• Genomics & Informatics
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• v.21 no.3
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• pp.43.1-43.13
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• 2023

Melanin is synthesized by tyrosinase to protect the skin from ultraviolet light. However, overproduction and accumulation of melanin can result in hyperpigmentation and skin melanoma. Tyrosinase inhibitors are commonly used in the treatment of hyperpigmentation. Natural tyrosinase inhibitors are often favoured over synthetic ones due to the potential side effects of the latter, which can include skin irritation, allergies, and other adverse reactions. Nuciferine, an alkaloid derived from Nelumbo nucifera, exhibits potent antioxidant and anti-proliferative properties. This study focused on the in silico screening of nuciferine for anti-tyrosinase activity, using kojic acid, ascorbic acid, and resorcinol as standards. The tyrosinase protein target was selected through homology modeling. The residues of the substrate binding pocket and active site pockets were identified for the purposes of grid box optimization and docking. Therefore, nuciferine is a potent natural tyrosinase inhibitor and shows promising potential for application in the treatment of hyperpigmentation and skin melanoma.

• Asian-Australasian Journal of Animal Sciences
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• v.2 no.3
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• pp.181-182
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• 1989

• Proceedings of the Korean Society of Food Hygiene and Safety Conference
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• 2005.11a
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• pp.21-70
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• 2005

• Proceedings of the Korea Water Resources Association Conference
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• 2005.09b
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• pp.1332-1332
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• 2005

• Bulletin of the Korean Chemical Society
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• v.34 no.11
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• pp.3491-3494
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• 2013

• Bulletin of the Korean Chemical Society
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• v.33 no.12
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• pp.4277-4279
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• 2012

• Korean Journal of Radiology
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• v.22 no.3
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• pp.489-491
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• 2021

• Journal of Electrical Engineering and Technology
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• v.12 no.1
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• pp.161-172
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• 2017

In the paper, a hybrid technique is proposed for detecting the location and capacity of distributed generation (DG) sources like wind and photovoltaic (PV) in power system. The novelty of the proposed method is the combined performance of both the Biography Based Optimization (BBO) and Particle Swarm Optimization (PSO) techniques. The mentioned techniques are the optimization techniques, which are used for optimizing the optimum location and capacity of the DG sources for radial distribution network. Initially, the Artificial Neural Network (ANN) is applied to obtain the available capacity of DG sources like wind and PV for 24 hours. The BBO algorithm requires radial distribution network voltage, real and power loss for determining the optimum location and capacity of the DG. Here, the BBO input parameters are classified into sub parameters and allowed as the PSO algorithm optimization process. The PSO synthesis the problem and develops the sub solution with the help of sub parameters. The BBO migration and mutation process is applied for the sub solution of PSO for identifying the optimum location and capacity of DG. For the analysis of the proposed method, the test case is considered. The IEEE standard bench mark 33 bus system is utilized for analyzing the effectiveness of the proposed method. Then the proposed technique is implemented in the MATLAB/simulink platform and the effectiveness is analyzed by comparing it with the BBO and PSO techniques. The comparison results demonstrate the superiority of the proposed approach and confirm its potential to solve the problem.

• Korean journal of communication and information
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• v.76
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• pp.7-30
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• 2016

The purpose of this study is to review and criticize the articles that analyzed Frozen by using the semiotic method of Greimas. The study also aims to apply the semiotic method of Greimas correctly to find the deep structure of the narrative of Frozen. The results of the narrative analysis based on the actantial model and the semiotic square show that Frozen is not Elsa's heroic narrative but Anna's one. Because Elsa and Anna are the opposing elements in this narrative, the success of Anna is the failure of Elsa. Frozen does not convey the subversive message about the gender roles by representing an independent and active woman who resists the patriarchal discourse. Instead, Frozen reproduces the conformist ideology by saying that love is the most valuable thing and that everyone should accept the role given to him/her by the community.

• The Journal of the Korea Contents Association
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• v.15 no.7
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• pp.643-654
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• 2015

The purpose of this study is to examine the implications of religious activities to longevity in a perspective of religious people in the ancient near east. The major sources of the study are the records of Adad-Guppi in the Neo-Babylonian Empire, prayers of Daniel in the Old Testament and records of Anna in the New Testament. The research method is a synchronic method based on final forms of the texts. Adad-Guppi lived for 104 years with temple-centered lives, fasting-like dedication, prayer and mission for the nation. Daniel fasted and prayed for the return of Jewish nation, and restoration of the city and the temple in Jerusalem, resulting in longevity of late eighties in the court of Babylon. Anna lived for more than 100 years old with her life mission for the messiah in spite of limitations of her times as an old widow. The implications of religious activities with temple-centered lives, fasting, prayer, and mission for the ages are understood to be beneficial to longevity in a perspective of the ancient near east.