• Proceedings of the Korean Society of Disaster Information Conference
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• 2023.11a
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• pp.278-281
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• 2023

연구목적: 본 연구는 요양병원 등 재난취약시설에 재난이 발생할 경우 잔류한 요구조자를 정확하게 파악하여 소방 등 대응기관에 제공하는 APC(Auto People Counting)의 인식률 개선에 목적이 있다. 현재 재난 발생 시 건물 내 요구조자의 현황 파악을 위해 대응기관이 재난 현장에 도착하여 건물관계자에게 직접 물어보고 있다. 이는 요구조자에 대한 부정확한 정보일 가능성이 있어 대응기관의 업무범위가 확대되고 이로인해 구조자의 안전에도 위험이 될 수 있다. APC는 건물내 출입하는 인원을 자동으로 집계하여 실시간 잔류인원 정보를 제공함으로써 재난 시 요구조자 현황을 정확히 파악할 수 있다. 본 연구에서는 APC가 보다 정확하게 출입 인원을 집계할 수 있도록 최적의 인공지능 알고리즘을 선정하는데 목적이 있다. 연구방법: 본 연구에서는 실제 재난취약시설에 설치되어 운영 중인 APC를 대상으로 카메라를 통해 출입 인원의 이미지를 인식하는 알고리즘을 개선하기 위해 CNN모델을 활용하여 베이스라인 모델링을 하였다. 다양한 알고리즘의 성능을 분석하여 상위 7개의 후보군을 선정하고 전이학습 모델을 활용하여 성능이 가장 우수한 최적의 알고리즘을 선정하는 방법으로 연구를 수행하였다. 연구결과: 실험결과 시간과 성능이 가장 좋은 Densenet201, Resnet152v2 모델의 정밀도와 재현율을 확인한 결과 모든 라벨에 대해서 정확도 100%를 나타내는 것을 확인할 수 있었다. 이 중 Densenet201 모델이 더 높은 성능을 보여주었다. 결론: 다양한 인공지능 알고리즘 중 APC에 적용할 수 있는 최적의 알고리즘을 선정하였고 이는 APC의 인식률을 개선하여 재난시 요구조자의 정보를 정확하게 파악하여 신속하고 안전한 구조작업이 가능할 것이다. 이는 요구조자의 안전한 구조뿐만 아니라 구조작업을 수행하는 구조자의 안전을 확보하는 데 기여할 것으로 기대된다. 향후 연무 등 다양한 재난상황에서 재난취약시설 내 출입인원을 정확하게 파악할 수 있도록 알고리즘 분석 및 학습에 대한 추가 연구가 요구된다.

• Proceedings of the Korean Vacuum Society Conference
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• 2016.02a
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• pp.181.2-181.2
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• 2016

OLED 소자는 발광 방향에 따라 Bottom Emission 방식과 Top Emission 방식으로 나뉜다. 이 중 대면적 OLED TV 적용에 개구율이 더 높은 Top Emission방식을 선호하는 추세이다. 높은 개구율을 가진 Top Emission OLED소자를 위해서는 투명하고 전도성이 높은 캐소드가 중요하다. 본 연구에서는 Themal Evaporation 시스템을 이용하여 증착한 $SnO_2/Ag-Pd-Cu(APC)/SnO_2$ hybrid 전극의 특성을 연구하고 Oxide/Metal/Oxide(OMO) hybrid 박막의 bending mechanism을 제시하였다. base pressure는 $1{\times}10^{-6}Torr$로 고정하고 $SnO_2$ 박막은 0.34A / 0.32V, APC 박막은 0.46A / 0.40V의 power로 성막하였다. APC와 $SnO_2$의 두께를 변수로 OMO 전극을 제작하였고 그 전기적, 광학적 특성을 Hall measurement, UV/Visible spectroscopy을 이용하여 분석하고 Figure of merit 값을 바탕으로 최적 두께를 설정하였다. UPS(Ultraviolet Photoelectron Spectroscopy) 분석으로 $SnO_2/APC/SnO_2$ 전극의 일함수을 통해 투명 cathode로 쓰였을 때 $SnO_2$ 층이 buffer layer역할을 함을 확인하였다. XPS(X-ray photoelectron spectroscopy)를 이용하여 정성분석과 정량분석을 하였고 OMO hybrid 전극의 bending mechanism 연구를 위해 다양한 bending test (Inner/Outer dynamic fatigue test, twisting test, rolling test)를 진행하였다. 물리적 힘이 가해진 OMO hybrid 전극의 표면과 구조는 FE-SEM(Field Emission Scanning Electron Microscope) 분석을 통해서 확인할 수 있었다.

