• Journal of the Korea Institute of Military Science and Technology
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• v.17 no.4
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• pp.551-559
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• 2014

The influence of the battle damage hole on the velocity and vorticity flow field have been studied by using particle image velocimetry. Time averaged velocity and vorticity vector fields in the vicinity of jet are presented. The perforated damage hole on a wing created from a hit by anti-air artillery was modeled as a 10% chord size hole which positioned at quarter chord. At low angles of attack, the vorticity in the forward side of the jet is cancelled due to mixing with the wing surface boundary layer. Stretching of vorticity in the backside of the jet generates a semi-cylindrical vortical layer that enclosing a domain with slow moving reverse flow. Conversely, at higher the angles of attack, the jet vorticity advected away from the wing surface and remains mostly confined to the jet. The mean flow behind the jet has a wake-like structure.

• Korean Journal of Clinical Pharmacy
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• v.16 no.1
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• pp.23-27
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• 2006

Doxorubicin (DXR) is a type of anti-cancer drug called an 'anthracycline glycoside', It works by impairing DNA synthesis, a crucial feature of cell division, and thus is able to target rapidly dividing cells. Doxorubicin is a very serious anti-cancer medication with definite potential to do great harm as well as great good. A liquid chromatography-tandem mass spectroscopy (LC-MS/MS) method was developed to identify and quantify DXR in small-volume biological samples. After the addition of internal standard (IS, $5{\mu}L\;of\;1{\mu}M/ml$ daunorubicin methanol solution) into the serum sample, the drug and IS were extracted by methanol. Following vortex for a 1min and centrifugation at 15,000g for 10 min the organic phase was transferred and evaporated under a vacuum. The residue was reconstituted with $350{\mu}L$ of mobile phase and $10{\mu}L$ was injected into C18 column with mobile phase composed of 0.05M ammonium acetate (0.1 M acetic acid adjusted to pH 3.5) and acetonitrile (40:60, v/v). The flow rate was kept constant at $350{\mu}L/min$. The ions were quantified in the multiple reaction mode (MRM), using positive ions, on a triple quadrupole mass spectrometer. The lower limits of quantification for Doxorubicin in plasma and small tissues were approximately 0.5 ng/mL and 0.5 ng/mL respectively. Intra- and inter-assay accuracy (% of nominal concentration) and precision (% CV) for all analytes were within 15%, respectively.