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Effectiveness of the Shugan Jieyu Capsule against Psychiatric Symptoms in Epilepsy: a protocol for systematic review and meta-analysis

  • Sejin Kim;Yunna Kim;Seung-Hun Cho
    • Journal of Pharmacopuncture
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    • v.26 no.1
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    • pp.38-43
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    • 2023
  • Objectives: Psychiatric symptoms in epilepsy are very common, and the most common symptoms are depression, insomnia, and anxiety. These symptoms not only lower the quality of life of epilepsy patients, but also elevate the risk of epileptic seizures. There are no specific criteria for the available antiepileptic drugs to ameliorate these symptoms in patients with epilepsy, and there is a lack of evidence to support the efficacy and safety of existing drugs. The Shugan Jieyu capsule (SJC) is a traditional herbal medicine composed of Acanthopanax senticosus and Hypericum perforatum and is reported to be effective in relieving psychiatric symptoms. The purpose of this study was to assess the efficacy of SJC as a treatment for psychiatric symptoms in epilepsy patients. Methods: Electronic databases will be investigated for publications in English, Korean, Japanese, and Chinese. The participants of the study are epilepsy patients with psychiatric symptoms diagnosed using any validated criteria. All types of controls will be compared-placebo, conventional treatments, and no treatment-to groups treated with SJC or modified SJC. We will measure the degree of improvement in psychiatric symptoms and check epileptic symptoms, such as the frequency of seizures. The study selection and data extraction will be performed by two independent reviewers, who will also assess methodological quality using the risk-of-bias tool by Cochrane. We will use Review Manager software (RevMan) to carry out all statistical analyses. Results: This systematic review and meta-analysis will be performed in accordance with the PRISMA-P statement. Conclusion: This systematic review is the first study to assess the efficacy and safety of SJC for the treatment of psychiatric symptoms in epilepsy. We expect that this study will provide clinically applicable evidence for patients with epilepsy when selecting drug treatments.

Effect of fineness of high lime fly ash on pozzolanic reactivity and ASR mitigation

  • Afshinnia, Kaveh;Rangaraju, Prasada R.
    • Computers and Concrete
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    • v.20 no.2
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    • pp.197-204
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    • 2017
  • Typically, high lime fly ash (Class C) has been characterized as a fly ash, which at lower replacement levels is not as effective as the low lime (Class F) fly ash, in mitigating alkali-silica reaction (ASR) in portland cement concrete. The influence of fineness of Class C, obtained by grinding virgin fly ash into finer particles, on its pozzolanic reactivity and ASR mitigation performance was investigated in this study. In order to assess the pozzolanic reactivity of mortar mixtures containing virgin or ground fly ashes, the strength activity index (SAI) test and thermo-gravimetric analysis (TGA) were conducted on the mortar cubes and paste samples, respectively, containing virgin fly ash or two ground fly ashes. In addition, to evaluate any improvement in the ASR mitigation of ground fly ashes compared to that of the virgin fly ash, the accelerated mortar bar test (AMBT) was conducted on the mortar mixtures containing different dosages of either virgin or ground fly ashes. In all tests crushed glass aggregate was used as a highly reactive aggregate. Results from this study showed that the finest fly ash (i.e., with an average particle size of 3.1 microns) could increase the flow ability along with the pozzolanic reactivity of the mortar mixture. However, results from this study suggested that the fineness of high lime fly ash does not seem to have any significant effect on ASR mitigation.

A Study of Modular Architecture's Design to Dwelling Environment in Antarctica (극한지 모듈러 건축물의 설계, 시공 및 거주환경에 대한 연구)

  • Lee, Won-Hak;Song, Young-Hak;Lim, Seok-Ho
    • Journal of the Korean housing association
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    • v.25 no.2
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    • pp.11-18
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    • 2014
  • This study looked at designing, building and operating temporary camp, the first structures that South Korea built in the Antarctica. While there may be differences in accordance with the topography, ground surfaces in the Antarctica are covered broken stones, glaciers and snow. Hence, such topographical characteristics should be taken into account when conducting any construction work. To ensure successful assembly construction in the Antarctica using modules, prior trial assembly work should be done in Korea to identify any possible trouble in the actual construction process. Assuming that the workers will have to spend at least one winter in the temporary camp, the work will be more severely affected by adverse weather conditions and snow drift, resulting in the need to clear snow. This can be by designing roofs with curved surfaces. Also, quantitative effects will need to be verified through simulation and actual measurement. It will also be necessary to assess the camp's thermal environment and examine its air-conditioning methods. To identify the temporary camp's thermal system, the temperatures and humidities were measured, and the heating system was designed not to offer automatic control or desired value selection functions.

