• 생약학회지
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• 제48권1호
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• pp.10-17
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• 2017

Ursi Fel's component ursodeoxycholic acid (UDCA), a traditional medicine, is used for the treatment of hepatic diseases. UDCA derivatives prepared by conjugation with antioxidant moiety such as maltol, sesamol, eugenol, mesitol and 3,4-(methylenedeoxy)aniline were expected to have various biological activity caused by synergistic effect of UDCA. Therefore, in this study, it was conducted the study of the manufacture of the UDCA derivatives and their biological activity. As a result, UDCA derivatives showed weak antioxidant activity in TBA method in vitro compared to original agents. SJ-505, SJ-502 and SJ-504 showed the effect of reducing ALT, AST, sorbitol dehydrogenase and ${\gamma}-glutamyltransferase$ in $CCl_4-induced$ liver injury experiment in vivo, even if the effects are weaker than UDCA and silymarin of the control group.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2007년도 춘계학술대회
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• pp.320-322
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• 2007

A new binder-free $TiO_{2}$ paste was prepared by common ion applying effect, enabling low temperature fabrication required for flexible solar cells. The binder-free and high viscosity $TiO_{2}$ coating solution was produced by adding 7.5% aniline in $TiO_{2}$ colloid solution obtained from the high pressure water-heat response method. The resulting pastes had high level of viscosities proper for optimal coating and thus revealed excellent performances in terms of thickness uniformity and I-V characteristics.

• 대한물리치료과학회지
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• 제8권2호
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• pp.1091-1097
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• 2001

The main experiments was investigated the skin tissue damage changing for the skin bum having influence on the skin and the liver and also observed the radical liver weight, ALT in the serum, the fluctuating of AST for the skin bum causing to the liver damage. Anatomically the edema formation of skin after thermal injury was showed, and skin bum increased liver weight (% of body weight, p<0.05) and the activity of serum aniline aminotrasferase (p<0.05), and also histologically induced wes of epidermal layer, protein degeneration of connective tissue, local hemorrhage and degeneration of glandular epithelium in the skin tissue. Liver tissue showed the evidences of postbum damage, they were sinusoidal dilatation, cell swelling, infiltration of inflammatory cells.

• Elastomers and Composites
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• 제12권1호
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• pp.27-32
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• 1977

The kinetics of azo-coupling reaction of N-acetyl-H-acid (1-acetamino-8-hydroxynaphthalene-3, 6-disulfonic acid) with several heterocyclic diasonium compounds such as diazotiged 3-aminopyridine, 3-aminoquinoline, 8-aminoauinoline and aniline was studied. It was found that reactions proceeded at remarkably different rate. Reaction rate was in increasing order; 3-aminopyridine, 3-aminoquinoline, 8-aminoauinoline and aniline. And the activation energies were 9.62, 10.10, 10.39, 10.70 Kcal/mole, respectively. Especially, the rate constant of 3-aminopyridine was 100 times larger than that of benzene diasonium compound even in strong acidity. Hammett plot was also made of the rate constants obtained against the heterocyclic substituent constants reported in the literature. A good linear relationship was obtained and the reaction constant of N-acetyl H-acid was calculated to be 3.14.

• Bulletin of the Korean Chemical Society
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• 제26권4호
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• pp.619-628
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• 2005

We attempted to replace a benzopyran ring of 4-[(N-imidazol-2-ylmethyl)-4-chloroanilino]benzopyran, previously discovered as anti-angiogenic agent with antitumor activity, with pyranopyridines. The [3,2-c]-, [3,2-b]-, [2,3-c]-, and [2,3-b]-pyranopyridines with -(imidazol-2-ylmethyl)aniline moiety at the 4-position, were synthesized respectively, and evaluated for primary anti-angiogenic properties through primary cultured HUVEC tube formation assay. From this study, we found that the pyranopyridine ring, especially [3,2-b]- and [2,3-c]-isomer, can replace the benzopyran ring of the compound 1 and can be optimized through the introduction of substituents both on the pyranopyridine ring and the aniline moiety for the identification of a novel anti-angiogenic agent.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 하계학술대회 논문집 D
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• pp.1481-1483
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• 1998

we have investigated the effect of aromatic compounds and tree inception and growth in low density polyethylene, for AC voltage and Impulse voltage. 2kinds of aromatic compounds are selected. Each additive (m-cresol, aniline) was mixed in low density polyethylene. For AC voltage, 10wt% $\sim$ 15wt% m-cresol can be shown to be the effective inhibitor to tree initiation. But, For Impulse voltage, 10wt% $\sim$ 15wt% aniline is effective inhibitor to tree initiation.