• BMB Reports
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• v.50 no.8
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• pp.391-392
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• 2017

Overexpression of mammalian 2-Cys peroxiredoxin (Prx) enzymes is observed in most cancer tissues. Nevertheless, their specific roles in colorectal cancer (CRC) progression has yet to be fully elucidated. Here, a novel molecular mechanism by which PrxII/Tankyrase (TNKS) interaction mediates survival of adenomatous polyposis coli (APC)-mutant CRC cells was explored. In mice with an inactivating APC mutation, a model of spontaneous intestinal tumorigenesis, deletion of PrxII reduced intestinal adenomatous polyposis and thereby increased survival. In APC-mutant human CRC cells, PrxII depletion hindered PARP-dependent Axin1 degradation through TNKS inactivation. $H_2O_2-sensitive$ Cys residues in the zinc-binding domain of TNKS1 was found to be crucial for PARsylation activity. Mechanistically, direct binding of PrxII to ARC4/5 domains of TNKS conferred vital redox protection against oxidative inactivation. As a proof-of-concept experiment, a chemical compound targeting PrxII inhibited the growth of tumors xenografted with APC-mutation-positive CRC cells. Collectively, the results provide evidence revealing a novel redox mechanism for regulating TNKS activity such that physical interaction between PrxII and TNKS promoted survival of APC-mutant colorectal cancer cells by PrxII-dependent antioxidant shielding.

• Korean Journal of Food Science and Technology
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• v.34 no.3
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• pp.380-384
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• 2002

For the screening of gamma-irradiated grains, domestic rice, glutinous rice, barley, and wheat were irradiated with 0.1, 0.3, 0.5, 0.7, and 1.0 kGy and screened using the DEFT/APC (Direct Epifluorescent Filter Technique/Aerobic Plate Count) method. The log DEFT/APT units increased with the dose increment in all samples, whereas the log APC unit decreased gradually. For rice, barley, and wheat, unirradiated and irradiated samples with below 0.3 kGy had 2.0 or lower logarithmic units, whereas those with 0.5 kGy or higher had 2.0 or higher logarithmic units. For glutinous rice, the sample irradiated with 0.5 kGy showed 1.92 logarithmic unit and those with 0.7 kGy or higher had 2.0 or higher logarithmic units. These results suggest that if the grains show 2.0 or higher logarithmic units, they could be assumed to have been irradiated at a dose level of at least 0.5 kGy. In conclusion, grains could be easily screened through the DEFT/APC method.

• Environmental Mutagens and Carcinogens
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• v.8 no.1
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• pp.1-12
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• 1988

The effects of aphidicolin (APC), an inhibitor of DNA polymerase alpha, or 2', 3'-dideoxythymidine 5'-triphosphate (ddTTP), an inhibitor of DNA polymerase beta, on the repair of DNA damage induced by ethyl methanesulfonate (EMS) or bleomycin (BLM) were investigated in Chinese hamster ovary (CHO)-K1 cells. Three assays were employed in this study: unscheduled DNA synthesis, alkaline elution and alkaline sucrose gradient sedimentation. It was shown that APC or ddTTP inhibited DNA induced by EMS, and thus, the post-treatment with APC or ddTTP following EMS treatment was resulted in the more amount of unscheduled DNA synthesis, and the more accumulation of DNA single-stand breaks than the cells post-incubated without APC or ddTTP. While, in the BLM induced DNA repair, only ddTTP inhibited DNA repair induced by BLM. And thus, the groups post-incubated with or without APC after BLM treatment had the same value in the amount of unscheduled DNA synthesis and of DNA single-strand breaks, while post-treatment with ddTTP was resulted in the increased amount of unscheduled DNA synthesis and the increased DNA sin -strand breaks than the group without ddTTP. These results suggested that both of DNA polymerase $\alpha$ and $\beta$ participated in the repair of DNA damage induced by EMS, but in BLM-induced DNA repair, polymerase $\beta$ participated.ipated.

• Journal of KIISE:Computer Systems and Theory
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• v.37 no.3
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• pp.172-183
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• 2010

Virtual memory systems (VM) reduce disk I/Os caused by page faults using page prefetching, which reads pages together with a desired page at a page fault in a single disk I/O. Operating systems including 4.4BSD attempt to prefetch as many pages as possible at a page fault regardless of page access patterns of applications. However, such an approach increases a disk access time taken to service a page fault when a high portion of the prefetched pages is not referenced. More seriously, the approach can cause the memory pollution, a problem that prefetched pages not to be accessed evict another pages that will be referenced soon. To solve these problems, we propose an adaptive page prefetching control scheme (APC), which periodically monitors access patterns of prefetched pages in a process unit. Such a pattern is represented as the ratio of referenced pages among prefetched ones before they are evicted from memory. Then APC uses the ratio to adjust the number of pages that 4.4BSD VM intends to prefetch at a page fault. Thus APC allows 4.4BSD VM to prefetch a proper number of pages to have a better effect on reducing disk I/Os, though page access patterns of an application vary in runtime. The experiment of our technique implemented in FreeBSD 6.2 shows that APC improves the execution times of SOR, SMM, and FFT benchmarks over 4.4BSD VM by up to 57%.

