• Ocean and Polar Research
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• 제43권4호
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• pp.229-243
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• 2021

Quality control (QC) to process observed time series has become more critical as the types and amount of observed data have increased along with the development of ocean observing sensors and communication technology. International ocean observing institutions have developed and operated automatic QC procedures for these observed time series. In this study, the performance of automated QC procedures proposed by U.S. IOOS (Integrated Ocean Observing System), NDBC (National Data Buy Center), and OOI (Ocean Observatory Initiative) were evaluated for observed time-series particularly from the Yellow and East China Seas by taking advantage of a confusion matrix. We focused on detecting additive outliers (AO) and temporary change outliers (TCO) based on ocean temperature observation from the Ieodo Ocean Research Station (I-ORS) in 2013. Our results present that the IOOS variability check procedure tends to classify normal data as AO or TCO. The NDBC variability check tracks outliers well but also tends to classify a lot of normal data as abnormal, particularly in the case of rapidly fluctuating time-series. The OOI procedure seems to detect the AO and TCO most effectively and the rate of classifying normal data as abnormal is also the lowest among the international checks. However, all three checks need additional scrutiny because they often fail to classify outliers when intermittent observations are performed or as a result of systematic errors, as well as tending to classify normal data as outliers in the case where there is abrupt change in the observed data due to a sensor being located within a sharp boundary between two water masses, which is a common feature in shallow water observations. Therefore, this study underlines the necessity of developing a new QC algorithm for time-series occurring in a shallow sea.

• 한국식품영양과학회지
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• 제45권6호
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• pp.789-796
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• 2016

본 연구에서 고당식이로 비알코올성 지방간을 유도한 마우스의 체중 변화는 대조군보다 백미군, 혼합잡곡군, 항비만혼합잡곡군에서 체중증가율이 낮았고 간 무게 또한 유의적으로 감소했으며, 간 내 조직학적 지방구 수와 크기가 감소한 것을 관찰할 수 있었다. 혈청 지질 수치 역시 개선 효과를 보였는데 모든 실험군이 대조군보다 중성지방, 총콜레스테롤 및 저밀도 콜레스테롤의 농도가 감소하였고, 혈청 고밀도 콜레스테롤은 모두 증가하였다. 간 조직 내 지질합성 및 지방산 침투와 관련 유전자 인자에서 대조군보다 SREBP-1c mRNA 유전자 발현 수준은 백미군, 혼합잡곡군 및 항비만혼합잡곡군에서, ACC 및 FAS mRNA 유전자 발현 수준은 혼합잡곡군과 항비만혼합잡곡군에서, SCD-1 mRNA 유전자 발현 수준은 항비만혼합잡곡군에서 감소하였다. CD36 및 $PPAR-{\gamma}$ mRNA 유전자 발현 수준 또한 대조군보다 백미군, 혼합잡곡군, 항비만혼합잡곡군에서 감소하였다. 간 내 ${\beta}$산화로 지방축적 억제와 관련된 유전자 인자인 $PPAR-{\alpha}$ 및 CPT-1 mRNA 유전자 발현 수준은 대조군보다 혼합잡곡군, 항비만혼합잡곡군에서 증가하였다. 본 실험 결과를 종합해 볼 때 고당식이로 비알코올성 지방간질환을 유도한 마우스에서 백미군, 혼합잡곡군 및 항비만혼합잡곡군 모두 지질 대사 개선 효과가 나타났으며 항비만혼합잡곡군이 가장 효과적이었다.

• Molecules and Cells
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• 제26권5호
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• pp.468-473
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• 2008

Low-density lipoprotein (LDL) induces cell proliferation in human aortic smooth muscle cells (hAoSMCs), which may be involved in atherogenesis and intimal hyperplasia. Recent studies have demonstrated that $Cl^-$ channels are related to vessel cell proliferation induced by a variety of stimuli. In this study, we investigated a potential role of $Cl^-$ channels in the signaling pathway of LDL effects on hAoSMC proliferation with a focus on the activation of Erk1/2-PI3K/Akt and the subsequent upregulation of Egr-1. $Cl^-$ channel blockers, DIDS, but neither NPPB nor Furosemide, completely abolished the LDL-induced DNA synthesis and cell proliferation. Moreover, DIDS, but not NPPB, significantly decreased LDL-stimulated $Cl^-$ concentration, as judged by flow cytometry analysis using MQAE as a $Cl^-$-detection dye. DIDS pretreatment completely abolished the activation of Erk1/2 and PI3K/Akt in a dose-dependent manner that is the hallmark of LDL activation, as judged by Western blot and proliferation assays. Moreover, pretreatment with DIDS ($Cl^-$ channel blockers) but not LY294002 (PI3K inhibitors) completely abolished the LDL-induced upregulation of Egr-1 to the same extent as PD98059 (MEK inhibitors to inhibit Erk), as judged by Western blot and luciferase reporter assays. This is the first report, to our knowledge, that DIDS-sensitive $Cl^-$-channels play a key role in the LDL-induced cell proliferation of hAoSMCs via the activation of Erk1/2 and PI3K/Akt and the upregulation of Egr-1.