• Toxicological Research
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• 제11권2호
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• pp.253-259
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• 1995

To investigate an effect of ethanol pretreatment on the bromobenzene metabolism, the brornobenzene (400 mg/kg body wt. i. p.) was given 3 times at intervals of one day to the male rats orally pretreated with 5% ethanol throughout 2 months. In the ethanol pretreated rats, liver injuries were not demonstrated on the basis of the liver weight per body weight, serum levels of alanine aminotransferase (ALT) activity and histopathologic findings. By the bromobenzene treatment, ethanol pretreated rats showed the more decreased levels of serum ALT and liver weight/body weight(%), and decreased degree of liver damage on histopathological observation than the control group. The ethanol pretreated rats showed the more increased activities of hepatic aniline hydroxylase, glutathione Stransf erase (GST) and the more decreased contents of glutathione than the control. Concomitantly the ethanol pretreated rats showed the more decreased contents of hepatic glutathione and increased activities of GST by the bromobenzene treatment. Above results indicate that ethanol pretreatment enhance the metabolizing ability of bromobenzene in rats.

• 한국식물병리학회지
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• 제11권2호
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• pp.101-106
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• 1995

Deep blue fluorescence of resorcin blue-stained callose was observed only in the potato leafroll virus (PLRV)-infected potato plants, but not in other potato viruses investigated. The plant sections stained with aniline blue showed non-specific fluorescence regardless of PLRV infection, which means that aniline blue is not suitable for the staining of callose induces by PLRV infection. The fluorescence of resorcin blue-stained callose was more easily detectable than autofluorescence by a direct fluorescence detection method because of its deep blue color. The lateral branch of lower leaves was turned out to be the best material for fluorescence observation of all plant parts tested. In comparison of diagnostic efficacy of this technique to enzyme-linked immunosorbent assay (ELISA), PLRV infected potato plants showed corresponding increment of the fluorescence of resorcin blue stained callose as absorption values in ELISA increased. In the future, the criteria measuring the fluorescence objectively are thought to be determined for the practical application to the diagnosis of potato leafroll disease.

• 대한화학회지
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• 제25권3호
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• pp.199-205
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• 1981

Aniline과 alcohol류에서 4-aminoalkylbenzene을 合性하여, 이것을 아세틸化, 니트로化, 加水分解하여 3-nitro-4-aminoalkylbenzene을 얻고 아미노기 이탈반응을 통해 3-nitroalkylbenzene을 合成하여 anthranilic acid와 반응시켜 7-alkyl-1-carboxyphenazine 유도체를 合成하였다. 生成物은 元素分析, IR, NMR 스펙트럼으로 確認하였다. 이들 誘導體들의 水溶液에 대한 表面張力을 測定하였고, 아울러 Gram 陽性菌, Gram 陰性菌, 眞性菌에 대한 抗菌性을 調査하였다. 試驗結果 alkyl기가 치환된 phenazine 誘導體의 抗菌性은 alkyl기가 없는 1-carboxyphenazine 보다 强한 것으로 나타났다.

• Journal of Photoscience
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• 제6권4호
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• pp.159-163
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• 1999

The fluorescence quenching of 2-phenyl-5-(4-biphenylyl)-1,3,4-oxadiazole (PBD) and 1,4-di-[2-(5-phenyloxazolyl)]-benzene (POPOP) by aniline has been carried out in different solvent mixtures of dioxane and acetonitrile at room temperature. The quenching is found to be appreciable and a positive deviation from linearity was observed in the Stern-Volmer plot in all the solvent mixtures. Various rate constants for the quenching processes have been determined using a modified Stern-Volmer equation. From the positive deviations of linear Stern-Volmer plots and the dependence of rate constants on the polarity of the solvents, it has been concluded that both static and dynamic quenching processes are responsible for the observed positive deviation in the Stern-Volmer plot.