Clinical Features of the Midgut Volvulus in Children (소아 중장 염전의 임상 양상)

  • Kim, Hyun-Ah;Choi, Kum-Ja
    • Advances in pediatric surgery
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    • v.10 no.2
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    • pp.112-116
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    • 2004
  • Midgut volvulus secondary to intestinal malrotation usually presents within the first month of life. Diagnostic delay may result in midgut infarction and mortality. In this retrospective study, we review seventeen cases of midgut volvulus to assess the importance of early recognition for midgut volvulus in pediatric patients of any age.. These patients were diagnosed as having a midgut volvulus by operation at Ewha Womans University Hospital. Eleven patients (64.7 %) were less than 1 month of age, and fifteen were boys (88.2 %). The mean gestational age was 38.3 weeks and the birth weight was 3.1 kg. Eight patients (47.1 %) had one or more combined anomalies such as heart malformation, brain ischemia, Down's syndrome or duodenal atresia. Vomiting was the most common symptom. Only thirteen patients underwent preoperative diagnostic procedures; 13 abdominal sonography demonstrated the whirlpool sign in 8 patients, upper gastrointestinal tract roentgenography showed a cork-screw pattern in 7 patients, and barium enema or small bowel series demonstrated positive findings in 7 patients. A Ladd's procedure was was formed on all patients.. There was no mortality or severe morbidity such as short bowel syndrome. Midgut volvulus should be included in the differential diagnosis in any infant or child who presents with the symptoms of acute abdomen, especially with vomiting.

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Pattern of Tobacco Use and its Correlates among Older Adults in India

  • Mini, G.K.;Sarma, P.S.;Thankappan, K.R.
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.15
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    • pp.6195-6198
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    • 2014
  • Purpose: We examined tobacco use pattern and its correlates among older adults. Materials and Methods: We used data of 9,852 older adults (${\geq}60$ years) (men 47% mean age 68 years) collected by the United Nations Population Fund on Ageing from seven Indian states. Logistic regression analysis was used to assess the correlates of tobacco use. Results: Current use of any form of tobacco was reported by 27.8% (men 37.9%, women 18.8%); 9.2% reported only smoking tobacco, 16.9% smokeless tobacco only and 1.7% used both forms. Alcohol users (OR:5.20, 95% CI:4.06-6.66), men (OR:2.92, CI :2.71-3.47), those reporting lower income (OR:2.74, CI:2.16-3.46), rural residents (OR 1.34, CI 1.17-1.54) and lower castes (OR:1.29, CI:1.13-1.47) were more likely to use any form of tobacco compared to their counterparts. Conclusions: Tobacco cessation interventions are warranted in this population focusing on alcohol users, men, those from lower income, rural residents and those belonging to a lower caste.

An integrated structural health monitoring system for the Xijiang high-speed railway arch bridge

  • He, Xu-hui;Shi, Kang;Wu, Teng
    • Smart Structures and Systems
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    • v.21 no.5
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    • pp.611-621
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    • 2018
  • Compared with the highway bridges, the relatively higher requirement on the safety and comfort of vehicle makes the high-speed railway (HSR) bridges need to present enhanced dynamic performance. To this end, installing a health monitor system (HMS) on selected key HSR bridges has been widely applied. Typically, the HSR takes fully enclosed operation model and its skylight time is very short, which means that it is not easy to operate the acquisition devices and download data on site. However, current HMS usually involves manual operations, which makes it inconvenient to be used for the HSR. Hence, a HMS named DASP-MTS (Data Acquisition and Signal Processing - Monitoring Test System) that integrates the internet, cloud computing (CC) and virtual instrument (VI) techniques, is developed in this study. DASP-MTS can realize data acquisition and transmission automatically. Furthermore, the acquired data can be timely shared with experts from various locations to deal with the unexpected events. The system works in a Browser/Server frame so that users at any places can obtain real-time data and assess the health situation without installing any software. The developed integrated HMS has been applied to the Xijiang high-speed railway arch bridge. Preliminary analysis results are presented to demonstrate the efficacy of the DASP-MTS as applied to the HSR bridges. This study will provide a reference to design the HMS for other similar bridges.