• 복식
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• 제50권3호
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• pp.59-72
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• 2000

Dragon robe was defined as a robe on which the principal design consisted of dragon. Dragon patterns have been used on princess robes during T'and Dynasty. In Sung, Dragon-figured robes seem to have an Imperial prerogative. Yuan took over the use of robes with dragons patterns as a definite institition. Ming tried to reject all Yuan innovations, the dragon robe was retained as an unofficial court costume. The Emperor's semiformal robes which at first had four dragon medallions, later had twelve along with the 12 Symbols(십이장문). As Ch'ing dragon robes were only intended fro semiformal use. The Later Ch'ing robes date from after 1719, when the Ch'ien-lung(건륭) introduced 12 Symbols on Ch'ing robes. The Ch'ien-lung laws were disobeyed, notably the ones that specified the number of claws on the dragons. THe Emperor's dragon robe, lung-p'ao, (용포) was described as bright yellow in color, having four slits and horsefoof cuffs. The basic pattern consisted of nin dragons, in addition it had 12 Symbols. The elaborate textile techniques reached their peak in Ch'ing Dynasty-with its Weaving and Dyeing Office in Peking, and this factories at Hangchow(항주), Soochow(소주), and Naking(남경) -helps to explain why the decay of the Ch'ing bureaucracy hastended the decline of dragon robes. In the Ch'ing Dynasty tow terms were used for dragon robe, depending on the number of claws on the dragons. Those with five-clawed dragons were called lung-p'ao, while those with four-clawed dragons were called mang-p'ao(망포). The Court felt compelled to take corrective meausres. It decreeed that Ninisters of State and other officials, who had been bestowed five-clawed lung dragons, must take out one claw. Finally, the sale of ranks and the attendant privilege of wearing dragon robes gradually increased during the 18 th century, reaching its height in the 19 th century, Finally, after the Taiping Rebellion, when the Imperial Treasury was depleted by the wholesale destruction of revenue-producing lands, the Chinese government came to depend on such sales as an important source of revenue and the practice became even more widespread. The ensuing mass production of dragon robes, and the necessity of conforming to the fairly rigid basic pattern established in 1759, resulted in marked deterioration of workmanship, and a comparative monotony of decoration. The patterns on the dragon robes slight changes continued to be made in the ways of representign them. The li shui (입수) portion at the base of the robe become inreasingly wider throughout the 19th century. The background became cluttered with symbols of good fortune, scattered among the clouds and waves. As a result of all this extraneous decoration, the dragons were so crowded that they had to shrink back into the small size that they had originally occupied in the medallons. Kuang-hsu(광저) was a long one, allowing time for the manufacture of numerous robes. Also, it would seem likely that Occidental museums and collections would have a considerable number of his robes, in view of the widespread looting of his palaces during the Allied occupation of Peking in 1900, and the frequent sales of Late Ch'ing imperial textiles by destitute Manchu courtiers in the '20's.

• Journal of Nutrition and Health
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• 제32권5호
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• pp.526-532
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• 1999

