• 음성과학
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• 제13권2호
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• pp.7-18
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• 2006

An aphasia screening test can serve a main purpose of differentiating aphasics from non-aphasic patients in a quick as well as efficient manner. As a preliminary study for developing a standardized aphasia screening test for Korean patients, we constructed an aphasia screening test constituting items from the Paradise' Korean version-the Western Aphasia Battery(P K-WAB). All test items were analyzed in order to extract items with optimal item discrimination and adequate item difficulty indices. From the results, we were able to select some items from each subtest with optimal results of discriminant function analysis for aphasic and normal control groups. It is expected, thus, that information on the item analysis could be utilized in developing a Korean aphasia screening test.

• 대한한방내과학회지
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• 제39권6호
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• pp.1105-1115
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• 2018

Objectives: The aim of this review is to investigate clinical studies on Oriental medicine treatment for aphasia after cerebrovascular disease. Methods: Using the keywords 'Aphasia', 'Oriental medicine', 'Stroke' 'Cerebral infarction', 'Cerebral hemorrhage', and 'Clinic', we searched domestic databases, including "NDSL (National Discovery for Science Leaders)", "Korean Traditional Knowledge Portal", "OASIS (Oriental Medicine Advanced Searching Integrated System)", and "RISS (Research Information Sharing Service)". Each keyword was not searched individually, but combined in various ways. To investigate recent trends, we limited our search to papers published after 2000. Papers that did not include a specific treatment method or did not match the subject "Aphasia after stroke" were excluded. Results: Using the searching method, 13 studies were found. Of these, 12 studies were in the form of case reports, while one was in the form of a non-randomized controlled trial. These studies showed positive results for the use of Oriental medicine in terms of the Korean version of the Western Aphasia Battery (K-WAB), the evaluation form on functional performance capability and accuracy of articulatory organs developed by Lee, aphasia screening test refered in 'Assessment in Speech-Language Pathology' and adapted properly to Korean, the Communicative Ability in Daily Living Test (CADLT), the Korean Version-Boston Naming Test (K-BNT), and language assessment items included in CNS, and NIHSS. Conclusions: Of the 12 case reports, 11 studies showed positive results of the use of Oriental medicine for treatment of aphasia after cerebrovascular disease. However, more sophisticated and large-scale clinical research on aphasia should be conducted.

• 대한한방내과학회지
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• 제41권1호
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• pp.97-110
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• 2020

The purpose of this case study was to report the effectiveness of aphasia in patients with cerebral infarction with hydrocephalus. A patient diagnosed with a middle cerebral artery infarction and hydrocephalus was treated with Gami-cheongeumjowi-tang, acupuncture, and moxibustion. The degree of improvement of symptoms was evaluated using the Korean version of the Frenchay Aphasia Screening Test (K-FAST) and the Mini-Mental State Examination-Korea (MMSE-K). At the time of admission, the K-FAST score was 7 points and the MMSE-K score was 4 points because no words other than 'Yes' could be spoken. At discharge, the K-FAST score was 22 points and the MMSE-K score was 19 points. A particularly noticeable improvement was found in spoken and written comprehension, reading, and repetition. The study findings indicate that Korean medicine treatment can be used to treat the symptoms of patients with aphasia. The periventricular region may be distorted by hydrocephalus, resulting in Broca's aphasia in a cerebral infarction of the middle cerebral artery inferior division.

• 한국콘텐츠학회논문지
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• 제11권9호
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• pp.407-413
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• 2011

