• International Journal of Industrial Entomology and Biomaterials
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• v.15 no.1
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• pp.9-16
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• 2007

The present study was aimed to screen different antibiotics in vivo for their effects against the bacterium Bacillus coagulans in silkworm Bombyx mori in three experimental conditions viz., a) healthy larvae treated with the antibiotics b) larvae which were first inoculated with Bacillus coagulans immediately after the $2^{nd}$ moult and treated with the antibiotics from 24 hour after inoculation up to the end of the $5^{th}$ instar(pre-inoculated larvae) and c) larvae which were treated with the antibiotics right from hatching up to the end of the $5^{th}$ instar and inoculated with Bacillus coagulans immediately after the $2^{nd}$ moult(post-inoculated larvae). All the antibiotics used in this study stimulated better performance in improving the rearing performance and economic characters of the cocoons in healthy, pre-inoculated and post-inoculated larvae, besides reducing the mortality of infected larvae. Cephelexin and Tetracycline were more effective than the others in their overall performance under all the three experimental conditions. Chloramphenical caused greater increase in the length of the reelable silk filament, but was not as good in elevating the other parameters compared to the remaining antibiotics. Of the four concentrations of antibiotics tested, 2.0% performed better under all the three experimental conditions.

• Journal of Radiation Industry
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• v.4 no.1
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• pp.39-45
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• 2010

The pollution of antibiotics is a major cause of spreading antibiotics resistant bacteria in the environment. Applications of ozonation, UV, and ${\gamma}-ray$ irradiations have been introduced to remove antibiotics in the effluents from wastewater treatment system. In this study, we compared the chemical (HPLC) and biological (antimicrobial susceptibility test, AMS) assays in measuring of the concentrations of residual antibiotics after ${\gamma}-ray$ and UV irradiation. Most samples were degraded by ${\gamma}-ray$ irradiation (1~2 kGy). However, lincomycin and tetracycline were not degraded by UV irradiation. The concentration of residual antibiotics, that was treated with ${\gamma}-ray$ and UV irradiation, measuring by bioassay was similar to HPLC. The concentrations of ${\gamma}-ray$ irradiated cephradine measured by AMS test were 2 times higher than that of HPLC assay, indicating AMS test is more sensitive than HPLC assay. These results indicate that ${\gamma}-ray$ irradiation technique is more useful than UV irradiation, and biological assay is more useful to detect the antibiotics and toxic intermediates in antibiotics degradation.

• Korean Journal of Poultry Science
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• v.36 no.3
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• pp.223-229
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• 2009

The objective of this study was to investigate the effect of the supplementation of antibiotics on meat quality grade of broiler carcasses under the Korean meat grading system. A total of 34,000 broiler carcasses, which were randomly selected 100 broilers from each farm in 340 broiler farms (305 farms with antibiotics; 35 farms without antibiotics), were used in this study. Average daily weight gain of broilers was not significantly affected by the use of antibiotics. The ratio of quality grade A was higher in the broiler carcasses from the farms with antibiotics supplementation (78.87%) than those without antibiotics (73.46%, P<0.05). The numbers of carcass defects, which are down-grade factors of meat grading system, were much higher in the broiler carcasses produced from the farms without antibiotics supplementation when compared with those with antibiotics. In particular, the incidence of the carcass defect on conformation was approximately 1.8 times higher in the carcasses from the farms without antibiotics supplementation than those with antibiotics, which showed the highest negative correlation with quality grade A. Therefore, the improvement of farm management system, the use of antibiotics alternatives from natural products, and a proper incentive should be considered in various ways to encourage farmers to reduce antibiotics usage in their farm and earn consumers' trust for antibiotics-free products.

• Korean Journal of Organic Agriculture
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• v.9 no.4
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• pp.135-148
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• 2001

Antibiotics supplementation in animal feeds results in bacterial resistance to the antibiotics and residue of the antibiotics in animal products, which can cause serious problems in human health. Therefore, the finding of new substances replacing antibiotics are needed. New substances are egg york antibody, probiotics, organic acid, mannanoligosaccharide(MOS), fructooligosaccharide(FOS), and chitosan etc. Egg york antibody is antibody to obtain from egg york of the chicken injected the specific antigen. Probiotics can prevent the problems of residue of the antibiotics and resistance to the antibiotics. Organic acids ctrl preservation of colostrum inhibit the rottenness and increase the beneficial bacteria. MOS and FOS increase the beneficial bacteria, too. Chitosan is used the immune material to active the anti-bacteria.

