• Title/Summary/Keyword: Antibacterialo Stille coupling

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An Efficient Synthesis of 3-(E)-Hydroxypropenyl Cephem Derivatives, Key intermediates for 3-(E)-Ammoniopro-penylcephalosporing Antibiotics

  • Lee, Yong-Sup;Lee, Jae-Yeol;Jeong, Jin-Hyun;Park, Hokoon
    • Archives of Pharmacal Research
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    • v.20 no.3
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    • pp.288-290
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    • 1997

  • An efficient synthesis of 3-(E)-hydroxy- and 3-(E)-acetoxypropenylcephem derivatives, key intermediates for the synthesis of 3-(E)-propenylcephalosporins was achieved via Stille coupling reaction of 3-trifloxycephem with 3-(E)-tributylstannylallylic alcohol.

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