The aim of this study was to observe whether the dietary supplementation of docosahexaenoic acid(DHA). In growing rats requires extra supplementation of arachidonic acid(AA) for brain development. Sprague-Dawley rats were divided into three groups, each fed a different diet. In the FO group, dams were fed a DHA-rich FO diet during pregnancy and lactation and pups were fed the same diet until 10 weeks old. In the AO group dams and pups were similarly fed a FO diet after weaning. DHA and AA were most effetively deposited in the developing brain during pregnancy and lactation in rats. However, FO-W pups showed significantly lower level of DHA at 0-3 weeks compared with the FO and AO groups and than slowly increased DHA levels to about 87% of other groups at 10 weeks with the introduction of the FO diet after weaning. The total amount of DNA in whole brain rapidly reached a maximum level at 3 weeks and then was sustained at a constant level after 5 weeks of age. The DNA content was positively correlated with DHA level but not with AA level in the developing brain. DNA content was significantly lower in the FO-W group compared to the FO and AO group at 3 weeks of age. However, the DNA content of brain in FO-W pups increased to 80% of the FO group level at 10 weeks after feeding the FO diet after weaning. The relative percentage of AA in brain lipids was significantly reduced in the early stage of brain development when only DHA was supplemented. However, DHA supplementation had no significant effect on the incorporation of AA when the approximately 35% of LA in the FO diet was substituted by preformed AA. These results suggest that large quantities of DHA could interfere with the normal conversion of LA to AA if LA is not supplemented enough together with DHA. Therefore, high DHA supplementation may require preformed AA in the diet even though AA has no significant correlation with the DNA content in brain. DHA supplementation after weaning also improved the incorporation of DHA into brain and content of DNA even though brain development was almost completed, suggesting that a low level of DHA supplementation without AA addition might be necessary to improve brain development during infancy as well as during pregnancy and lactation.

• 토지주택연구
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• 제15권1호
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• pp.167-177
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• 2024

본 연구에서는 하이드로사이클론, 응결/응집, 용존공기부상 단일 공정이 결합한 실 규모 물순환 조합공정(HCFD)의 오염 지표수 처리 성능을 평가하였다. 실 규모 물순환 공정은 수질 변동이 큰 유입 원수를 대상으로 안정적인 수처리 효율을 보였으며, 유입수의 주요 수질 지표가 매우 나쁨(BOD, TP, COD) 혹은 약간 나쁨(SS)이었으나, 방류수는 매우 좋음(BOD, SS, TP) 혹은 좋음(COD) 수준으로 향상되었다. 물순환 시스템 방류수의 후속 고도 처리를 위해 활성탄 기반 흡착 공정의 용존성 유기물 및 미량오염물질(잔류의약물질 APAP 및 산업 화학물질 AO7) 처리 잠재성을 평가하였다. 오염원 흡착 특성은 흡착동역학 및 등온 흡착실험과 관련된 모델링 기법을 이용하여 관찰하였다. 실험 결과, 후처리 활성탄 흡착은 잔류 유기물, APAP, AO7 유기물에 대한 높은 오염원 제거 잠재성이 있음이 확인되었으며, 오염원 흡착속도 및 최대 흡착량 값은 유사 2차 반응속도 모델과 Langmuir 등온흡착 모델에 의해 결정되었다. 본 연구 결과, 활성탄 기반 흡착 공정은 기존의 물순환 조합공정과 연계시 수처리 효율을 상호 보완적으로 높이고, 흡착 공정은 전단의 입자 분리 공정으로 제거가 어려운 용존성 오염원의 후속 처리에 대한 높은 잠재성이 있음을 시사한다.

• Journal of Astronomy and Space Sciences
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• 제26권4호
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• pp.589-602
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• 2009

조선(朝鮮)의 보천가(步天歌) 가운데 가장 나중인 1862년에 간행된 신법보천가(新法步天歌)를 연구하였다. 청(淸)에서 들어온 신법천문학(新法天文學)의 영향으로 구도보천가(舊圖步天歌)의 성도(星圖)만을 고쳐서 새로 신도보천가(新圖步天歌)를 간행하였다. 그러나 옛 가결(歌訣)이 새로운 성도(星圖)와 맞지 않았고, 이에 따라 천문학자를 뽑는 과거 시험에 혼란이 일어났다. 이것을 극복하고자 조선(朝鮮)의 관상감(觀象監)은, 1845년에 청(淸)에서 간행된 흠정의상고성속편(欽定儀象考成續編)의 권(卷)3인 성도보천가(星圖步天歌)를 전재하고 주석을 달아, 1862년에 신법보천가(新法步天歌)를 출간하였다. 이 책은 중인(中人)인 이준양(李俊養)이 편찬하고 토대부(土大夫)인 남병길(南秉吉)이 교정(校正)하였다. 우리는 이준양(李俊養)의 열대기를 처음으로 재구성하였다. 신법보천가(新法步天歌)에는 기존의 조선(朝鮮) 보천가(步天歌)들이 갖는 특정을 유지하려는 노력이 엿보인다. 즉, 각 숙(宿)의 제목이 기존의 형식을 따르고 있고, 또한 기존의 조선(朝鮮) 보천가(步天歌)들에 천하기몰(天河起沒)이 있음을 의식하고 흠정의상고성속편(欽定儀象考成續編)의 권(卷)31과 권(卷)32의 천한적도경위도표(天漢赤道經緯度表)를 바탕으로 천한계도(天漢界度)를 저술하였다.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2014년도 춘계학술대회 및 임시총회
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• pp.25-25
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• 2014