뇌졸중 환자의 실어증 유무를 정확히 판별하고 환자의 미세한 언어적 변화를 적절히 관찰하기 위해서는 일차적으로 신뢰로운 검사도구를 사용하여야 하고, 또한 검사자가 해당 도구의 사용에 있어 충분히 숙지하고 있어야 한다. 본 연구에서는 뇌졸중 환자의 실어증 및 말장애 유무의 진단에서 검사자의 전공영역에 따른 관찰자간 신뢰도를 살펴보고 훈련 전과 후의 차이를 비교해보고자 하였다. 이를 위해, 침상에 있는 뇌졸중 환자 46명을 대상으로 언어치료사, 신경과 전공의, 그리고 간호사 각각 4명씩 총 12명이 동시에 실어증 및 말장애 유무를 평가하였다. 연구 결과, 서로 다른 전공 영역의 전문가들 간에 말명료도 과제와/아/모음연장발성 과제의 '음질' 영역에서만 'acceptable'로 나타났고, 나머지 하부검사 영역에서는 'good-excellent'로 나타났다. 관찰자간 신뢰도가 'acceptable'로 나타난 과제들에 대해 3주간의 비디오 훈련 전후의 점수 차이를 비교하였다. 그 결과, 훈련 후 말명료도 과제에서 검사자들 간의 평정 점수의 차이는 유의하게 줄어들었으며, '음질' 평정의 정확성도 유의하게 증가하였다. 임상 경험 정도와 각 하부검사에 대한 평정 정확성 간의 상관관계를 알아본 결과, 언어치료사들은 임상 경험 정도가 증가할수록 그림설명하기 과제와 말명료도 과제에서, 그리고 의사 및 간호사들은 그림설명하기 과제에서 판정 정확도가 높아지는 것으로 나타났다. 결론적으로, 이 연구 결과는 뇌졸중 환자의 의사소통장애 진단에 있어 신경언어장애 환자 중, 특히 말장애환자에 대한 꾸준한 경험과 훈련이 반드시 필요하며, 훈련을 통해 평정 신뢰도를 확보할 수 있음을 시사한다.

• Journal of Genetic Medicine
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• 제17권2호
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• pp.79-82
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• 2020

In epilepsy-aphasia spectrum (EAS) disorders, mutations in the glutamate receptor ionotropic N-methyl-D-aspartate type subunit 2A (GRIN2A) have become important for screening the disease. Research into the phenotypic variability of several types of neurologic impairment involving these mutations is in progress. However, the non-neurological problems related to these mutations are poorly understood. EAS disorders usually have epileptic, cognitive, or behavioral manifestations. In this case report, we present a female patient with epilepsy, delay in expressive language and social development, and intellectual disability with low intelligence quotient and memory quotient, but normal motor development. Through genetic analysis, she was found to have a missense and a nonsense mutation in GRIN2A (c.1770A>C; p.Lys509Asn and c.3187G>T; p.Glu1063∗, respectively) and we consider the nonsense mutation as 'pathogenic variant'. She was also discovered to have congenital hypothyroidism, growth hormone deficiency and Rathke's cleft cyst in the brain, which were previously unknown features of GRIN2A mutation. Our findings should widen understanding of the spectrum of GRIN2A phenotypes, and emphasize the need for more research into the association between GRIN2A mutations and non-neurologic clinical presentations.

• Journal of Yeungnam Medical Science
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• 제27권1호
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• pp.27-36
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• 2010

본 연구에서는 주관적인 기억력 저하를 호소하는 환자의 인지기능 특성에 대해 알아보기 위해, 2005년 3월 1일부터 2009년 5월 31일까지 영남대학교 의료원 건강검진 센터를 방문한 대상자들 중 주관적인 기억력 저하를 호소하는 155명을 대상으로 인지평가참고 진단시스템 (CARDS)을 실행하였다. 대상자 138명 중 정상은 107명(약 78%), 치매 21명(약 15 %), 10명(7 %)은 우울장애, 불안장애, 적응장애 등의 정신과적 환자로 진단되었다. CARDS의 6개 소검사 중 기억력, 실인증, 실어증, 집중력과 계산력, 고위수행 불능증에서는 WNL군에 비해 DEM군, PSY군이 유의하게 낮은 수행을 보였다. 한편, 실행증에서는 DEM군이 PSY군과 WNL군에 비해 낮은 수행을 보였다. 기억력 저하 증상을 호소하는 환자들은 치매 초기와 다른 정신과 질환 이환의 가능성이 있으므로, 민감도가 높은 치매 선별검사와 정신과적 조기 진단이 필요할 것으로 보인다.