• The Korean Journal of Pesticide Science
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• v.2 no.3
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• pp.79-84
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• 1998

Tandem HPLC and atmospheric pressure chemical ionization(APcI) LC/MS method was used for the determination and confirmation of carbendazim residues in soybean sprout. Fluorescence(FL) detector was connected in tandem with the ultraviolet(UV) detector for dual detection of the carbendazim residue at the excitation and emission wavelength of 280 nm and 310 nm, respectively. The limit of detection for carbendazim was $0.1{\mu}g/kg$ sample. Recoveries of carbendazim from fortified soybean sprout at 0.5, 1.0 and 2.0 ppm were averaged 89.1%. Mass spectrometry using a APcI source confirmed the carbendazim residue in the soybean sprout sample. Fragmentation pattern on the APcI LC/MS spectrum of carbendazim was simpler than that from electron impact(EI) mass spectrum. Carbendazim produced 3 major ions including m/z 133, m/z 159 and m/z 191($M^{+}$). This method was sensitive enough to provide reliable and reproducible results for practical applications.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5101-5104
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• 2012

Background: Genetic mutation is a significant factor in colon CA pathogenesis. Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary disease characterized by multiple colorectal adenomatous polyps affecting a number of cases in the family. This report focuses on a family with attenuated familial adenomatous polyposis (AFAP) with exon 4 mutation, c.481C>T p.Q161X of the APC gene. Methods: We analyzed 20 members of a family with AFAP. Clinical and endoscopic data were collected for phenotype determination. Genetic analysis was also performed by direct sequencing of the APC gene. Result: Five patients with a phenotype of AFAP were found. Endoscopic polyposis was demonstrated among the second generation with genotype mutation of the disease (age > 50 years) consistent with delayed phenotypic adenomatous polyposis in AFAP. APC gene mutation was identified in exon 4 of the APC gene, with mutation points of c.481C>T p.Q161X. Laparoscopic subtotal colectomy was performed to prevent carcinogenesis. Conclusion: A family with attenuated familial adenomatous polyposis of APC related to exon 4 mutation, c.481C>T p.Q161X, was reported and the phenotypic finding was confirmed by endoscopic examination. Genetic mutation analysis might be advantageous in AFAP for long term colon cancer prevention and management due to subtle or asymptomatic phenotype presentation in early adulthood.

• Korean Journal of Construction Engineering and Management
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• v.9 no.3
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• pp.118-125
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• 2008

In Korea, five days per week system, duration reduction bidding system, and post sale system have recently stimulated an interest in productivity improvement in construction project. However, analysis result of productivity in Korean construction industry found that the productivity is too low. APC (Architectural PC) is alternative of reveal wall and parapet in apartment housing prcjects and is used abroad broadly because of duration reduction for productivity improving. APC is used as external curtain wall in Dubai, North America, and Southeast Asia. Therefore, it is proposed that necessary to Introduce APC in Korea. The objective of this study is to draw up introduction of APC in apartment housing projects. We analysed the feasibility of the use of APC. The survey results reported that APC would be able to improve the productivity in the eight productivity factors.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.121-126
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• 2013

Background: Significance of HPV infection and genic mutation of APC and K-ras in rectal cancer has been investigated but not clarified. The objective of our study was to investigate these parameters in patients with rectal cancer to analyze correlations with biological behaviour, to determine relationships among the three, and also to demonstrate survival prognosis effects. Methods: From December 2007 to September 2008, 75 rectal cancer cases confirmed by histopathology in the Tumor Hospital of Xinjiang Medical University were enrolled. The control group consisted of normal rectal mucous membrane taken simultaneously, a least 10 cm distant from the carcinoma fringe. HPV DNA, the MCR of APC and exon-1 of K-ras were detected by PCR and PCR-SSCP. All results were analyzed in relation to clinical pathological material, using chi-square and correlation analysis via SPSS.13 and Fisher's Exact Probability via STATA. 9.0. All 75 patients were followed up for survival analysis using Kaplan-Meier and Log-rank tests. Results: 55 out of 75 cases demonstrated gene HPV L1 while it was notdetected in normal rectal mucosa tissue. HPV infection was correlated with age and lymphatic metastasis (P<0.05) but not other characteristics, such as ethnicity, tumor size, histological type, tumor type, Duke's stage and infiltration depth. Some 43 cases exhibited APC genic mutation (57.3%) and 34 K-ras genic mutation (45.3%). APC genic mutation was correlated with gender(P<0.05), but not age, histological type, infiltration depth, lymphatic metastasis and Duke's stage. In 55 cases of rectal cancer with HPV infection, there were 31 cases with genic mutation of APC (56.4%) and 24 with genic mutation of K-ras (43.6%). For the 20 cases of rectal cancer with non-HPV infection, the figures were 12 cases (60%) and 10 (50.0%), respectively, with no significant relation. Survival analysis showed no statistical significance for K-ras genic mutation, APC genic mutation or HPV infection (P>0.05). However, the survival time of the patients with HPV infection was a little shorter than in cases without HPV infection. Conclusions: Our results suggest that HPV infection might be an important factor to bring about malignant phenotype of rectal cancer and influence prognosis. Genic mutation of APC and K-ras might be common early molecular events of rectal cancer, but without prognostic effects on medium-term or early stage patients with rectal cancer.