Koji molds are comprised of yellow, black and white. Black and white koji molds were recently re-visited by this author and it is concluded that they consists of Aspergillus luchuesnsis, A. niger and A. tubingensis, and the most important species for alcoholic beverage production is A. luchuensis. In the case of yellow koji mold, it is comprised of Aspergillus oryzae, A. sojae and A. tamari. In the case of A. sojae, the species is scarcely isolated from nature and rarely used for industry in Korea. Aspergillus tamari is often isolated from traditional Korean Meju, a fermented soybean product, and the classification of the species is clear. However, in the case of A. oryzae, differentiation between A. oryzae and A. flavus is still in controversy. In this study, we collected 415 strains of Aspergillus flavus/oryzae complex from air, rice straw, soybean, corn, peanut, arable soil and Meju in Korea and we examined the aflatoxin producing capacity of the strains. The norB-cypA, omtA and aflR genes in the aflatoxin biosynthesis gene cluster were analyzed. We found that 367 strains (88.4%) belonged to non-aflatoxigenic group (Type I of norB-cypA, IB-L-B-, IC-AO, or IA-L-B- of omtA, and AO type of aflR), and only 48 strains (11.6%) belonged to aflatoxin-producible group (Type II of norB-cypA, IC-L-B+/B- or IC-L-B+ of omtA, and AF type of aflR). In the case of A. flavus/oryzae strains from Meju, almost strains (178/192, 92.7%) belonged to non-aflatoxigenic group and only 14 strains (7.3 %) belonged to aflatoxin-producible group. It is proposed in this study that non-aflatoxigenic strain from Meju is classified as A. oryzae, considering that Meju is food material.

• Bulletin of the Korean Chemical Society
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• 제2권1호
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• pp.12-16
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• 1981

Alkyl and alkenyl substituent effects on nonbonded interactions of hexatriene were examined using CNDO/2 method. The results showed that: (1) rapid rate of thermal electrocyclization of 3-vinyl hexa-1, 3, 5-triene is due to increased overlap population between atom pair reacting resulting from strong electron repelling interaction of vinly group on the triene moiety; (2) stability of a conformer is determined by additive effect of composite ${\pi}$ structures; (3) a substituent on positions 2 and 3 increases the HOMO AO coefficient of sites 1 and 4 considerably and activates interactions with these sites.

• 대한음성학회지:말소리
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• 제19_20호
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• pp.33-42
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• 1990

Those who are interested in the German diphthongs wil1 find that they are classified into three kinds of forms in accordance with their gliding directions: closing, centring and rising. The German [aI], for example, which derives its origin from [i:] of the riddle high German. Is regarded as a distinctive feature that distinguishes the new high German from the middle high German. The diphthong [aI] is cal led fall ing one, because the sonority of the sound undergoes a diminution as the articulation proceeds. The end part of the diphthong [aI] is less sonorous than the beginning part. In most of the German diphthongs the diminution of prominence is caused by the fact that the end part is inherently less sonorous than the beginning. This applies to the other c los Ing and centring diphthongs. This way of diminution of sonority exerts influence on methods of constructing systems of phonetic notation. The above mentioned less sonorous end part of diphthong [I] shows that it differs from some analogous sound in another context. It is useful to demonstrate the occurrence of particular allophones by introducing special symbols to denote them (here: at→ae). Forms of transcription embodying extra symbol s are cal led narrow. But since strict adherence to the principle 'one sound one symbol' would involve the introduction of a large number of symbols, this would render phonetic transcriptions cumbrous and difficult to read. A broad style of transcription provides 'one symbol for each phoneme' of the language that is transcribed. Phonemic transcriptions are simple and unambiguous to everyone who knows the principles governing the use of allophones in the language transcribed. Among those German ways of transcriptions of diphthongs ( a?, a?, ??: ae, ao, ?ø; ae, ao, ?ø) the phonemic (broad) transcription is general Iy to be recommended, for Instance, in teaching the pronunciation of a foreign language, since it combines accuracy with the greatest measure of simplicity (Some passages and terms from Daniel Jones) .