• YAKHAK HOEJI
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• v.39 no.2
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• pp.131-136
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• 1995

Clinically isolated bacterial strains resistant to almost of all the clinically superior .betha.-lactam antibiotics can be used to screen the promising ones among the newly synthesized $\beta$-lactam antibiotics. To select the resistant strains, the susceptibility of 389 strains of S. aureus, 144 strains of coagulase negative staphylococci, 509 strains of E. coli, 115 strains of E. cloacae and 187 strains of P. aeruginosa to methicillin, ampicillin, piperacillin and gentamicin was determined. The susceptibility of 19 bacterial strains selected through the first screening to cefixime, cefotiam, cefotaxime, flomoxef, cepfirome, cefdnir, SCE-2787, panipenem and imipenem was determined. Four strains of S. aureus finally selected have high degree of resistance to almost of all $\beta$-lactam antibiotics used and also produce $\beta$-lactamases. These 4 strains of S. aurues can be used to screen effectively the promising $\beta$-lactam antibiotics among the numerous numbers of the newly synthesized $\beta$-lactam antibiotics.

• Journal of Korean Neurosurgical Society
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• v.62 no.4
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• pp.487-491
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• 2019

Conservative therapy with appropriate antibiotics is essential for most patients with infectious spondylitis. Although most antibiotics do not cause problems if it used properly and serious side effects are rare, side effects can occur with any class of drugs and adverse reactions of antibiotics can range from mild allergic reactions to serious and fulminant adverse events. These side effects are also extremely variable from patient to patient and from antibiotic to antibiotic. A side effect of antibiotics may paradoxically increase inflammatory marker levels. Here, the author presents two cases of antibiotic-induced increase in inflammatory markers in cured infectious spondylitis. The patients were successfully treated after stopping the antibiotic therapy. The differential diagnosis between antibiotic side effects and infection should be considered very carefully because the treatment is completely different. Although the exact mechanisms underlying successful treatment without antibiotics are unclear, we should consider the side effects of antibiotics when following inflammatory markers during treatment of infectious spondylitis.

• Proceedings of the PSK Conference
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• 2001.04a
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• pp.180.3-181
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• 2001

• The Plant Pathology Journal
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• v.17 no.6
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• pp.363.4-363
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• 2001

• Korean Journal of Soil Science and Fertilizer
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• v.43 no.5
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• pp.734-740
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• 2010

Overuse of veterinary antibiotics threats public health and surrounding environment due to the occurrence of antibiotic resistant bacteria. The objective of this study was to evaluate the antibiotic's concentrations of tetracycline (TC), chlortetracycline (CTC), and oxytetracycline (OTC) in a tetracycline group (TCs), sulfamethazine (SMT), sulfamethoxazole (SMX), and sulfathiazole (STZ) in a sulfonamide group, lasalocid (LSL), monensin (MNS), and salinomycin (SLM) in a ionophore (IPs), and tylosin (TYL) in a macrolide (MLs) group from soil, water, and sediment samples adjacent to a cattle manure composting facility. For all samples of soil, water, and sediment, the highest concentrations were detected in TCs among the tested antibiotics because of its higher annual consumption in veterinary farms, Korea and its higher cohesiveness with divalent or trivalent cations in soil. Moreover, the concentrations of residual antibiotics in September were generally higher than in June because of heavier rainfall in June. We suggest that continual monitoring and developing guideline of antibiotics are needed to control residual antibiotics in the environment.

• Journal of Life Science
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• v.9 no.3
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• pp.241-247
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• 1999

Antibiotics have been routinely used to control the disease of farm-raised animals in the aquaculture facilities without any criterion based on a pharmacokinetic study. This lack of information on the effective usage of antibiotics would have brought the farmers to use excessive and/or less dosages, causing the advent of drug-resistant bacteria as well as economic loss and possible contamination of the local farming area. Until recently, few studies on a detailed manual for the antibiotic usage including chemotherapy procedure, dosage, and treatment schedule of the aquatic antibiotics have been conducted throughout the world. To the worse, there is no available criterion for optimal usage of aquatic antibiotics to control diseases in aquatic farms in this country because every country has its own aquacultural system. Therefore, based on the previous studies on the usage of the various antibiotics, our studies are to focus on the development of optimal method for the detection of various antibiotics on the fate of antibiotics applied to the fish, including absorption, circulation, and secretion physiology. Pharmacokinetic study were to sep up the optimal detective condition against residual antibiotics of fish by HPLC. The grinding pefloxacin for 15 min is most effective in dissolution test and pharmacokinetic parameters. Pharmacokinetic parameters were satisfactory for 15 min-grinding products and they can be explained as one-compartment model.