 비뇨기계 등을 침범하여 다양한 증상을 나타 내고 있다. 베체트병에서의 폐동맥의 침범은 드물지만 다량의 객혈이 발생될 수 있으며 동맥류의 파열에 의 한 사망의 위험성이 높다. 29세의 남자 환자가 6개월간 지속된 객혈과 동반된 호흡곤란을 주소로 내원하였 다. 우측폐하엽에 종괴가 발견되어 우측 중엽 및 하엽 절제술을 시행 받았다. 수술소견상 우측 폐하엽에 4$\times$ 5$\times$4 cm의 박동 원형종괴가 있었으며 우중엽 및 우하엽의 폐동맥이 종괴와 연결이 되어 있었다. 병리소견과 병력상 베체트병에 의한 폐동맥류를 경험하였기에 문헌 고찰과 함께 보고하고자 한다.

• Journal of Yeungnam Medical Science
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• 제3권1호
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• pp.307-311
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• 1986

Behcet씨 병의 경우 중추 신경계 침범여부는 조기에 진단 치료되어야 할 정도로 불량한 예후를 나타내는 지표로써 아프타성 구내염, 생식기 궤양, 표피성 혈관염, 포도막염, 활막염 등 전신적 증상에 주의를 기울임으로써 조기 진단 및 치료를 하여야 예후의 호전에 기여할 것으로 생각된다. 저자들은 51세 여자 환장서 중추 신경계 증상을 동반한 Behcet씨 병 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Journal of Pharmaceutical Investigation
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• 제29권2호
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• pp.127-136
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• 1999

In order to eliminate demerits of conventional dosage forms, dipotassium glycyrrhizate was formulated as a slim mucoadhesive film type dosage form. The mucoadhesive drug layer gel containing dipotassium glycyrrhizate was prepared using $Noveon^{\circledR}$ AA-1, hydroxypropylcellulose-M, ethylcellulose N 100 and citric acid, and the protective layer gel by using ethylcellulose N 100, $Eudragit^{\circledR}$ RS and castor oil. The viscosity of drug layer gel of mucoadhesive film was enhanced as the increased amount of $Noveon^{\circledR}$ AA-1 or hydroxypropyl cellulose-M. The drug content was unifonnly $1160{\pm}14.6\;{\mu}g$, and was varied within 3.5%. The optimum film dosage form showed a good fluidity and malleability of drug layer, with 179 g of thickness, pH 5.7, 411 min of in vitro adhesion time and 172 g in gravity adhesive strength. The release time of drug from the mucoadhesive film was significantly shorter but was delayed when polymers such as ethylcellulose was added. From these results, the new mucoadhesive film may be effective for the treatment of aphthous stomatitis.

• The Korean Journal of Pain
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• 제22권1호
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• pp.104-106
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• 2009

Behcet's disease is a chronic relapsing vasculitis characterized by recurrent aphthous oral and genital ulcers with uveitis. Multiple organs can be involved. Entero-Behcet's disease is often uncontrollable, relapsing, and can cause acute intestinal bleeding, fistula formation, or perforation. Corticosteroids, immunosuppressors, and colchicines are used to treat Entero-Behcet's disease with varying degree of success. Thalidomide may also be feasible. We present a 29-year-old male Entero-Behcet's patient suffering from abdominal pain, diarrhea, and back pain. He did not respond to prior treatments, but responded to thalidomide.

• Journal of Oral Medicine and Pain
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• 제42권1호
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• pp.25-27
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• 2017

Crohn's disease is an inflammatory bowel disease which affects whole gastrointestinal tract from mouth to anus. Crohn's disease may present both oral manifestation and gastrointestinal symptom-abdominal pain, diarrhea, weight loss, anorexia, fever, and growth failure. The prevalence rate of oral manifestation is approximately between 0.5% and 20%. The oral lesion could be the first sign of Crohn's disease. We present a case of Crohn's disease in a patient who did not show typical oral manifestations but had nonspecific aphthous like ulceration and burning sensation for many years. Through this case, we suggest approaches for the diagnosis and treatment of the oral lesion of Crohn's disease.

• 구강회복응용과학지
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• 제29권4호
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• pp.391-398
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• 2013

보툴리눔 독소는 사시, 안검경련, 뇌성마비, 경부근 근육긴장이상, 다한증, 얼굴의 주름 같은 미용 치료, 그리고 만성 편두통 치료에 미국 식약청의 승인을 받아 사용되고 있다. 이외에도 강직유발 통증, 포진후 신경통, 근막통증, 아프타성 구내염 등과 같은 통증을 조절하는 데 효과가 있을 것이라 기대되어 다양한 의료영역에서 연구가 진행되고 있는데, 최근 코골이 및 수면무호흡 치료에 있어서 보툴리눔 독소의 효과에 관한 연구들이 보고된 바 있어 그 유용성에 관해 고찰해 보고자 한다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제2권2호
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• pp.227-232
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• 1999

저자들은 발열, 복통, 관절통, 구강내 궤양의 증상으로 내원한 6세 남아에서 발생한 Crohn 병 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Clinical and Experimental Pediatrics
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• 제59권1호
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• pp.30-34
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• 2016

Purpose: Although Bednar's aphthae are common and regress spontaneously, these lesions may lead to feeding intolerance and are often misdiagnosed, rendering examinations useless. This study sheds new light on the clinical features of Bednar's aphthae. Methods: Sixteen neonates and infants were newly diagnosed with Bednar's aphthae via routine health check-ups in an outpatient clinic. Medical records were retrospectively reviewed, and the following parameters were analyzed; sex, gestational age, birth weight, mode of delivery, and perinatal problems. A physical examination was carried out during the next outpatient visit to examine the healing process and check for the existence of scars or complications. Results: Initial presentation included changes in feeding habits (n=10), longer feeding time, reduced intake, and increased irritability. In 6 patients, Bednar's aphthae were discovered incidentally, without prior symptoms. Feeding posture and method of feeding are important causes of Bednar's aphthae. Eleven patients were fed in a horizontal position, whereas 5 patients were fed in a semiseated position. Fifteen patients were bottle-fed, whereas 1 patient was exclusively breastfed. After correcting the feeding position, the ulcerative lesions disappeared within 1 month of diagnosis. During the follow-up period, lesions did not recur in any of the patients. Conclusion: This study suggests that Bednar's aphthae are caused by mechanical pressure. A diagnosis of Bednar's aphthae should be considered when lesions are found on the palate of infants and when symptoms seem to be feeding related. Proper education of parents can both treat Bednar's aphthae and easily prevent its recurrence.

• Tuberculosis and Respiratory Diseases
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• 제43권1호
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• pp.96-101
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• 1996

저자들은 과거력상 반복되는 구강내 아프타성 궤양 및 결절홍반양 피부병변이 있었고, 객혈을 주소로 내원한 37세 남자환자에서 혈관조영술상 다발성 폐동맥류, 심부 정맥의 협착 및 폐색소견이 관찰되었고, 조직학적으로는 폐혈관염 소견을 보여, Hughes-Stovin 증후군으로 진단하였으며, 코일을 이용한 폐동맥색전술로 폐동맥류를 성공적으로 치료하였기에 문헌고찰과 함께 보고하는 바이다.