• The Korean Journal of Community Living Science
• /
• v.14 no.2
• /
• pp.41-47
• /
• 2003

To investigate the effects of hot water soluble extract from Angelicae Gigantis Radix on lipid metabolism and antioxidant defense system in rats fed hypercholesterol diet, Sprague-Dawley male rats were fed either hypercholesterol diet with water or hot water soluble extract from Angelicae Gigantis Radix. Hypercholesterol diet contained 18 % beeftallow and 5 % cholesterol. After 4 weeks of experimental periods serum and liver obtained. The level of serum lipid and the activities of GOT and GPT was measured. The level of lipid and TBARS and the activity of GSH-Px was measured also. The results obtained were: 1) Food intake in the experimental group supplied hot water soluble extract from Angelicae Gigantis Radix was low significantly. 2) In the experimental group supplied hot water soluble extract from Angelicae Gigantis Radix of serum total lipid and total cholesterol was significantly low. 3) Serum GOT activity was significantly low in the experimental group supplied hotwater soluble extract from Angelicae Gigantis Radix. There was no difference of serum GPT activity between control and experimental group supplied hot water soluble extract from angelical Gigantis Radix. 4) There was no difference of lipid composition, TBARS level and GSH-px activity in liver between control and experimental group. The result of this study indicates that the hot water soluble extract from Angelicae Gigantis Radix was effective in decreasing the food intake of the experimental animals in the hypercholesterol diet and also effective in decreasing the levels of serum total lipid, total cholesterol and GOT activity. However it was not effective to change the level of lipid, TBARS and GSH-Px activity of liver.

• Herbal Formula Science
• /
• v.15 no.2
• /
• pp.1-8
• /
• 2007

The source of Gwibitang(歸脾湯) is the book of Jesaebang(濟生方), The formulae is excluded Angelicae gigantis radix(當歸) and Polygalae radis(遠志) in the Jesaebang(濟生方), Jn the Guch iryuyo(口齒類要), Jeongcheryuyo(正體類要) and Gyojubuinyangbang(校註婦人良方), has been bec ame White Pria cocos Wolf(白茯笭) instead of Hoelen cum Pini Radix(白茯神), and is followed constitution of Uihagypmun(醫學入門) in the Donguibogam(東醫寶鑑). Basic formulae of Gwibitang(歸脾湯) consist of Sanjointang(酸棗仁湯), Sagunjatang(四君子湯). Hwanggitang, Danggwibohyeoltang(當歸補血湯), a kind of Jeongjihwan(定志丸類), a kind of Chongmyeongtang(聰明湯類). To deficiency of the heart and spleen, apply Sanjointang(酸棗 仁場), a kind of Jeongjihwan(定志丸), Sagunjatang(四君子湯) and Hwanggitang. To insufficiency of the spleen-gi(脾氣), apply Sagunjatang(四君子湯), Hwanggitang and a kind of Jeonssiigongsan(定志小丸). To deficiency of blood, apply Danggwibohyeoltang(當歸補血湯). Gwibitang(歸脾湯) is used for a mnesia and severe palpitation as a result of deficiency of the heart and spleen and deficiency of both gi(氣) and blood(血).