Methylenetetrahydrofolate Reductase C677T Polymorphism and Cervical Cancer Risk: a Meta-Analysis

  • Guo, Li-Na
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.5
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    • pp.2193-2197
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    • 2012
  • Background: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, and the role of MTHFR C677T polymorphism in cervical carcinogenesis is still controversial. Method: We performed a meta-analysis of all relevant case-control studies that examined any association between the C677T polymorphism and cervical cancer risk. We estimated summary odds ratios (ORs) with their confidence intervals (CIs) to assess links. Results: Finally, 10 studies with a total of 2113 cervical cancer cases and 2804 controls were included. Results from this meta-analysis showed that significantly elevated cervical cancer risk was associated with the MTHFR T allele in the Asian population under conditions of two genetic comparison models (for TT vs. CC, OR = 1.37, 95%CI 1.00-1.87, P = 0.050; for TT vs. TC+CC: OR = 1.34, 95%CI 1.01-1.77, P = 0.039). However, there was no obvious association between the MTHFR C677T polymorphism and cervical cancer risk in the other populations. Conclusion: The MTHFR C677T polymorphism is associated with cervical cancer risk in Asians, while any possible link in the Caucasian population needs further studies.

Association of Cyclin D1 Variants with Head and Neck Cancer Susceptibility: Evidence from a Meta-analysis

  • Lin, Hai;Fang, Lian;Lin, Dong
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.14
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    • pp.5645-5651
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    • 2014
  • Whether cyclin D1 (CCND1) gene variants increase susceptibility to head and neck cancer (HNC) is undetermined. Therefore, we performed the present meta-analysis to systematically assess any possible association between CCND1 variants (G870A and G1722C) and HNC risk. Seventeen studies for CCND1 G870A and three studies for CCND1 G1722C were included. Overall, CCND1 polymorphisms (G870A and G1722C) had no association with increased HNC risk (p>0.05). In the subgroup analysis by smoking status, significantly increased HNC risk was found among smokers under allele contrast, homozygous comparison and recessive models (p<0.05), smoking carriers of A allele and AA genotype appearing at elevated risk. In conclusion, while there was overall a lack of any association between CCND1 polymorphisms (G870A and G1722C) and HNC risk, smokers carrying the A allele and AA genotype of the CCND1 G870A polymorphism may be susceptible to HNC development.

THE EFFECTS OF WAVELENGTH AND INTENSITY OF VISIBLE LIGHT ON THE CURING OF VISIBLE LIGHT CURED COMPOSITE RESIN (가시광선의 파장과 광도가 광중합형 복합레진의 경화에 미치는 영향)

  • Lee, Chae-Gyeong;Hur, Bok
    • Restorative Dentistry and Endodontics
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    • v.14 no.1
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    • pp.149-159
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    • 1989
  • The purpose of this study was to assess the effects of wavelength and intensity of light curing units on the curing of composite resin. The wavelength and intensity of nine units were evaluated with Optical Multichannel Analyzer and Radiometer. Two-part split stainless steel mold with a cylindrical hole-3.0mm in diameter, 6.0mm in hgieht-was prepared. After placing a Mylar strip between two parts, 100 specimens were made by inserting each of four composite resins into the mold and irradiating for 20 seconds with five light units alternatively. The curing depths were measured by scraping method and evaluated by two-way ANOVA. And Vicker's hardness measurements were made on the longitudinally sectioned surface at 0.5mm interval. The results were as follows: 1. Visilux 2 showed a narrow spectral band within the effective wavelength in initiating polymerization and the highest intensity. Translux showed the diffuse spectrum of wavelength and the lower light intensity. 2. Visilux 2 showed the highest curing effect in any composite resin and then followed by Optilux, Efos 35, Heliomat and Translux. (p < 0.01) 3. Durafill showed the deepest curing depth in any light unit and then followed by Bisfil M, Silux and Heliosit. (p < 0.01). 4. Maximum hardness values showed 0.1mm and 0.5mm under top surface and then gradually decreased with depth.

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Exploring Teachers' Pedagogical Design Capacity: How Mathematics Teachers Plan and Design Their Mathematics Lessons (수업지도안 분석을 통한 수학교사의 수업설계역량(Pedagogical Design Capacity) 탐색)

  • Kim, Gooyeon;Jeon, MiHyun
    • The Mathematical Education
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    • v.56 no.4
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    • pp.365-385
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    • 2017
  • This study aims to explore mathematics teachers' pedagogical design capacity. For this purpose, we googled and collected 327 lesson plans for middle-school mathematics and investigated how mathematics teachers plan and design their mathematics lessons through the format and structures, objectives and mathematical tasks, anticipation for students' thinking, and assessment and technology use. The findings from the data analysis suggest as follows: a) all the lesson plans are structured in a very similar way; b) the lesson plans seem to be based on the textbooks exclusively, that is, the mathematical tasks and flow is strictly followed and kept in the lesson plans in the way the textbooks suggested; c) the lesson plans do not include any evidence of what teachers anticipate for students' thinking and would do to resolve the students' issues; and d) the lesson plans do not contain any specific plans to assess students' thinking processes and reasoning qualitatively, and not intend to use technology in order to promote effective teaching and meaningful understanding.